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Unilateral Impact of Altered Loading by Changing Teeth Height on the TMJ Fibrocartilage: Disc and Condyle of Wistar Rats

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Microscopy Research 2016年第2期4卷 20-31页

作者： Roxanne M. Olvera-Farias Jose Raymundo Cruz-Perez Rogelio Salinas-Gutierrez Jose Antonio Guerrero-Diaz de Leon Juan B. Kouri-Flores Raul Rosales-Ibañez David Masuoka ito Alma Lilian Guerrero Barrera departamento de Morfología Universidad Autónoma de Aguascalientes Aguascalientes México departamento de Infectómica y Patogénesis Molecular CINVESTAV-IPN Mexico City Mexico departamento de Estadística Universidad Autónoma de Aguascalientes Aguascalientes México departamento de Estomatología Universidad Autónoma de San Luis Potosí San Luis Potosi México departamento de Estomatología Universidad Autónoma de Aguascalientes Aguascalientes México Laboratorio de Biología Celular y Tisular Departamento de Morfología Universidad Autónoma de Aguascalientes Aguascalientes México

Temporomandibular joint (TMJ) is sensitive to loading and mechanical stress that provokes morphological changes produced by the impact in the occlusal plane. Here, this impact is evaluated in TMJ articular disc and articular cartilage using an in vivo model of unilateral occlusal plane impact and by analysis of serial tissue sections stained with Hematoxylin-Eosin (H-E) or with Masson trichrome technique. Thus, six groups of 5 Wistar rats (200 - 250 g) are subjected to biomechanical dental stimulation by placing unilateral resin occlusal interference, or unilateral tooth wear made by upper left molars artificial mechanical devastation (1 control and 2 experimental groups for each treatment). Each treatment is evaluated two times at 1 and 15 days post-treatment. By H-E staining, control groups show chondrocytes arrangement as several cord cell groups in comparison with the experimental groups, which show an arrangement in one cord cell along of articular disc. However, this yields no significant difference (p decrease (p degenerative process biomechanically induced by unilateral occlusal plane modification, causes cell and tissue changes on the TMJ structures that remain the degenerative changes observed in early osteoarthritis.

关键词： Articular Disc Articular Cartilage dental Occlusion Collagen Temporomandibular Joint

A NEW HEURISTIC APPROACH FOR deSIGN OF FIR FILTERS WITH SP2 COEFFICIENTS IN A MIN-MAX SENSE

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A NEW HEURISTIC APPROACH FOR DESIGN OF FIR FILTERS WITH SP2 ...

Influence of Size of ZnO Nanorods on Light Extraction Enhancement of GaN-Based Light-Emitting Diodes

第七届国际信号处理会议

作者： Rika ito Tetsuya FUJIE Kenji SUYAMA Ryuichi HIRABAYASHI Tokyo University of Science University of Hyogo Tokyo deNKI University MEJIRO University

Since FIR ?lters can easily obtain a linear phase property, it is great useful in many ?elds. In this paper, we consider de- sign problems of linear phase FIR ?lter with Signed Power of Two (SP2) c

关键词： FIR ?lter CSD coe?cients SP2 coef- ?cients allocation optimization

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Chinese Physics Letters 2011年第9期28卷 263-266页

作者： DAI Ke-Hui WANG Lian-Shan HUANG de-Xiu SOH Chew-Beng CHUA Soo-Jin Wuhan National Laboratory for Optoelectronics School of Optoelectronic Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074 College of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074 Institute of Materials Research and Engineering 3 Research LinkSingapore 117602Singapore Centre for Optoelectronics Department of Electrical and Computer EngineeringNational University of Singapore2 Engineering Drive 3Singapore 117576Singapore

We investigate the influence of size of ZnO nanorods on the light extraction efficiency(LEE)enhancement of GaN-based light-emitting diodes(GaN-LEDs).ZnO nanorods with different sizes are hydrothermally grown on patterned indium-doped tin oxide(ito)electrodes of the GaN-LEDs in zinc acetate aqueous solutions of different *** are conducted for the LEE enhancement of the LEDs with ZnO nanorods,compared to these without ZnO *** results suggest that the LEE of the LEDs with ZnO nanorods increases with the increasing size of ZnO ***,a saturation trend for the LEE improvement is also observed,which is attributed to the maximum limitation of light coupled into ZnO nanorods from GaN-based LEDs,and the reflection is increased by the increasing top surface of the ZnO nanorods.

关键词： GaN diodes sizes

Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”

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Bone Research 2019年第3期7卷 225-242页

作者： Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan Center for Musculoskeletal Research University of Rochester Medical Center Rochester NY USA department of Biomedical Engineering University of Rochester Medical Center Rochester NY USA department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA department of Orthopaedics University of Rochester Medical Center Rochester NY USA department of Microbiology & Immunology University of Rochester Medical Center Rochester NY USA department of Orthopaedic Surgery Kyoto University Kyoto Japan department of Orthopaedic Surgery Virginia Commonwealth University Medical Center Richmond VA USA

Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, *** intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure.

