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Current state of practice for colonic diverticular bleeding in 37 hospitals in Japan:A multicenter questionnaire study

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World Journal of Gastrointestinal Endoscopy 2016年第20期8卷 785-794页

作者： Ryota Niikura Naoyoshi Nagata Hisashi Doyama Ryosuke Ota Naoki Ishii Katsuhiro Mabe Tsutomu Nishida Takuto Hikichi kazuki Sumiyama Jun Nishikawa Toshio Uraoka Shu Kiyotoki Mitsuhiro Fujishiro Kazuhiko Koike Department of Gastroenterology Graduate School of Medicinethe University of TokyoBunkyo-kuTokyo 113-8655Japan Department of Gastroenterology and Hepatology National Center for Global Health and MedicineShinjuku-kuTokyo 162-8655Japan Department of Gastroenterology Ishikawa Prefectural Central HospitalKanazawa-shiIshikawa 920-8201Japan Department of Gastroenterology St.Luke’s International HospitalChuo-kuTokyo 104-8560Japan Division of Endoscopy Hokkaido University HospitalKita-kuSapporo 060-0808HokkaidoJapan Department of Gastroenterology National Hospital Organization Hakodate HospitalKawaharachouHakodate-shi 041-0844HokkaidoJapan Department of Gastroenterology Toyonaka Municipal HospitalToyonaka-shiOsaka 560-0055Japan Department of Endoscopy Fukushima Medical University HospitalFukushima-shiFukushima 960-1295Japan Department of Endoscopy the Jikei University School of MedicineMinato-kuTokyo 105-8471Japan Department of Clinical Laboratory Science Yamaguchi University Graduate School of MedicineUbe-shiYamaguchi 755-0046Japan Department of Gastroenterology National Hospital Organization Tokyo Medical CenterMeguro-kuTokyo 150-0021Japan Department of Gastroenterology Shuto General HospitalYanai-shiYamaguchi 742-0032Japan Endoscopy and Endoscopic Surgery the University of Tokyo HospitalBunkyo-kuTokyo 113-8655Japan

AIMTo clarify the current state of practice for colonic diverticular bleeding(CDB)in *** conducted multicenter questionnaire surveys of the practice for CDB including clinical settings(8 questions),diagnoses(8 questions),treatments(7 questions),and outcomes(4 questions)in 37 hospitals across *** answers were compared between hospitals with high and low number of inpatient beds to investigate which factor influenced the *** at all 37 hospitals answered the questions,and the mean number of endoscopists at these hospitals was *** all the hospitals,computed tomography was performed before colonoscopy in 67%of the *** rate of bowel preparation was 46.0%.Early colonoscopy was performed within 24 h in 43.2%of the *** the hospitals,83.8%performed clipping as first-line endoscopic *** than half of the hospitals experienced less than 20%rebleeding events after endoscopic *** significant difference was observed in the annual number of patients hospitalized for CDB between high-(≥700 beds)and low-volume *** emergency visits(P=0.012)and endoscopists(P=0.015),and less frequent participation of nursing staff in early colonoscopy(P=0.045)were observed in the high-volume *** practices unique to Japan were found,such as performing computed tomography before colonoscopy,no bowel preparation,and clipping as first-line ***,the number of staff differed,the practices for CDB were common irrespective of hospital size.

关键词： Colonic diverticular hemorrhage Lower gastrointestinal bleeding Computed tomography Endoscopy Bowel preparation

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Mechanisms and anatomical risk factors of pneumothorax after Bevacizumab use:A case report

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World Journal of Clinical Oncology 2020年第7期11卷 504-509页

作者： Yuri Ozaki Akiyo Yoshimura Masataka Sawaki Masaya Hattori Naomi Gondo Haruru Kotani Yayoi Adachi Ayumi Kataoka Kayoko Sugino Nanae Horisawa Yuka Endo kazuki Nozawa Shoko Sakamoto Hiroji Iwata Department of Breast Oncology Aichi Cancer Center HospitalNagoya 464-8681Japan

