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Downregulation of Kυ4.2 and Kυ4.3 channel gene expression in right ventricular hypertrophy induced by monocrotaline in rat

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Acta Pharmacologica Sinica 2004年第2期 100-104页

作者： Tian-tai ZHANG, Bing CUI, de-zai DAI2 Research Division of Pharmacology, China Pharmaceutical University, Nanjing 210009, China

AIM: To investigate the differences in gene expression of transient outward potassium ion channel between the free wall of right ventricle, free wall of left ventricle, and the septum in monocrotaline (MCT)-induced right ventricular hypertrophy of rat. METHODS: Twenty rats were randomly divided into two groups: a single injection of monocrotaline (MCT) 60 mg/kg (model) or saline (control). Four weeks later, hemodynamic parameters were measured and the gene expression of ito channels were detected by semi-quantitative RT-PCR. RESULTS: After 28 d, the right ventricular systolic pressure and central venous pressure were remarkably elevated by 128 % and 533 % in the MCT-treated group, accompanied by an overt right ventricle (RV) remodeling. The difference of mRNA expression of Kv1.4 was not significant in free wall of RV, left ventricle (LV), and septum in MCT group compared with control group. In contrast, mRNA of Kv4.2 and Kv4.3 in the free wall of RV in MCT-induced rat was dramatically decreased by 45.2 % and 51.1 % vs control, however, in free wall of LV and septum, no differ- ence was found. In addition, mRNA expression level of Kv4.2 in control rat was significantly lower in septum than that in free wall of RV and LV. CONCLUSION: Expression of Kv1.4, Kv4.2, and Kv4.3 differs between regions in normal rat hearts. The down-regulation of Kv4 family gene expression of ito contributed to the pathophysiologi- cal changes in ventricular hypertrophy and pulmonary hypertension induced by MCT.

关键词： right ventricular hypertrophy potassium channels messenger RNA monocrotaline

Association of a cytosine-adenine repeat polymorphism in the estrogen receptor β gene with occurrence and severity of rheumatoid arthritis

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Open Journal of Internal Medicine 2013年第1期3卷 3-7页

作者： Kanako Watanabe Hiromi Sato Ayano ito Tomomi Sato Aránzazu González-Canga Hana Sugai Masahiko Suzuki Takao Namiki Koichi Ueno department of Geriatric Pharmacology and Therapeutics Graduate School of Pharmaceutical SciencesChiba UniversityChibaJapan Assessment Area Medicines for Veterinary Use DepartmentAgencia Espanola de Medicamentosy Productos Sanitarios(AEMPS)MadridSpain Research Center for Frontier Medical Engineering Chiba UniversityChibaJapan department of Frontier Japanese-Oriental(Kampo)Medicine Graduate School of MedicineChiba UniversityChibaJapan

We investigated the influence of the cytosine-adenine (CA) dinucleotide repeat polymorphism in intron 6 of estrogen receptor β (ERβ) gene on rheumatoid arthritis (RA) risk. One hundred and ninety-three RA patients and 77 control subjects with osteoarthritis (OA) were recruited. The CA repeat polymorphism was assayed by a dye-terminator cycle sequencing analysis. No statistically significant difference in the mean number of CA repeats between the RA and OA patients was observed (RA: 21.47, OA: 21.23, P = 0.324). The alleles were categorized according to the number of repeats: short (S, ≦21) and long (L, ≧22), in which the genotypes SS, SL, and LL were observed. No significant differences were observed for the allele and genotype distributions of this polymorphism in both patient groups. The RA patients were classified according to RA severity: mild (least erosive disease) and severe (more erosive and mutilating disease). Again, no significant difference in genotype frequency between these groups was observed, even after stratifying by sex. The present study indicates that additional studies are needed to clarify the roles of this polymorphism, estrogen, and ER in the development of autoimmune diseases.

