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Gastroduodenal ulcer bleeding in elderly patients on low dose aspirin therapy

World Journal of Gastroenterology 2018年第34期24卷 3908-3918页

作者： Koh Fukushi Keiichi Tominaga kazunori nagashima Akira Kanamori Naoya Izawa Mimari Kanazawa Takako Sasai Hideyuki Hiraishi Department of Gastroenterology Dokkyo Medical University Department of General Internal Medicine 2 Kawasaki Medical School General Medical Center

AIM To determine the clinical characteristics of elderly patients of hemorrhagic gastroduodenal ulcer on low-dose aspirin(LDA)*** A total of 1105 patients with hemorrhagic gastroduodenal ulcer treated in our hospital between January 2000 and March 2016 were grouped by age and drugs used,and these groups were compared in several *** groups were compared in terms of length of hospital stay,presence/absence of hemoglobin(Hb)decrease,presence/absence of blood transfusion,Forrest Ⅰ,percentage of Helicobacter pylori infection,presence/absence of underlying disease,and percentage of severe *** The percentage of blood transfusion(62.6%vs 47.7%,P<0.001),Hb decrease(53.8% vs 40.8%,P<0.001),and the length of hospital stay(23.5 d vs 16.7 d,P<0.001)were significantly greater in those on drug *** percentage of blood transfusion(65.3%vs 47.8%,P<0.001),Hb decrease(54.2%vs 42.1%,P<0.001),and length of hospital stay(23.3 d vs 17.5 d,P<0.001)were significantly greater in the *** comparison with the LDA monotherapy group,the percentage of severe cases was significantly higher in the LDA combination therapy group when elderly patients were concerned(16.1%vs34.0%,P=0.030).Meanwhile,among those on LDA monotherapy,there was no significant difference between elderly and non-elderly(16.1%vs 16.0%,P=0.985).CONCLUSION A combination of LDA with antithrombotic drugs or nonsteroidal anti-inflammatory drugs(NSAIDs)contributes to *** advanced age is not an aggravating factor when LDA monotherapy is used.

关键词： Hemorrhagic gastroduodenal ulcer Low-dose aspirin Antithrombotic drugs Elderly patients Proton pump inhibitor

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Hydrodynamic performance of spouted beds with different types of draft tubes

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Particuology 2013年第5期11卷 475-482页

作者： Hiroshi nagashima Kazumi Suzukawa Toshifumi Ishikura Department of Chemical Engineering Fukuoka University19-1Nanakuma 8-chomeJonan-kuFukuoka 814-0180Japan

Hydrodynamic performance of spouted beds with four different types of draft tubes has been investigated experimentally. In this work, irregular and angular particles were used as the spouting solids and the results were compared with those of the previous work in which regular and round particles had been used. It was found that the conical-cylindrical porous draft tube was the best option for solid-gas contact and solids circulation as in the case of round particles. Moreover, by using conical-cylindrical porous draft tube, the gas flow rate through the annulus reached 65-70%, equal to the level of a conventional spouted bed.

关键词： Spouted bedConical-cylindrical porous draft tubeAngular sandGas-solid contactSolids circulation rate

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Cryogenic Cavitating Flow in 2D Laval Nozzle

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Journal of Thermal Science 2003年第2期12卷 157-161页

作者： Naoki Tani Toshio nagashima Department of Aeronautics and Astronantics University of TokyoJapanDepartment of Aeronautics and AstronanticsUniversity of TokyoJapan

Cavitation is one of the troublesome problems in rocket turbo pumps,and since most of high-efficiency rocket propellants are cryogenic fluids,so called 'thermodynamic effect' becomes more evident than in *** the present *** and experimental study of liquid nitrogen cavitation in 2D Laval nozzle was carried out ,so that the influence of thermodynamic effect was *** was revealed that temperature and cavitation have strong inter-relationship with each other in thermo-sensitive cryogenic fluids.

关键词：计算流体力学 CFD 喷流两相流空化低温

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A Blowdown Cryogenic Cavitation Tunnel and CFD Treatment for Flow Visualization around a Foil

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Journal of Thermal Science 2005年第4期14卷 346-351页

作者： Yutaka ITO Kazuya SAWASAKI Naoki TANI Takao NAGASAKI Toshio nagashima Tokyo Institute of Technology G3-334259Nagatsuta-choMidori-kuYokohama226-8502Japan Honda Motor Co.Ltd. 2-1-1Minami-AoyamaMinato-kuTokyo107-8556Japan Japan Aerospace Exploration Agency 2-1-1SengenTsukuba305-8505Japan University of Tokyo 7-3-1HongoBunkyo-kuTokyo113-8656Japan

成穴是在火箭引擎的发展的主要问题之一。有很少试验性的研究设想低温实验法的陪衬成穴。因此， blowdown 类型的一条新低温实验法的成穴隧道被造。陪衬形状是鈥減l ano 凸的鈥吗？因为简洁，这侧面被选择，而且类似于为火箭 inducer im... 详细信息

