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Pharmacology & Pharmacy 2013年第2期4卷 240-243页

作者： Atsushi kawase Tetsuya Ohgami Iho Yoshida Yu Tsunokuni Masahiro Iwaki Department of Pharmacy School of Pharmacy Kinki University Osaka Japan Department of Physiology Hyogo College of Medicine Nishinomiya Japan.

Nuclear receptors such as pregnane X receptor (PXR) and constitutive androstane receptor (CAR) regulate the transcription of transporter and cytochrome P450 (CYP). The diurnal variation was observed in some transporters regulated by nuclear receptors. We investigated whether diurnal variation in PXR and CAR exists in mice. We also examined the effect of food intake on the diurnal rhythm of hepatic PXR and CAR using fed and fasted mice. In liver and small intestine of fed mice, the mRNA levels of PXR and CAR were unchanged between 7:00 AM and 7:00 PM. In contrast to fed mice, fasting mice partly exhibited the diurnal variation in PXR, not in CAR. The mRNA levels of PXR at 7:00 AM were significantly higher than that those at 7:00 PM in liver of fasting mice. These results indicated the different effects of fasting in mice on diurnal variation of PXR in each tissue.

关键词： CAR Circadian Rhythm Diurnal Variation Fasting Nuclear Receptor PXR

Tracking Selection Signatures Based on Variation in <i>OsLEA</i>27 within Myanmar Landraces of Upland and Dryland Rice

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American Journal of Plant Sciences 2015年第12期6卷 1937-1950页

作者： Wunna Syed Abdullah Gilani Makoto kawase Ryo Ohsawa Kazuo N. Watanabe Graduate School of Life and Environmental Sciences University of Tsukuba Tsukuba Japan Department of Biological Sciences and Chemistry University of Nizwa Nizwa Sultanate of Oman Gene Bank National Institute of Agrobiological Sciences Tsukuba Japan

To track the selection evident along the genome segment of OsLEA27?gene, a member of dehydrin gene family, 2.9-kbp nucleotide sequence containing the promoter 5’ upstream and transcribed region of OsLEA27?was determined for 35 upland and dryland Myanmar landraces from drought-prone areas. Nucleotide diversity, neutrality tests, haplotype network analysis, and linkage disequilibrium (LD) analysis were performed to infer the impact of selection and to investigate nonrandom associations of SNPs within all or part of the entire OsLEA27?region. The evidence for LD, the presence of two distinct haplotype groups across four different geographical regions, and the significant values obtained in a sliding-window analysis of mutation-drift tests all suggest the effects of selection on OsLEA27?in a set of 30 landraces. The neutrality test values for 5’ upstream region of OsLEA27?were significantly negative (p OsLEA27 region was significantly negative in accessions of the northern group, indicating a recent increase in population size or selection pressure. This evidence for selection signatures at OsLEA27 in this study sample provides insight into the roles of selection, crop adaptation, and genetic diversity in establishing present-day variation at the OsLEA27 locus.

关键词： Dehydrine Linkage Disequilibrium (LD) Nucleotide Diversity Haplotype Selection Signature Upland Rice Dryland Rice

Activation Analysis of Metals in Hair from Animals Dosed Natural Medicines and Health Foods

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Activation Analysis of Metals in Hair from Animals Dosed Nat...

作者： M.kawase S.Morimoto T.Saito Faculty of Bioscience Nagahama Institute of Bio-science and Technology Department of Pharmacy Osaka Ohtani University Radioisotope Research Center Osaka University

INTRODUCTION:The plant is one of important raw material of the herbal ***,the effect of the herbal medicine is largely affected by the home and the quality of a used *** trace elements are considered to be related with the quality of herbal medicine, but the study about the trace elements in plant is not done ***,the role of trace elements in herbal medicine is little clarified. We confirmed that the polyphenol promotes the exhaust

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家蚕传染性软化病病毒的结构蛋白的特性

中国蚕业 1985年第1期 29-34页

作者： Hashimoto kawase 郭锡杰

本文记述了传染性软化病病毒(IFV)的结构蛋白及其性质。经高浓度十二烷基磺酸钠—聚丙烯酰胺凝胶电泳(SDS—PAGE)证明:纯化的 IFV 有四种主要的结构蛋白和一些次要蛋白。这四种结构蛋白的分子量分别为35,000(vp)、33,000(vp)、31,200(vp... 详细信息

本文记述了传染性软化病病毒(IFV)的结构蛋白及其性质。经高浓度十二烷基磺酸钠—聚丙烯酰胺凝胶电泳(SDS—PAGE)证明:纯化的 IFV 有四种主要的结构蛋白和一些次要蛋白。这四种结构蛋白的分子量分别为35,000(vp)、33,000(vp)、31,200(vp)和11,600(vp),每个病毒粒子的各种蛋白质的分子数分别为62、57、54和31。vp、vp、vp三者的氨基酸组成是相似的,而 vp则有些区别。经等电聚焦和双向电泳并用银染色法获得了高清晰度的结构蛋白谱

关键词：结构蛋白等电聚焦蛋白质氨基酸氨基羧酸衣壳蛋白

A Case Report of Multiple Cylindroma with Immunohistochemical Features

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Open Journal of Pathology 2016年第3期6卷 134-139页

