Regulated genes in mesenchymal stem cells and gastric cancer

作     者：Shihori Tanabe Kazuhiko Aoyagi Hiroshi Yokozaki Hiroki Sasaki 

作者机构：Division of Safety Information on Drug Food and Chemicals National Institute of Health Sciences Setagayaku Tokyo 158-8501 Japan Department of Translational Oncology National Cancer Center Research Institute Chuo-ku Tokyo 104-0045 Japan Department of Pathology Kobe University of Graduate School of Medicine Chuo-ku Kobe 650-0017 Japan 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2015年第7卷第1期

页      面：208-222页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Cancer Research from the Ministry of Health Labour and Welfare 

主　　题：Mesenchymal stem cells Gastric cancer Stem cells Gene Epithelial-mesenchymal transition 

摘      要：AIM: To investigate the genes regulated in mesenchymal stem cells(MSCs) and diffuse-type gastric cancer(GC),gene expression was analyzed. METHODS: Gene expression of MSCs and diffuse-type GC cells were analyzed by microarray. Genes related to stem cells, cancer and the epithelial-mesenchymal transition(EMT) were extracted from human gene lists using Gene Ontology and reference information. Gene panels were generated, and messenger RNA gene expression in MSCs and diffuse-type GC cells was analyzed. Cluster analysis was performed using the NCSS ***: The gene expression of regulator of G-protein signaling 1(RGS1) was up-regulated in diffuse-type GC cells compared with MSCs. A panel of stem-cell related genes and genes involved in cancer or the EMT were examined. Stem-cell related genes, such as growth arrest-specific 6, musashi RNA-binding protein 2 and hairy and enhancer of split 1(Drosophila), NOTCH family genes and Notch ligands, such as delta-like 1(Drosophila) and Jagged 2, were ***: Expression of RGS1 is up-regulated, and genes related to stem cells and NOTCH signaling are altered in diffuse-type GC compared with MSCs.