关键词： disease caused by soft tissue necrotic tissuel

Phase Unwrapping in Magnetic Resonance Elastography

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Open Journal of Medical Imaging 2018年第4期8卷 111-125页

作者： Surendra Maharjan Tomokazu Numano Tetsushi Habe Daiki ito Takamichi Ueki Keisuke Igarashi Toshiki Maeno department of Radiological Sciences Graduate School of Human Health Sciences Tokyo Metropolitan University Tokyo Japan Health Research Institute National Institute of Advanced Industrial Science and Technology Tsukuba Japan Office of Radiation Technology Keio University Hospital Tokyo Japan

Phase Unwrapping (PU) is an ill-posed problem in Magnetic Resonance Elastography (MRE). The phase information is not usable until the phases are retrieved by using PU algorithms. In this present study, we attempt to determine the ideal PU method for MRE using both phantom and volunteer psoas major (PM) muscle images. All the MRE experiments were carried out in Philips MRI (Achieva 3.0 T, Best, The Netherlands). A multi-echo gradient-echo MRE pulse sequence was employed and the four PU methods were considered based on their easy user platform. They are namely, Minimum Discontinuity (MD), Laplacian-Based Estimate (LBE), Region Growing (RG) and Dilate-Erode (de) Propagate. Phantom images were successfully unwrapped by all four methods, whereas MD and LBE could only unwrap PM muscle images properly. RG and de failed to unwrap the PM muscle images.

关键词： Phase Unwrapping Magnetic Resonance Elastography Minimum Discontinuity Laplacian-Based Estimate Region Growing Dilate-Erode Propagate

development of the Press-Through Package Recognizable with Abdominal X-Ray Image of Abdominal Soft Tissue Phantom

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Open Journal of Radiology 2018年第2期8卷 91-98页

作者： Kyoichi ito Morio Shimada Kiyomi Sadamoto Mikio Murata Kiyoshi Kubota Motoyoshi itoh Kohki Yoshikawa department of Radiation International Goodwill Hospital Yokohama Japan department of Radiological Sciences Faculty of Health Sciences Komazawa University Tokyo Japan department of Clinical Pharmacy Yokohama University of Pharmacy Yokohama Japan Sanko Alumi Inc. Konosu Saitama Japan

Background: Patients with dementia who accidentally swallowed a press- through package (PTP) have been increased in recent years. Swallowed PTP is usually detected with CT having a risk of radiation exposure since PTP is very difficult to detect with abdominal X-ray image. Purpose: This study is aimed at developing the new PTP sheet recognizable with abdominal X-ray by improving the conventional PTP sheet. Material and Methods: The PTP sheet samples used in this study are: No. 1 Control: Commercially available tablet 100 mg, No. 2 Triple-stacked aluminum foil, 6-overcoated with BaSO4 10.3 g/m2, No. 3 Aluminum foil, 6-overcoated with BaSO4 10.3 g/m2, No. 4 Five-stacked aluminum foil, 6-overcoated with BaSO4 No. 5 Aluminum foil, single-coated with WO3 2.55 g/m2, No. 6 Aluminum foil, double-coated with WO3 5.1 g/m2, No. 7 Aluminum foil, triple-coated with WO3 7.66 g/m2, No. 8 Three-stacked aluminum foil, triple-coated with WO3. PTP sheets (No. 1 - No. 8) were placed inside the abdominal soft tissue phantom, and the images were obtained using FUJIFILM DR CALNEO PT. Region of interest (ROI) was placed on PTP sheets (No. 1 - No. 8) and abdominal soft tissue liquid phantom, and each contrast was measured from the average pixel of the two ROIs. Contrast was calculated by the calculation formula. Each ROI was measured three times, and their average value and standard deviation were estimated. Results: Statistical significance in contrast was not observed in commercial PTP sheet (No. 1), PTP sheet (No. 3), and PTP sheet (No. 5), while there was a significant difference between PTP sheet (No. 1) and PTP sheet (No. 2), PTP sheet (No. 4) PTP sheet (No. 6), PTP sheet (No. 7) (p Conclusion: The other all prototype PTP sheets (No. 2, No. 4, No. 6, No. 7 and No. 8) were well recognized. PTP sheets (No. 2, No. 4) of BaSO4 is considered to be more suitable than PTP sheets of WO3 (No. 6, No. 7, No. 8) because it is easier to produce. We will develop oral PTP sheets for patients with de

关键词： Press-Through Package (PTP) Soft Tissue Phantom Abdominal X-Ray development BaSO4 WO3

在ito导电衬底上室温电沉积高取向的CuBr薄膜

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无机化学学报 2009年第2期25卷 231-235页

作者：李赫徐铸德浙江树人大学生物与环境工程学院杭州310015 浙江大学化学系物理化学研究所杭州310027

室温下,通过简单的电沉积过程还原CuBr2水溶液可在ito导电衬底上生长出高取向的CuBr晶体。用X-射线衍射仪(XRD)、扫描电镜(SEM)对样品进行了表征。结果表明:CuBr晶体生长沿着晶轴方向具有优先取向。通过烷基咪唑四氟硼酸盐[Bmim][BF4]... 详细信息

