检索结果-南通市图书馆

Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第5期15卷 4201-4211页

作者： Tsukasa Akasaka Miho Tamai Yoshitaka Yoshimura Natsumi Ushijima Shinichiro Numamoto Atsuro Yokoyama Hirofumi Miyaji Ryo Takata Shuichi Yamagata Yoshiaki Sato Ko nakanishi Yasuhiro Yoshida Department of Biomaterials and Bioengineering Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Immune Signal Unit Okinawa Institute of Science and Technology Graduate UniversityOkinawa 904-0495Japan Department of Pharmacology Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Support Section for Education and Research Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Oral Functional Prosthodontics Division of Oral Functional ScienceFaculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Periodontology and Endodontology Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Orthodontics Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan

The surface topography of a material can influence osteoclast ***,the surface structural factors that promote osteoclast activity have not yet been investigated in ***,we investigated osteoclastogenesis by testing various defined patterns with different dimensions and *** systematic patterns,made of a cyclo-olefin polymer,were prepared at a micron-,submicron-,and nano-scale with a groove,hole,or pillar shape with a 1:1 pitch ***264.7 cells were cultured on these patterns in the presence of the receptor activator of NF-κB ligand(RANKL).Osteoclast formation was induced in the order:pillar>groove≥*** two-dimensional factors also indicated that submicron-sized patterns strongly induced osteoclast *** optimal pillar dimension for osteoclast formation was 500 nm in diameter and 2μm in ***,we observed two types of characteristic actin structure,i.e.,belt-like structures with small hollow circles and isolated ring-like structures,which formed on or around the pillars depending on size and ***,resorption pits were observed mainly on the top of calcium phosphate-coated ***,osteoclasts prefer convex shapes,such as pillars for differentiation and *** results indicate that osteoclastogenesis can be controlled by designing surfaces with specific morphologies.

关键词： micro/nano-pattern pillar RAW264.7 osteoclast actin structure resorption pit

Breast cancer resistance protein(BCRP/ABCG2):its role in multidrug resistance and regulation of its gene expression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2012年第2期31卷 73-99页

作者： Takeo nakanishi Douglas D.Ross Department of Membrane Transport and Biopharmaceutics Kanazawa University School of Pharmaceutical SciencesKanazawa 920-1192Japan University of Maryland Greenebaum Cancer Center the Departments of Medicine Pathology and Pharmacology and Experimental TherapeuticsUniversity of Maryland School of Medicineand the Baltimore VA Medical CenterBaltimoreMaryland 21201USA

Breast cancer resistance protein(BCRP)/ATP-binding cassette subfamily G member 2(ABCG2) is an ATP-binding cassette(ABC) transporter identified as a molecular cause of multidrug resistance(MDR) in diverse cancer *** physiologically functions as a part of a self-defense mechanism for the organism;it enhances elimination of toxic xenobiotic substances and harmful agents in the gut and biliary tract,as well as through the blood-brain,placental,and possibly blood-testis *** recognizes and transports numerous anticancer drugs including conventional chemotherapeutic and targeted small therapeutic molecules relatively new in clinical ***,BCRP expression in cancer cells directly causes MDR by active efflux of anticancer *** BCRP is also known to be a stem cell marker,its expression in cancer cells could be a manifestation of metabolic and signaling pathways that confer multiple mechanisms of drug resistance,self-renewal(stemness),and invasiveness(aggressiveness),and thereby impart a poor ***,blocking BCRP-mediated active efflux may provide a therapeutic benefit for *** the precise molecular mechanisms for BCRP gene expression may lead to identification of a novel molecular target to modulate BCRP-mediated *** evidence suggests that BCRP gene transcription is regulated by a number of trans-acting elements including hypoxia inducible factor 1α,estrogen receptor,and peroxisome proliferator-activated ***,alternative promoter usage,demethylation of the BCRP promoter,and histone modification are likely associated with drug-induced BCRP overexpression in cancer ***,PI3K/AKT signaling may play a critical role in modulating BCRP function under a variety of *** biological events seem involved in a complicated *** the events would be an essential first step to developing a method to modulate BCRP function to aid patients with *** review will present a sy

关键词：多重耐药性基因表达调控组蛋白修饰乳腺癌过氧化物酶体增殖物激活受体分子机制多药耐药肿瘤细胞

Sintering Formation of Low Temperature Phase MnBi and Its Disordering in Mechanical Milling

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 1996年第5期12卷 335-341页

作者： Yin, FX Gu, NJ Shigematsu, T nakanishi, N KONAN UNIV FAC SCIDEPT CHEMKOBE 658JAPAN

