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Tumor Segmentation on <sup>18</sup>F FDG-PET Images Using Graph Cut and Local Spatial Information

Open Journal of Medical Imaging 2015年第3期5卷 174-181页

作者： Mizuho Nishio Atsushi K. Kono kazuhiro kubo Hisanobu Koyama Tatsuya Nishii Kazuro Sugimura Clinical PET Center Institute of Biomedical Research and Innovation Kobe Japan Division of Functional and Diagnostic Imaging Research Department of Radiology Kobe University Graduate School of Medicine Kobe Japan Division of Radiology Department of Radiology Kobe University Graduate School of Medicine Kobe Japan Center for Radiology and Radiation Oncology Kobe University Hospital Kobe Japan

The purpose of this study was to develop methodology to segment tumors on 18F-fluorodeoxyg- lucose (FDG) positron emission tomography (PET) images. Sixty-four metastatic bone tumors were included. Graph cut was used for tumor segmentation, with segmentation energy divided into unary and pairwise terms. Locally connected conditional random fields (LCRF) were proposed for the pairwise term. In LCRF, three-dimensional cubic window with length L was set for each voxel, and voxels within the window were considered for the pairwise term. Three other types of segmentation were applied: region-growing based on 35%, 40%, and 45% of the tumor maximum standardized uptake value (RG35, RG40, and RG45, respectively), SLIC superpixels (SS), and region-based active contour models (AC). To validate the tumor segmentation accuracy, dice similarity coefficients (DSC) were calculated between the result of each technique and manual segmentation. Differences in DSC were tested using the Wilcoxon signed-rank test. Mean DSCs for LCRF at L = 3, 5, 7, and 9 were 0.784, 0.801, 0.809, and 0.812, respectively. Mean DSCs for the other techniques were: RG35, 0.633;RG40, 0.675;RG45, 0.689;SS, 0.709;and AC, 0.758. The DSC differences between LCRF and other techniques were statistically significant (p < 0.05). Tumor segmentation was reliably performed with LCRF.

关键词： Image Segmentation FDG-PET Graph Cut

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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

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Generalized periodontitis treated with periodontal,orthodontic,and prosthodontic therapy:A case report

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World Journal of Clinical Cases 2021年第21期9卷 6110-6124页

作者： Masato Kaku Shinji Matsuda Takayasu kubo Saiji Shimoe kazuhiro Tsuga Hidemi Kurihara Kotaro Tanimoto Department of Anatomy and Functional Restorations Hiroshima University Graduate School of Biomedical SciencesHiroshima 734-8553Japan Department of Periodontal Medicine Hiroshima University Graduate School of Biomedical SciencesHiroshima 734-8553Japan Department of Advanced Prosthodontics Hiroshima University Graduate School of Biomedical SciencesHiroshima 734-8553Japan Department of Orthodontics and Craniofacial Developmental Biology Hiroshima University Graduate School of Biomedical SciencesHiroshima 734-8553Japan

BACKGROUND Generalized periodontitis is a severe periodontal disease characterized by rapid periodontal destruction in healthy *** case report describes the treatment of a severe crowding,large overjet,and occlusal collapse due to the loss of anterior guidance with generalized *** SUMMARY A 35-year-old female patient with a chief complaint of crowding and maxillary protrusion was diagnosed with generalized periodontitis by clinical and radiographic *** improve crowding and overjet,orthodontic treatment was performed after basic periodontal *** damaged upper right lateral incisor and left canine were extracted,and lower right first premolar and left second premolar were also removed to treat severe *** orthodontic treatment,periodontal flap surgery for upper left molars and guided tissue regeneration for the lower left second molar was ***,a dental implant was inserted in the upper left canine *** esthetics of the maxillary anterior tooth was improved by prosthetic *** treatment result showed a well-improved occlusion with proper anterior guidance and healthy periodontal tissue after a retention period of 10 *** Periodontal,orthodontic,and prosthodontic treatments are extremely useful to improve function and stable periodontal tissue for generalized periodontitis.

关键词： Generalized periodontitis Orthodontic treatment Periodontal regenerative therapy Prosthodontic treatment Comprehensive dental treatment Long-term case study Case report

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Optical and Electrochemical Properties of Non-Peripheral Thioaryl-Substituted Subphthalocyanine as Precursors for Dye-Sensitizer to Develop Photovoltaic Cells

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American Journal of Analytical Chemistry 2014年第15期5卷 1037-1045页

作者： Keiichi Sakamoto Satoru Yoshino Makoto Takemoto kazuhiro Sugaya Hitomi kubo Tomoe Komoriya Shinnosuke Kamei Shigeki Furukawa Department of Sustainable Engineering College of Industrial Technology Nihon University Tokyo Japan Academic Major of Applied Molecular Chemistry Graduate School of Industrial Technology Nihon University Tokyo Japan

Phthalocyanines-related compounds, subphthalocyanines, are the homologues consisting of three isoindole units with boron as the center. The absorption maximum of subphthalocyanines, called the Q band, appears around 560 - 630 nm, which is shifted by approximately 100 nm to shorter wavelengths compared to phthalocyanines. Subphthalocyanines are used as precursors to prepare unsymmetric phthalocyanines for ring enlargement reaction. In this decade, phthalocyanines are used for dye-sensitized solar cells (DSSCs), which require strong absorption of far-red light between 700 and 850 nm because of their highly efficiency. Non-peripheral thioaryl-substituted phthalocyanines have been synthesized. They show near-infrared absorption around 780 - 870 nm and have excellent electron transfer properties. However, their lack of affinity to basal plats inhibits their use as DSSC photosensitizer. Therefore, to synthesize unsymmetrical non-peripheral thioaryl-substituted phthalocyanines possessing good affinity to basal plates, the authors prepared subphthalocyanines having thioaryl substituents as precursors. Spectroscopic properties and electron transfer abilities to synthesize non-peripheral thioaryl-substituted subphthalocyanines were estimated using cyclic voltammetry. The Q band of non-peripheral thioaryl-substituted subphthalocyanines shows around 650 nm shifted to longer wavelength by 86 nm in comparison to subphthalocyanine. The compounds show many reduction potentials. They are acceptable electrons in the subphthalocyanine ring, meaning that the compounds have good electron transfer properties.

关键词： Thioaryl Substituents Phthalocyanines Subphthalocyanine Cyclic Voltammetry Precursor for Dye-Sensitizer

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