Mechanisms of Steatosis-Derived Hepatocarcinogenesis:Lessons from HCV Core Gene Transgenic Mice

作     者：Pan Diao Fangping Jia Xiaojing Wang Xiao Hu Takefumi Kimura Takero Nakajima Toshifumi Aoyama Kyoji Moriya Kazuhiko Koike Naoki Tanaka Pan Diao;Fangping Jia;Xiaojing Wang;Xiao Hu;Takefumi Kimura;Takero Nakajima;Toshifumi Aoyama;Kyoji Moriya;Kazuhiko Koike;Naoki Tanaka

作者机构：Department of Metabolic RegulationShinshu University School of MedicineMatsumoto 390-8621Japan State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesDepartment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China Department of GastroenterologyLishui HospitalZhejiang University School of MedicineLishui 323000China Department of PathophysiologyHebei Medical UniversityShijiazhuang 050017China Department of GastroenterologyShinshu University School of MedicineMatsumoto 390-8621Japan Molecular Signaling SectionLaboratory of Bioorganic ChemistryNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMD 20892USA Department of Infection Control and PreventionThe University of TokyoTokyo 113-0033Japan Department of GastroenterologyThe University of TokyoTokyo 113-0033Japan International Relations OfficeShinshu University School of MedicineMatsumoto 390-8621Japan Research Center for Social SystemsShinshu UniversityMatsumoto 390-8621Japan 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2021年第7卷第12期

页      面：1797-1805页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This review has partially supported by JSPS Grants-in-Aid for Scientific Research(C)(KAKENHI 16K08616 16K08734 and 19K07383) 

主　　题：Steatosis Hepatocellular carcinoma Trans fatty acid Saturated fatty acid Dietary restriction HCV core protein 

摘      要：Hepatitis C virus(HCV)is a major cause of chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma(HCC)*** the structural proteins of HCV,the HCV core protein has the ability to regulate gene transcription,lipid metabolism,cell proliferation,apoptosis,and autophagy,all of which are closely related to the development of *** mice carrying the HCV core gene exhibited age-dependent insulin resistance,hepatic steatosis,and HCC that resembled the clinical characteristics of chronic hepatitis C *** dietary modifications,including calorie restriction and diets rich in saturated fatty acids,trans fatty acids,or cholesterol,were found to influence hepatic steatogenesis and tumorigenesis in HCV core gene transgenic *** strategies modulated hepatocellular stress and proliferation,in addition to hepatic fibrotic processes and the microenvironment,thereby corroborating a close interconnection between dietary habits and steatosis-related *** this review,we summarize the findings obtained from mouse models transgenic for the HCV genome,with a special focus on HCV core gene transgenic mice,and discuss the mechanisms of steatogenesis and hepatocarcinogenesis induced by the HCV core protein and the impact of dietary habits on steatosis-derived HCC development.