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Sintering, thermal stability and mechanical properties of ZrO2-WC composites obtained by pulsed electric current sintering

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Frontiers of Materials Science 2011年第1期5卷 50-56页

作者： Shuigen HUANG Kim VANMEENSEL omer VAN DER BLEST Jozef VLEUGELS Department of Metallurgy and Materials Engineering Katholieke Universiteit Leuven Kasteelpark Arenberg 44 B-3001 Heverlee Belgium

ZrO2-WC composites exhibit comparable mechanical properties as traditional WC-Co materials, which provides an opportunity to partially replace WC-Co for some applications. In this study, 2 mol.% Y2O3 stabilized ZrO2 composites with 40 vol.% WC were consolidated in the 1150℃-1850℃ range under a pressure of 60 MPa by pulsed electric current sintering （PECS）. The densification behavior, microstructure and phase constitution of the composites were investigated to clarify the role of the sintering temperature on the grain growth, mechanical properties and thermal stability of ZrO2 and WC components. Analysis results indicated that the composites sintered at 1350℃ and 1450℃ exhibited the highest tetragonal ZrO2 phase transformability, maximum toughness, and hardness and an optimal flexural strength. Chemical reaction of ZrO2 and C, originating from the graphite die, was detected in the composite PECS for 20 min at 1850℃ in vacuum.

关键词： ceramic composite pulsed electric current sintering (PECS) grain size,mechanical property

Minimally invasive techniques in benign and malignant adrenal tumors

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World Journal of Clinical Cases 2022年第35期10卷 12812-12821页

作者： Ahmet Bulent Dogrul omer Cennet Anıl Hilmi Dincer Department of General Surgery Hacettepe University Faculty of MedicineHacettepe UniversityAnkara 06100Turkey

Minimally invasive adrenalectomy has become the main treatment modality for most adrenal *** laparoscopic transabdominal and retroperitoneoscopic approaches are safe and feasible options,each with respective advantages,including better surgical outcomes,fewer complications,and faster recovery over open *** open surgery remains a valid modality in treatment of adrenocortical cancer in the presence of some findings such as invasion,robotic platforms,and minimally invasive surgery have gained popularity as technology continues to *** preservation during adrenalectomy is feasible in some conditions to prevent adrenal *** technologies are increasingly utilized in benign and malignant tumors,including the adrenal gland,with various outcomes.A multidisciplinary team,an experienced surgeon,and a highvolume center are recommended for any surgical approaches and management of adrenal *** review article evaluated recent findings and current evidence on minimally invasive adrenalectomy.

关键词： Adrenalectomy Laparoscopy Retroperitoneoscopic Minimally invasive surgery Robotic

Microfluidics for cell-cell interactions： A review

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Frontiers of Chemical Science and Engineering 2016年第1期10卷 90-98页

作者： Rui Li Xuefei Lv Xingjian Zhang omer Saeed Yulin Deng School of Life Science Beijing Institute of Technology Beijing 100081 China

Micro fluidic chip has been applied in various biological fields owing to its low-consumption of reagents, high throughput, fuidic controllability and integrity. The well-designed microscale intermediary is also ideal for the study of cell biology. Particularly, microfluidic chip is helpful for better understanding cell-cell interactions. A general survey of recent publications would help to generalize the designs of the co-culture chips with different features. With ingenious and combinational utilization, the chips facilitate the implementation of some special coculture models that are highly concerned in a different spatial and temporal way.

关键词： microfluidic chip co-culture cell-cell interactions review

Effectiveness of royal jelly supplementation in glycemic regulation:A systematic review

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World Journal of Diabetes 2019年第2期10卷 96-113页

作者： Kamel omer Maxwell J Gelkopf Genevieve Newton Department of Human Health and Nutritional Sciences University of Guelph

BACKGROUND Royal jelly(RJ)has been observed to have therapeutic properties in diabetic individuals,including the reduction of high blood *** systematic review synthesized existing evidence to investigate the effectiveness of RJ supplementation in managing measures of blood *** To determine the effectiveness of RJ supplementation on glycemic responses in healthy and non-insulin dependent diabetic adults,as well as animal models of *** This was a systematic review employing the PRISMA ***-reviewed,published articles were extracted from several databases using key words related to target population,intervention and outcome and hand-selected for *** articles proceeded to data extraction phase,where information on target parameters and effectiveness of treatment was *** this,the risk of bias for each included study was ***,the long-term and immediate effectiveness of RJ supplementation in glycemic control were assessed using the Grading of Recommendations,Assessment,Development and Evaluations(GRADE)tool,which rates the quality of *** Of 168 articles extracted from database searching,eighteen were included for analysis in this systematic *** the studies,studied populations,intervention styles and outcome measures were largely *** this,the results in studies indicate a general trend of positive effect of RJ in glycemic regulation in vitro and in ***,some dose-dependent glycemic effects were observed,along with some large effect *** risk of bias for human and animal studies is generally low-unclear risk,although lack of blinding is a serious concern in both ***,as per the GRADE tool,the quality of evidence is low,and very low for long-term and immediate effectiveness of RJ,respectively.A major limitation affecting evidence quality is the heterogeneity among included *** blood glucose and glucose clearance a

