检索结果-南通市图书馆

Programmed cell death-1 inhibitor-related sclerosing cholangitis:A systematic review

World Journal of Gastroenterology 2020年第3期26卷 353-365页

作者： Takumi Onoyama Yohei Takeda Taro Yamashita Wataru Hamamoto Yuri Sakamoto Hiroki Koda Soichiro Kawata kazuya Matsumoto Hajime Isomoto Division of Medicine and Clinical Science Department of Multidisciplinary Internal MedicineFaculty of MedicineTottori UniversityTottori prefecture 683-8504Japan Internal Medicine Irisawa Medical ClinicShimane prefecture 690-0025Japan

BACKGROUND Programmed cell death-1(PD-1)inhibitor has been indicated for many types of ***,these inhibitors also cause immune-related adverse *** disorder is a phenotype of immune-related adverse event affecting 0%–4.5%of patients treated with PD-1 *** studies have reported PD-1 inhibitor-related sclerosing cholangitis(SC);however,the associated clinical and pathological features are *** To evaluate the clinical and pathological features of PD-1 inhibitor-related SC through a systematic review of the *** The review,conducted using electronic databases in PubMed,was restricted to the period from January 2014 to September 2019 and focused on case reports/series on PD-1 inhibitor-related SC published in *** scanned the references of the selected literature to identify any further relevant *** cases previously studied by us,including three that have not yet been published,were included in this *** Thirty-one PD-1 inhibitor-related SC cases were *** age of patients was 67 years(range,43–89),with a male to female ratio of 21:*** main disease requiring PD-1 inhibitor treatment was non-small cell lung *** that caused PD-1 inhibitor-related SC were nivolumab(19 cases),pembrolizumab(10 cases),avelumab(1 case),and durvalumab(1 case).The median number of cycles until PD-1 inhibitor-related SC onset was 5.5(range,1–27).Abdominal pain or discomfort(35.5%,11/31)was the most frequent *** serum tests identified liver dysfunction with a notable increase in biliary tract enzymes relative to hepatic enzymes,and a normal level of serum immunoglobulin *** dilation without obstruction(76.9%,20/26),diffuse hypertrophy of the extrahepatic biliary tract(90.5%,19/21),and multiple strictures of the intrahepatic biliary tract(30.4%,7/23)were *** 11/23(47.8%)cases,pathological examination indicated that CD8+T cells were the dominant inflammatory cells i

关键词： Nivolumab Pembrolizumab Avelumab Durvalumab Atezolizumab Programmed cell death-1 inhibitor Immune-related adverse events Cholangitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modifying oxygen tension affects bone marrow stromal cell osteogenesis for regenerative medicine

引用

World Journal of Stem Cells 2017年第7期9卷 98-106页

作者： Yusuke Inagaki Manabu Akahane Takamasa Shimizu kazuya Inoue Takuya Egawa Tsutomu Kira Munehiro Ogawa Kenji Kawate Yasuhito Tanaka Department of Orthopedic Surgery Nara Medical University Department of Public Health Health Management and PolicyNara Medical UniversityFaculty of Medicine Departments of Artificial Joint and Regenerative Medicine for Bone and Cartilage Nara Medical University

AIM To establish a hypoxic environment for promoting osteogenesis in rat marrow stromal cells(MSCs) using osteogenic matrix cell sheets(OMCSs).METHODS Rat MSCs were cultured in osteogenic media under one of four varying oxygen conditions: Normoxia(21% O_2) for 14 d(NN), normoxia for 7 d followed by hypoxia(5% O_2) for 7 d(NH), hypoxia for 7 d followed by normoxia for 7 d(HN), or hypoxia for 14 d(HH). Osteogenesis was evaluated by observing changes in cell morphology and calcium deposition, and by measuring osteocalcin secretion(ELISA) and calcium content. In vivo syngeneic transplantation using OMCSs and β-tricalcium phosphate discs, preconditioned under NN or HN conditions, was also evaluated by histology, calcium content measurements,and real-time quantitative *** In the NN and HN groups, differentiated, cuboidal-shaped cells were readily observed, along with calcium deposits. In the HN group, the levels of secreted osteocalcin increased rapidly from day 10 as compared with the other groups, and plateaued at day 12(P < 0.05). At day 14, the HN group showed the highest amount of calcium deposition. In vivo, the HN group showed histologically prominent new bone formation, increased calcium deposition, and higher collagen type Ⅰ?messenger RNA expression as compared with the NN *** The results of this study indicate that modifying oxygen tension is an effective method to enhance the osteogenic ability of MSCs used for OMCSs.

