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Pancreaticoduodenal artery aneurysm associated with coeliac artery occlusion from an aortic intramural hematoma

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World Journal of Gastroenterology 2016年第16期22卷 4259-4263页

作者： Akihiko Sakatani Yoshinori Doi Toshiaki Kitayama Takaaki Matsuda Yasutaka Sasai Naohiro Nishida Megumi Sakamoto Naoto Uenoyama kazuo kinoshita Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine Department of Gastroenterology Otemae Hospital Department of Radiology Otemae Hospital

Pancreaticoduodenal artery aneurysms are a rare type of visceral artery aneurysm, whose rupture is associated with high mortality. These aneurysms are of particular interest because local haemodynamic change caused by coeliac artery obstruction plays an important role in their development. However, the pathophysiological mechanism of coeliac artery obstruction is not completely understood. Pressure from the median arcuate ligament is most frequently reported cause. Although it is well-known that stenosis or occlusion of the visceral vessels may be caused by aortic syndrome, reports of pancreaticoduodenal artery aneurysm associated with coeliac artery occlusion due to aortic syndrome are extremely rare. Our case indicates a new aetiology for a pancreaticoduodenal artery aneurysm and demonstrates the rapid deterioration of the patient affected.

关键词： Pancreaticoduodenal artery Coeliac artery Visceral artery aneurysm Aortic dissection

A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations

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A novel mouse model of hepatocarcinogenesis triggered by AID...

免疫球蛋白单个转换区在类别转换时基因突变的研究

21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology

作者： Atsushi Takai Takae Toyoshima Munehiro Uemura Youko Niwa Hiroyuki Marusawa Hiroshi Hiai Tasuku Honjo Tsutomu Chiba kazuo kinoshita Shiga Medical Center Research Institute Moriyamajapan Shiga Medical Center Research Institute MoriyamaJapan

＜正＞Activation-induced cytidine deaminase（AID）,the only enzyme that is known to be able to induce mutations in the human genome,is required for somatic hypermutation and class-switch recombination in B ***, we demonstrated that AID is implicated in the pathogenesis of human cancers including hepatitis C virus（HCV）-induced human hepatocellular carcinoma （HCC）.In the present study,we established a new AID-transgenic

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中国免疫学杂志 2005年第11期21卷 822-825页

作者：田生和木下和生本庶佑武汉生物制品研究所武汉430060 日本京都大学医学部化学系

目的:观察在免疫球蛋白的类别转换(CSR)过程中单个转换区(S区)的基因重组情况。方法:通过构建包含单个S区(FS-α2)基因序列的人工载体,使目的基因位于四环素敏感的启动子下游,并转染到一株能够在体外诱导CSR反应的B淋巴细胞系,经细胞因... 详细信息

目的:观察在免疫球蛋白的类别转换(CSR)过程中单个转换区(S区)的基因重组情况。方法:通过构建包含单个S区(FS-α2)基因序列的人工载体,使目的基因位于四环素敏感的启动子下游,并转染到一株能够在体外诱导CSR反应的B淋巴细胞系,经细胞因子诱导CSR后,用PCR扩增目的基因,再进行序列分析以观察此S区基因的变异及其依赖的因素。结果:在细胞因子的诱导下,单个S区基因在CSR时可以出现基因变异包括点突变、序列缺失及序列插入等变化,并且当抑制上游启动子时,S区基因变异显著下降,表明S区基因重组受控于基因转录。结论:CSR重组机制在单个S区中同样发挥作用。

关键词：免疫球蛋白类别转换转换区突变

5-fluorouracil,Methotrexate,Leucovorin,CDDP and Epirubicin（FEPMTX）:A Wide-Spectrum Regimen of Salvage Chemotherapyfor High- Grade Advanced Gastric Cancer

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5-fluorouracil,Methotrexate,Leucovorin,CDDP and Epirubicin（...