关键词： Royal jelly Type 2 diabetes Dietary supplement Glycemic control 10-hydroxy-trans-2-decenoic acid Hyperglycemia Adults Animals

Detecting early changes in choroidal vascularity and thickness using optical coherence tomography in patients with corneal crosslinking for keratoconus

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1267-1272页

作者： Selim Doganay Mehmet omer Kiristioglu Derya Doganay Elif Kacmaz Department of Ophthalmology Bursa Uludag University School of MedicineBursa 16059Turkey Department of Ophthalmology University of Health Sciences Bursa Yuksek Ihtisas Training and Research HospitalBursa 16310Turkey

AIM:To investigate changes in choroidal thickness and vascularity in keratoconus patients treated with corneal ***:This study evaluated 28 eyes of 22 patients with keratoconus who underwent corneal *** choroidal thicknesses were evaluated on enhanced depth imaging optical coherence tomography at the preoperative and postoperative 3d,1,and *** thickness in the four cardinal quadrants and the fovea were *** choroidal vascularity index was also ***:There was no significant difference in central choroidal thickness between the preoperative and postoperative 3d,1mo(P>0.05).There was a significant increase in the 3mo(P=0.034)and a significant decrease in the horizontal choroidal vascularity index on the postoperative 3d(P=0.014),there was no statistically significant change in vertical axes and other visits in horizontal sections(P>0.05).CONCLUSION:This study sheds light on choroidal changes in postoperative corneal crosslinking for *** it suggests the procedure’s relative safety for submacular choroid,more extensive research is necessary to confirm these findings and their clinical significance.

关键词： keratoconus corneal crosslinking choroidal vascularity index enhanced depth imaging optical coherence tomography

Bio-fabrication of liver cancer stem cells and testing of gemcitabine

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Journal of Cancer Metastasis and Treatment 2023年第1期9卷 497-505页

作者： Evrim Cevik omer Erdogan Ozge Cevik Department of Machinery and Metal Technologies Aydin Adnan Menderes UniversityKocarli Vocational High SchoolAydin 09970Turkey Department of Medicinal Biochemistry Aydin Adnan Menderes UniversitySchool of MedicineAydin 09010Turkey

Aim:Cancer stem cells are cell populations that are essential in drug resistance and cancer *** liver cancer cells exhibit the characteristics of cancer stem cells,and it is crucial to study the activities and interactions of drugs in these ***7 is a human liver cancer cell with stem cell biomarkers and is used with induced pluripotent stem cells to form various cancer organoids through encapsulation *** to their ease of use without animal testing,bio-fabrication studies of cell-encapsulated models have gained importance in the pharmaceutical industry in recent *** study aimed to biofabricate Huh7 human liver cancer stem cells by alginate encapsulation and test gemcitabine’s ***:Huh7 cells were encapsulated with alginate(0.8%w/v)and fibronectin,and their viability was evaluated with 3.2μM gemcitabine on days 1,3,6,9,and ***,gene expressions of stem cell markers CD90 and AFP were evaluated in encapsulated Huh7 cells by *** addition,IL-6 secretion in the cell medium was measured by ELISA for the tumor ***:Encapsulation of Huh7 cells was found to maintain their viability and stem cell properties for up to 12 *** addition,alginate-encapsulated Huh7 cells were bio-fabricated to demonstrate long-term gemcitabine *** the effect of the gemcitabine was evaluated in alginate-encapsulated Huh7 cells,CD90 and AFP mRNA levels were significantly reduced in the cells and IL-6 secretion was decreased in the tumor ***:This study demonstrated that bio-fabrication of alginate-encapsulated Huh7 cells is a novel approach for long-term drug testing in liver cancer ***-fabricated alginate-encapsulated cancer stem cells may be a cheaper and faster method for the testing of many drugs.

