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Proton Beam Therapy for Hepatocellular Carcinoma after the Fontan Procedure

Journal of Cancer Therapy 2021年第10期12卷 554-562页

作者： Haruko Numajiri Masashi Mizumoto Toshiyuki Okumura Nobuyoshi Fukumitsu Naoyuki Hasegawa kazunori ishige Kuniaki Fukuda Tomoko Ishizu Katsutoshi Tokushige Hideyuki Sakurai Department of Radiation Oncology Proton Medical Research Center University of Tsukuba Hospital Tsukuba Japan Department of Radiation Oncology Kobe Proton Center Kobe Japan Department of Gastroenterology University of Tsukuba Hospital Tsukuba Japan Department of Gastroenterology Kasumigaura Medical Center Tsuchiura Japan Department of Cardiology University of Tsukuba Hospital Tsukuba Japan Department of Internal Medicine Institute of Gastroenterology Tokyo Women’s Medical University Tokyo Japan

Background: Hepatocellular carcinoma (HCC) is more likely to occur in patients with a history of Fontan surgery, possibly due to long-term liver congestion. Proton beam therapy (PBT) may be effective for HCC that develops after Fontan surgery. Methods: Six lesions in 5 patients (3 females, 2 males) received PBT. The median age of the patients was 33 (range 21 - 42) years, and the median age at the time of the Fontan procedure was 6 (5 - 13) years. Four patients had multiple HCC at the time of PBT. The median tumor size was 57 (22 - 80) mm and 4 patients were classified as Child-Pugh B. Two patients received transcatheter arterial chemoembolization before PBT. The schedule of PBT was 66 Gy (RBE) in 10 fractions for 2 lesions, 72.6 Gy (RBE) in 22 fractions for 2 lesions, and 74 GyE (RBE) in 37 fractions for 2 lesions. Results: The median follow-up period was 31 (10 - 46) months, and the numbers of survivors, deaths from primary diseases, and deaths from other diseases were 3, 1, and 1, respectively. There were no local recurrences, one intrahepatic metastasis, one lung metastasis, and one intrathoracic metastasis. Conclusion: Although experiences on a small number of patients cannot conclude things, we believe that PBT can be a reasonable choice of radical treatment for HCC occurring after the Fontan procedure.

关键词： Radiotherapy Proton Beam Therapy Hepatocellular Carcinoma Fontan Pro-cedure

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Serum magnesium concentration in children with functional constipation treated with magnesium oxide

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World Journal of Gastroenterology 2011年第6期17卷 779-783页

作者： Maiko Tatsuki Reiko Miyazawa Takeshi Tomomasa Takashi ishige Tomoko Nakazawa Hirokazu Arakawa Department of Pediatrics Gunma University Graduate School of Medicine PAL Clinic 694 Tanakajima-machiIsesakiGunma 372-0802Japan

AIM:To determine whether hypermagnesemia recently reported in adult patients possibly develops in children with functional constipation taking daily magnesium ***:We enrolled 120 patients (57 male and 63 female) aged 1-14 years old (median:4.7 years) with functional constipation from 13 hospitals and two private *** patients fulfilled the Rome Ⅲ criteria for functional constipation and were treated with daily oral magnesium oxide for at least 1 *** median treatment dose was 600 (500-800) mg/*** were assessed by an interview and laboratory examination to determine possible *** magnesium concentration was also measured in sex-and agematched control subjects (n=38).RESULTS:In the constipation group,serum magnesium concentration [2.4 (2.3-2.5) mg/dL,median and interquartile range] was significantly greater than that of the control group [2.2 (2.0-2.2) mg/dL] (P < 0.001).The highest value was 3.2 mg/*** magnesium clearance was significantly increased in the constipation *** magnesium concentration in the constipation group decreased significantly with age (P < 0.01).There was no significant correlation between the serum level of magnesium and the duration of treatment with magnesium oxide or the daily *** of the patients had side effects associated with ***:Serum magnesium concentration increased significantly,but not critically,after daily treatment with magnesium oxide in constipated children with normal renal function.

关键词：治疗剂量氧化镁便秘血清浓度实验室检查中位数记者采访

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车辆技术研发最新进展

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国外铁道机车与动车 2022年第3期 14-17,20页

作者： [日]Makoto ishige 刘志荣(译) 不详

为提高铁路安全性,降低维护成本,提高运行速度以提升铁路服务,日本铁道综合技术研究所进行了相关研发。近半数的车辆研发工作集中在安全性方面,主要研究轮缘爬轨脱轨、防碰撞性评定等运行安全性的评定方法。为提高铁路的服务质量,开展... 详细信息

为提高铁路安全性,降低维护成本,提高运行速度以提升铁路服务,日本铁道综合技术研究所进行了相关研发。近半数的车辆研发工作集中在安全性方面,主要研究轮缘爬轨脱轨、防碰撞性评定等运行安全性的评定方法。为提高铁路的服务质量,开展了其他研发工作,通过减少振动、开发倾摆技术和降噪来提高乘坐舒适度。文章概述了防碰撞性评定现状及提高乘坐舒适性等方面的研发。

