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Advances in Atmospheric Sciences 2015年第11期32卷 1533-1538页

作者： Ying ZHANG kayo IDE Eugenia KALNAY Department of Atmospheric and Oceanic Science University of MarylandCollege Park

The breeding method has been widely used in studies of data assimilation, predictability and instabilities. The bred vectors （BVs）, which are the nonlinear difference between the control and perturbed runs, represent the time-evolving rapidly growing errors in dynamic systems. The Lorenz （1963） model （hereafter Lorenz63 model） has chaotic dynamics similar to weather and climate. This study investigates the features of BVs of the Lorenz63 model and its impact on regime prediction of the Lorenz63 model. The results show that the Lorenz63 model has two different BVs for each breeding cycle, and the two BVs approach being identical when growth rate is high. The duration of the current and next regime is associated with the relative directions between the BV with high growth rate and the model trajectory.

关键词： bred vectors chaos Lorenz63 model regime prediction

Development of nanocrystal formulation of mebendazole with improved dissolution and pharmacokinetic behaviors

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 122-123页

作者： Naofumi Hashimoto kayo Yuminoki Haruka Takeuchi Chiaki Okada Setsunan University

Nanosizing by wet beads milling is a method to improve the solubility of poorly water soluble compounds[1,2].Mebendazole(MBZ)is a well-known anthelmintic drug in wide clinical *** were some reports that MBZ had the anticancer effect in preclinical ***,the bioavailability of MEB is low(<10%)due to the poor solubility in water(0.5μg/mL).The present study aimed to develop the nanocrystal formulations of MEB to improve dissolution behavior and enhance oral absorption.

关键词： Mebendazole Nanocrystal Wet beads milling Oral absorption

Topology of Prion Proteins

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Journal of Mathematics and System Science 2012年第4期2卷 237-248页

作者： Akio Kawauchi kayo Yoshida Department of Mathematics Osaka City University Sugimoto Sumiyoshi-ku Osaka 558-8585 Japan

A conformal structure of a prion protein is thought to cause a prion disease by S.B. Prusiner＇s theory. Knot theory in mathematics is useful in studying a topological difference of topological objects. In this article, concerning this conjecture, a topological model of prion proteins （PrPc, PrPsc） called a prion-tangle is introduced to discuss a question of whether or not the prion proteins are easily entangled by an approach from the mathematical knot theory. It is noted that any prion-string with trivial loop which is a topological model of a prion protein can not be entangled topologically unless a certain restriction such as ＂Rotaxsane Property＂ is imposed on it. Nevertheless, it is shown that any two split prion-tangles can be changed by a one-crossing change into a non-split prion-tangle with the given prion-tangles contained while some attentions are paid to the loop systems. The proof is made by a mathematical argument on knot theory of spatial graphs. This means that the question above is answered affirmatively in this topological model of prion-tangles. Next, a question of what is the simplest topological situation of the non-split prion-tangles is considered. By a mathematical argument, it is determined for every n 〉 1 that the minimal crossing number of n-string non-split prion-tangles is 2n or 2n-2, respectively, according to whether or not the assumption that the loop system is a trivial link is counted.

关键词： Topological model prion protein prion-string prion-tangle spatial graph prion-bouquet unknotting number.

Gene Polymorphisms and Chemotherapy in Non-small Cell Lung Cancer

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中国肺癌杂志 2009年第8期12卷 837-840页

作者： kayo OSAWA Faculty of Health Sciences Kobe University Graduate School of Health Sciences 7-10-2 Tomogaoka Suma-ku Kobe 654-0142 Japan

The phamacogenetics is being used to predict whether the selected chemotherapy will be really effective and tolerable to the patient. Irinotecan,oxidized by CYP3A4 to produce inactive compounds,is used for treatment of various cancers including advanced non small cell lung cancer (NSCLC) patients. CYP3A4*16B polymorphism was associated with decreased metabolism of irrinotecan. Irinotecan is also metabolized by carboxylesterase to its principal active metabolite,SN-38,which is subsequently glucuronidated by UGT1As to form the inactive compound SN-38G. UGT1A1*28 and UGT1A1*6 polymorphisms were useful for predicting severe toxicity with NSCLC patients treated with irinotecan-based chemotherapy. Platinum-based compounds (cisplatin,carboplatin) are being used in combination with new cytotoxic drugs such as gemcitabine,paclitaxel,docetaxel,or vinorelbine in the treatment of advanced NSCLC. Cisplatin activity is mediated through the formation of cisplatin-DNA adducts. Gene polymorphisms of DNA repair factors are therefore obvious candidates for determinants of repair capacity and chemotherapy efficacy. ERCC1,XRCC1 and XRCC3 gene polymorphisms were a useful marker for predicting better survival in advanced NSCLC patients treated with platinum-based chemotherapy. XPA and XPD polymorphisms significantly increased response to platinum-based chemotherapy. These DNA repair gene polymorphisms were useful as a predictor of clinical outcome to the platinum-based chemotherapy. EGFR kinase inhibitors induce dramatic clinical responses in NSCLC patients with advanced disease. EGFR gene polymorphism in intron 1 contains a polymorphic single sequence dinucleotide repeat (CA-SSR) showed a statistically significant correlation with the gefitinib response and was appeared to be a useful predictive marker of the development of clinical outcome containing skin rashes with gefitinib treatment. The other polymorphisms of EGFR were also associated with increased EGFR promoter activity. EGFR gen