关键词： Bio-fabrication cancer stem cells gemcitabine liver cancer alginate beads

Computer Simulation of Fe-Al-Si System Diffusion Couples

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Journal of Materials Science & Technology 2011年第8期27卷 729-734页

作者： Zhongping He Yanlin He YiGao Lin Li Shuigen Huang omer Van der Blest School of Materials Science and Engineering Shanghai University Shanghai 200072 China Cold Rolling Plant of Ansteel Anshan 114021 China Department of Metallurgy and Materials Engineering Katholieke Universiteit Leuven Kasteelpark Arenberg 44 B-3001 Heverlee Belgium

DifFusion couples, Fe-6.8 wt% Al-1.0 wt% Si/Fe and Fe-6.3 wt% Al-0.9 wt% Si/Fe were constructed and separately annealed at 1050℃ for 3 h and at 1000℃ for 64 h. The concentration profiles of Fe, Al and Si atoms in these couples were measured by electron probe micro-analysis （EPMA）, while the diffusion behavior was also simulated by coupling thermodynamic and kinetic properties of Fe-Al-Si system. The simulation results were in good agreement with the measured concentration profiles showing the validity of dynamic parameters of Fe-Al-Si system, Calculation was made for Fe-7 wt% Al-1 wt% Si/Fe diffusion couples at 1000℃ with different diffusion time. Silicon uphill was found under the influence of aluminum.

关键词： Diffusion kinetics Fe-Al-Si system Thermo-calc and DICTRA

Correlation of gene content in selected bifidobacteria with folate supplier or scavenger status during growth in laboratory media

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Food Bioscience 2023年第1期51卷 1057-1066页

作者： omer F.Celik Daniel J.O’Sullivan Department of Food Science and Nutrition Microbial and Plant Genomics InstituteUniversity of MinnesotaSt.PaulMinnesotaUSA Department of Food Engineering Faculty of AgricultureOrdu University52200OrduTurkey

Five different bifidobacterial cultures were screened to investigate if their de novo folate production ability could be predicated based on their folate biosynthetic gene *** previously developed folate free media could not adequately support the growth of these five strains,even with added folate,an alternative medium(YNB+)was *** with its genome prediction,Bifidobacterium animalis *** strain Bb-12 required folate for its growth even in the presence of p-aminobenzoic acid(PABA).Although *** DJO10A and *** ATCC 15701 lack an alkaline phosphatase gene for the formation of one pathway intermediate(DHPPP),both were found to be able to grow independent from folate and PABA suggesting that lack of these genes in genome annotations cannot be used to predict folate dependency in ***,having all required genes cannot always predict folate production,as *** *** RECb4 contained a full set of pathway genes,but required folate or PABA for *** many bifidobacteria can produce folate,this also cannot be used to predicate their ability to supply folate as some can act as scavengers when folate is readily available in the environment,such as *** ATCC 15701 in this *** bifidobacterial cultures are sometimes considered for use in foods based on their folate production abilities,it is important to consider whether they function as folate scavengers or suppliers when growing in folate containing media.

关键词： Folic acid PABA Probiotics Folate

Characterizing conservative and protective needs of the aridland forests of Sudan

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Journal of Forestry Research 2021年第6期32卷 2365-2373页

作者： Nasradeen A.H.Gadallah Abdelnasir I.A.Hano Eiman Diab Galal omer Dep.of Forest Conservation and Protection Faculty of ForestryUniversity of KhartoumKhartoum North 13314Sudan Desrtification and Desert Cultivation Studies Institute University of KhartoumKhartoum North 13314Sudan National Center for Research Institute of Environment and Natural ResourcesKhartoum 1111Sudan

Forests in the aridlands of Sudan are distinctive in nature and require special attention due to the great role they play as a first and last line of defense against southward ***,to determine their conservative and protective needs based on current conditions in the Wad Al-Bashir Forest(WF),toward ensuring sustainable forest resources in these areas,we used a systematic field survey,existing and available documents review and key informant interviews(KII),to collect data from 08 December 2017 to 15 May 2018.A severe depletion and changes in the forest tree cover and composition were found during the field survey,where species such as Balanitis aegyptiaca is threatened and invasive species(e.g.,Acacia nubica)have started to *** documents have credited illegal cutting and agricultural activities for the changes in the forest status,whereas the KII indicated that past and current forest conservative and protective practices(CPPs),where forest clearance for agricultural,grazing,pests and disease control,were not given a deserved consideration as they relate to tree cutting and reforestation ***,negligence of the needs of those who depend on the forest and inadequate funds have constrained implementation of some ***,on the basis of the results of this study,we recommend that CPPs associated with agriculture,grazing,forest fire,pest and disease control should be a top priority concern of forest *** financial support,which could be enriched by involving governmental and non-governmental organizations,is also needed to boost CPPs in the *** species also need to be cleared and replaced by trees such as *** and *** that are of economic and environmental value.

关键词： Dry forest Forest conservation Protection Desertification