成穴是在火箭引擎的发展的主要问题之一。有很少试验性的研究设想低温实验法的陪衬成穴。因此， blowdown 类型的一条新低温实验法的成穴隧道被造。陪衬形状是鈥減l ano 凸的鈥吗？因为简洁，这侧面被选择，而且类似于为火箭 inducer impeller 的。工作液体是在房间温度，热水和液体氮的水。在攻击(AOA )=8 掳的角度的情况下，期刊洞离开在 90 掳 C 和氮在两水的实验被观察在 ? 在一样的速度下面的 190 掳 C 10 m/sec 和一样的成穴数 0.7。频率被观察分别地，是 110 和 90 Hz 并且几乎旋涡从陪衬流与那些与一致。温度消沉特别在低温实验法的成穴在实验和模拟由于热力学的效果被证实。关键词成穴 - 隧道 - 致冷剂 - CFD - 可视化 - 模拟 - 陪衬 CLC 数字

关键词：低温气穴通道空气动力学 CFD 火箭工程

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An Experimental Study on Transverse Hydrogen Gas Injection into Mach 1.8 Airflow Channel-The 1st report:Single Circular Injector

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Journal of Thermal Science 1997年第3期6卷 207-217页

作者： T.nagashima Y.Kotani 等 DepartmentofAeronauticsandAstronautics UniversityofTokyo DepartmentofMechanicalEngineering TokyoElect

Experimental results from a series of injection tests of pressurized H2, N2 gases into Mach 1.8 airfiows between parallel channel walls through a flush-mounted circular sonic opening have been *** pictures revealed complex interaction flow features including the occurrence of bow/separation shock waves due to the injection as well as the barrel shock/Mach disc structure inside the injected gas stream. The injectant penetration measured by the Mach disc height against the injection pressure showed a good agreement with the correlation curve based upon the "effective back pressure" concept. The reversed flow region beneath the separation shock wave, the injectant wake and its associated flow entraimment were also visualized by the oil paint method. Wall static pressure distributions around the injector were measured in detail, which corresponded very well to the above results of flow *** samplings were also undertaken by using the pressure taps to confirm the presence of H2 gas in the separation region ahead of the injector. Traversing of total pressure and H2 gas concentration at the exit of the test channel showed monotonous increase of the loss while its profile was kept very similar with the injection pressure. The area indicating the loss and the presence of H2 gas almost coincided with each other, which remained to be small to indicate very slow gas mixing/diffusion with the main air flow. With the increase of airflow total temperature to 1200 K, a bulk flame was first observed at the exit section. Further increase up to 1460 K observed an ignition flame at the injector. However,the reflection of the bow shock wave was found to be a more likely trigger of the bulk flame ignition within the test section.

关键词：气流通道横向氢气喷射单环形喷射器

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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

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Effects of the 23-Valent Pneumococcal Polysaccharide Vaccine on the Mortality of Pneumonia among Elderly over 70 Years Old after the Great East Japan Earthquake—PPV Vaccination Program in Iwate Prefecture, Japan

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Advances in Infectious Diseases 2023年第2期13卷 216-226页

作者： Hiromi nagashima Kozo Tanno Kiyomi Sakata Masachica Akiyama Yu Utsumi Kohei Yamauchi Department of Internal Medicine Iwate Medical University Yahaba Japan Department of Hygiene and Preventive Medicine Iwate Medical University Yahaba Japan Takizawa Central Hospital Takizawa Japan

Objective: To estimate the efficacy of 23-valent pneumococcal polysaccharide vaccine (PPSV23) among the elderly, we analyzed the relationship between the mortality of the elderly for pneumonia and the vaccination rate of PPSV23 from 2008 to 2016 in Iwate Prefecture, Japan. Study Design: The present study was a retrospective, observational, database study adopting an ecological design. The mortality for pneumonia among the elderly over 70 years old from 2006 to 2016 in Iwate Prefecture was calculated based on the data from the Japanese Vital Statistics. We compared the mortality rate (MR) of pneumonia among the elderly over 70 years old between the low-vaccinated period (LVP) (2006-2010) and high-vaccinated period (HVP) (2012-2016) using a Poisson regression model. Results: While the vaccination rate of PPSV23 among the elderly over 65 years old was 3.3% in 2010, it increased rapidly up to 40.7% in 2012 and reached 66.4% in 2016. The MR ratio of the total population during HVP to the average MR during LVP was 0.749. The MR of the total population during HVP was significantly lower than that during LVP (p Conclusion: The increase in vaccination rate of PPSV23 during HVP (2012-2016) may contribute to the decrease in mortality for pneumonia among the elderly over 70 years old in Iwate Prefecture.