关键词：非小细胞肺癌基因多态性化学疗法疗效

Changes in choroidal thickness in healthy pediatric individuals: a longitudinal study

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1179-1184页

作者： Eiko Ohsugi Yoshinori Mitamura kayo Shinomiya Masanori Niki Hiroki Sano Toshihiko Nagasawa Yukiko Shimizu Daisuke Nagasato Hitoshi Tabuchi Department of Ophthalmology Saneikai Tsukazaki Hospital Department of Ophthalmology Institute of Biomedical Sciences Tokushima University Graduate School

AIM： To investigate the changes in the choroidal thickness in healthy pediatric children in a longitudinal study, and to determine the ocular and systemic parameters that were significantly correlated with the changes in the choroidal thickness. METHODS： This study included 64 eyes of 34 healthy Japanese children with a mean age（±SD） of 4.4（±0.4）y（range, 3.6-5.8 y） at baseline. Swept-source optical coherence tomography（SS-OCT） was used to record images of the retina and choroid at the baseline and after a mean followup period of about 1.5 y. The 3 D raster scan protocol was used to construct the choroidal thickness map. Mean choroidal thickness was calculated for each of the nine sectors of the Early Treatment Diabetic Retinopathy Study grid. Best-corrected visual acuity, axial length, body height, and weight were also measured. Changes in measurements were defined as the baseline values subtracted from the values at the final visit. A generalized estimating equation was used to eliminate the effect of within-subject intereye correlations. RESULTS： The mean central choroidal thickness was significantly reduced during the follow-up period（baseline, 301.8±8.6 μm; final visit, 286.6±8.0 μm, P〈0.001）. The decrease in the choroidal thickness was greatest in the central sector, followed by the sectors of the inner and outer rings. The inner and outer rings had diameters of 1 to 3 mm and 3 to 6 mm, respectively. The changes in the choroidal thickness in the central, inner ring, and outer ring sectors were significantly and negatively correlated with the age, baseline body height, baseline body weight, and elongation of the axial length. CONCLUSION： These results indicate that the choroidal thickness among preschool-aged Japanese children decreased significantly during the follow-up period. The choroidal thinning is significantly associated with the elongation of axial length. These characteristics should be considered in the evaluation of choroidal thickness in younger chi

关键词： choroidal thickness longitudinal study pediatrics swept-source optical coherence tomography

Effectiveness of Somatic Balance Restoration Therapy to Alleviate Pain of Musculoskeletal System

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Health 2017年第10期9卷 1390-1403页

作者： Munehiro Mike kayo Yoshiaki Ohkami Institute of System Design and Management Yokohama Japan

Chronic pain and general physical discomfort are common symptoms among those seeking medical or physiotherapy treatment, as it relates to disorders found in the Human Musculoskeletal System (HMS). Since this system is highly complex and large in scale, clinical pain research has been confounded by many complex factors. The goal of our research is to overcome these obstacles by applying multidisciplinary approaches including systems engineering, traditional oriental techniques, conventional medicine and related sciences. To pursue such an integrated approach this paper examines the therapist-guided exercise for restoring human musculoskeletal balance called the Somatic Balance Restoration Therapy (SBRT). The SBRT is a simple but effective self-exercise therapy with minimal assistance by a trained therapist. This therapy is analyzed by a mechanical engineering method by modeling the human body as a multi-body subject to a static equilibrium condition. In addition, the wording has been rewritten in functional anatomical terms, enabling smooth communication between specialists of three different disciplines: therapy, conventional medicine and systems engineering. Examples will be given to demonstrate an integrated and systematic approach for identifying and remedying malfunctions within the HMS.