关键词： Polymorphism Rheumatoid Arthritis Sex Estrogen Receptor β CA Repeat

二叠系乐平统疑似罩笼虫(放射虫)在华南广西地区的发现及其演化意义

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微体古生物学报 2022年第4期39卷 316-327页

作者：张磊吴俊常珊 MARIE Béatrice Forel 王夏 ito Tsuyoshi 冯庆来何卫红刘倩李星霖 TANIEL Danelian 成都理工大学油气藏地质及开发工程国家重点实验室成都610059 成都理工大学沉积地质研究院成都610059 自然资源部沉积盆地与油气资源重点实验室成都610081 中国地质调查局武汉地质调查中心(中南地质科技创新中心) 武汉430205 古生物与地质环境演化湖北省重点实验室武汉430205 湖北师范大学城市与环境学院黄石435002 Centre de Recherche en Paléontologie–Paris UMR7207MNHN-CNRS-Sorbonne UniversitéMuséum National d'Histoire Naturelle75005 ParisFrance Research Institute of Geology and Geoinformation Geological Survey of JapanTsukubaIbaraki 305-8567Japan 地球科学学院中国地质大学(武汉)武汉430074 UniversitéLille CNRSF-59000 LilleFrance

由于二叠纪罩笼虫化石材料极度稀缺,我们对罩笼虫从古生代向中生代类型演化的过程仍然一无所知。本文在广西晚二叠世大隆组与领薅组中报道了少量疑似罩笼虫化石。它们的形态简单,与三叠纪的罩笼虫属Bipedis形态相似,但缺少外饰,可能是... 详细信息

由于二叠纪罩笼虫化石材料极度稀缺,我们对罩笼虫从古生代向中生代类型演化的过程仍然一无所知。本文在广西晚二叠世大隆组与领薅组中报道了少量疑似罩笼虫化石。它们的形态简单,与三叠纪的罩笼虫属Bipedis形态相似,但缺少外饰,可能是中生代罩笼虫的先驱分子。如果本文描述的这些?Bipedis化石真属于罩笼虫目,那么该目从石炭纪晚期到二叠纪的演化可能经历了一段形态简化的阶段;在早三叠世,伴随其辐射过程,它们的形态也开始逐渐变得复杂。这些化石形态上介于古生代和中生代的罩笼虫之间,它们在吴家坪阶-长兴阶界线附近的出现可能是二叠-三叠纪之交深水放射虫由阿尔拜虫向罩笼虫动物群转变的序曲。

关键词：放射虫罩笼虫先驱分子二叠纪三叠纪

Microbial Quality of “Tchachanga”, a Barbecued Mutton Sold in Benin

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Advances in Microbiology 2017年第8期7卷 633-640页

作者： Kadoéito Cyrille Boko Martial Gangnito Soumanou S.Toleba Philippe Sessou Ulbad Polycarpe Tougan Oscar Nestor Aguidissou Marc T.Kpodekon Souaibou Farougou Université d’Abomey-Calavi Ecole Polytechnique d’Abomey-CalaviDépartement de Production et Santé AnimalesUnité de Recherche en Biotechnologie de la Production et de la Santé AnimalesAbomey-CalaviRépublique du Bénin Université d’Abomey-Calavi Faculté des Sciences AgronomiquesCotonouRépublique du Bénin Université de Parakou Faculté d’AgronomieParakouRépublique du Bénin

The microbial quality of Tchachanga, a barbecued mutton sold at Bohicon and Hilla-Condji bus stations in Benin was assessed in accordance with French standards (DGAL, 2000). The analyses revealed that the average total viable counts (TVC) recorded in Bohicon (3.96 × 108 cfu/g) and Hilla-Condji (5.51 × 108 cfu/g) exceeded standard safety limits (3 × 105 cfu/g). Similar observations were made for other parameters such as fecal coliforms count, Escherichia coli count, sulphite-reducing anaerobes, Staphylococcus aureus, yeasts and molds. Salmonella sp were absent in all samples. There was no significant difference (P > 0.05) between the microbial loads obtained in Bohicon and Hilla-Condji. This study shows that barbecued mutton sold in these two stations is unsafe for human consumption. It is therefore important for food safety authorities in Benin to take appropriate measures and sensitize sellers on strict observance of hygiene rules in order to preserve public health.

