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Inflammation is king in liver resection for hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 839-841页

作者： Xavier Muller kayvan mohkam Jean-Yves Mabrut Department of General Surgery and Liver Transplantation Croix-Rousse University HospitalHospices Civils de LyonUniversity of Lyon ILyonFrance Cancer Research Center of Lyon INSERM U1052LyonFrance Department of Pediatric Surgery and Liver Transplantation Hôpital Femme Mère EnfantUniversitéClaude Bernard Lyon 1Hospices Civils de LyonBronFrance

We read with great interest the paper by Miyata et ***:The Impact of Histologic Liver Inflammation on Oncology and the Prognosis of Patients Undergoing Hepatectomy for Hepatocellular Carcinoma(1).In this single center retrospective study,the authors included 500 patients undergoing curative surgical liver resection for primary hepatocellular carcinoma(HCC)without any neoadjuvant *** liver specimen underwent postoperative pathological analysis to identify fibrosis but also lymphocyte infiltration and hepatocyte necrosis as surrogate marker for hepatic *** hepatic inflammation was graded from A0:no necro-inflammatory reaction,to A3:severe necro-inflammatory *** follow-up was 47.3 ***,19.4%of the patients had severe liver inflammation A3(n=97)and presented with higher postoperative morbidity and reduced overall and recurrence-free survival compared to patients with none to moderate inflammation A0-A2(n=403).Furthermore,inflammation grade A3 was an independent predictor of HCC recurrence independent of underlying liver disease and fibrosis grade.

关键词： inflammation hepatocellular Carcinoma

Double cholecystectomy in case of accessory gallbladder:Not as easy as two cholecystectomies

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 93-95页

作者： Benjamin Darnis kayvan mohkam Fran?ois Cauchy Jean-Yves Mabrut Department of General Surgery and Liver Transplantation Hospices Civils de Lyon Croix-Rousse University Hospital Ecole Doctorale EDISS 205 Université Lyon 1 HPB Surgery and Liver Transplantation Unit Beaujon Hospital

To the Editor:Accessory gallbladders(AG)are rare and their management are usually *** variations are related with an abnormal division of the bile ducts precursors between the 5th and the 12th week of *** et al.[1]proposed an anatomical classification of these variations based on the embryologic abnormalities *** type 1 both gallbladders are connected to the common bile duct at the same *** type 2 the AG can reach either the common bile duct(ductular type)or an intrahepatic biliary duct(trabecular type).In type 3,three gallbladders are present.

关键词： gallbladders Harlaftis

Polymorphic multiple hepatocellular adenoma including a non-steatotic HNF1α-inactivated variant

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 552-555页

作者： kayvan mohkam Benjamin Darnis Jean-Baptiste Cazauran Agnès Rode Anne-Frédérique Manichon Christian Ducerf Brigitte Bancel Jean-Yves Mabrut Department of General Surgery and Liver Transplantation Hospices Civils de Lyon Croix-Rousse University HospitalLyon France Department of Radiology Hospices Civils de Lyon Croix-Rousse University HospitalLyon France Department of Surgical Pathology Hospices Civils de Lyon Croix-Rousse University HospitalLyon France Equipe Mixte de Recherche 3738 Ecole Doctorale EDISS 205 Université Lyon 1 France

To the Editor:Hepatocellular adenomas(HCAs)consist of benign liver tumors favored by the use of oral contraceptives,which preferentially occur in women.[1,2]They expose to the risk of hemorrhage(20%of cases)and more rarely,to the risk of malignant transformation(4%-10%of cases).[3,4]Multiple HCAs,which are defined by the presence of 10 or more

关键词： HNF Polymorphic multiple hepatocellular adenoma including a non-steatotic HNF1 HCA

A simple multiplex PCR for assessing prevalence of extended-spectrumβ-lactamases producing Klebsiella pneumoniae in Intensive Care Units of a referral hospital in Shiraz,Iran

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Asian Pacific Journal of Tropical Medicine 2013年第9期6卷 703-708页

作者： Younes Ghasemi Talieh Archin Mohammad Kargar Milad mohkam Parmaceutical Sciences Research Center School of PharmacyShiraz University of Medical Sciences Department of Pharmaceutical Biotechnology School of PharmacyShiraz University of Medical Sciences Department of Microbiology Jahrom BranchIslamic Azad University

Objective:To identify three common genes(bla_(TEM),bla_(SHV)and bla_(CTX-M)responsible for ESBL production in Klebsiella pneumnniae(***)isolated from Intensive Care Units of Namazi Hospital,Shiraz,***:A total of 60 non-repetitive nosocomial isolates from 60patients were selected during *** phenotypic identification of ESBL production was confirmed by Double Disk Synergy Test(DDST)according to CLSI *** ESBL's genotype was then analyzed by multiplex PCR of bla_(TEM),bla_(SHV)and bla_(CTX-M)genes and DNA ***:The primary susceptibility tests of *** showed that among 10 examined antibiotics,the most resistant and susceptible antibiotics identified in this study were ampicillin and imipenem,*** phenotypic determination of ESBL by DDST showed that 60%(n=36)of isolates produced *** PCR of genes among *** isolates showed that 39%(n=18)of them have TEM,39%in=18)of then have both CTX-M and TEM and 13%(n=8)of them have TEM,SHV,***:Our findings reveal the high prevalence(60%)of ESBL prcxducing *** from ICL patients along with a new pattern of bla_(TEM)distribution differ from other countries.