With X-ray diffraction and DSC analysis, it is found that 4 cycles of sintering at 593 K are necessary for the complete production of the low-temperature phase (LTP) MnBi. The c/a of the fabricated LTP MnBi is 1.4286. Metastable phase MnBip formed in primary sintering stage of LTP MnBi has the similar crystal structure and lattice constant with the quenched high-temperature phase (HTP) Mn1.08Bi. The structural differences between MnBip phase and Mn1.08Bi phase are discussed. The LTP MnBi phase is unstable for strong mechanical milling as Bi appears after milling over 7200 s in the present milling condition. Strains caused by the mechanical attrition are difficult to accumulate in the MnBi crystals, and the crystal size of the milled MnBi is only 30 nm before the presence of grains coalescence. The whole milling process can be classified into 3 stages indicated by the structural changes. Based on the structural parameter calculation, the changes of atomic configurations in every stage have been discussed. The existence of Bi equivalent vacancy site is considered to play an important role in the disordering processes of Mn and Bi atoms.

关键词： Binary alloys

Awake thoracoscopic surgery under epidural anesthesia: is it really safe?

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2014年第4期26卷 368-370页

作者： Ryoichi nakanishi Manabu Yasuda Department of Thoracic Surgery Shin-Kokura Hospital Federation of National Public Service Personnel Mutual Aid Associations

Thoracoscopic surgeries usually require single-lung ventilation under general anesthesia because of the need to obtain a sufficient working *** patients with impaired pulmonary function,if the patient can undergo general anesthesia,a more selected collapse of the lung is considered to be beneficial for intraoperative *** selective bronchial blockade of the lobe to be resected has been reported by several investigators （1-3）.Mukaida and coworkers first reported thoracoscopic surgery for pnenmothorax under local and epidural anesthesia in 1998 in high-risk patients contraindicated for general anesthesia （4）.

关键词： is it really safe lung Awake thoracoscopic surgery under epidural anesthesia

Non-Contact Measurements of Water Jet Spreading Width with a Laser Instrument

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2016年第4期25卷 349-354页

作者： Yuki Funami Ryo Hasuya Kotaro Tanabe Yuji nakanishi Kanagawa University: 3-27-1 Rokkakubashi Kanagawa-ku Yokohama Kanagawa 221-8686 Japan

Jet spreading width is one of the important characteristics of water jets discharging into the *** researchers have dealt with measuring this width,and contact measuring methods on the water jet surface were employed in a lot of the *** order to avoid undesirable effects caused by the contact on the jet surface,we introduce non-contact measuring methods with a laser instrument to the measurements of jet spreading *** measurements,a transmitter emits sheet-like laser beam to a *** water jet between the transmitter and the receiver interrupts the laser beam and makes a *** minimum and maximum values of the shadow width are *** addition,pictures of the water jet are taken with a scale,and the shadow width is measured from the *** experiments on various needle strokes were *** kinds of width consistent with the jet structure were *** the results,it can be concluded that our non-contact measuring methods are *** data of jet spreading widths and jet taper were obtained and are useful for future applications.

关键词：非接触测量宽度测量水射流激光仪器测量方法激光接收器研究人员发射器

Rice-Specific Mitochondrial Iron-Regulated Gene （MIR） Plays an Important Role in Iron Homeostasis

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2009年第5期2卷 1059-1066页

作者： Yasuhiro Ishimaru Khurram Bashir Masaru Fujimoto Gynheung An Reiko nakanishi Itai Nobuhiro Tsutsumi Hiromi nakanishi Naoko K Nishizawa Graduate School of Agricultural and Life Sciences The University of Tokyo 1-1-1 Yayoi Bunkyo-Ku Tokyo 113-8657 Japan Department of Life Sciences Pohang University of Science and Technology Pohang 790-784 Republic of Korea Research Institute for Bioresources and Biotechnology Ishikawa Prefectural University Ishikawa 921-8836 Japan

Mitochondria utilize iron （Fe）, but the proteins involved in mitochondrial Fe regulation are not characterized in plants. We cloned and characterized a mitochondrial iron-regulated （MIR） gene in rice involved in Fe homeostasis. MIR, when expressed in tobacco BY-2 cells, was localized to the mitochondria. MIR transcripts were greatly increased in response to Fe deficiency in roots and shoot tissue. MIR is not homologous to any known protein, as homologs were not found in the rice or Arabidopsis genome databases, or in the EST database for other organisms. Growth in the MIR T-DNA knockout rice mutant （mir） was significantly impaired compared to wild-type （WT） plants when grown under Fe-deficient or -sufficient conditions. Furthermore, mir plants accumulated more than twice the amount of Fe in shoot and root tissue compared to WT plants when grown under either Fe-sufficient or -deficient conditions. Despite the high accumulation of Fe in roots and shoots, mir plants triggered the expression of Fe-deficiency-inducible genes, indicating that mir may not be able to utilize Fe for physiological functions. These results clearly suggest that MIR is a rice-specific mitochondrial protein, recently evolved, and plays a significant role in Fe homeostasis.

