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Endoscopic submucosal dissection of gastric adenomas using the clutch cutter

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World Journal of Gastrointestinal Endoscopy 2017年第7期9卷 334-340页

作者： Kazuya Akahoshi Masaru Kubokawa Junya Gibo Shigeki Osada Kayo Tokumaru Eriko Yamaguchi Hiroko Ikeda Takao Sato Kazuaki Miyamoto Yusuke Kimura Yuki Shiratsuchi Kazuaki Akahoshi Masafumi Oya Hidenobu Koga Eikichi Ihara kazuhiko nakamura Department of Gastroenterology Aso Iizuka Hospital Department of Pathology Aso Iizuka Hospital Clinical Research Support Office Aso Iizuka Hospital Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu University

To evaluate the efficacy and safety of endoscopic submucosal dissection (ESD) using the clutch cutter (CC) (ESD-CC) for gastric adenoma (GA). METHODSFrom June 2007 to August 2015, 122 consecutive patients with histological diagnoses of GA from specimens resected by ESD-CC were enrolled in this prospective study. The CC was used for all ESD steps (marking, mucosal incision, submucosal dissection, and hemostatic treatment), and its therapeutic efficacy and safety were assessed. RESULTSBoth the en-bloc resection rate and the R0 resection rate were 100% (122/122). The mean surgical time was 77.4 min, but the time varied significantly according to tumor size and location. No patients suffered perforation. Post-ESD-CC bleeding occurred in six cases (4.9%) that were successfully resolved by endoscopic hemostatic treatment. CONCLUSIONESD-CC is a technically efficient, safe, and easy method for resecting GA.

关键词： Endoscopic submucosal dissection Clutch cutter Gastric adenoma

Contemplative neuroaesthetics and architecture:A sensorimotor exploration

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Frontiers of Architectural Research 2024年第1期13卷 97-111页

作者： Zakaria Djebbara Juliet King Amir Ebadi Yoshio nakamura Julio Bermudez Department of Architecture DesignMediaand TechnologyAalborg UniversityAalborgDenmark Biopsychology und Neuroergonomy Technical University BerlinBerlinGermany Art Therapy Department The George Washington UniversityWashington DCUnited States Department of Neurology Indiana University School of MedicineIndianapolisUnited States Dellustration Washington DCUnited States Pain Research Center Division of Pain MedicineDepartment of AnesthesiologyUniversity of Utah School of MedicineUtahUnited States School of Architecture and Planning The Catholic University of AmericaWashington DCUnited States

This paper takes initial steps towards developing a theoretical framework of contemplative neuroaesthetics through sensorimotor *** first argue that this new area has been largely omitted from the contemporary research agenda in neuroaesthetics and thus remains a domain of untapped *** seek to define this domain to foster a clear and focused investigation of the capacity of the arts and architecture to induce phenomenological states of a contemplative *** proposing a sensorimotor account of the experience of architecture,we operationalize how being attuned to architecture can lead to contemplative *** contrasting the externally-induced methods with internally-induced methods for eliciting a contemplative state of mind,we argue that architecture may spontaneously and effortlessly lead to such states as certain built features naturally resonate with our sensorimotor *** suggest that becoming sensible of the resonance and attunement process between internal and external states is what creates an occasion for an externallyinduced contemplative ***,we review neuroscientific studies of architecture,elaborate on the brain regions involved in such aesthetic contemplative responses,provide architectural examples,and point at the contributions that this new area of inquiry may have in fields such as the evidence-based design movement in architecture.