BACKGROUND Bevacizumab is an antiangiogenic agent,and that synergizes with chemotherapeutic *** used in combination therapies,Bevacizumab is associated with adverse events such as hemorrhage,gastrointestinal perforation,delayed wound healing,and ***,the molecular mechanisms underlying these adverse events are not fully *** SUMMARY A 45-year-old female with multiple lung metastases that were derived from primary breast cancer,was placed on Bevacizumab+paclitaxel therapy,since this combination has a potent antitumor *** reported dyspnea before cycle 3,day 1 and we therefore ran a chest X-ray,which detected a right *** coronal plane computed tomography revealed that one solid mass rapidly necrosed and was replaced by a cavity that passed through the bronchus in the right lower *** cavity eventually ruptured the pleura and made the bronchopleural fistula that led to this *** cavity drainage using an intercostal catheter was *** the 7th day of drainage,the patient was discharged from our hospital on *** of pneumothorax was not reported,and continuation of chemotherapy was made possible by changing the *** Patients with lung metastases surrounding the bronchi and on the pleura should be monitored for pneumothorax by Bevacizumab-containing chemotherapies.

关键词： Breast cancer Lung metastasis Bevacizumab Adverse event Pneumothorax Case report

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Fabrication of MEMS Diaphragm Transducer Array Based on Epitaxial PZT Thin Film for 2-D Hydrophone Application

Fabrication of MEMS Diaphragm Transducer Array Based on Epit...

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2008 IEEE International Ultrasonics Symposium

作者： Nagaya Okada kazuki Higuchi Yoshiyuki Asakura Kazuto Kobayashi Mikinori Ito Masashi Takabe Mikito Otonari Ikuo Kanja Daisukc Akai Kazuaki Sawada Makoto Ishida HONDA ELECTRONICS CO. LID. Toyohashi University of Technology

＜正＞Background,Motivation and Objective The increasing interest in 3-D imaging and high frequency applications leads to investigate new solutions for transducer *** an adequate signal-to-noise ratio with piezoelectr...

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Si-Al-Sn合金熔体中块体硅定向生长行为研究

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无机材料学报 2016年第8期31卷 791-796页

作者：李亚琼李佳艳谭毅张立峰森田一樹北京科技大学冶金与生态工程学院北京100083 大连理工大学材料科学与工程学院大连116024 东京大学工学院材料工程学院日本东京1538505

为从Si-Al-Sn合金中有效分离初晶硅,本研究提出并实现了三元合金定向生长块体硅的技术。通过考察冷却速度、合金成分、温度梯度与晶体生长速度比值(G/R)等参数及其影响机制,确定促进块体硅稳定生长的有利条件;对比Si-Al、Si-Sn二元合金... 详细信息

为从Si-Al-Sn合金中有效分离初晶硅,本研究提出并实现了三元合金定向生长块体硅的技术。通过考察冷却速度、合金成分、温度梯度与晶体生长速度比值(G/R)等参数及其影响机制,确定促进块体硅稳定生长的有利条件;对比Si-Al、Si-Sn二元合金体系,采用成分过冷理论分析金属Sn对三元合金中块体硅生长行为的影响;采用电子探针显微分析仪考察块体硅微观组织形貌与杂质分布。研究结果表明:定向凝固方法能有效分离块体硅,同时抑制块体硅内金属夹杂物生成,并将杂质含量控制在其固溶度范围内,成为一种有效分离、回收高纯初晶硅的新途径。

关键词： Si-Al-Sn合金定向凝固块体硅

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Feasibility of gastric endoscopic submucosal dissection in elderly patients aged≥80 years

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World Journal of Gastrointestinal Endoscopy 2022年第1期14卷 49-62页

作者： Yasuhiro Inokuchi Ayaka Ishida Kei Hayashi Yoshihiro Kaneta Hayato Watanabe kazuki Kano Mitsuhiro Furuta Kosuke Takahashi Hirohito Fujikawa Takanobu Yamada Kouji Yamamoto Nozomu Machida Takashi Ogata Takashi Oshima Shin Maeda Department of Gastroenterology Kanagawa Cancer CenterYokohama 241-8515KanagawaJapan Department of Gastrointestinal Surgery Kanagawa Cancer CenterYokohama 241-8515KanagawaJapan Department of Biostatics Yokohama City University School of Medicine.Yokohama 236-0004KanagawaJapan Department of Gastroenterology Yokohama City UniversityYokohama 236-0004KanagawaJapan