关键词： Hypoxia Osteogenesis Tissue engineering Marrow stromal cells Regenerative medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Helicobacter pylori infection and liver diseases: Epidemiology and insights into pathogenesis

引用

World Journal of Gastroenterology 2018年第32期24卷 3617-3625页

作者： kazuya Okushin Takeya Tsutsumi Kazuhiko Ikeuchi Akira Kado Kenichiro Enooku Hidetaka Fujinaga Kyoji Moriya Hiroshi Yotsuyanagi Kazuhiko Koike Department of Gastroenterology Graduate School of Medicine The University of Tokyo Department of Infection Control and Prevention Graduate School of Medicine The University of Tokyo Division of Infectious Diseases Advanced Clinical Research Center Institute of Medical Science The University of Tokyo Department of Infectious Diseases The University of Tokyo

Both Helicobacter pylori(H. pylori) infection and liver diseases, including nonalcoholic fatty liver disease(NAFLD), viral hepatitis, and hepatocellular carcinoma(HCC), have high prevalences worldwide, and the relationship between H. pylori infection and liver disease has been discussed for many years. Although positive correlations between H. pylori and NAFLD have been identified in some clinical and experimental studies, nega-tive correlations have also been obtained in high-quality clinical studies. Associations between H. pylori and the pathogenesis of chronic viral hepatitis, mainly disease progression with fibrosis, have also been suggested in some clinical studies. Concerning HCC, a possible role for H. pylori in hepatocarcinogenesis has been identified since H. pylori genes have frequently been detected in resected HCC specimens. However, no study hasrevealed the direct involvement of H. pylori in promoting the development of HCC. Although findings regarding the correlations between H. pylori and liver disease pathogenesis have been accumulating, the existing data do not completely lead to an unequivocal conclusion. Further high-quality clinical and experimental analyses are necessary to evaluate the efficacy of H. pylori eradication in ameliorating the histopathological changes observed in each liver disease.

关键词： Helicobacter pylori Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Hepatitis C virus Hepatitis B virus Viral hepatitis Hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of the preoperative usefulness of the pathological diagnosis of pancreatic diseases

引用

World Journal of Gastrointestinal Oncology 2016年第9期8卷 656-662页

作者： kazuya Matsumoto Yohei Takeda Takumi Onoyama Soichiro Kawata Hiroki Kurumi Masaru Ueki Norimasa Miura Hajime Isomoto Department of Gastroenterology Tottori University Hospital Department of Next Generation Advanced Medical Promotion Center Tottori University Hospital Division of Pharmacotherapeutics Department of Pathophysiological and Therapeutic ScienceFaculty of MedicineTottori University

Pancreatic cancer is the fifth leading cause of cancer death and has the lowest survival rate of any solid *** ultrasound-guided fine-needle aspiration biopsy(EUS-FNA) is currently capable of providing a cytopathological diagnosis of pancreatic malignancies with a higher diagnostic power,with a sensitivity and specificity of 85%-89% and 98%-99%,compared to pancreatic juice cytology(PJC),whose sensitivity and specificity are only 33.3%-93% and 83.3%-100%.However,EUS-FNA is not effective in the cases of carcinoma in situ and minimally invasive carcinoma because both are undetectable by endoscopic ultrasonography,although PJC is able to detect *** for the frequency of complications such as post endoscopic retrograde cholangiopancreatography pancreatitis,EUS-FNA is safer than *** diagnose pancreatic cancer appropriately,it is necessary for us to master both procedures so that we can select the best methods of sampling tissues while considering the patient's safety and condition.

