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BIOCELL 2023年第5期47卷 1095-1106页

作者： MIZUNA YANO KOTA HIROI TETSUYA YUASA KENJI INOUE OSAMU YAMAMOTO TAKAO nakamura DAISUKE SATO ZHONGGANG FENG Graduate School of Science and Engineering Yamagata UniversityYonezawa9928510Japan Faculty of Health Sciences Japan Healthcare UniversitySapporo0620053Japan

Background:Human heart changes its energetic substrates from lactate and glucose to fatty acids during the neonatal *** the lack of fatty acids in media for the culture of cardiomyocytes derived from human pluripotent stem cells(hiPS-CM),researchers have supplemented mixtures of fatty acids to hiPS-CM and reported the enhancement in the maturation of *** our previous studies,we separately supplemented two polyunsaturated fatty acids(PUFAs),docosahexaenoic acid(DHA)or arachidonic acid(AA),to rat fetal cardiomyocytes and found that the supplementations upregulated the expressions of mRNAs for cardiomyocyte differentiation,fatty acid metabolism,and cellular *** enhancement in cellular contractility was attributed to the improvement in intercellular connection rather than a direct enhancement of the contractile ***:This study reports the successive results of the effects of DHA or AA supplementation on *** addition to the contractile force and mRNA measurements used in the previous study,we further investigated the effect of different cellular aggregations on the contractile force output by means of finite element analysis,measured glucose and fatty acids metabolites,and assessed cTNT and MLC2v expressions through immunofluorecsence ***:It showed that the sole supplementation of albumin-conjugated DHA or AA can be taken up by hiPS-CM without other uptake-enhancing factors,and the supplementations may activate the CD36_ERRγmetabolic *** or AA supplementation increased the cellular contractile ratio on collagen gels and AA supplementation stimulated hiPS-CM aggregation to form cellular *** enhancement effect on the hiPS-CM contractile force was modest since the increase in contractile force was not *** supplementation was more effective than DHA supplementation because it significantly upregulated mRNA expressions of P300 and ***,finite element analysis showed that the formati

关键词： Human iPS cells Cardiomyocytes Polyunsaturated fatty acid mRNA expression Contractility Fatty acid metabolism

Pattern sourcebook : Chinese style : 250 patterns for projects and designs / Shigeki nakamura.

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Pattern sourcebook : Chinese style : 250 patterns for projec...

Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy

2008年

作者： Shigeki nakamura.

Title translated: 图案资料集: 中国风格 Originally published in Japan by MdN Corporation, Tokyo, Japan.

ISBN: (纸本)9781592534975

Title translated: 图案资料集: 中国风格 Originally published in Japan by MdN Corporation, Tokyo, Japan.

关键词： Decoration and ornament China.

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Asian Journal of Andrology 2022年第1期24卷 116-118页

作者： Hiroshi Hongo Takeo Kosaka Hideyuki Hayashi Kohei nakamura Hiroshi Nishihara Shuji Mikami Himisha Beltran Mototsugu Oya Department of Urology Keio University School of Medicine35 ShinanomachiShinjuku-kuTokyo 160-8582Japan Genomics Unit Keio Cancer CenterKeio University School of Medicine35 ShinanomachiShinjuku-kuTokyo 160-8582Japan Division of Diagnostic Pathology Keio University Hospital35 ShinanomachiShinjuku-kuTokyo 160-8582Japan Department of Medical Oncology Dana-Farber Cancer Institute450 Brookline AvenueBostonMA 02215USA

Dear Editor,Spinal and bulbar muscular atrophy(SBMA)or Kennedy’s disease is a rare X-linked,recessive,lower motor neuron disease caused by a CAG repeat expansion within the first exon of the androgen receptor(AR)*** of the CAG-triplet repeat impacts AR function;therefore,men with SBMA are thought to be at a very low risk of prostate *** previously reported a case of high-risk prostate cancer with SBMA(repeat length 46).

