Serum magnesium concentration in children with functional constipation treated with magnesium oxide

作     者：Maiko Tatsuki Reiko Miyazawa Takeshi Tomomasa Takashi Ishige Tomoko Nakazawa Hirokazu Arakawa 

作者机构：Department of PediatricsGunma University Graduate School of Medicine PAL Clinic694 Tanakajima-machiIsesakiGunma 372-0802Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第6期

页      面：779-783页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Children Constipation Hypermagnesemia Magnesium oxide Renal dysfunction 

摘      要：AIM:To determine whether hypermagnesemia recently reported in adult patients possibly develops in children with functional constipation taking daily magnesium ***:We enrolled 120 patients (57 male and 63 female) aged 1-14 years old (median:4.7 years) with functional constipation from 13 hospitals and two private *** patients fulfilled the Rome Ⅲ criteria for functional constipation and were treated with daily oral magnesium oxide for at least 1 *** median treatment dose was 600 (500-800) mg/*** were assessed by an interview and laboratory examination to determine possible *** magnesium concentration was also measured in sex-and agematched control subjects (n=38).RESULTS:In the constipation group,serum magnesium concentration [2.4 (2.3-2.5) mg/dL,median and interquartile range] was significantly greater than that of the control group [2.2 (2.0-2.2) mg/dL] (P 0.001).The highest value was 3.2 mg/*** magnesium clearance was significantly increased in the constipation *** magnesium concentration in the constipation group decreased significantly with age (P 0.01).There was no significant correlation between the serum level of magnesium and the duration of treatment with magnesium oxide or the daily *** of the patients had side effects associated with ***:Serum magnesium concentration increased significantly,but not critically,after daily treatment with magnesium oxide in constipated children with normal renal function.