关键词： Endoscopic ultrasound-guided fine-needle aspiration biopsy Cytology Pathology Pancreatic juice cytology Pancreatic cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inflammation-based factors and prognosis in patients with colorectal cancer

引用

World Journal of Gastrointestinal Oncology 2015年第8期7卷 111-117页

作者： Kiyoshi Maeda Masatusne Shibutani Hiroshi Otani Hisashi Nagahara Tetsuro Ikeya Yasuhito Iseki Hiroaki Tanaka kazuya Muguruma Kosei Hirakawa Department of Surgical Oncology Osaka City University Graduate School of MedicineOsaka 545-8585 Japan

Several parameters for predicting survival in patients with colorectal cancer have been identified, including the performance status, age, gender and tumor-nodemetastasis(TNM) stage. Although the TNM stage is important and useful for predicting the prognosis and determining the appropriate treatment, it is well known that the survival time varies widely, even in patients with the same stage of disease. Therefore, the identification of new parameters capable of more precisely predicting patient survival is needed to help select the optimal treatment, especially in patients in the advanced stage of disease. Although the TNM stage reflects the tumor characteristics, cancer progression and survival are not determined solely based on the local characteristics of the tumor, but also the host systemic immune/inflammatory response. Therefore, using a combination of parameters that reflect both tumor characteristics and the host systemic inflammatory status is thought to be important for accurately predicting patient survival.

关键词： Colorectal cancer Platelet-to-lymphocyteratio Prognosis Glasgow Prognostic Score C-reactiveprotein Neutrophil-to-lymphocyte ratio Inflammationbasedfactor Nutritional Prognostic Index

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endoscopic ultrasound-guided fine-needle aspiration biopsy-Recent topics and technical tips

引用

World Journal of Clinical Cases 2019年第14期7卷 1775-1783页

作者： kazuya Matsumoto Yohei Takeda Takumi Onoyama Soichiro Kawata Hiroki Kurumi Hiroki Koda Taro Yamashita Hajime Isomoto Division of Internal Medicine Irisawa Medical ClinicMatsue 690-0025Japan Department of Multidisciplinary Internal Medicine Tottori UniversityYonago 683-8504Japan

Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA) is a useful procedure that enables reliable pathological diagnoses of pancreatobiliary diseases, subepithelial lesions, and swollen lymph nodes. In recent years, a pathological diagnosis based on EUS-FNA has made it possible to provide accurate treatment methods not only in these fields, but also in respiratory organs and otorhinolaryngology. This review discusses the latest topics pertaining to EUS-FNA as well as procedural tips.

关键词： Endoscopic ultrasound-guided fine-needle aspiration biopsy Cytology Pathology Pancreatobiliary diseases Subepithelial lesions Lymph nodes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Space Robotics for Orbital Operation and Surface Exploration

Space Robotics for Orbital Operation and Surface Exploration

引用

中国空间科学学会第七次学术年会

作者： kazuya Yoshida Tohoku University Japan

＜正＞In this talk,several topics around space robotics research are *** fields of space robots are broad,but roughly divided into two regions;orbital operation and surface *** for the orbital operation,free-flying robots have received increased *** idea to conduct servicing missions onto existing satellites has been discussed since 80’s. However,the opportunity of in-flight demonstration of such technology is *** well-known examples are ETS-Ⅶmission（Orihime ＆ Hikoboshi） in Japan,1997-1999[1]and Orbital Express,U.S.A.,*** both missions,autonomous rendezvous/docking and manipulator operation for looking around the spacecraft surface,exchanging on-board components, and transferring liquid fuel are *** both missions,soft docking and manipulator berthing experiments were conducted with a stabilized （cooperative） ***,in practical cases,unstabilized （non-cooperative） targets must be *** this talk,technical issues for future challenges are discussed from the viewpoint of dynamics and control of free-floating systems[2].

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Genetic Diversity and Structure in Japanese Populations of the Osprey (<i>Pandion haliaetus</i>), Based on mtDNA

引用

Open Journal of Genetics 2021年第3期11卷 42-55页

作者： kazuya Nagai Takayuki Sakakibara Atsuki Azuma Faculty of Agriculture Iwate University Iwate Japan Research and Education Centre for Natural Sciences Keio University Kanagawa Japan Graduate School of Agriculture Hokkaido University Hokkaido Japan Civil Engineering & Eco-technology Consultants Co. Ltd. Tokyo Japan

