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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Ryo Nishikawa kazuhiko mishima Jun-ichi Adachi Department of Neuro-Oncology/Neurosurgery Comprehensive Cancer CenterInternational Medical CenterSaitama Medical University

＜正＞[INTRODUCTION] The prognosis of primary central nervous system lymphoma（PCNSL） has improved with the use of pre-irradiation methotrexate （MTX）-based chemotherapy. However,benefit from the addition of other

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MGMT promoter methylation status in newly-diagnosed pediatric gliomas

MGMT promoter methylation status in newly-diagnosed pediatri...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Jun-ichi Adachi Tomonari Suzuki Takaaki Yanagisawa Kohei Fukuoka kazuhiko mishima Kenji Wakiya Masao Matsutani Ryo Nishikawa Department of Neuro-Oncology Saitama Medical University International Medical Center

＜正＞＜Objectives＞ The methylation status of the MGMT（O6-methylguanine-DNA methyltransferase） gene has been shown to be a predictive marker in adult gliomas treated with alkylating agents such as temozolomide.

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Serum sIL-2R and LDH as markers for primary central nervous system lymphoma （PCNSL）

Serum sIL-2R and LDH as markers for primary central nervous ...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Takamitsu Fujimaki Nahoko Uemiya kazuhiko mishima Gohji Fushihara, Hiroaki Neki Kohei Fukuoka Tomonari Suzuki Kenji Wakiya, Junichi Adachi Takaaki Yanagisawa Masao Matsutani Ryo Nishikawa Department of Neurosurgery Saitama Medical University Hospital Department of Neuro-oncology Saitama Medical University International Medical Center Moroyama-machi Saitama Japan

＜正＞Introduction : Serum markers for lymphoproliferative diseases includes soluble IL-2 receptor alpha（sIL-2R）, Lactate dehydrogenase （LDH） and thymidine kinase. However these markers are non-specific and can be...

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Circulating RNAs as new biomarkers for detecting pancreatic cancer

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World Journal of Gastroenterology 2015年第28期21卷 8527-8540页

作者： Takahiro Kishikawa Motoyuki Otsuka Motoko Ohno Takeshi Yoshikawa Akemi Takata kazuhiko Koike Department of Gastroenterology Graduate School of Medicine The University of Tokyo Japan Science and Technology Agency PRESTO

Pancreatic cancer remains difficult to treat and has a high mortality *** is difficult to diagnose early mainly due to the lack of screening imaging modalities and specific ***,it is important to develop biomarkers that enable the detection of early stage *** evidence is accumulating that tumor cells release substantial amounts of RNA into the bloodstream that strongly resist RNases in the blood and are present at sufficient levels for quantitative *** circulating RNAs are upregulated in the serum and plasma of cancer patients,including those with pancreatic cancer,compared with healthy *** majority of RNA biomarker studies have assessed circulating microRNAs(miRs),which are often *** are few reports of the tumorspecific upregulation of other types of small noncoding RNAs(ncRNAs),such as small nucleolar RNAs and Piwi-interacting *** ncRNAs(IncRNAs),such as HOTAIR and MALAT1,in the serum/plasma of pancreatic cancer patients have also been reported as diagnostic and prognostic *** tissuederived RNAs,some miRs show increased expression even in pre-cancerous tissues,and their expression profiles may allow for the discrimination between a chronic inflammatory state and ***,some miRs and IncRNAs have been reported with significant alterations in expression according to disease progression,and they may thus represent potential candidate diagnostic or prognostic biomarkers that may be used to evaluate patients once detection methods in peripheral blood are well ***,recent innovations in high-throughput sequencing techniques have enabled the discovery of unannotated tumor-associated ncRNAs and tumor-specific alternative splicing as novel and specific biomarkers of *** much work is required to clarify the release mechanism,origin of tumor-specific circulating RNAs,and selectivity of carrier complexes,and technical advances must also be

关键词： MicroRNA Non-coding RNA Pancreaticcancer Biomarkers Early detection

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Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma

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World Journal of Hepatology 2015年第1期7卷 1-6页

作者： Chikako Shibata Motoyuki Otsuka Takahiro Kishikawa Motoko Ohno Takeshi Yoshikawa Akemi Takata kazuhiko Koike Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Japan Science and Technology Agency PRESTOKawaguchiSaitama 332-0012Japan

Micro RNAs(mi RNAs) are small,noncoding RNA molecules that regulate gene expression posttranscriptionally,targeting thousands of messenger RNAs. Long noncoding RNAs(lnc RNAs),another class of noncoding RNAs,have been determined to be also involved in transcription regulation and translation of target genes. Since deregulated expression levels or functions of miR NAs and lncR NAs in hepatocellular carcinoma(HCC) are frequently observed,clinical use of noncoding RNAs for novel diagnostic and therapeutic applications in the management of HCCs is highly and emergently e xpe c t e d. H e r e,we s ummar iz e r e c e nt f indings regarding deregulated mi RNAs and lnc RNAs for their potential clinical use as diagnostic and prognostic biomarkers of HCC. Specifically,we emphasize the deregulated expression levels of such noncoding RNAs in patients' sera as noninvasive biomarkers,a field that requires urgent improvement in the clinical surveillance of HCC. Since nucleotide-based strategies are being applied to clinical therapeutics,we further summarize clinical and preclinical trials using oligonucleotides involving the use of miR NAs and small interfering RNAs against HCC as novel therapeutics. Finally,we discuss current open questions,which must be clarified in the near future for realistic clinical applications of these new strategies.

关键词： MicroRNA Long noncoding RNA Hepatocellularcarcinoma Clinical trials Biomarker

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