关键词： PPSV23 Mortality of the Elderly for Pneumonia

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Adaptor Protein Crk is Implicated in Mucus Formation in Mucinous Epithelial Ovarian Cancer (mEOC) Cells MCAS

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Chinese Journal of Cancer Research 2008年第2期20卷 121-125页

作者：徐冬梅令狐华 Masumi Tsuda Shinya Tanaka Kazuo nagashima Department of Obstetrics & Gynecology First Affiliated HospitalChongqing Medical UniversityChongqing 400016China Department of Obstetrics & Gynecology First Affiliated HospitalChongqing Medical UniversityChongqing 400016China Laboratory of Molecular and Cellular PathologyHokkaido University Graduate School of Medicine N15W7Sapporo 060-8638Japan Laboratory of Molecular and Cellular Pathology Hokkaido University Graduate School of MedicineN15W7Sapporo 060-8638Japan

Objective： The mucus production is an indicator for the histological grade of mucinous epithelial ovarian cancer （mEOC）. In our previous study, Crk expression was targeted in the human ovarian mucinous adenocarcinoma cell line MCAS through RNA interference, resulting in the establishment of Crk knock down cells. These cells exhibited decreased tumorigenic potential both in vitro and in vivo. The purpose of this study was to investigate if there is any change in the capability of forming mucus in these Crk knock down cells. Methods： Cytoplasmic periodic acid Schiff （PAS） staining and particle excluding assay were conducted to assess the mucus formation within and around cells, respectively. Additionally, the amount of mucus formed in tumor lumps from nude mice model was measured following HE and PAS staining. Results： The increased mucus production in Crk knockdown mEOC cells （MCAS） was manifested by increased number of enlarged cells filled with vacuoles-like mucus observed by phase-contrast microscope and cytoplasmic PAS staining; and enhanced mucus secretion was represented by the assembly of pericellular matrix in particle excluding assay and increased mucus area in tumor lumps from nude mice models. Conclusion： The course of carcinogenesis in mEOC is associated with the altered pattern of mucus production and secretion. The adaptor protein Crk is implicated in both pathways.

关键词： Adaptor protein Crk MCAS cell Mucinous epithelial ovarian cancer(Meoc)

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In Vivo Development of Fetal Pig Kidneys in Mature Monkeys under Clinically Approved Immunosuppressant Drugs

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Engineering 2022年第3期8卷 65-73页

作者： Tsuyoshi Takamura Kenji Matsui Naoto Matsumoto Yatsumu Saito Toshinari Fujimoto Susumu Tajiri Shuichiro Yamanaka Kei Matsumoto Akimitsu Kobayashi Izumi Yamamoto Hiroshi Sasaki Haruyuki Hirayama Hitomi Matsunari Kazuaki Nakano Hiroshi nagashima Akihiko Kiyoshi Takao Kuroda Makoto Inoue Takeshi Miyawaki Takashi Yokoo Eiji Kobayashi Division of Nephrology and Hypertension Department of Internal MedicineThe Jikei University School of MedicineTokyo 105-8461Japan Department of Urology The Jikei University School of MedicineTokyo 105-8461Japan Department of Plastic and Reconstructive Surgery The Jikei University School of MedicineTokyo 105-8461Japan Meiji University International Institute for Bio-Resource Research Kanagawa 214-8571Japan Sumitomo Dainippon Pharma Co. Ltd.Osaka-fu 564-0053Japan Department of Kidney Regenerative Medicine The Jikei University School of MedicineTokyo 105-8461Japan

Controlling the immune response with only clinically approved immunosuppressant drugs is difficult in renal heterotra ns plantation from pigs to nonhuman ***,to the best of our knowledge,no reports exist on the use of fetal pigs as kidney *** study aimed to compare the degree of transplant rejection between neonatal and fetal kidneys,with genetically unmodified pigs as donors and cynomolgus monkeys as *** left kidneys of the recipient monkeys were removed,followed by transplantation of neonatal as well as fetal pig kidneys,which had undergone vascular anastomosis at the same site,into the *** was performed with only US Food and Drug Administration-approved *** fetal kidneys were transplanted into the omentum and paraaortic regions of cynomolgus ***,the engraftment and development of the transplanted tissues were pathologically examined by sampling over time(twice in each experiment).An acute rejection was observed after a few weeks in neonatal renal grafts with vascular ***,fetal pig kidneys were spared from rejection despite the administration of the same immunosuppressive protocol to the monkeys and the recipient blood vessels flowing into the fetal *** immunogenicity of fetal kidneys in pig-monkey renal heterotransplantation was lower than that of neonatal kidneys.

关键词： Cynomolgus monkey Pig Kidney Fetal kidney Immunosuppression

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超导磁悬浮列车基础研究进展及磁悬浮技术在常规铁路系统的应用

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国外铁道机车与动车 2022年第2期 5-8页

作者： [日]Ken nagashima 张霓虹(译) 不详

RTRI正对超导磁悬浮列车进行基础研究。该领域涉及的主要议题包括对REBCO高温超导线圈的试验评定,尤其是对地面线圈传感器收集数据系统进行的研发。RTRI还进行磁悬浮技术在常规铁路系统的应用研究,该领域包括无线输电系统和飞轮储能系统。

关键词：磁悬浮常规铁路超导磁体地面线圈无线输电飞轮储能系统

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