BACKGROUND Endoscopic resection,especially endoscopic submucosal dissection(ESD),is increasingly performed in elderly patients with early gastric cancer,and lesions beyond the expanded indications are also resected endoscopically in some *** is essential to assess whether gastric ESD is safe and suitable for elderly patients and investigate what type of lesions carry an increased risk of ESD-related *** To assess the efficacy and feasibility of gastric ESD for elderly patients,and define high-risk lesions and prognostic *** Among a total of 1169 sessions of gastric ESD performed in Kanagawa Cancer Center Hospital from 2006 to 2014,179 sessions(15.3%)were performed in patients aged≥80 years,and 172 of these sessions were done in patients with a final diagnosis of gastric *** patients were studied retrospectively to evaluate short-term outcomes and *** short-term outcomes included the rates of en bloc resection and curative resection,complications,and procedurerelated *** was assessed according to the Japanese Gastric Cancer Treatment Guidelines ***’s exact test was used to statistically analyze risk *** characteristics of each group were compared using Fisher’s exact test and Mann-Whitney U *** rates at each time point were based on Kaplan-Meier *** survival rates were compared between patients with gastric cancer in each group with use of the log-rank *** identify prognostic factors that jointly predict the hazard of death while controlling for model overfitting,we used the least absolute shrinkage and selection operator(LASSO)Cox regression model including factors curative/noncurative,age,gender,body mass index,prognostic nutritional index,Charlson comorbidity index(CCI),Glasgow prognostic score,neutrophil-to-lymphocyte ratio,and antithrombotic agent *** selected the LASSO Cox regression model that resulted in minimal prediction error in 10-f

关键词： Endoscopic submucosal dissection Elderly Charlson comorbidity index Early gastric cancer Complications Prognostic indicators

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1978和2005年宫城近海地震的动力学震源模拟:破裂能解释

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世界地震译丛 2010年第6期41卷 1-13页

作者： Takeshi Kimura kazuki Koketsu Hiroe Miyake Changjiang Wu Takashi Miyatake 袁志祥（译）徐世芳（校）不详陕西省地震局

对1978和2005年发生在同一板块边界而震级不同的日本宫城近海地震建立了自发动力破裂模型,再现了由运动学震源模型所预测的滑动和破裂速度。对这两次地震的动力学震源参数进行比较,可使我们看到同一断层上不同震源过程的破裂动力学特征... 详细信息

对1978和2005年发生在同一板块边界而震级不同的日本宫城近海地震建立了自发动力破裂模型,再现了由运动学震源模型所预测的滑动和破裂速度。对这两次地震的动力学震源参数进行比较,可使我们看到同一断层上不同震源过程的破裂动力学特征。特别是,我们比较了应力降和破裂能,在这两次地震中,二者可以进行稳定的评估。在整个断层面上和两次地震破裂的凹凸体上,两个模型中应力降的最大值和平均值几乎相同。另外,1978年地震的震级比2005年的大,它的破裂能值不仅是在整个断层面上,而且在多次破裂的凹凸体上也比2005年的大。这些结果与先前用地震矩所做的破裂能标度的研究结果一致。我们还将破裂能值与以前研究中所估算的其他内陆地震的能值进行了对比,我们得到的宫城近海地震的值较小。造成这种不一致的原因可能是内陆浅源地震和俯冲带深源地震在构造背景上的差异。

关键词：动力学特征破裂模型近海地震震源模型宫城模拟内陆地震断层面

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Risk factors for lymph node metastasis in patients with pancreatic neuroendocrine neoplasms

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World Journal of Clinical Oncology 2022年第6期13卷 520-528页

作者： Yosuke Nakao Hiromitsu Hayashi Yo-ichi Yamashita Ofuchi Takashi kazuki Matsumura Norio Uemura Fumimasa Kitamura Rumi Itoyama Toshihiko Yusa Katsunobu Taki Tatsunori Miyata Takaaki Higashi Shigeki Nakagawa Hirohisa Okabe Katsunori Imai Hideo Baba Department of Gastroenterological Surgery Kumamoto UniversityKumamoto 860-8556Japan