室温下,通过简单的电沉积过程还原CuBr2水溶液可在ito导电衬底上生长出高取向的CuBr晶体。用X-射线衍射仪(XRD)、扫描电镜(SEM)对样品进行了表征。结果表明:CuBr晶体生长沿着晶轴方向具有优先取向。通过烷基咪唑四氟硼酸盐[Bmim][BF4]离子液体来调控电沉积CuBr的晶体形貌,添加[Bmim][BF4]后,CuBr晶体生长(111)面优先取向大大削弱。对离子液体调控CuBr晶体形貌的机理进行了初步探讨。

关键词： CuBr 电沉积高取向离子液体

Enhancing light absorption for organic solar cells using front ito nanograting and back ultrathin Al layer

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Chinese Physics B 2021年第10期30卷 334-341页

作者： Li Zhang Wei-Ning Liu Yan-Zhou Wang Qi-Ming Liu Jun-Shuai Li Ya-Li Li de-Yan He Key Laboratory of Special Function Materials&Structure design of the Ministry of Education Lanzhou UniversityLanzhou 730000China School of Physical Science&Technology Lanzhou UniversityLanzhou 730000China School of Materials&Energy Lanzhou UniversityLanzhou 730000China

To address the discrepancy between carrier collection and light absorption of organic solar cells caused by the limited carrier mobility and optical absorption coefficient for the normally employed organic photoactive layers,a light management structure composed of a front indium tin oxide(ito)nanograting and ultrathin Al layer inserted in between the photoactive layer and the electron transport layer(ETL)is *** to the antireflection and light scattering induced by the ito nanograting and the suppression of light absorption in the ETL by the inserted Al layer,the light absorption of the photoactive layer is significantly enhanced in a spectral range from 400 nm to 650 nm that also covers the main energy region of solar irradiation for the normally employed active materials such as the P3HT:PC_(61)BM *** simulation results indicate that comparing with the control device with a planar configuration of ito/PEDOT:PSS/P3HT:PC_(61)BM(80-nm thick)/ZnO/Al,the short-circuit current density and power conversion efficiency of the optimized light management structure can be improved by 32.86%and 34.46%.Moreover,good omnidirectional light management is observed for the proposed device *** to the fact that the light management structure possesses the simple structure and excellent performance,the exploration of such a structure can be believed to be significant in fabricating the thin film-based optoelectronic devices.

关键词： light management structures ito nanograting organic solar cells thin film-based optoelectronic devices

Beat-to-Beat Variability in Field Potential Duration in Human Embryonic Stem Cell-derived Cardiomyocyte Clusters for Assessment of Arrhythmogenic Risk, and a Case Study of Its Application

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Pharmacology & Pharmacy 2014年第1期5卷 117-128页

作者： Kazuto Yamazaki Taro Hihara Hiroshi Kato Tatsuto Fukushima Kazuyuki Fukushima Tomohiko Taniguchi Takashi Yoshinaga Norimasa Miyamoto Masashi ito Kohei Sawada Biomarkers and Personalized Medicine CFU Eisai Product Creation Systems Eisai Co. Ltd. Tsukuba Japan Biopharmaceutical Assessment CFU Eisai Product Creation Systems Eisai Co. Ltd. Tsukuba Japan Global Discovery Research Neuroscience and General Medicine PCU Eisai Product Creation Systems Eisai Co. Ltd. Tsukuba Japan Next Generation Systems CFU Eisai Product Creation Systems Eisai Co. Ltd. Tsukuba Japan

We established a QT interval assessment system that uses human embryonic stem cell-derived cardiomyocyte clusters (hES-CMCs) in which the field potential duration (FPD) or corrected FPD (FPDc) was measured as an indicator of drug-induced QT interval prolongation. To investigate the applicability of the hES-CMC system to drug safety assessment, we investigated short-term variability in FPDc (STVFPDc) (beat rate rhythmicity) as a marker of torsadogenic risk. We investigated the FPDc and STVFPDc of hES-CMCs treated with hERG channel blockers (E-4031 or cisapride) or with our proprietary compounds X, Y, and Z. We also evaluated the electrocardiograms and hemodynamics of dogs treated with compound X, Y, or Z. The torsadogenic hERG channel blockers increased STVFPDc and prolonged FPDc. Compounds X, Y, and Z had hERG inhibitory activity. Compound X prolonged FPDc with increased STVFPDc, whereas compounds Y and Z tended to shorten FPDc in the hES-CMC system. In the in vivo canine study, compound X prolonged corrected QT (QTc), and compounds Y and Z tended to shorten QTc, showing a good correlation with the results in hES-CMCs. These findings suggest that combined assessment of FPDc and STVFPDc in the hES-CMC system increases the predictability of torsadogenic risk.

关键词： Human Embryonic Stem Cell-derived Cardiomyocytes Field Potential Duration Short-Term Variability QT Interval Torsades de Pointes Risk Assessment