关键词： Neuropheno menology Neuroaesthetics Contemplative states Architectural experience Well-being

Prognosis value of heat-shock proteins in esophageal and esophagogastric cancer:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1578-1595页

作者： Eric Toshiyuki nakamura Amanda Park Marina Alessandra Pereira Daniel Kikawa Francisco Tustumi Department of Gastroenterology Instituto do CâncerHospital das Clínicas da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Scientific Initiation Universidade Mogi das CruzesSão Paulo 08780911Brazil Department of Evidence-Based Medicine Centro Universitário LusíadaCentre for Evidence-Based MedicineCentro Universitário Lusíada(UNILUS)SantosBrazil Department of Surgery Hospital Israelita Albert EinsteinSão Paulo 05652900Brazil

BACKGROUND Heat shock proteins(HSPs)are molecular chaperones that play an important role in cellular protection against stress events and have been reported to be overex-pressed in many *** prognostic significance of HSPs and their regulatory factors,such as heat shock factor 1(HSF1)and CHIP,are poorly *** To investigate the relationship between HSP expression and prognosis in esophageal and esophagogastric *** A systematic review was conducted in accordance with PRISMA recommend-ations(PROSPERO:CRD42022370653),on Embase,PubMed,Cochrane,and ***,case-control,and cross-sectional studies of patients with eso-phagus or esophagogastric cancer were ***-positive patients were compared with HSP-negative,and the endpoints analyzed were lymph node metastasis,tumor depth,distant metastasis,and overall survival(OS).HSPs were stratified according to the HSP family,and the summary risk difference(RD)was calculated using a random-effect *** The final selection comprised 27 studies,including esophageal squamous cell carcinoma(21),esophagogastric adenocarcinoma(5),and mixed neoplasms(1).The pooled sample size was 3465 ***40 and 60 were associated with a higher 3-year OS[HSP40:RD=0.22;95%confidence interval(CI):0.09-0.35;HSP60:RD=0.33;95%CI:0.17-0.50],while HSF1 was associated with a poor 3-year OS(RD=-0.22;95%CI:-0.32 to-0.12).The other HSP families were not associated with long-term ***1 was associated with a higher probability of lymph node metastasis(RD=-0.16;95%CI:-0.29 to-0.04).HSP40 was associated with a lower probability of lymph node dissemination(RD=0.18;95%CI:0.03-0.33).The expression of other HSP families was not significantly related to tumor depth and lymph node or distant *** The expression levels of certain families of HSP,such as HSP40 and 60 and HSF1,are associated with long-term survival and lymph node dissemination in patients with esophageal and esophagogastric cancer.

关键词： Heat-shock proteins Heat-shock response Prognosis Esophageal neoplasms Meta-analysis

基于减压脱水干燥装置的高浓度切削液废水的处理及回收利用

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北京大学学报（自然科学版） 2018年第6期54卷 1267-1275页

作者：范怡邹振东李瑞利吴晓芳邱国玉中村一彦高健深圳市太阳能与风能海水淡化关键技术工程实验室北京大学深圳研究生院环境与能源学院深圳518055 深圳市大井和环保科技有限公司深圳518000

设计并改进减压脱水干燥装置,改善金属加工过程中产生的大量切削液废水的处理与回收工艺,以期达到污水零排放和资源化的目标。实验结果表明,减压脱水干燥装置对废水中总悬浮物的平均去除率超过99.38%,对油脂类(n-HEX)、BOD5、CODMn、总... 详细信息

设计并改进减压脱水干燥装置,改善金属加工过程中产生的大量切削液废水的处理与回收工艺,以期达到污水零排放和资源化的目标。实验结果表明,减压脱水干燥装置对废水中总悬浮物的平均去除率超过99.38%,对油脂类(n-HEX)、BOD5、CODMn、总氮、总磷、铜和锌的平均去除率分别为99.07%,96.67%,98.64%, 81.28%, 99.33%, 98.69%和99.79%。另外,结合臭氧处理可以进一步提高对有机污染物的去除率。与其他处理方法相比,本装置在处理污水的过程中气味小,噪音少,不需要添加大量化学药剂,占地面积小,成本较低,适合大批量地处理高浓度切削液废水。

关键词：减压脱水干燥装置切削液废水废水处理回收利用

A Survey of Digital Content Required for STD Prevention Education Taught by School Nurses