Osprey is a type of bird of prey that lives almost all over the world. In Japan, it is designated as a near-threatened species because it has less than 1000 individuals. In recent years, it inhabits more inland than in coastal areas. In this study, we conducted a population genetic analysis focusing on what kind of genetic structure Japanese Osprey retains and whether there are differences between coastal and inland populations. We also performed genetic diversity assessments. We sequenced about 2.3 kb of mtDNA for 27 individuals in Japan, and phylogenetic analysis, network analysis, neutrality test and mismatch distribution analysis were performed. Eighteen haplotypes were detected in 27 individuals, indicating that genetic diversity was sufficiently high. Both unique and common haplotypes were detected between inland and coastal populations, suggesting gene flow between the two populations. Phylogenetic analysis results show no genetic differentiation in the Japanese Osprey population. From the results of network analysis, neutrality test and mismatch distribution analysis, it was inferred that the Japanese Osprey had a population expansion in the past. This study indicated that the dispersion of Japanese Osprey was random and there were no restrictions on the breeding area. The information presented here can be used towards implementing future conservation actions.

关键词： Genetic Diversity Osprey MtDNA Phylogeography Cytochrome b Control Region

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Visualization of High-Speed Impact of Penetrator into Icy Target

引用

Journal of Flow Control, Measurement & Visualization 2016年第2期4卷 56-69页

作者： Kojiro Suzuki kazuya Namba Yasumasa Watanabe Department of Advanced Energy Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan Department of Aeronautics and Astronautics Graduate School of Engineering The University of Tokyo Tokyo Japan

For application to exploration under the surface of icy objects in the solar system, the penetration of an impact probe into an icy target was experimentally simulated by using the ballistic range. Slender projectiles with a cylindrical body and various nose shapes were tested at the impact velocity 130 - 420 m/s. The motion of the penetrator, fragmentation of ice and crater forming were observed by the high-speed camera. It revealed that the crown-shaped ejection was made for a short time after the impact and then the outward normal jet-like stream of ice pieces continued for much longer time. The concave shape of the crater was successfully visualized by pouring the plaster into it. The two-stage structure, the pit and the spall, was clearly confirmed. The rim was not formed around the crater. Observation of the crater surface and the ice around the trace of the penetrator shows that both crushing into smaller ice pieces and recompression into ice blocks are caused by the forward motion of the penetrator. In case of a body with a flow-through duct, ice pieces entering the inlet at the nose tip were ejected from the tail, resulting in relaxation of the impact force. The correlation of the penetration distance and the crater diameter with the impact velocity was investigated.

关键词： Penetrator Ice Impact Crater Forming Ballistic Range High-Speed Camera

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characteristics Improvement of PEDOT:PSS Transparent Conductive Film Prepared by Ink-Jet Printing

引用

Advances in Materials Physics and Chemistry 2016年第8期6卷 239-247页

作者： Atsushi Nitta kazuya Kawahara Kohei Miyata Department of Electronic Control Engineering National Institute of Technology Kagoshima CollegeKirishima Japan Advanced Mechanical and Electronic Systems Engineering National Institute of Technology Kagoshima College Kirishima Japan

Recently, a high-performance and low-priced transparent conductive film has been expected to be developed because flexible devices produced using organic materials have been actively studied. An indium tin oxide (ITO) thin film, which has been generally used as a material for a transparent conductive film, has problems, such as fragility to bending stress and depletion of the resource. The present study used poly(3, 4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT:PSS), an organic electroconductive material, and examined the improvement in the resistance value and visible light transmittance of a transparent conductive film produced using the ink-jet method. In previous studies, we reported that, to improve the resistance value and visible light transmittance of a thin film, it was effective to clean the film substrate with ultraviolet/ozone (UV/O3) treatment, anneal the film after it was deposited on the substance, and dip the annealed film into a polar solvent. Focusing on the thin film processing between printing operations, the present study improved resistance value and visible light transmittance by examining both the application methods of a polar solvent and the annealing time between printing operations. As a result, the resistance value and visible light transmittance of a PEDOT:PSS thin film were 390.4 Ω and 86.6%, respectively. This film was obtained by applying a polar solvent and performing annealing for 30 min between printing operations. The printing was performed three times.

关键词： PEDOT:PSS Ink-Jet Printing Transparent Conductive Film Flexible Devices

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：