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Gene expression and pathway analysis of CTNNB1 in cancer and stem cells

World Journal of Stem Cells 2016年第11期8卷 384-395页

作者： Shihori Tanabe Takeshi Kawabata kazuhiko aoyagi Hiroshi Yokozaki Hiroki Sasaki Division of Risk Assessment National Institute of Health Sciences Laboratory of Protein Informatics Institute for Protein Research Osaka University Department of Translational Oncology National Cancer Center Research Institute Department of Pathology Kobe University of Graduate School of Medicine

AIM To investigate β-catenin(CTNNB1) signaling in cancer and stem cells, the gene expression and pathway were analyzed using bioinformatics.METHODS The expression of the catenin β 1(CTNNB1) gene, which codes for β-catenin, was analyzed in mesenchymal stem cells(MSCs) and gastric cancer(GC) cells. Beta-catenin signaling and the mutation of related proteins were also analyzed using the cB ioP ortal for Cancer Genomics and HOMology modeling of Complex Structure(HOMCOS) databases.RESULTS The expression of the CTNNB1 gene was up-regulated in GC cells compared to MSCs. The expression of EPH receptor A8(EPHA8), synovial sarcoma translocation chromosome 18(SS18), interactor of little elongation complex ELL subunit 1(ICE1), patched 1(PTCH1), mutS homolog 3(MSH3) and caspase recruitment domain family member 11(CARD11) were also shown to be altered in GC cells in the cB ioP ortal for Cancer Genomics analysis. 3D complex structures were reported for E-cadherin 1(CDH1), lymphoid enhancer binding factor 1(LEF1), transcription factor 7 like 2(TCF7L2) and adenomatous polyposis coli protein(APC) with β-catenin. CONCLUSION The results indicate that the epithelial-mesenchymal transition(EMT)-related gene CTNNB1 plays an important role in the regulation of stem cell pluripotency and cancer signaling.

关键词： β-catenin CTNNB1 Epithelial-mesenchymal transition Mesenchymal stem cell Stem cell

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Regulation of CTNNB1 signaling in gastric cancer and stem cells

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World Journal of Gastrointestinal Oncology 2016年第8期8卷 592-598页

作者： Shihori Tanabe kazuhiko aoyagi Hiroshi Yokozaki Hiroki Sasaki Division of Risk Assessment Biological Safety Re-search Center National Institute of Health ScienceTokyo Department of Translational Oncology National Cancer Center Research InstituteTokyo Department of Pathology Kobe University of Graduate School of Medicine

Recent research has shown that the alteration of combinations in gene expression contributes to cellular phenotypic changes. Previously, it has been demonstrated that the combination of cadherin 1 and cadherin 2 expression can identify the diffuse-type and intestinaltype gastric cancers. Although the diffuse-type gastric cancer has been resistant to treatment, the precise mechanism and phenotypic involvement has not been revealed. It may be possible that stem cells transform into gastric cancer cells, possibly through the involvement of a molecule alteration and signaling mechanism. In this review article, we focus on the role of catenin beta 1(CTNNB1 or β-catenin) and describe the regulation of CTNNB1 signaling in gastric cancer and stem cells.

关键词： CTNNB1 signaling β-catenin Epithelial-mesenchymal transition Gastric cancer Stem cell

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Regulated genes in mesenchymal stem cells and gastric cancer

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World Journal of Stem Cells 2015年第1期7卷 208-222页

作者： Shihori Tanabe kazuhiko aoyagi Hiroshi Yokozaki Hiroki Sasaki Division of Safety Information on Drug Food and Chemicals National Institute of Health Sciences Setagayaku Tokyo 158-8501 Japan Department of Translational Oncology National Cancer Center Research Institute Chuo-ku Tokyo 104-0045 Japan Department of Pathology Kobe University of Graduate School of Medicine Chuo-ku Kobe 650-0017 Japan

AIM: To investigate the genes regulated in mesenchymal stem cells(MSCs) and diffuse-type gastric cancer(GC),gene expression was analyzed. METHODS: Gene expression of MSCs and diffuse-type GC cells were analyzed by microarray. Genes related to stem cells, cancer and the epithelial-mesenchymal transition(EMT) were extracted from human gene lists using Gene Ontology and reference information. Gene panels were generated, and messenger RNA gene expression in MSCs and diffuse-type GC cells was analyzed. Cluster analysis was performed using the NCSS software.RESULTS: The gene expression of regulator of G-protein signaling 1(RGS1) was up-regulated in diffuse-type GC cells compared with MSCs. A panel of stem-cell related genes and genes involved in cancer or the EMT were examined. Stem-cell related genes, such as growth arrest-specific 6, musashi RNA-binding protein 2 and hairy and enhancer of split 1(Drosophila), NOTCH family genes and Notch ligands, such as delta-like 1(Drosophila) and Jagged 2, were regulated.CONCLUSION: Expression of RGS1 is up-regulated, and genes related to stem cells and NOTCH signaling are altered in diffuse-type GC compared with MSCs.

关键词： Mesenchymal stem cells Gastric cancer Stem cells Gene Epithelial-mesenchymal transition

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