作者： Naoki Watanabe Kana kawase Chisato Tawada Kazufumi Yoneda Kuniaki Hirai Ayumi Niwa Takuji Tanaka Department of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP) Gifu Municipal Hospital Gifu City Japan Department of Dermatology Gifu Municipal Hospital Gifu City Japan Department of Radiology Ehime University Graduate School of Medicine Shitsukawa Toon City Japan

Cylindroma is a benign skin appendageal tumor arising from pluripotent stem cells in the follicle. Multiple cylindroma typically occurs as a component of Brooke-Spiegler syndrome or as the only skin lesion of familial cylindromatosis. We herein report an unusual case of multiple cylindroma involving the trunk without any other features of Brooke-Spiegler syndrome and no family history supporting the possibility of familial cylindromatosis. Immunohistochemical features of CYLD and NF-κB, which are involved in the pathogenesis of cylindroma, in the tumors are also presented.

关键词： Multiple Cylindroma Immunohistochemistry CYLD NF-κB

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用于同步轨道确定的地面站天线指向性能

飞行器测控技术 1990年第3期9卷 43-53页

作者： kawase,S 陈洵

Anchor-wire technique for multiple plastic biliary stents to prevent stent dislocation

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World Journal of Gastroenterology 2011年第28期17卷 3366-3368页

作者： Tsuyoshi Hamada Yousuke Nakai Saburo Matsubara Hiroyuki Isayama Akiko Narita Kazuhiro Watanabe Yukihiro Koike Shigeo Matsukawa Tateo kawase Kazuhiko Koike Department of Gastroenterology Kanto Central Hospital Department of Gastroenterology Graduate School of MedicineThe University of Tokyo

In endoscopic placement of multiple plastic biliary stents (PBSs),we sometimes experience proximal dislocation of the first PBS at the time of subsequent PBS *** describe the case of a 79-year-old male with obstructive jaundice caused by cholangiocarcinoma who needed to receive multiple PBS placements for management of *** proximal dislocation of the first PBS was observed,we prevented the dislocation via our technique of using guidewire inserted from the distal end of the first PBS to the side hole as the *** could complete this technique only by inserting guidewire through the side hole of the first PBS during the process of releasing the first PBS and pulling out the guidewire and the inner *** did not matter whether the anchor-wire went towards the third portion of the duodenum or the duodenal *** we introduce this "anchor-wire technique",which is useful for the prevention of PBS proximal dislocation in placing multiple PBSs.

关键词： Plastic biliary stent Anchor-wire technique Proximal dislocation Prevention Endoscopic retrograde cholangiography

Pure laparoscopic hepatectomy as repeat surgery and repeat hepatectomy

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World Journal of Gastroenterology 2015年第3期21卷 961-968页

作者： Masashi Isetani Zenichi Morise Norihiko Kawabe Hirokazu Tomishige Hidetoshi Nagata Jin kawase Satoshi Arakawa Department of Surgery Fujita Health University School of MedicineBanbuntane Houtokukai HospitalAichiNagoya 454-8509Japan

AIM:To assess clinical outcomes of laparoscopic hepatectomy(LH) in patients with a history of upper abdominal surgery and repeat ***:This study compared the perioperative courses of patients receiving LH at our institution that had or had not previously undergone upper abdominal *** the 80 patients who underwent LH,22 had prior abdominal surgeries,including hepatectomy(n = 12),pancreatectomy(n = 3),cholecystectomy and common bile duct excision(n = 1),splenectomy(n = 1),total gastrectomy(n = 1),colectomy with the involvement of transverse colon(n = 3),and extended hysterectomy with extensive lymph-node dissection up to the upper abdomen(n = 1).Clinical indicators including operating time,blood loss,hospital stay,and morbidity were compared among the ***:Eighteen of the 22 patients who had undergone previous surgery had severe adhesions in the area around the ***,there were no conversions to laparotomy in this *** the 58 patients without a history of upper abdominal surgery,the median operative time was 301 min and blood loss was 150 m *** patients with upper abdominal surgical history or repeat hepatectomy,the operative times were 351 and 301 min,and blood loss was 100 and 50 m L,*** median postoperative stay was 17,13 and 12 d for patients with no history of upper abdominal surgery,patients with a history,and patients with repeat hepatectomy,*** were five cases with complications in the group with no surgical history,compared to only one case in the group with a prior *** were no statistically significant differences in the perioperative results between the groups with and without upper abdominal surgical history,or with repeat ***:LH is feasible and safe in patients with a history of upper abdominal surgery or repeat hepatectomy.

关键词： Chronic liver disease Laparoscopic hepatectomy Liv

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热喷涂陶瓷涂层超声无损评价方法

无损检测 1995年第1期17卷 28-30页

作者： R.kawase H.Haraguchi T.Hamamoto 孙国平

本研究旨在建立热喷涂陶瓷涂层超声无损评价的方法。热喷涂二氧化二铝涂层中的超声速度由所试制的实验装置测得,并对超声速度与喷涂涂层特性的关系作了探讨。

关键词：超声检验覆层陶瓷热喷涂