PREPARATION AND CHARACTERIZATION OF SHISH-KEBAB TYPE LIQUID CRYSTALLINE POLY(p-PHENYLENEVINYLENE)

2000全国肿瘤学术大会

作者： kazuo kinoshita Yutaka Yonemura Toshiharu Sawa Tatsukazu Miyata Hiroshi Sakuma Nobuo Matsuki Sigehiro Tanaka Sachio Fushida Takashi Fujimura Young Jae Mok Byung Sik Kim Jong In Lee Dong Wook Choi Young Jin Song Doo Hyun Yang Sung Joon Kwon Itsuo Miyazaki Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Korea University Hospital M.D. Ulsan University Hospital M.D. Korean Cancer Center Hospital M.D. Korean Cancer Center Hospital M.D. Chungbuk National University Hospital M.D. Chonbuk National University Hospital M.D. Hanyang University Hospital Korea M.D. Department of Surgery Ⅱ School of medicine Kanazawa University13-1 Takara-machiKanazawaJapan M.D.

＜正＞Twenty-one patients with primary high-grade advanced gastric cancer in whom the presence of stage ? was con- firmed by preoperative diagnostic imaging,were treated with a wide-spectrum regimen,designated as FEPMTX therapy to establish an effective salvage *** therapy consisted of 5-fluorouracil（5-FU）and the triple biochemical modulators;methotrexate（MTX）,calcium leucovorin（LV）,cisplatin（CDDP）,and in addition of epiru- bicin（EPI）.The schedule comprised 3 days continuous administration of 5-FU（350 mg/m2/day）and MTX（35 mg/ m2）on day 1,LV（30 mg/m2）on the day 2,LV（30 mg/m2）and CDDP（30 mg/m2）and EPI（20 mg/m2）on day *** treatment was performed two or more courses with 2 weeks interval in *** partial responses（PR）, five no changes（NC）and five progressive diseases（PD）were obtained,and the response rate was 52%.Ten patients （PR 7,NC 2,PD 1）were received gastrectomy（resectability rate 48%）.The survival in all cases resulted in median survival of 184 days and one-year survival rate of 23%.While there is no significant difference insurvival between the cases with or without the resection of the primary lesion,the survival of responders was significantly longer than that of non-responders（median survival time;responder 356days,non-responder 152days）.Adverse effects such as myelo- suppression and anorexia and fatigue sometimes occurred,but were mild and all the patients well *** therapy is thought to be an effective regimen for neoadjuvant chemotherapy with longer survival and little toxic for patients with stage?gastric cancer.

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Chinese Journal of Polymer Science 2006年第4期24卷 353-361页

作者： kazuo Akagi 郑世军 Institute of Materials Science University of Tsukuba Tsukuba 305-8573Japan College of the Material Science and Engineering Zhengzhou University Zhengzhou 450052 China

Novel shish-kebab type liquid crystalline poly（p-phenylenevinylene） derivatives were synthesized by Stille coupling reaction from 2,5-bis[（4-n-alkoxyl）benzoyloxy]1,4-dibromobenzene （monomer l） and 1,2-bis（tributylstannyl） ethylene （monomer 2）. The polymers with alkoxy groups are soluble in common organic solvents and exhibit blue fluorescence. Both the cast film and the annealed film have large red-shifts in fluorescence spectra and show yellow fluorescence. The polymers with CN and NO2 groups show poor solubility and green fluorescence. All the polymers possess liquid crystalline smectic phases. The melting point （Tm） of the polymers decreases when the length of the alkoxy tails of the mesogenic units increases. The polymers are easily aligned under a magnetic field of 10 Tesla. It is found that the conjugated backbone and LC side chain are aligned perpendicular and parallel to the magnetic field, respectively. The polymers show optical dichroism in fluorescence spectra, suggesting that they are available for advance materials with linear optical polarization.

关键词： Liquid crystalline conjugated polymers Poly(p-phenylenevinylene) Shish-kebab Linearly polarized dichroism Fluorescence.

Threshold dynamics of reaction-diffusion partial differential equations model of Ebola virus disease

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International Journal of Biomathematics 2018年第8期11卷 235-264页

作者： kazuo Yamazaki University of Rochester Department of Mathematics Rochester NY 14627 USA

We study the reaction-diffusion Ebola PDE model that consists of equations that govern the evolution of susceptible, in fee ted, recovered and deceased human individuals, as well as Ebola virus pathogens in the environment, with diffusive terms in all except the equation of the deceased human individuals. Under the setting of a spatial domain that is bounded, we prove the global well-posedness of the system;in contrast to the previous work on similar models such as cholera, avian influenza, malaria and dengue fever, diffusion coefficients may be different. Moreover, we derive its basic reproduction number, and under the condition that the diffusion coefficients of the susceptible and infected hosts are same, we prove the global stability of the disease-free-equilibrium, and uniform persistence in cases when the basic reproduction number lies beneath and above one, respectively. Again, we do not require that the diffusion coefficients of the recovered hosts be the same as the diffusion coefficients of the susceptible and infected hosts, in contrast to previous work on other models of infectious diseases. Another technical difficulty in our model is that the solution semiflow is not compact due to the lack of diffusion in the equation of the deceased human individuals;we overcome this difficulty using functional analysis techniques concerning Kura to wski measure of non-compactness.