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Health 2024年第4期16卷 350-370页

作者： Tomoko nakamura Faculty of Nursing Hyogo University Kakogawa Japan

Purpose: In recent years, there has been concern in Japan about the increase in STDs among adolescents aged 15 - 19. In order to prevent STDs and guide adolescents toward desirable sexual behavior, this study’s goal was to examine the actual state of STD prevention education taught by school nurses as part of the school curriculum, as well as the kinds of digital content they wish to have for teaching on the subject. Method: An anonymous, self-administered questionnaire was distributed by email and leaflet. Targeting the 100 valid responses received from the surveyed school nurses, descriptive statistics were made for each survey item and comparisons were made between the early- and mid-career groups based on years of experience. Results: 70.0% of respondents reported teaching about STDs in Health & Physical Education classes. School nurses in the early-career group used ready-made materials, while the mid-career group used both ready-made and self-made materials. 95% of respondents reported that they had little or no knowledge of STDs, while 84% reported that they were “good” or “fairly good” at teaching classes on sexuality. Both groups reported difficulty with the topics of “phimosis” and “nocturnal emissions” in the physiological category, “sexual behavior” in the “sex-adjacent” category, and “sexual and reproductive issues” in the psychosocial category. Respondents expressed a need for digital content covering the topics of “sexual violence”, “sexual abuse”, “sexually transmitted diseases”, and “how to turn down sex”. The mid-career group desired digital content for more items than the early-career group, with significant differences in the pathogens involved in sexually transmitted diseases and sex-adjacent items. 32.0% of respondents answered that they had done self-study for sex education classes in the past three years, and both groups desired self-study on “sexually transmitted diseases”, with the mid-career group significantly higher than the early-career

关键词： High School Students Sexually Transmitted Diseases Digital Content School Nurses

基于减压脱水干燥技术的高浓度工业污水中重金属的去除与资源化

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环境工程学报 2017年第12期11卷 6266-6275页

作者：吴晓芳沈小雪邹振东李瑞利范怡邱国玉中村和彦高健北京大学深圳研究生院环境与能源学院深圳市太阳能与风能海水淡化关键技术工程实验室深圳518055 深圳市大井和环保科技有限公司深圳518000

工业污水中高浓度重金属的去除一直是环境污染治理领域的一个难题。至今为止,在实验室水平上有很多可以借鉴的技术,但能在实际工程领域实用的技术还比较缺乏。为此,通过利用改进的减压脱水干燥装置,对多种含有重金属(Cu、Zn、Ni、Pb)的... 详细信息

工业污水中高浓度重金属的去除一直是环境污染治理领域的一个难题。至今为止,在实验室水平上有很多可以借鉴的技术,但能在实际工程领域实用的技术还比较缺乏。为此,通过利用改进的减压脱水干燥装置,对多种含有重金属(Cu、Zn、Ni、Pb)的高浓度工业废水的处理流程和技术进行研究。结果表明,无论污染源和污水种类如何,减压脱水干燥装置对废水中Cu、Zn、Pb、Ni的去除效果都非常明显,去除率均保持在93.33%~99.99%,对高浓度重金属去除率可达99.99%。浓缩以后的重金属可以回收再利用;不同类型工业废水中悬浮物(SS)、有机物(COD和BOD_5)和油类的浓度高低,不影响其中重金属的去除;除了重金属以外,本技术对其他污染物质也有明显的去除效果,去除效果的排序为:重金属>SS>COD>BOD_5>油类。本装置处理过程无需添加药剂、对废水的前处理要求低、它的封闭性减轻了气味和噪音,是一种操作简便且高效环保的污水处理系统。

关键词：减压脱水干燥装置高浓度工业废水重金属 Pb Zn Cu Ni 零排放资源化

Steroidal scaffold decorations in Solanum alkaloid biosynthesis

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Molecular Plant 2024年第8期17卷 1236-1254页

作者： Rosalind Lucier Mohamed O.Kamileen Yoko nakamura Sofiia Serediuk Ranjit Barbole Jens Wurlitzer Maritta Kunert Sarah Heinicke Sarah E.O'Connor Prashant D.Sonawane Department of Natural Product Biosynthesis Max Planck Institute for Chemical Ecology07745 JenaGermany Research Group Biosynthesis and NMR Max Planck Institute for Chemical Ecology07745 JenaGermany Biochemical Sciences Division CSIR-National Chemical LaboratoryPune 411008MaharashtraIndia