关键词： Fe-deficiency-regulated gene Fe homeostasis mitochondria Oryza sativa.

Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第22期25卷 2743-2751页

作者： Koki nakanishi Mitsuro Kanda Yasuhiro Kodera Department of Gastroenterological Surgery(Surgery Ⅱ) Nagoya University Graduate School of Medicine

Gastrectomy with radical lymph node dissection is the most promising treatment avenue for patients with gastric cancer. However, this procedure sometimes induces excessive intraoperative blood loss and requires perioperative allogeneic blood transfusion. There are lasting discussions and controversies about whether intraoperative blood loss or perioperative blood transfusion has adverse effects on the prognosis in patients with gastric cancer. We reviewed laboratory and clinical evidence of these associations in patients with gastric cancer. A large amount of clinical evidence supports the correlation between excessive intraoperative blood loss and adverse effects on the prognosis. The laboratory evidence revealed three possible causes of such adverse effects: anti-tumor immunosuppression, unfavorable postoperative conditions, and peritoneal recurrence by spillage of cancer cells into the pelvis. Several systematic reviews and meta-analyses have suggested the adverse effects of perioperative blood transfusions on prognostic parameters such as all-cause mortality, recurrence, and postoperative complications. There are two possible causes of adverse effects of blood transfusions on the prognosis: Anti-tumor immunosuppression and patient-related confounding factors (e.g., preoperative anemia). These factors are associated with a worse prognosis and higher requirement for perioperative blood transfusions. Surgeons should make efforts to minimize intraoperative blood loss and transfusions during gastric cancer surgery to improve patients’ prognosis.

关键词： Gastric cancer Blood loss Prognosis Transfusion Adverse effect Immunosuppression Mortality Recurrence Complication

An Efficient Framework to Utilize Grover Search

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

南京邮电大学学报（自然科学版） 2011年第2期31卷 49-58页

作者： Shigeru Yamashita Masaki nakanishi College of Information Science and Engineering Ritsumeikan University

This paper proposes an efficient framework to utilize quantum search *** the best of our knowledge,this is the first paper to show a concrete usage of quantum search in general *** our framework,we can utilize a quantum computer as a coprocessor to speed-up some parts of a program that runs on a classical *** do so,we propose several new ideas and techniques,such as a practical method to design a large quantum circuits for search problems and an efficient quantum comparator.

关键词： quantum search general programming cooperation of quantum and classical computers quantum comparator quantum circuit design

Is the measurement of drain amylase content useful for predicting pancreas-related complications after gastrectomy with systematic lymphadenectomy?

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第14期26卷 1594-1600页

作者： Koki nakanishi Mitsuro Kanda Junichi Sakamoto Yasuhiro Kodera Department of Gastroenterological Surgery(Surgery Ⅱ) Nagoya University Graduate School of MedicineNagoya 466-8550Japan Tokai Central Hospital Kakamigahara 504-8601Japan

Many studies investigating postoperative pancreatic fistula(POPF)after gastrectomy,including studies measuring drain amylase content(D-AMY)as a predictive factor have been *** article reviews previous studies and looks to the future of measuring D-AMY in patients after *** causes of pancreatic fluid leakage are;the parenchymal and/or thermal injury to the pancreas,and blunt injury to the pancreas by compression and *** of D-AMY to predict POPF has become common in clinical practice after pancreatic surgery and was later extended to the gastric *** studies have reported associations between D-AMY and POPF after gastrectomy,and the high value of D-AMY on postoperative day(POD)1 was an independent risk *** improve both sensitivity and specificity,attempts have been made to enhance the predictive accuracy of factors on POD 1 as well as on POD 3 as combined *** several studies have shown a high predictive ability of POPF,it has not necessarily been exploited in clinical *** problems remain unresolved;ideal timing for measurement,optimal cut-off value,and means of intervention after *** clinical trial could be imperative in order to develop D-AMY measurement in common clinical practice for gastric surgery.

关键词： Gastric cancer Drain amylase Postoperative pancreatic fistula Pancreasrelated complications Gastrectomy Early prediction