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National Science Review 2020年第11期7卷 1656-1666页

作者： Xuanming Lu Kazuyoshi Kanamori kazuki nakanishi Department of Chemistry Graduate School of ScienceKyoto University Institute for Integrated Cell-Material Sciences Kyoto University Institute for Advanced StudyKyoto University Division aof Materials Research Institute of Materials and Systems for Sustainability Nagoya University

Hierarchically porous monoliths based on copper (Cu), cobalt (Co) and manganese (Mn) oxides with three-dimensionally (3D) interconnected macropores and open nanopores were prepared using metal bromides as precursors via a sol–gel process accompanied by phase separation. The difficulty of gelation for low-valence metal cation was overcome by introducing a highly electronegative Br atom near to the metal atom to control the rates of hydrolysis and polycondensation. The 3D interconnected macropores were obtained using appropriate polymers to induce phase separation. The domain sizes of macropores and skeletons can be controlled by reaction parameters such as concentration and/or average molecular weight of polymers, and the amount of hydrochloric acid. The crystalline metal oxide monoliths with their 3D interconnected macroporous structure preserved were obtained after heat treatment in air.

关键词： hierarchically porous monolith low-valence transition metal oxide 3D interconnected macropore sol–gel process phase separation

Blastomas of the digestive system in adults:A review

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1030-1042页

作者： Yu Liu Tony El Jabbour Jonathan Somma Yukihiro nakanishi Saverio Ligato Hwajeong Lee Zhi-Yan Fu Department of Pathology LSU Health Sciences Center School of MedicineNew OrleansLA 70112United States Department of Pathology Hartford HealthCareHartfordCT 06102United States Department of Pathology Moffitt Cancer CenterTampaFL 33612United States Department of Pathology and Laboratory Medicine Albany Medical CenterAlbanyNY 12208United States

Blastomas,characterized by a mixture of mesenchymal,epithelial,and undifferentiated blastematous components,are rare malignant neoplasms originating from precursor blast *** review focuses on digestive system blastomas in adult patients,including gastroblastoma,hepatoblastoma,and *** is a biphasic,epitheliomesenchymal tumor,with only sixteen cases reported to *** addition to the characteristic histology,metastasisassociated lung adenocarcinoma transcript 1-glioma-associated oncogene homolog 1 gene fusion is typical,although recently novel ewing sarcoma breakpoint region 1-c-terminal binding protein 1 and patched 1-glioma-associated oncogene homolog 2 fusions have been *** is exceptionally rare in adults and can show a variety of histologic patterns which may cause diagnostic ***,primarily a pediatric tumor,displays acinar differentiation and squamoid nests with other lines of differentiation also present,especially *** approaches for these blastomas include a combination of imaging modalities,histopathological examination,and molecular *** treatment generally involves surgical resection,which may be supplemented by chemotherapy or radiotherapy in some *** vary with gastroblastoma generally showing favorable outcomes post-surgery whereas hepatoblastoma and pancreatoblastoma often have poorer outcomes,particularly in the setting of *** review highlights the complexity of diagnosing and managing these rare adult blastomas as well as the need for ongoing research to better understand their pathogenesis and improve treatment strategies.

关键词： Adult blastomas Gastroblastoma Hepatoblastoma Pancreatoblastoma Digestive system

Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?

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World Journal of Gastroenterology 2024年第10期30卷 1368-1376页

作者： Nobukazu Agatsuma Takahiro Utsumi Yoshitaka Nishikawa Takahiro Horimatsu Takeshi Seta Yukitaka Yamashita Yukari Tanaka Takahiro Inoue Yuki nakanishi Takahiro Shimizu Mikako Ohno Akane Fukushima Takeo Nakayama Hiroshi Seno Department of Gastroenterology and Hepatology Kyoto University Graduate School of MedicineKyoto 606-8507Japan Department of Gastroenterology and Hepatology Japanese Red Cross Wakayama Medical CenterWakayama 640-8558Japan Department of Health Informatics Kyoto University School of Public HealthKyoto 606-8501Japan Institute for Advancement of Clinical and Translational Science(iACT) Kyoto University HospitalKyoto 606-8507Japan Medical Support Section Medical Affairs DivisionKyoto University HospitalKyoto 606-8507Japan

BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor *** efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside *** identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less *** the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related *** To clarify the stage at CRC diagnosis based on diagnostic *** We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two *** diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and *** early-stage was defined as Stages 0 or *** and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up *** adjusted covariates were age,sex,and tumor *** Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,*** the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,*** symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening gro

关键词： Colorectal neoplasms Cancer registry Diagnostic route Cancer screening Stage at diagnosis

组蛋白激活晚期糖基化终末产物受体并引发炎症反应

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食品与发酵工业 2024年第2期50卷 78-84页

作者：孙常津杨岩刘国玉中西秀树江南大学生物工程学院江苏无锡214122 中国食品发酵工业研究院有限公司功能主食创制与慢病营养干预北京市重点实验室北京100015

晚期糖基化终末产物受体(receptor for advanced glycation end product,RAGE)是免疫球蛋白受体,能够与多种配体结合,研究发现RAGE参与了非专职吞噬细胞对组蛋白修饰的微米颗粒的吞噬过程,但目前没有研究证明组蛋白是RAGE的配体。该研... 详细信息