关键词： atrophy muscular cancer

The relationship between formate adsorption energy and electronic properties: A first principles density functional theory study

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Science China Chemistry 2009年第9期52卷 1427-1433页

作者： MORIKAWA Yoshitada nakamura Junji The Institute of Scientific and Industrial Research (ISIR) Osaka University Research Institute for Computational Sciences (RICS) National Institute of Advanced Industrial Science and Technology (AIST) Institute of Materials Science University of Tsukuba

First principles density functional theory calculations have been performed for the chemisorption of formate adsorption on some metal surfaces. For the most stable adsorption site of short-bridge, the calculated formate adsorption energy follows the order of Au(110) < Ag(110) < Cu(110) < Pd(110) < Pt(110) < Ni(110) < Rh(110) < Fe(100) < Mo(100), and a clear linear correlation exists between the adsorption energy and the corresponding heat of formation of metal oxides. Moreover, it has been found that the formate adsorption energy for the transition metals can be correlated well with its d-band center (εd), and the IB Group metals can be described by the coupling matrix element square (Vad2).

关键词： formate metal DFT-GGA slab model adsorption energy d-band center

Identification of shared and unique gene families associated with oral clefts

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International Journal of Oral Science 2017年第2期9卷 104-109页

作者： Noriko Funato Masataka nakamura Department of Signal Gene Regulation Research Center for Medical and Dental SciencesTokyo Medical and Dental University1-5-45 YushimaBunkyo-kuTokyoJapan

Oral clefts, the most frequent congenital birth defects in humans, are multifactorial disorders caused by genetic and environmental factors. Epidemiological studies point to different etiologies underlying the oral cleft phenotypes, cleft lip(CL),CL and/or palate(CL/P) and cleft palate(CP). More than 350 genes have syndromic and/or nonsyndromic oral cleft associations in humans. Although genes related to genetic disorders associated with oral cleft phenotypes are known, a gap between detecting these associations and interpretation of their biological importance has remained. Here, using a gene ontology analysis approach, we grouped these candidate genes on the basis of different functional categories to gain insight into the genetic etiology of oral clefts. We identified different genetic profiles and found correlations between the functions of gene products and oral cleft phenotypes. Our results indicate inherent differences in the genetic etiologies that underlie oral cleft phenotypes and support epidemiological evidence that genes associated with CL/P are both developmentally and genetically different from CP only, incomplete CP, and submucous CP. The epidemiological differences among cleft phenotypes may reflect differences in the underlying genetic causes. Understanding the different causative etiologies of oral clefts is important as it may lead to improvements in diagnosis, counseling, and prevention.

关键词： cleft palate epidemiology gene ontology mutations soft palate syndrome

Identification of an intronic enhancer regulating RANKL expression in osteocytic cells

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骨研究:英文版 2023年第3期11卷 607-616页

作者： Minglu Yan Masayuki Tsukasaki Ryunosuke Muro Yutaro Ando Kazutaka nakamura Noriko Komatsu Takeshi Nitta Tadashi Okamura Kazuo Okamoto Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Microbiology Tokyo Dental CollegeTokyoJapan Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The bony skeleton is continuously renewed throughout adult life by the bone remodeling process,in which old or damaged bone is removed by osteoclasts via largely unknown *** regulate bone remodeling by producing the osteoclast differentiation factor RANKL(encoded by the TNFSF11 gene).However,the precise mechanisms underlying RANKL expression in osteocytes are still ***,we explored the epigenomic landscape of osteocytic cells and identified a hitherto-undescribed osteocytic cell-specific intronic enhancer in the TNFSF11 gene *** analyses showed that transcription factors involved in cell death and senescence act on this intronic enhancer ***-cell transcriptomic data analysis demonstrated that cell death signaling increased RANKL expression in osteocytic *** deletion of the intronic enhancer led to a high-bone-mass phenotype with decreased levels of RANKL in osteocytic cells and osteoclastogenesis in the adult stage,while RANKL expression was not affected in osteoblasts or *** data suggest that osteocytes may utilize a specialized regulatory element to facilitate osteoclast formation at the bone surface to be resorbed by linking signals from cellular senescence/death and RANKL expression.