关键词： Klebsiella pneumoniae ESBLs ICUs Multiplex PCR

Exploring the potential and safety of quantum dots in allergy diagnostics

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Microsystems & Nanoengineering 2023年第6期9卷 1-23页

作者： Milad mohkam Mohammad Sadraeian Antonio Lauto Ahmad Gholami Seyed Hesamodin Nabavizadeh Hossein Esmaeilzadeh Soheila Alyasin Allergy Research Center Shiraz University of Medical SciencesShirazIran Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia School of Science University of Western SydneyCampbelltownNSW2560Australia School of Medicine University of Western SydneyCampbelltownNSW2560Australia Biotechnology Research Center Shiraz University of Medical SciencesShirazIran Department of Pharmaceutical Biotechnology School of PharmacyShiraz University of Medical SciencesShirazIran Department of Allergy and Clinical Immunology Namazi HospitalShiraz University of Medical SciencesShirazIran

Biomedical investigations in nanotherapeutics and nanomedicine have recently intensified in pursuit of new therapies with improved *** dots(QDs)are promising nanomaterials that possess a wide array of advantageous properties,including electronic properties,optical properties,and engineered biocompatibility under physiological *** to these characteristics,QDs are mainly used for biomedical labeling and theranostic(therapeutic-diagnostic)*** can be functionalized with ligands to facilitate their interaction with the immune system,specific IgE,and effector cell ***,undesirable side effects such as hypersensitivity and toxicity may occur,requiring further *** review systematically summarizes the potential uses of QDs in the allergy *** overview of the definition and development of QDs is provided,along with the applications of QDs in allergy studies,including the detection of allergen-specific IgE(sIgE),food allergens,and sIgE in cellular *** potential treatment of allergies with QDs is also described,highlighting the toxicity and biocompatibility of these ***,we discuss the current findings on the immunotoxicity of *** favorable points regarding the use of QDs for allergy diagnosis and treatment are noted.

关键词： allergy diagnosis potential

Modification in Media Composition to Obtain Secretory Production of STxB-based Vaccines using Escherichia coli

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Virologica Sinica 2013年第1期28卷 43-48页

作者： Mohammad Sadraeian Mohammad Bagher Ghoshoon Milad mohkam Zeinab Karimi SaraRasoul-Amini Younes Ghasemi Pharmaceutical Sciences Research Center Shiraz University of Medical Sciences Department of Pharmaceutical Biotechnology School of Pharmacy Shiraz University of Medical Science Department of Medicinal Chemistry School of Pharmacy Shiraz University of Medical Sciences

Shiga toxin B-subunit （STxB） from Shigella dysenteriae targets in vivo antigen to cancer cells, dendritic cells （DC） and B cells, which preferentially express the globotriaosylceramide （Gb3） receptor. This pivotal role has encouraged scientists to investigate fusing STxB with other clinical antigens. Due to the challenges of obtaining a functional soluble form of the recombinant STxB, such as formation of inclusion bodies during protein expression, scientists tend to combine STxB with vaccine candidates rather than using their genetically fused forms. In this work, we fused HPV16 E7 as a vaccine candidate to the recombinantly-produced STxB. To minimize the formation of inclusion bodies, we investigated a number of conditions during the expression procedure. Then various strategies were used in order to obtain high yield of soluble recombinant protein from E. coli which included the use of different host strains, reduction of cultivation temperature, as well as using different concentrations of IPTG and different additives （Glycin, Triton X-100, ZnC12）. Our study demonstrated the importance of optimizing incubation parameters for recombinant protein expression in E. coli; also showed that the secretion production can be achieved over the course of a few hours when using additives such as glycine and Triton X-100. Interestingly, it was shown that when the culture mediums were supplemented by additives, there was an inverse ratio between time of induction （TOI） and the level of secreted protein at lower temperatures. This study determines the optimal conditions for high yield soluble E7-STxB expression and subsequently facilitates reaching a functionally soluble form of STxB-based vaccines, which can be considered as a potent vaccine candidate for cervical cancer.

关键词： Protein vaccine STxB Soluble expression Triton X- 1 O0

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“注浆盾构”—隧道掘进技术的一项革新

隧道译丛 1990年第8期 54-57页

作者： mohkam,M 胡时友