关键词： Basic reproduction number Ebola persistence stability

Concept of Intelligent Mechanical Design for Autonomous Mobile Robots

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Journal of Bionic Engineering 2007年第4期4卷 217-226页

作者： Amir A. F Nassiraei kazuo Ishii Kyushu Institute of Technology Kitakyushu Fukuoka 808-0196 Japan

The concept of Intelligent Mechanical Design （IMD） is presented to show how a mechanical structure can be designed to affect robot controllability, simplification and task performance. Exploring this concept produces landmarks in the territory of mechanical robot design in the form of seven design principles. The design principles, which we call the Mecha-Telligence Principles （MTP）, provide guidance on how to design mechanics for autonomous mobile robots. These principles guide us to ask the right questions when investigating issues concerning self-controllable, reliable, feasible, and compatible mechanics for autonomous mobile robots. To show how MTP can be applied in the design process we propose a novel methodology, named as Mecha-Telligence Methodology （MTM）. Mechanical design by the proposed methodology is based on preference classification of the robot specification described by interaction of the robot with its environment and the physical parameters of the robot mechatronics. After defining new terms, we investigate the feasibility of the proposed methodology to the mechanical design of an autonomous mobile sewer inspection robot. In this industrial project we show how a passive-active intelligent moving mechanism can be designed using the MTM and employed in the field.

关键词： mechanical design intelligent autonomous robot mobile robot

A Switching Controller System for a Wheeled Mobile Robot

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Journal of Bionic Engineering 2007年第4期4卷 281-289页

作者： Masanori Sato Atushi Kanda kazuo Ishii Department of Brain Science and Engineering Kyushu Institute of Technology Kitakyushu 808-0196 Japan

A wheeled mobile mechanism with a passive and/or active linkage mechanism for rough terrain environment is developed and evaluated. The wheeled mobile mechanism which has high mobility in rough terrain needs sophisticated system to adapt various environments. We focus on the development of a switching controller system for wheeled mobile robots in rough terrain. This system consists of two sub-systems： an environment recognition system using link angles and an adaptive control system. In the environment recognition system, we introduce a Self-Organizing Map （SOM） for clustering link angles. In the adaptive controllers, we introduce neural networks to calculate the inverse model of the wheeled mobile robot. The environment recognition system can recognize the environment in which the robot travels, and the adjustable controllers are tuned by experimental results for each environment. The dual sub-system switching controller system is experimentally evaluated. The system recognizes its environment and adapts by switching the adjustable controllers. This system demonstrates superior performance to a well-tuned single PID controller.

关键词： mobile robot rough terrain neural network Self-Organizing Map

Creep-fatigue interaction properties of nickel-based superalloy 617

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Acta Metallurgica Sinica(English Letters) 2011年第2期24卷 125-131页

作者： kazuo KOBAYASHI Masao HAYAKAWA Megumi KIMURA National Institute for Materials Science (NIMS) Materials Reliability Center

High-temperature fatigue properties were investigated for a nickel-based superalloy 617 as a typical candidate material for high-temperature components using an advanced ultra super critical （A-USC） power plant. Creep-fatigue data obtained by strain-controlled tests at 700 ？ C was analyzed for the superalloy 617 focused on position of hold at peak strain in comparison with continuously cycled tests. The fatigue life was the shortest with the hold tensile strain wave, which showed mainly intergranular fracture appearance. The life was the longest with symmetrical triangular wave which fractured from the specimen surface, while the wave with the hold compressive strain showed partially intergranular fracture appearance and the life was middle in the both waves. In this study, it is discussed with the creep-fatigue interaction for the superalloy 617.

关键词： A-USC power plant Nickel-based superalloy Creep-fatigue interaction Fractography