关键词： Food Safety Tchachanga Street-Vended Food Microorganisms Public Health

ELECTROCHEMICAL　FABRICATION　AND　PHOTOVOLTAIC　PROPERTY　OF　SIZE－QUANTIZED　NANOCRYSTALLINE　CdS　FILMS

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Chinese Chemical Letters 1994年第7期5卷 627-630页

作者： Bao Hui WANG de Jun WANG Yi CUI Dong ZHANG and Tie Jim LI(department of Chemistry, Jilin University ,Changchun, 130023)

Nanocrystalline CdS films of different sizes and thicknesses were electrochemically prepared on ito,The films exhibit size quantization effects,mainfested by large blue-shifts in their optical sbsorption *** Surface Photovoltaic Spectroscopy (SPS) Of these films shows particular photovoltaic behavior,It is for the first time to observe size quantization effects and a blue shift in the SPS of CdS films.

关键词： CdS FILMS ELECTROCHEMICAL AND

Compact TE-pass polarizer based on lithium-niobate-on-insulator assisted by indium tin oxide and silicon nitride

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Chinese Physics B 2023年第6期32卷 284-289页

作者：刘家敏张德龙 department of Opto-electronics and Information Engineering School of Precision Instruments and Opto-electronics EngineeringKey Laboratory of Optoelectronic Information Technology(Ministry of Education)and Key Laboratory of Micro-Opto-Electro-Mechanical Systems(MOEMS)Technology(Ministry of Education)Tianjin UniversityTianjin 300072China

An indium tin oxide(ito) and silicon nitride(Si_(3)N_(4)) assisted compact TE-pass waveguide polarizer based on lithiumniobate-on-insulator is proposed and numerically *** properly designing the ito and Si_(3)N_(4) assisted structure and utilizing the epsilon-near-zero effect of ito,the TM mode is strongly confined in the ito layer with extremely high loss,while the TE mode is hardly affected and passes through the waveguide with low *** simulation results show that the polarizer has an extinction ratio of 22.5 dB and an insertion loss of 0.8 dB at the wavelength of 1.55 μm,and has an operating bandwidth of about 125 nm(from 1540 nm to 1665 nm) for an extinction ratio of>20 dB and an insertion loss ofdevice exhibits large fabrication *** notably,the device is compact,with a length of only 7.5 μm,and is appropriate for on-chip applications.

关键词： polarizer lithium-niobate-on-insulator integrated optics devices optical waveguide

基于三苯胺和螺(芴-9,9＇-氧杂蒽)的星射形蓝光寡聚材料的合成与光电性质

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物理化学学报 2012年第8期28卷 2000-2007页

作者：初增泽王丹张超邹德春北京大学化学与分子工程学院北京分子科学国家实验室北京100871

通过Sonogashira反应合成了基于三苯胺、螺(芴-9,9 -氧杂蒽)及芴的星射形寡聚物. 三种寡聚物(TPA-F、TPA-SFX和TPA-SFXCz)都具有很高的热分解温度,分别为417、439和425℃.差示扫描量热(DSC)分析研究表明,它们也具有高的玻璃化转变温度(T... 详细信息