BACKGROUND Although PNENs generally have a better prognosis than pancreatic cancers,some PNENs display malignant behavior including lymph node(LN)*** tumor resection can be the only potentially curative treatment for patients with resectable ***,the indications for LN dissection are still *** the last decade,minimally invasive surgery such as laparoscopic pancreatic surgery(LPS)has been increasingly performed for pancreatic tumors including *** To investigate the risk factors for LN metastasis in PNENs and to select appropriate patients for limited surgery by *** From April 2001 to December 2019,92 patients underwent pancreatic resection for PNENs at Kumamoto University ***,82 patients were enrolled in this *** perioperative factors,we examined the predictive factors for LN metastasis in *** Among the 82 patients,the percentage of LN metastasis according to the pathological findings was 12%(10/82 cases).The median tumor size was 12 mm(range:5-90 mm).The median tumor size in the LN-positive group(37 mm)was significantly larger than that in the LN-negative group(12 mm)(P=0.0001).Multivariate analyses revealed that larger tumor size(≥20 mm)was an independent risk factor for LN metastasis(odds ratio 16.8,P=0.0062).In patients with small tumors(≤10 mm),LN metastasis was not *** Larger tumor size(≥20 mm)is an independent risk factor for LN metastasis in *** smaller PNENs(≤10 mm),we may be able to choose limited surgery without LN dissection.

关键词： Lymph node metastasis Pancreatic neuroendocrine neoplasms Risk factor Tumor size

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Immunotherapy for colorectal cancer

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World Journal of Gastroenterology 2013年第46期19卷 8531-8542页

作者： Shigeo Koido Toshifumi Ohkusa Sadamu Homma Yoshihisa Namiki kazuki Takakura Keisuke Saito Zensho Ito Hiroko Kobayashi Mikio Kajihara Kan Uchiyama Seiji Arihiro Hiroshi Arakawa Masato Okamoto Jianlin Gong Hisao Tajiri Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of Medicine Department of Oncology Institute of DNA Medicine The Jikei University School of Medicine Institute of Clinical Medicine and Research The Jikei University School of Medicine Department of Endoscopy The Jikei University School of Medicine Division of Cellular Signaling Institute for Advanced Medical Research Keio University School of Medicine Department of Medicine Boston University School of Medicine Boston

The incidence of colorectal cancer(CRC)is on the rise,and the prognosis for patients with recurrent or metastatic disease is extremely *** chemotherapy and radiation therapy can improve survival rates,it is imperative to integrate alternative strategies such as immunotherapy to improve outcomes for patients with advanced *** this review,we will discuss the effect of immunotherapy for inducing cytotoxic T lymphocytes and the major immunotherapeutic approaches for CRC that are currently in clinical trials,including peptide vaccines,dendritic cell-based cancer vaccines,whole tumor cell vaccines,viral vector-based cancer vaccines,adoptive cell transfer therapy,antibody-based cancer immunotherapy,and cytokine *** possibility of combination therapies will also be discussed along with the challenges presented by tumor escape mechanisms.

关键词： Colorectal cancer Cytotoxic T lymphocyte Dendritic cell Immunotherapy vaccine

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Transnasal and standard transoral endoscopies in the screening of gastric mucosal neoplasias

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World Journal of Gastrointestinal Endoscopy 2011年第8期3卷 162-170页

作者： Hiroya Nakata Shotaro Enomoto Takao Maekita Izumi Inoue kazuki Ueda Hisanobu Deguchi Naoki Shingaki Kosaku Moribata Yoshimasa Maeda Yoshiyuki Mori Mikitaka Iguchi Hideyuki Tamai Hiroya Nakata Nobutake Yamamichi Mitsuhiro Fujishiro Jun Kato Masao Ichinose Department of Gastroenterology School of Medicine Wakayama Medical University Wakayama City Wakayama 641-0012 Japan Nakata Medical Clinic Wakayama 641-0006 Japan Department of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo 113-8655 Japan