晚期糖基化终末产物受体(receptor for advanced glycation end product,RAGE)是免疫球蛋白受体,能够与多种配体结合,研究发现RAGE参与了非专职吞噬细胞对组蛋白修饰的微米颗粒的吞噬过程,但目前没有研究证明组蛋白是RAGE的配体。该研究对组蛋白分子能否直接激活RAGE及其下游信号通路进行探究。使用共聚焦显微镜和流式细胞仪检测哺乳动物细胞对可溶性组蛋白分子的内化;采用钙黄绿素乙酰氧基甲酯/碘化丙啶染色法检测细胞活性;通过荧光探针2′,7′-二氯二氢荧光素二乙酸酯检测胞内活性氧水平;利用酶联免疫吸附剂测定法(enzyme-linked immunosorbent assay,ELISA)测定炎症因子的释放。结果表明,组蛋白分子能够被野生型HEK293T细胞内化并于胞内溶酶体中聚集,RAGE-敲除细胞则无法内化组蛋白;培养基组蛋白质量浓度在100μg/mL时对细胞无明显毒性,细胞活性正常;组蛋白能够通过RAGE刺激细胞活性氧水平升高,并释放炎症因子肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和白细胞介素-6(interleukin-6,IL-6);组蛋白与DNA结合能够增强对RAGE的刺激。以上结果表明,组蛋白能够激活RAGE及其下游炎症通路。

关键词：晚期糖基化终末产物受体组蛋白胞饮活性氧炎症

Application of yeast spores as β-glucan particles

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Particuology 2022年第12期71卷 34-40页

作者： Guoyu Liu Yan Yang Hiroyuki Tachikawa Xiao-Dong Gao Hideki nakanishi Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China Department of Applied Biological Chemistry Graduate School of Agricultural and Life SciencesUniversity of TokyoTokyo 113-8657Japan Collaborative Research Institute for Innovative Microbiology University of TokyoTokyo 113-8657Japan

β-Glucan exhibits various beneficial biological activities including *** polysaccha-ride is present in the cell wall of microorganisms including the yeast Saccharomyces *** vegetative yeast cells are used as dietary supplements,β-glucan in the vegetative cell wall is covered with *** nutrient starvation,yeast cells differentiate into dormant cell spores.β-Glucan is also present in the spore wall,but spores have been poorly studied as application *** spore wall consists of four layers andβ-glucan forms the third layer from the ***,unlike vegeta-tive cells,theβ-glucan layer can be exposed to the cell surface in spores by genetic *** example,chs3Δmutant spores exhibit such a spore wall ***-1 is the primary receptor forβ-glucan in mammals and,its activation induces phagocytosis and proinflammatory cytokine *** found that chs3Δspores are phagocytosed in mammalian cells in a manner dependent on dectin-1 and induce higher levels of TNF-αand IL-6 than vegetative *** results demonstrate that chs3Δspores areβ-glucan particles with immunostimulatory ***,they would be attractive materials for application in the food industry.

关键词： Saccharomycescerevisiae Sporewall β-glucan Dectin-1 Immunostimulation

Broadly tunable lens-coupled nonlinear quantum cascade lasers in the sub-THz to THz frequency range

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Photonics Research 2022年第3期10卷 703-710页

作者： Kazuue Fujita Shohei Hayashi Akio Ito Tatsuo Dougakiuchi Masahiro Hitaka Atsushi nakanishi Central Research Laboratory Hamamatsu Photonics K.K.5000 HirakuchiHamakita WardHamamatsu 434-8601Japan

Room-temperature terahertz(THz)quantum cascade laser sources with intracavity difference-frequency nonlinear mixing are electrically pumped monolithic semiconductor laser sources operating in the 0.6–6 THz spectral *** report widely tunable,low-frequency THz quantum cascade laser sources using a lens-coupled Cherenkov waveguide *** on a watt-class high-power,λ∼13.7μm quantum cascade laser,the monolithic THz source is strongly coupled with a high-resistivity silicon lens,which causes a major increase in the THz coupling efficiency and demonstrates significant performance improvements.A room-temperature 1.5 THz device produces a 0.2 mW peak output power with a high-quality beam *** THz outcoupling efficiency using the lens-coupled scheme enabled the demonstration of a high-performance external-cavity semiconductor THz source that is tunable from 420 GHz to 2 *** external-cavity,lens-coupled device configuration can technically be assembled into a butterfly-style package for a thumb-sized,widely frequency tunable THz semiconductor source.