关键词： Integrated Medicine Self-Exercise Therapy Musculoskeletal Pain Systems Approach

Application of povacoat as dispersion stabilizer of nanocrystal formulation

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 48-49页

作者： kayo Yuminoki Fuko Seko Shota Horii Haruka Takeuchi Katsuya Teramoto Yuichiro Nakada Naofumi Hashimoto Setsunan University 45-1Nagaotoge-choHirakataOsaka 573-0101Japan Santen Pharmaceutical Company Ltd. 40-20OfukachoKita-kuOsaka 530-8552Japan

Nanosizing by wet beads milling is one of the methods to improve the solubility of poorlywater soluble compounds[1,2].Hydrophilic polymers,such as Hydroxypropylcellulose-SSL(HPC),Polyvinylalcohol(PVA),and Polyvinylpyrrolidone-K30(PVP)*** used as dispersion stabilizer to prevent aggregation of ***,there are many compounds that cannot be dispersed by ordinary dispersion *** this study,we used Povacoat?as a dispersion stabilizer for several poorly water soluble compounds milled to *** influences of aggregation of the nanoparticles on the dissolution behavior and the oral absorption of the compoundswere studied using formulations with high and low dispersion characters.

关键词： Nanocrystal Wet beads milling Poorly water soluble compounds

Development of self-micellizing solid dispersion system employing amphipathic copolymer for the improvement of dissolution and oral bioavailability of cyclosporine A

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 50-51页

作者： Hiroki Suzuki Hideyuki Sato Yoshiki Kojo Takahiro Mizumoto kayo Yuminoki Naohumi Hashimoto Yoshiki Seto Satomi Onoue University of Shizuoka 52-1 YadaSuruga-kuShizuoka 422-8526Japan ILS Inc. 1-2-1 KubogaokaMoriyaIbaraki 302-0104Japan Setsunan University 45-1 Nagaotoge-choHirakataOsaka 573-0101Japan

The main objective of the present study is to develop a selfmicellizing solid dispersion(SMSD)system of cyclosporine A(CsA)using an amphiphilic copolymer,poly[MPC-co-BMA](pMB)to improve the biopharmaceutical properties of CsA(Fig.1A).Unlike conventional carrier compounds,pMB would perform the bifunctional ability as both polymeric carrier of solid dispersion system and solubilizer derived from a high micellizing property,which could be considered beneficial for the production of highly water soluble formulation of poorly water soluble compound[1].Improvement in the aqueous solubility has been believed to be a key consideration for acquiring potent pharmacological effects of BCS class II drug like CsA.

关键词： Cyclosporine A Amphipathic copolymer Self-micellizing solid dispersion Oral bioavailability

多色荧光碳量子点的合成及不同链长度烃的功能化改性（英文）

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新型炭材料 2017年第4期32卷 327-337页

作者： kayo Oliveira Vieira Jefferson Bettini Luiz Fernando Cappa de Oliveira Jefferson Luis Ferrari Marco Antonio Schiavon GrupodePesquisaemQuimicadeMaterials-(GPQM) DepartamentodeCienciasNaturaisUniversidadeFederaCampusDomBoscoPragaDomHelvecio74CEP36301-160SaoJoaodel-ReiMGBrazil LaboratorioNacionaldeNanotecnologia CentroNacionaldePesquisaemEnergiaeMaterialsCEP13083-970Campinas-SPBrazi NucleodeEspectroscopiaeEstruturaMolecular DepartamentodeQuimicaUniversidadeFederaldeJuizdeFora36036-330JuizdeForaMGBrazi

以多壁碳纳米管(MWCNTs)为原料,经肽键形成氨基功能化后合成出新型多色荧光碳量子点(CQDs)。所制CQDs由准球形石墨纳米晶体(平均尺寸为10 nm)包裹不同烃类,如丙胺、辛胺、十二胺和八乙胺得到的氨基。在CQDs表面引入氮原子和烃类对其荧... 详细信息

以多壁碳纳米管(MWCNTs)为原料,经肽键形成氨基功能化后合成出新型多色荧光碳量子点(CQDs)。所制CQDs由准球形石墨纳米晶体(平均尺寸为10 nm)包裹不同烃类,如丙胺、辛胺、十二胺和八乙胺得到的氨基。在CQDs表面引入氮原子和烃类对其荧光性能、量子产率和溶解性起重要影响。这种新型有机-溶解CQDs的荧光发射波长取决于激发波长。荧光量子产率根据CQDs表面上烃类取代物的链长而变化。

关键词：碳量子点碳纳米管荧光量子产率