关键词： utilize removed linking

A NEW APPROACH AND ERROR ANALYSIS FOR RECONSTRUCTING THE SCATTERED WAVE BY THE POINT SOURCE METHOD

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Journal of Computational Mathematics 2007年第2期25卷 113-130页

作者： Jijun Liu Gen nakamura Roland Potthast Department of Mathematics Southeast University Nanjing 210096 China Department of Mathematics Graduate School of Science Hokkaido University Sapporo 060-0810 Japan Institute for Numerical and Applied Mathematics University of Gottingen Lotzestr 16-1837085 Gottingen Germany

Consider an inverse scattering problem by an obstacle D belong to R^2 with impedance boundary. We investigate the reconstruction of the scattered field u^s from its far field pattern u^∞ using the point source method. First, by applying the boundary integral equation method, we provide a new approach to the point-source method of Potthast by classical potential theory. This extends the range of the point source method from plane waves to scattering of arbitrary waves. Second, by analyzing the behavior of the Hankel function, we obtain an improved strategy for the choice of the regularizing parameter from which an improved convergence rate （compared to the result of [15]） is achieved for the reconstruc- tion of the scattered wave. Third, numerical implementations are given to test the validity and stability of the inversion method for the impedance obstacle.

关键词： Inverse scattering Regularization Error estimate Numerics

Effects of Fasting on Plasma Lipoprotein(a) in Cynomolgus Monkeys: Preliminary Experiments Results

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Open Journal of Animal Sciences 2014年第5期4卷 222-227页

作者： Masataka Kusunoki kazuhiko Tsutsumi Daisuke Sato Tetsuro Miyata Takao nakamura Department of Internal Medicine Medical Clinic Aichi Medical University Nagoya Japan Okinaka Memorial Institute for Medical Research Tokyo Japan Department of Biomedical Information Engineering Graduate School of Medical Science Yamagata University Yamagata Japan Vascular Center Sanno Medical Center Tokyo Japan

Plasma lipoprotein(a) (Lp(a)) is known to be a strong independent risk factor for ischemic heart disease. However, it is not easily modulated by drugs that are presently available. Lp(a) is not present in many experimental animals except for Old World monkeys. In this study, we examined whether cynomolgus monkeys are useful model for research of human plasma Lp(a), and observed that plasma Lp(a) in cynomolgus monkeys varied as much as humans. As a result of 4 day-fasting in cynomolgus monkeys, the plasma Lp(a) level decreased in a monkey with originally high Lp(a) level. The Lp(a) level continued to decrease even 3 days after banana feeding, but returned to the original level 3 days after monkey chow feeding. On the other hand, in a monkey with low Lp(a) level, fasting had no effect on the Lp(a) level. However, in the third monkey having originally high Lp(a) level, the Lp(a) was not affected by decreasing the amount of monkey chow feeding by 50%. In summary, we found that cynomolgus monkeys may be an useful model for studying the effects of food on plasma Lp(a) in place of humans, and that high Lp(a) level may be controllable by strict diet regulation.

关键词： Lipoprotein(a) Fasting Cynomolgus Monkey Banana

THE LOCAL WELL-POSEDNESS OF A CHEMOTAXIS-SHALLOW WATER SYSTEM WITH VACUUM

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Acta Mathematica Scientia 2021年第1期41卷 231-240页

作者：樊继山栗付才 Gen nakamura Department of Applied Mathematics Nanjing Forestry UniversityNanjing 210037China Department of Mathematics Nanjing UniversityNanjing 210093China Department of Mathematics Hokkaido UniversitySapporo 060-0810Japan

In this paper we prove the local well-posedness of strong solutions to a chemotaxisshallow water system with initial vacuum in a bounded domainΩ■R^(2)without the standard compatibility condition for the initial *** ... 详细信息

关键词： chemotaxis shallow water vacuum local well-posedness strong solution