Steroidal glycoalkaloids(SGAs)are specialized metabolites produced by hundreds of Solanum species,including important vegetable crops such as tomato,potato,and *** it has been known that SGAs play important roles in defense in plants and“anti-nutritional"effects(e.g.,toxicity and bitterness)to humans,many of these molecules have documented anti-cancer,anti-microbial,antiinflammatory,anti-viral,and anti-pyretic *** these,α-solasonine andα-solamargine isolated from black nightshade(Solanum nigrum)are reported to have potent anti-tumor,anti-proliferative,and anti-inflammatory ***,α-solasonine andα-solamargine,along with the core steroidal aglycone solasodine,are the most widespread SGAs produced among the Solanum ***,it is still unknown how plants synthesize these bioactive steroidal *** comparative metabolomictranscriptome-guided approach,biosynthetic logic,combinatorial expression in Nicotiana benthamiana,and functional recombinant enzyme assays,here we report the discovery of 12 enzymes from *** that converts the starting cholesterol precursorto solasodine aglycone,and the downstreamα-solasonine,α-solamargine,and malonyl-solamargine SGA *** further identified six enzymes from cultivated eggplant that catalyze the production ofα-solasonine,α-solamargine,and malonyl-solamargine SGAs from solasodine aglycone via glycosylation and atypical malonylation *** work provides the gene tool box and platform for engineering the production of high-value,steroidal bioactive molecules inheterologoushosts usingsyntheticbiology.

关键词： steroidal glycoalkaloids Solanum biosynthetic pathway α-solamargine malonyl-solamargine specialized metabolites

Endoscopic approach through the minor papilla for the management of pancreatic diseases

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World Journal of Gastrointestinal Endoscopy 2013年第3期5卷 81-88页

作者： Nao Fujimori Hisato Igarashi Akira Asou Ken Kawabe Lingaku Lee Takamasa Oono Taichi nakamura Yusuke Niina Masayuki Hijioka Masahiko Uchida Kazuhiro Kotoh kazuhiko nakamura Tetsuhide Ito Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityHigashi-kuFukuoka 812-8582Japan Department of Gastroenterology National Hospital OrganizationKyushu Medical CenterChuou-kuFukuoka 810-8563Japan

AIM:To clarify the efficacy and safety of an endoscopic approach through the minor papilla for the management of pancreatic ***:This study included 44 endoscopic retrograde cholangiopancreatography(ERCP) procedures performed in 34 patients using a minor papilla approach between April 2007 and March *** retrospectively evaluated the clinical profiles of the patients,the endoscopic interventions,short-term outcomes,and ***:Of 44 ERCPs,26 were diagnostic ERCP,and 18 were therapeutic *** most common cause of difficult access to the main pancreatic duct through the major papilla was pancreas divisum followed by distortion of Wirsung's *** overall success rate of minor papilla cannulation was 80%(35/44),which was significantly improved by wire-guided cannulation(P = 0.04).Endoscopic minor papillotomy(EMP) was performed in 17 of 34 patients(50%) using a needle-knife(13/17) or a pull-type papillotome(4/17).EMP with pancreatic stent placement,which was the main therapeutic option for patients with chronic pancreatitis,recurrent acute pancreatitis,and pancreatic pseudocyst,resulted in short-term clinical improvement in 83% of *** post-ERCP pancreatitis occurred as an early complication in 2 cases(4.5%).CONCLUSION:The endoscopic minor papilla approach is technically feasible,safe,and effective when the procedure is performed in a high-volume referral center by experienced endoscopists.

关键词： Endoscopic papillotomy Endoscopic retrograde cholangiopancreatography Minor papilla Pancreas divisum Pancreatitis

The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

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International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro Ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi Okamura Akira Yamaguchi Kazuyuki Ishihara Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction