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Prognostic factors associated with mortality in patients with gastric fundal variceal bleeding

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World Journal of Gastroenterology 2017年第3期23卷 496-504页

作者： Keishi Komori Masaru Kubokawa Eikichi Ihara Kazuya Akahoshi kazuhiko Nakamura Kenta Motomura Akihide Masumoto Department of Gastroenterology Aso Iizuka HospitalIizuka 820-8505Japan Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityHigashi-kuFukuoka 812-8582Japan Department of Hepatology Aso Iizuka HospitalIizuka 820-8505Japan

AIM To determine the prognostic factors associated with mortality in patients with gastric fundal variceal (GFV) *** In total, 42 patients were endoscopically diagnosed with GFV bleeding from January 2000 to March 2014. We retrospectively reviewed the patients' medical records and assessed their history, etiology of liver cirrhosis, disease conditions, treatment options for GFV bleeding, medications administered before and after onset of GFV bleeding, blood test results(hemoglobin, albumin, and bilirubin concentrations), and imaging results(including computed tomography and abdominal ultrasonography). We also assessed the prognostic factors associated with short-term mortality(up to 90 d) and long-term mortality in all *** Multivariate analysis showed that prophylactic administration of antibiotics was an independent prognostic factor associated with decreases in short-term mortality (OR = 0.08, 95%CI: 0.01-0.52) and longterm mortality (OR = 0.27, 95%CI: 0.08-0.91) in patients with GFV bleeding. In contrast, concurrent hepatocellular carcinoma (HCC) and regular use of proton pump inhibitors (PPI) were independent prognostic factors associated with increases in shortterm mortality(HCC: OR = 15.4, 95%CI: 2.08-114.75; PPI: OR = 12.76, 95%CI: 2.13-76.52) and long-term mortality (HCC: OR = 7.89, 95%CI: 1.98-31.58; PPI: OR = 10.91, 95%CI: 2.86-41.65) in patients with GFV bleeding. The long-term overall survival rate was significantly lower in patients who regularly used PPI than in those who did not use PPI(P = 0.0074).CONCLUSION Administration of antibiotics is associated with decreased short- and long-term mortality, while concurrent HCC and regular PPI administration are associated with increased short- and long-term mortality.

关键词： Antibiotics Gastric varices Gastric fundus Proton pump inhibitors Hemorrhage

Molecule/Semiconductor Hybrid Materials for Visible-Light CO_(2) Reduction:Design Principles and Interfacial Engineering

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Accounts of Materials Research 2021年第6期2卷 458-470页

作者： Akinobu Nakada Hiromu Kumagai Marc Robert Osamu Ishitani kazuhiko Maeda Department of Chemistry School of ScienceTokyo Institute of TechnologyTokyo 152-8550Japan Precursory Research for Embryonic Science and Technology(PRESTO) Japan Science and Technology Agency(JST)KawaguchiSaitama 332-0012Japan Department of Applied Chemistry Faculty of Science and EngineeringChuo UniversityBunkyo-kuTokyo 112-8551Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University2-1-1 KatahiraAoba-kuSendai 980-8577Japan Universitéde Paris Laboratoire d’Electrochimie MoléculaireCNRSF75006 ParisFrance Institut Universitaire de France(IUF) F-75005 ParisFrance

CONSPECTUS:Because of increasing concerns over the depletion of energy sources and the concomitant increase in CO_(2)emissions,much attention has been devoted to carbon capture and utilization *** the various methods and schemes proposed,visible-light-driven CO_(2)reduction in combination with water oxidation,one of the representative models of artificial photosynthesis,is an attractive solution because it enables abundant water and inexhaustible solar energy to be used to produce value-added *** metal complexes and semiconductors are promising candidates for photocatalysts that can reduce CO_(2)to CO,formate,formaldehyde,or other *** both molecular metal complexes and semiconductors have strengths and weaknesses,their weaknesses(low oxidation ability and low selectivity for reduction reactions)can be overcome via the construction of a suitable molecule/semiconductor hybrid ***,facilitating electron transfer at the molecule/semiconductor junction while suppressing unfavorable back electron transfer events is ***,the number of molecule/semiconductor hybrid systems that show a reasonable level of visible-light photocatalytic activity is limited,despite the development of a large number of visible-light-driven semiconductors and molecular photocatalysts(or catalysts).In this Account,we describe our approaches to developing hybrid photocatalysts and photoelectrodes for CO_(2)*** have been developing both molecular(photo)catalysts and semiconductor photocatalysts individually,the latter of which are also designed for visible-light water *** example,supramolecular photocatalysts that possess both photosensitizer and catalyst units in a single molecule can reduce CO_(2)to formate or CO in a homogeneous system,with high selectivity toward the desired product and high quantum yields of several tens of ***,nonoxide semiconductors such as C/N-based polymers and mix

关键词： visible selectivity Visible

Computed tomography virtual endoscopy with angiographic imaging for the treatment of type Ⅳ-A choledochal cyst

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World Journal of Gastroenterology 2012年第28期18卷 3761-3764页

作者： Akihiko Tsuchida Yuichi Nagakawa kazuhiko Kasuya Bunso Kyo Takahisa Ikeda Yoshiaki Suzuki Tatsuya Aoki Takao Itoi Third Department of Surgery Tokyo Medical University Tokyo 160-0023 Japan Fourth Department of Internal Medicine Tokyo Medical University Tokyo 160-0023 Japan

Type Ⅳ-A choledochal cysts (CCs) are a congenital biliary anomaly which involve dilatation of the extrahepatic and intrahepatic bile ducts. We present the case of a 30-year-old woman with type Ⅳ-A CC, on whom threedimensional computed tomography (3D CT) and virtual endoscopy were performed. 3D CT revealed partial dilatation in the posterior branch of the intrahepatic bile duct and a relative stricture between it and the extrahepatic bile duct. Virtual endoscopy showed that this stricture was membrane-like and separated from the surrounding blood vessels. Based on these image findings, complete cyst resection, bile duct plasty for the stricture, and hepaticojejunostomy were safely performed. To the best of our knowledge, there are no reports of imaging by virtual endoscopy of the biliary tract which show the surrounding blood vessels running along the bile duct.

关键词： Choledochal cyst Bile duct dilatation Computed tomography Virtual endoscopy Bile duct plasty

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定向反射管束对辐照均匀性的影响

中国电机工程学报 2007年第2期27卷 103-108页

作者：路义萍李炳熙韩家德 KUDO kazuhiko 哈尔滨理工大学机械动力工程学院黑龙江省哈尔滨市150080 哈尔滨工业大学能源科学与工程学院黑龙江省哈尔滨市150001 北海道大学机械工程学院

为使多孔陶瓷板燃气辐射器加热物体能量定向集中,减少向周围环境散失的热量,在辐射器的前方,设计了定向反射管束,并进行了被加热物体表面辐照度分布特性数值计算研究。利用蒙特卡罗法中的辐射分配因子计算并分析了相关参数,例如管束布置... 详细信息

为使多孔陶瓷板燃气辐射器加热物体能量定向集中,减少向周围环境散失的热量,在辐射器的前方,设计了定向反射管束,并进行了被加热物体表面辐照度分布特性数值计算研究。利用蒙特卡罗法中的辐射分配因子计算并分析了相关参数,例如管束布置(顺排、叉排及节距)、加热距离、管间距及管长与半径比等对被加热物体表面辐照度均匀性的影响。通过计算得出定向反射管间距是影响均匀加热面积大小的主要因素,管束布置方式对辐照度均匀性影响较小;随管长与半径比增加,物体表面辐照度均匀时,对应的加热距离增加。计算结果为实际装置的优化设计提供了理论依据。

关键词：辐射传热红外加热辐照度均匀性蒙特卡罗法

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Generation of insulin-producing β-like cells from human iPS cells in a defined and completely xeno-free culture system

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Journal of Molecular Cell Biology 2014年第5期8卷 394-408页

作者： Hussain Md. Shahjalal Nobuaki Shiraki Daisuke Sakano Kazuhide Kikawa Soichiro Ogaki Hideo Baba kazuhiko Kume Shoen Kume Department of Stem Cell Biology Institute of Molecular Embryology and Genetics Kumamoto University Honjo 2-2-1 Chuo-Ku Kumamoto 860-0811 Japan Global-Center of Excellence (6-COE) Kumamoto University Honjo 2-2-1 Chuo-ku Kumamoto 860-0811 Japan Department of Pediatrics Graduate School of Medical Sciences Kumamoto University Honjo 1-1-1 Chuo-Ku Kumamoto 860-8556 Japan Department of Gastroenterological Surgery Graduate School of Medical Sciences Kumamoto University Honjo 1-1-1 Chuo-Ku Kumamoto 860-8556 Japan Department of Neuropharmacology Graduate School of Pharmaceutical Sciences Nagoya City University 3-1 Tanabe Street Mizuho Nagoya 467-8603 Japan Program for Leading Graduate Schools 'HIGO (Health Life Science Interdisciplinary and Glocal Oriented) Program ' Kumamoto University Honjo 2-2-1 Chuo-ku Kumamoto 860-0811 Japan

Human induced pluripotent stem （hiPS） cells are considered a potential source for the generation of insulin-producing pancreatic β-ceUs because of their differentiation capacity. In this study, we have developed a five-step xeno-free culture system to efficiently dif- ferentiate hiPS cells into insulin-producing cells in vitro. We found that a high NOGGIN concentration is crucial for specifically inducing the differentiation first into pancreatic and duodenal homeobox-1 （PDX1）-positive pancreatic progenitors and then into neurogenin 3 （NGN3）-expressing pancreatic endocrine progenitors, while suppressing the differentiation into hepatic or intestinal cells. We also found that a combination of 3-isobutyl-l-methylxanthine （IBMX）, exendin-4, and nicotinamide was important for the differentiation into insulin single-positive cells that expressed various pancreatic β-cell markers. Most notably, the differentiated cells contained en- dogenous C-peptide pools that were released in response to various insulin secretagogues and high levels of glucose. Therefore, our results demonstrate the feasibility of generating hiPS-derived pancreatic β-ceUs under xeno-free conditions and highlight their poten- tial to treat patients with type I diabetes.

关键词： diabetes pancreas ceil therapy hiPS ceils xeno-free differentiation β-cells

Mutations in carboxy-terminal part of E2 including PKR/eIF2αphosphorylation homology domain and interferon sensitivity determining region of nonstructural 5A of hepatitis C virus 1b:Their correlation with response to interferon monotherapy and viral load

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World Journal of Gastroenterology 2006年第23期12卷 3722-3728页

作者： Koji Ukai Masatoshi Ishigami Kentaro Yoshioka Naoto Kawabe Yoshiaki Katano kazuhiko Hayashi Takashi Honda Motoyoshi Yano Hidemi Goto Division of Gastroenterology Department of Internal MedicineNagoya University Graduate School of MedicineNagoyaJapan Division of Liver and Biliary Diseases Department of Internal MedicineFujita Health University School of MedicineAichiJapan

AIM： To study the amino acid substitutions in the carboxy （C）-terminal part of E2 protein and in the interferon （IFN） sensitivity determining region （ISDR） and their correlation with response to IFN and viral load in 85 hepatitis C virus （HCV）-lb-infected patients treated with IFN. METHODS： The C-terminal part of E2 （codons 617-711） including PKR/eIF2α phosphorylation homology domain （PePHD） and ISDR was sequenced in 85 HCV-1b-infected patients treated by IFN monotherapy. RESULTS： The amino acid substitutions in PePHD detected only in 4 of 85 patients were not correlated either with response to iFN or with viral load. The presence of substitutions in a N-terminal variable region （codons 617-641） in the C-terminal part of E2 was significantly correlated with both small viral load （33.9% vs 13.8%, P = 0.0394） and sustained response to iFN （25.0% vs 6.9 %, P = 0.0429）. Four or more substitutions in ISDR were significantly correlated with both small viral load （78.6% vs 16.2%, P 〈 0.0001） and sustained response to iFN （85.7% vs 2.9%, P 〈 0.0001）. In multivariate analysis, ISDR in nonstructural （NS） 5A （OR = 0.39, P 〈 0.0001） and N-terminal variable region （OR = 0.51, P = 0.039） was selected as the independentpredictors for small viral load, and ISDR （OR = 39.0, P 〈 0.0001） was selected as the only independent predictor for sustained response. CONCLUSION： The N-terminal variable region in the C-terminal part of E2 correlates with both response to IFN monotherapy and viral load and is one of the factors independently associated with a small viral load.

关键词： E2 Genotype HCV Interferon ISDR NS5A PePHD PKR SVR

深过冷Si-Al合金的凝固过程和组织特征研究

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铸造技术 2005年第10期26卷 918-921页

作者：常芳娥坚增运 KURIBAYASHI kazuhiko 西安工业学院材料与化工学院陕西西安710032 The Institute of Space and Astronautical Science

用高速摄影和扫描电镜研究了电磁悬浮熔炼条件下,Si-20%Al合金的凝固过程及其组织特征。结果发现,将Si-20%Al合金在氩气中进行电磁悬浮熔炼可使其获得375K的过冷度。过冷合金先结晶相的形貌和尺寸与其形核过冷度有关。在小过冷度下,合... 详细信息

用高速摄影和扫描电镜研究了电磁悬浮熔炼条件下,Si-20%Al合金的凝固过程及其组织特征。结果发现,将Si-20%Al合金在氩气中进行电磁悬浮熔炼可使其获得375K的过冷度。过冷合金先结晶相的形貌和尺寸与其形核过冷度有关。在小过冷度下,合金的初生硅为粗大的长片多面体;过冷度增大到126 K后,初生硅变为均匀细小的等轴多面体。在过冷度小于328 K以前,初生硅的表面有明显棱角,表现出小平面生长的特征;过冷度大于328 K后,初生硅变为细小均匀表面有圆滑钟乳石状凸起、没有明显棱角的不规则多面体,表现出了非小平面生长的特征。

关键词：硅过冷度组织形核生长

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Mechanisms of Steatosis-Derived Hepatocarcinogenesis:Lessons from HCV Core Gene Transgenic Mice

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Engineering 2021年第12期7卷 1797-1805页

作者： Pan Diao Fangping Jia Xiaojing Wang Xiao Hu Takefumi Kimura Takero Nakajima Toshifumi Aoyama Kyoji Moriya kazuhiko Koike Naoki Tanaka Department of Metabolic Regulation Shinshu University School of MedicineMatsumoto 390-8621Japan State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesDepartment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China Department of Gastroenterology Lishui HospitalZhejiang University School of MedicineLishui 323000China Department of Pathophysiology Hebei Medical UniversityShijiazhuang 050017China Department of Gastroenterology Shinshu University School of MedicineMatsumoto 390-8621Japan Molecular Signaling Section Laboratory of Bioorganic ChemistryNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMD 20892USA Department of Infection Control and Prevention The University of TokyoTokyo 113-0033Japan Department of Gastroenterology The University of TokyoTokyo 113-0033Japan International Relations Office Shinshu University School of MedicineMatsumoto 390-8621Japan Research Center for Social Systems Shinshu UniversityMatsumoto 390-8621Japan

Hepatitis C virus(HCV)is a major cause of chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma(HCC)*** the structural proteins of HCV,the HCV core protein has the ability to regulate gene transcription,lipid metabolism,cell proliferation,apoptosis,and autophagy,all of which are closely related to the development of *** mice carrying the HCV core gene exhibited age-dependent insulin resistance,hepatic steatosis,and HCC that resembled the clinical characteristics of chronic hepatitis C *** dietary modifications,including calorie restriction and diets rich in saturated fatty acids,trans fatty acids,or cholesterol,were found to influence hepatic steatogenesis and tumorigenesis in HCV core gene transgenic *** strategies modulated hepatocellular stress and proliferation,in addition to hepatic fibrotic processes and the microenvironment,thereby corroborating a close interconnection between dietary habits and steatosis-related *** this review,we summarize the findings obtained from mouse models transgenic for the HCV genome,with a special focus on HCV core gene transgenic mice,and discuss the mechanisms of steatogenesis and hepatocarcinogenesis induced by the HCV core protein and the impact of dietary habits on steatosis-derived HCC development.

关键词： Steatosis Hepatocellular carcinoma Trans fatty acid Saturated fatty acid Dietary restriction HCV core protein

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Risk factors for retinopathy associated with interferonα-2b and ribavirin combination therapy in patients with chronic hepatitis C

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World Journal of Gastroenterology 2006年第23期12卷 3756-3759页

作者： Chiaki Okuse Hiroshi Yotsuyanagi Yoshihiko Nagase Yuhtaro Kobayashi Kiyomi Yasuda kazuhiko Koike Shiro Iino Michihiro Suzuki Fumio Itoh Division of Gastroenterology and Hepatology Department of Internal Medicine St. Marianna University School of MedicineKawasakiKanagawa 216-8511Japan Department of Infectious Diseases Internal MedicineFaculty of MedicineUniversity of Tokyo7-3-1HongoBunkyoTokyo 113-8655Japan Division of Gastroenterology and Hepatology Department of Internal MedicineSt.Marianna University School of MedicineKawasakiKanagawa 216-8511Japan Center for Liver Diseases Kiyokawa HospitalMinamiasagayaSuginamiTokyo166-0004Japan Department of Infectious Diseases Internal MedicineFaculty of MedicineUniversity of Tokyo7-3-1KongoBunkyoTokyo 113-8655Japan Division of Gastroenterology and Hepatology Department of Internal MedicineSt.Marianna University School of MedicineKawasakiKanagawa216-8511Japan

AIM： To elucidate the frequency and risk factors for retinopathy in patients with chronic hepatitis C who are treated by interferon-ribavirin combination therapy. METHODS： We prospectively analyzed 73 patients with histologically confirmed chronic hepatitis C, who underwent combination therapy for 24 wk. Optic fundi were examined before, and 2, 4, 12 and 24 wk alter the start of combination therapy. RESULTS： Fourteen patients （19%） developed retinopathy, which was initially diagnosed by the appearance of a cotton wool spot in 12 patients. Retinal hemorrhage was observed in 5 patients. No patient complained of visual disturbance. Retinopathy disappeared in 9 patients （64%） despite the continuation of combination therapy. However, retinopathy persisted in 5 patients with retinal hemorrhage. A comparison of the clinical background between the groups with and without retinopathy showed no significant differences in age, gender, viral genotype, RNA level, white blood cell count, platelet count, prothrombin time, complications by diabetes mellitus or hypertension, or pretreatment arteriosclerotic changes in the optic fundi. However, multiple logistic regression analysis revealed that complication by hypertension was observed with a high frequency in the group with retinopathy （P = 0.004, OR = 245.918, 95% CI = 5.6-10786.2）.CONCLUSION： Retinopathy associated with combination therapy of interferon α-2b and ribavirin tends to develop in patients with hypertension.

关键词： Retinopathy Ribavirin Chronic hepatitis C Interferon