AIM: To compare the diagnostic performances of transnasal and standard transoral esophagogastroduodenoscopy (EGD) in gastric cancer screening of asymptomatic healthy subjects. METHODS: Between January 2006 and March 2010, a total of 3324 subjects underwent examination of the upper gastrointestinal tract by EGD for cancer screening, with 1382 subjects (41.6%) screened by transnasal EGD and the remaining 1942 subjects (58.4%) by standard transoral EGD. Clinical profiles of the screened subjects, detection rates of gastric neoplasia and histopathology of the detected neoplasias were compared between groups according to the stage of Helicobacter pylori (H. pylori)-related chronic gastritis. RESULTS: Clinical profiles of subjects did not differ significantly between the two EGD groups, except that there were significantly more men in the transnasal EGD group. During the study period, 55 cases of gastric mucosal neoplasias were detected. Of these, 23 cases were detected by transnasal EGD and 32 cases by standard transoral EGD. The detection rate for gastric mucosal neoplasia in the transnasal EGD group was thus 1.66%, compared to 1.65% in the standard transoral EGD group, with no significant difference between the two groups. Detection rates using the two endoscopies were likewise comparable, regardless of H. pylori infection. However, detection rates when screening subjects without extensive chronic atrophic gastritis (CAG) were significantly higher with standard transoral EGD (0.70%) than with transnasal EGD (0.12%, P < 0.05). In particular, standard transoral EGD was far better for detecting neoplasia in subjects with H. pylori-related non-atrophic gastritis, with a detection rate of 3.11% compared to 0.53% using transnasal EGD (P < 0.05). In the screening of subjects with extensive CAG, no significant differences in detection of neoplasia were evident between the two endoscopies, although the mean size of detected cancers was significantly smaller and the percentage o

关键词： Transnasal endoscopy Gastric cancer Gastric adenoma Atrophic gastritis Helicobacter pylori Cancer screening

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Clinical effects of adalimumab treatment with concomitant azathioprine in Japanese Crohn's disease patients

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World Journal of Gastroenterology 2013年第17期19卷 2676-2682页

作者： Kumi Ishida Takuya Inoue Kaori Fujiwara Taisuke Sakanaka Ken Narabayashi Sadaharu Nouda Toshihiko Okada kazuki Kakimoto Takanori Kuramoto Ken Kawakami Yosuke Abe Toshihisa Takeuchi Mitsuyuki Murano Satoshi Tokioka Eiji Umegaki Kazuhide Higuchi the Second Department of Internal Medicine Osaka Medical College Takatsuki City

AIM:To assess adalimumab's efficacy with concomitant azathioprine (AZA) for induction and maintenance of clinical remission in Japanese Crohn's disease (CD) patients. METHODS:This retrospective, observational, singlecenter study enrolled 28 consecutive CD patients treated with adalimumab (ADA). Mean age and mean disease duration were 38.1 ± 11.8 years and 11.8 ± 10.1 years, respectively. The baseline mean Crohn's disease activity index (CDAI) and C-reactive protein were 177.8 ± 82.0 and 0.70 ± 0.83 mg/dL, respectively. Twelve of these patients also received a concomitant stable dose of AZA. ADA was subcutaneously administered:160 mg at week 0, 80 mg at week 2, followed by 40 mg every other week. Clinical response and remission rates were assessed via CDAI and C-reactive protein for 24 wk. RESULTS:The mean CDAI at weeks 2, 4, 8, and 24 was 124.4, 120.2, 123.6, and 135.1, respectively. The CDAI was significantly decreased at weeks 2 and 4 with ADA and was significantly suppressed at 24 wk with ADA/AZA. Overall clinical remission rates at weeks 4 and 24 were 66.7% and 63.2%, respectively. Although no statistically significant difference in C-reactive protein was demonstrated, ADA with AZA resulted in a greater statistically significant improvement in CDAI at 24 wk, compared to ADA alone. CONCLUSION:Scheduled ADA with concomitant AZA may be more effective for clinical remission achievement at 24 wk in Japanese Crohn's disease patients.

关键词： Crohn’s disease Adalimumab Immunomodulator Azathioprine Inflammatory bowel disease

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