通过Sonogashira反应合成了基于三苯胺、螺(芴-9,9 -氧杂蒽)及芴的星射形寡聚物. 三种寡聚物(TPA-F、TPA-SFX和TPA-SFXCz)都具有很高的热分解温度,分别为417、439和425℃.差示扫描量热(DSC)分析研究表明,它们也具有高的玻璃化转变温度(Tg), 都在100℃以上,其中两种螺芴取代的寡聚物(TPA-SFX和TPA-SFXCz)的Tg分别达到141和127℃.光物理的研究发现, 在薄膜中,TPA-F具有很宽的双发射峰, 峰值为424和455nm;而TPA-SFX和TPA-SFXCz仍保持单一蓝光发射, 发射峰分别为434和442nm.这表明将三苯胺非平面结构和螺形取代基团相结合,能有效抑制在薄膜中聚集和激基缔合物的产生.电化学的研究表明,由于引入富电子的三苯胺核心结构,三者都具有-5.4 eV左右的较高的HOMO能级.通过旋涂法制备了结构为ito(氧化铟锡)/PEDOT:PSS(聚3,4-乙撑二氧噻吩:聚苯乙烯磺酸盐)/寡聚物/TPBI(1,3,5-三(1-苯基-1H-苯并咪唑-2-基)苯)/LiF/Al电致发光器件.器件测试结果表明,TPA-SFX的器件具有最好的光电性能. 以它为发光层,获得最大亮度为2680 cd·m-2、最大电流效率为0.35 cd·A-1、色坐标为(0.17, 0.13)的蓝光器件.

关键词：有机发光二极管三苯胺: 螺(芴-9 9’-氧杂蒽): 星射形: 蓝光材料

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银纳米颗粒对聚合物太阳能电池性能的提高

发光学报 2015年第4期36卷 449-453页

作者：林龙邓振波刘贤德北京交通大学光电子技术研究所发光与光信息技术教育部重点实验室北京100044

采用水溶性银纳米颗粒附着在反型太阳能电池的电子传输层上,用以提高有机太阳能电池的短路电流。所制备的器件结构为ito/Zn O/Ag NPs/P3HT(Poly 3-hexylthiophene)∶PC[60]BM/Mo O3/Ag。其金属银纳米颗粒的表面等离激元在410 nm处出现... 详细信息

采用水溶性银纳米颗粒附着在反型太阳能电池的电子传输层上,用以提高有机太阳能电池的短路电流。所制备的器件结构为ito/Zn O/Ag NPs/P3HT(Poly 3-hexylthiophene)∶PC[60]BM/Mo O3/Ag。其金属银纳米颗粒的表面等离激元在410 nm处出现了共振吸收峰,半峰全宽约为60 nm。器件的光电流在可见光范围内均有所增加,短路电流相对于标准器件提高了20.2%,光电转化效率相对提高了17.2%。

关键词：金属银纳米颗粒表面等离激元 P3HT∶PCBM

溶胶凝胶钽酸锂薄膜热释电红外探测器的设计与制备(英文)

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光电工程 2006年第12期33卷 113-118页

作者：张德银黄大贵董政电子科技大学机电学院

在带微桥结构的石英玻璃基底上设计了一种新型Al-LiTaO3-ito红外探测结构。在响应／参考双单元结构框架下，由振动、环境温度变化和日照变化引起的无效信号输出在前置放大电路处被消除掉了。用醋酸锂和乙醇钽作为起始反应物，通过溶胶... 详细信息

在带微桥结构的石英玻璃基底上设计了一种新型Al-LiTaO3-ito红外探测结构。在响应／参考双单元结构框架下，由振动、环境温度变化和日照变化引起的无效信号输出在前置放大电路处被消除掉了。用醋酸锂和乙醇钽作为起始反应物，通过溶胶凝胶工艺生成了对红外敏感的钽酸锂薄膜，并详细讨论了基于钽酸锂薄膜的红外探测器件制备工艺。用ito衬底作下电极，蒸镀的Al点作上电极，在室温条件下测试了薄膜的介电特性，在1kHz处，介电常数为53．28，在40～10kHz内，介电损耗和介电系数呈下降趋势。器件的电压响应和比探测率测试结果表明75Hz处得到响应电压峰值9685V／W，器件的比探测率在70-100Hz区域保持在6．12×10^8cmHz^1／2 W^-1附近。

关键词：钽酸锂薄膜红外探测器结构设计溶胶凝胶