关键词：车辆防碰撞性乘坐舒适度

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Gender Differences in Frontal Activation While Perceiving Pathologically Thin Female Body Forms

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Journal of Behavioral and Brain Science 2011年第3期1卷 102-110页

作者： Toru Uehara Yoko ishige Masashi Suda Perminder Sachdev 不详

Brain mechanisms underlying body image disturbances are a focus of research in the realm of eating disorders, and functional imaging studies have revealed gender differences in the processing of body shape. In this study, using 16-channel near infrared spectroscopy, we investigated frontal lobe activation in 46 healthy university students during viewing of photographs of pathologically thin female forms, and compared gender differences in activation, and examined the correlations between the relative changes in cerebral blood volume, eating attitudes, and perceived feelings. Participants completed the Eating Attitudes Test (EAT26) and rated a visual analogue scale for anxiety/disgust. Significant gender differences in the pattern of activation were noted in the prefrontal region (predominantly right side, dorsolateral to ventral), with male participants showing greater and more widespread frontal activation. The total and subscale scores on EAT26 were significantly correlated with the frontal activation, and perceived feelings were significantly associated with increased prefrontal activation on the left side. Gender differences in frontal activation suggest differential expectations between men and women of pathologically thin female body forms. The study results suggest that anorexic psychopathology may be associated with abnormal right frontal activation while viewing thin bodies of others.

关键词： Body Image Anorexia Nervosa Prefrontal Cortex Eating Attitudes Near Infrared Spectroscopy

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Patient characteristics with high or low blood urea nitrogen in upper gastrointestinal bleeding

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World Journal of Gastroenterology 2015年第24期21卷 7500-7505页

作者： Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Yoshinori Shirai Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Naoki ishige Department of Gastroenterology National Hospital Organization Shimoshizu Hospital Department of Radiology National Hospital Organization Shimoshizu Hospital Yotsukaido City Department of Surgery National Hospital Organization Shimoshizu Hospital Department of Neurology National Hospital Organization Shimoshizu Hospital Department of Rheumatology National Hospital Organization Shimoshizu Hospital Department of Pediatrics National Hospital Organization Shimoshizu Hospital Department of Neurosurgery National Hospital Organization Shimoshizu Hospital

AIM: To examine characteristics of patients with blood urea nitrogen(BUN) levels higher and lower than the normal ***: Patient records between April 2011 and March 2014 were analyzed retrospectively. During this time, 3296 patients underwent upper endoscopy. In total, 50 male(69.2 ± 13.2 years) and 26 female(72.3 ± 10.2 years) patients were assessed. Patients were divided into two groups based on BUN levels: higher than the normal limit(21.0 mg/d L)(H) and lower thanthe normal limit(L). One-way analysis of variance was performed to reveal differences in the variables between the H and L groups. Fisher's exact test was used to compare the percentage of patients with gastric ulcer or gastric cancer in the H and L ***: White blood cell count was higher in the H group than in the L group(P = 0.0047). Hemoglobin level was lower in the H group than in the L group(P = 0.0307). Glycated hemoglobin was higher in the H group than in the L group(P = 0.0264). The percentage of patients with gastric ulcer was higher in the H group(P = 0.0002). The H group contained no patients with gastric ***: Patients with BUN ≥ 21 mg/d L might have more severe upper gastrointestinal bleeding.

关键词： Blood urea nitrogen Forrest classification Hemoglobin White blood cell count

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Laboratory test variables useful for distinguishing upper from lower gastrointestinal bleeding

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World Journal of Gastroenterology 2015年第20期21卷 6246-6251页

作者： Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Yoshinori Shirai Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Naoki ishige Department of Gastroenterology National Hospital Organization Shimoshizu Hospital Department of Radiology National Hospital Organization Shimoshizu Hospital Department of Surgery National Hospital Organization Shimoshizu Hospital Department of Neurology National Hospital Organization Shimoshizu Hospital Department of Rheumatology National Hospital Organization Shimoshizu Hospital Department of Pediatrics National Hospital Organization Shimoshizu Hospital Department of Neurosurgery National Hospital Organization Shimoshizu Hospital

AIM: To distinguish upper from lower gastrointestinal(GI) bleeding. METHODS: Patient records between April 2011 and March 2014 were analyzed retrospectively(3296 upper endoscopy, and 1520 colonoscopy). Seventysix patients had upper GI bleeding(Upper group) and 65 had lower GI bleeding(Lower group). Variables were compared between the groups using one-way analysis of variance. Logistic regression was performed to identify variables significantly associated with the diagnosis of upper vs lower GI bleeding. Receiveroperator characteristic(ROC) analysis was performed to determine the threshold value that could distinguish upper from lower GI bleeding. RESULTS: Hemoglobin(P = 0.023), total protein(P = 0.0002), and lactate dehydrogenase(P = 0.009) were significantly lower in the Upper group than in the Lower group. Blood urea nitrogen(BUN) was higher in the Upper group than in the Lower group(P = 0.0065). Logistic regression analysis revealed that BUN was most strongly associated with the diagnosis of upper vslower GI bleeding. ROC analysis revealed a threshold BUN value of 21.0 mg/d L, with a specificity of 93.0%.CONCLUSION: The threshold BUN value for distinguishing upper from lower GI bleeding was 21.0 mg/d L.

关键词： Logistic regression analysis Likelihoodanalysis Receiver-operator characteristic analysis Blood urine nitrogen Hemoglobin

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Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse

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World Journal of Gastroenterology 2007年第16期13卷 2289-2297页

作者： Miho Kato Atsushi ishige Naoko Anjiki Masahiro Yamamoto Yoshifumi Irie Mitsue Taniyama Ryoko Kibe Junichiro Oka Yoshimi Benno Kenji Watanabe Department of Kampo Medicine Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Faculty of Pharmaceutical Science Tokyo University of Science 264 Yamazaki Noda City Chiba 278-8519 Japan Japan Collection of Microorganisms Riken 2-1 Hirosawa Wako-shi Saitama 351-0198 Japan Department of Kampo Medicine Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Department of Kampo Medicine Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Pharmacology Research Department Tsumura Research Institute Research Division 3586 Yoshiwara Ami-machi Inashiki-gun Ibaraki 300-1192 Japan Pharmacology Research Department Tsumura Research Institute Research Division 3586 Yoshiwara Ami-machi Inashiki-gun Ibaraki 300-1192 Japan Japan Collection of Microorganisms Riken 2-1 Hirosawa Wako-shi Saitama 351-0198 Japan Faculty of Pharmaceutical Science Tokyo University of Science 264 Yamazaki Noda City Chiba 278-8519 Japan

AIM: To evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. METHODS: The multi-herbal medicine Juzentaihoto (JTX) was administered to five germ-free mice and regular mice for 2 wk. Among the results of the comprehensive gene chip analysis of the intestine and liver, we featured heat shock proteins (HSPs) 70 and 105 because their gene expression changed only in the presence of microflora. Real-time RT-PCR was performed to confirm the expression levels of these HSP genes. To determine whether JTX acts directly on the HSP genes, sodium arsenite (SA) was used to induce the heat shock proteins directly. To examine the change of the intestinal microflora with administration of JTX, the terminal restriction fragment polymorphism (T-RFLP) method was used. To identify the changed bacteria, DNA sequencing was performed. RESULTS: Heat shock protein gene expression,documented by gene chip and real-time RT-PCR, changed with the administration of JTX in the regular mice but not in the germ-free mice. JTX did not suppress the direct induction of the HSPs by SA. T-RFLP suggested that JTX decreased unculturable bacteria and increased Lactobacillus johnsoni. These data suggested that JTX changed the intestinal microflora which, in turn, changed HSP gene expression. CONCLUSION: Intestinal microflora affects multi-herbal product JTX on the gene expression in the gut and liver.

关键词：十全大补汤草药肝脏肠道热休克蛋白基因表达小鼠小肠菌群

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Hepatocyte selection medium eliminating induced pluripotent stem cells among primary human hepatocytes

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World Journal of Methodology 2015年第3期5卷 108-114页

作者： Minoru Tomizawa Fuminobu Shinozaki Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Naoki ishige Department of Gastroenterology National Hospital Organization Shimoshizu Hospital Department of Radiology National Hospital Organization Shimoshizu Hospital Department of Neurology National Hospital Organization Shimoshizu Hospital Department of Rheumatology National Hospital Organization Shimoshizu Hospital Department of Pediatrics National Hospital Organization Shimoshizu Hospital Department of Neurosurgery National Hospital Organization Shimoshizu Hospital

Hepatic insufficiency is a fatal liver disease with a significant decrease in functioning hepatocytes. If hepatocytes could be generated from human induced pluripotent stem(hi PS) cells and transplanted into patients with hepatic insufficiency, the disease may become curable. However, a major limitation to this therapeutic strategy is due to the tumorigenicity of hi PS cells and their ability to form cancer. Current methods for eliminating unwanted hi PS cells use genetic manipulation or reagents that are potentially hazardous for hepatocytes; therefore, revised methods are necessary and anticipated. Glucose and arginine are essential cell culture medium ingredients for the survival of most cells, including hi PS cells. However, hepatocytes can produce its own glucose and arginine through galactokinase and ornithine transcarbamylase, respectively. Therefore, it was hypothesized that unwanted hi PS cells could be eliminated in a medium without glucose and arginine, and supplemented with galactose and ornithine instead. This modified medium has been established as hepatocyte selection medium(HSM). So far, attempts to generate a pure colony of mature hepatocytes from hi PS cells have not been successful. After establishment of co-culture in HSM,primary human hepatocytes survive while hi PS cells die within three days. Our latest results regarding a modification of HSM will be introduced in this manuscript.

关键词： Ornithine transcarbamylase Galactokinase Arginine Galactose Urea cycle

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