关键词： tunable waveguide pumped

Estimating effects from trapped magnetic fluxes in superconducting magnetic levitation measurement

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仪器仪表学报 2008年第3期29卷 449-452页

作者： Masakazu nakanishi Metrology Institute of Japan National Institute of Advanced Industrial Science and Technology 1-1-1 Umezono Tsukuba-shi Ibaraki 305-8563 Japan

Superconducting magnetic levitation measurement is one of the most promising approaches to define mass standard based on the fundamental physical constants. However, the present system has unknown factors causing error larger than 50 ppm. We examined the effects of magnetic fluxes trapped in the superconducting coil and the superconducting floating body. When fluxes were trapped in either coil or floating body, their effects were able to be cancelled by reversing polarities of current and magnetic field, as had been believed. However, fluxes trapped in both coil and body induced an attractive force between them and caused error. In order to reduce the fluxes, the coil and the floating body should be cooled in low magnetic field in magnetic and electromagnetic shields.

关键词：截留磁通量超导电磁飘浮测量基本物理常量

Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging

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Neural Regeneration Research 2020年第1期15卷 25-29页

作者： Hiroshi nakanishi Department of Pharmacology Faculty of Pharmacy Yasuda Women’s University

Interleukin-1βis a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer’s disease,Parkinson’s disease,stroke and persistent *** microglia are the main cellular source of interleukin-1βin the *** B is associated with the production and secretion of interleukin-1βthrough pyrin domain-containing protein 3 inflammasome-independent processing of procaspase-3 in the *** leakage of cathepsin B from the endosomal-lysosomal system during aging is associated with the proteolytic degradation of mitochondrial transcription factor A,which can stabilize mitochondrial ***,microglial cathepsin B could function as a major driver for inflammatory brain diseases and brain *** active and blood-brain barrier-permeable specific inhibitors for cathepsin B can be potentially effective new pharmaceutical interventions against inflammatory brain diseases and brain aging.

关键词： brain aging caspase-1 cathepsin B inflammatory brain diseases interleukin-1β microglia mitochondrial transcription factor A neuroinflammation nuclear factor-κB oxidative stress

Fragmented QRS complex with an additional R-wave attenuated by short RR interval in a patient with acute pulmonary embolism and cardiogenic shock

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Journal of Geriatric Cardiology 2022年第12期19卷 995-1000页

作者： Koji Takahashi Hiromasa Nakahara Eiji Arimitsu Satoshi Imamine Yoshiyasu Obata Kimio nakanishi Yoshiyasu Taniguchi Maiko Amano Chika Omori Takafumi Okura Department of Community Emergency Medicine Ehime University Graduate School of MedicineEhimeJapan Department of Cardiology Yawatahama City General HospitalEhimeJapan Department of Internal Medicine Oozu City HospitalEhimeJapan Department of Clinical Laboratory Oozu City HospitalEhimeJapan

Registries and hospital discharge datasets of unselected patients with pulmonary embolism show 30-day all-cause mortality rates of approximately 10%.[1]Clinical findings from histories and physical examinations,such as age,systemic blood pressure,and respiratory rate at presentation,classify patients into risk classes of increasing risk of death and other adverse medical outcomes.

关键词： mortality patients Clinical

Estimating freight production/attraction using nighttime satellite imagery

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Communications in Transportation Research 2022年第1期2卷 167-180页

作者： Tomoya Kawasaki Wataru nakanishi Satoshi Hyodo Yusaku Namba Hirokazu Mori Hirotoshi Kishi Department of Systems Innovation The University of TokyoTokyo113-8656Japan Institute of Science and Engineering Kanazawa UniversityIshikawa920-1192Japan Department of Transportation Systems Engineering Nihon UniversityChiba274-8501Japan Nomura Research Institute Tokyo100-0004Japan

An appropriate understanding and accurate estimation of zonal freight production(FP)and attraction(FA)volume is one of the most important topics and the initial step in developing the origin and destination(OD)*** general,zonal FP and FA are difficult to be obtained as observed data,particularly in developing countries,owing to the lack of large-scale freight ***,several proxy indicators are often used for estimating FP and FA,such as the gross regional product(GRP),population,and the number of ***,these indicators do not often estimate the zonal FP and FA accurately and are even not available *** nighttime light intensity(NLI)data that is human-induced light emission data and one of the open alternative data,possibly improves the accuracy of FP and FA ***,few studies have examined the relationship between NLI and FP/***,the objectives of this study are to examine whether NLI can be a significant indicator for estimating zonal FP and FA relative to other socio-economic indicators and to examine the types of NLIs that can accurately estimate the FP and FA through a case study in *** a result of the analysis,NLI data are identified as a significant variable for the estimation of FP and FA among various socio-economic *** some of the indicators related to secondary industries provide higher accuracy,NLI exhibits better estimates than the popular indicators such as GRP and *** addition,we propose three types of total NLI that multiply the unit NLI by the zonal area and this generates higher accuracy of unit NLI,the average light intensity of all pixels in a *** have also found that the use of habitable area for the estimation of total NLI provides the highest accuracy among the four types of NLIs including unit *** the analysis,NLI data is sufficiently applicable for estimating zonal FP and FA,relative to other important socio-economic indicators,although space tr

关键词： Nighttime light intensity Freight production and attraction Land cover data Elastic net Regression analysis