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Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases

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Translational Neurodegeneration 2023年第1期12卷 791-800页

作者： Vaibhav sharma Fredrik Nikolajeff Saroj kumar Department of Health Education and TechnologyLulea University of TechnologyLuleaSweden Department of Biophysics All India Institute of Medical SciencesNew DelhiIndia

Neurodegenerative diseases are a set of progressive and currently incurable diseases that are primarily caused by neuron *** diseases often lead to cognitive impairment and *** is now well recognized that molecular events precede the onset of clinical symptoms by *** the past decade,intensive research attempts have been aimed at the early diagnosis of these ***,exosomes have been shown to play a pivotal role in the occurrence and progression of many diseases including cancer and neurodegenerative ***,because exosomes can cross the blood-brain barrier,they may serve as a diagnostic tool for neural *** this review,we detail the mechanisms and current challenges of these diseases,briefly review the role of exosomes in the progression of neurodegenerative diseases,and propose a novel strategy based on salivary neuronal exosomes and nanoparticle tracking analysis that could be employed for screening the early onset of neurodegenerative diseases.

关键词： Exosomes Parkinson’s disease Alzheimer’s disease Neurodegenerative disease Diagnosis Prognosis Extracellular vesicles Nanoparticle tracking analysis

Comparative Performance Analysis of Differential Evolution Variants on Engineering Design Problems

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Journal of Bionic Engineering 2022年第4期19卷 1140-1160页

作者： Sanjoy Chakraborty Apu kumar Saha Sushmita sharma Saroj kumar Sahoo Gautam Pal Department of Computer Science and Engineering National Institute of Technology AgartalaAgartalaTripura 799046India Department of Computer Science and Engineering Iswar Chandra Vidyasagar CollegeBeloniaTripura 799155India Department of Mathematics National Institute of Technology AgartalaAgartalaTripura 799046India Department of Computer Science and Engineering Tripura Institute of TechnologyNarsingarhTripura 799015India

Because of their superior problem-solving ability,nature-inspired optimization algorithms are being regularly used in solving complex real-world optimization *** academics have recently focused on meta-heuristic algorithms to solve various optimization *** the state-of-the-art algorithms,Differential Evolution(DE)is one of the most successful algorithms and is frequently used to solve various industrial *** the previous 2 decades,DE has been heavily modified to improve its *** DE variations secured positions in IEEE CEC competitions,establishing their ***,to our knowledge,there has never been a comparison of performance across various CEC-winning DE versions,which could aid in determining which is the most *** this study,the performance of DE and its eight other IEEE CEC competition-winning variants are ***,the algorithms have evaluated IEEE CEC 2019 and 2020 bound-constrained functions,and the performances have been *** unconstrained problem from IEEE CEC 2011 problem suite and five other constrained mechanical engineering design problems,out of which four issues have been taken from IEEE CEC 2020 non-convex constrained optimization suite,have been solved to compare the *** analyses like Friedman's test and Wilcoxon's test are executed to verify the algorithm’s ability *** analysis exposes that none of the DE variants can solve all the problems *** of SHADE and ELSHADE-SPACMA are considerable among the methods used for comparison to solve such mechanical design problems.

关键词： Differential evolution Metaheuristics IEEE CEC Mechanical design problem

Development of prosthetic arm using body actioned SEMG signals

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Journal of Innovative Optical Health Sciences 2016年第6期9卷 58-65页

作者： Karan Veer Tanu sharma Amod kumar EIED Department Thapar UniversityPatialaIndia CSED Department Global College of EngineeringKhanpur KuiIndia Chief Scientist CSIO-CSIRChandigarhIndia

People's working capability is badly affected when they sufer an amputated *** replacements with prosthetic devices to get a satisfactory level of performance for essential functions with the currently available prosthetic technology are very *** arm prostheses are becoming popular because they are operated by a natural contraction of intact ***,SEMG based artifdal arm was *** system cousists of diferent electronic and mechanical assemblies for operation of hand utilizing microcontroller in order to have minimum signal loss during its *** the hep of relay switching connected to low power DC motor,system is capable of opening and closing of grip according to individual wish.

关键词： SEMG electrodes variable gripping myoelectric controls electronic interface signals processing.

Defect induced room-temperature ferromagnetism and enhanced photocatalytic activity in Ni-doped ZnO synthesized by electrodeposition

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Chinese Physics B 2020年第10期29卷 566-572页

作者： Deepika Raju kumar Ritesh kumar Kamdeo Prasad Yadav Pratyush Vaibhav Seema sharma Rakesh kumar Singh Santosh kumar College o f Commerce Arts and SciencePatna.BiharIndia Jaypee University o f Engineering and Technology GunaMadhya PradeshIndia Anugrah Narayan College PatnaBiharIndia Aryabhatta Knowledge University PatnaBiharIndia

Zn0.90Ni0.10O nanoparticles have been synthesized by single-bath two-electrode electrodeposition at constant voltage. X-ray diffraction, UV vis and photoluminescence studies reveal that a single-phase polycrystalline hcp wurtzite crystal structure of ZnO is evolved. The material consists of a large number of defects such as oxygen vacancy (Ov) and zinc interstitial (Zi). The magnetization study reveals that the sample exhibits room-temperature global ferromagnetism and the ferromagnetic ordering seems to be defect induced via bound magnetic polaron mechanism, and double exchange is also expected to have played role. Interesting optoelectronic properties have been found in the synthesized sample and the material seems to be a potential candidate to be used as a UV sensor. Such a transition metal doped ZnO based dilute magnetic semiconducting system exhibiting room-temperature ferromagnetism is likely to be first of its kind in the sense that such materials have not yet been reported to be synthesized by the simple method of electrodeposition to the best of our knowledge on the basis of ample literature review.

关键词： dilute magnetic semiconductors(DMS) bound magnetic polaron photoluminescence ferromagnetism

The effect of pH on stability and thermal performance of graphene oxide and copper oxide hybrid nanofluids for heat transfer applications:Application of novel machine learning technique

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Journal of Energy Chemistry 2023年第7期82卷 359-374,I0009页

作者： Praveen kumar Kanti Prabhakar sharma K.V.sharma M.P.Maiya Department of Mechanical Engineering Indian Institute of Technology MadrasChennai 600036India Department of Mechanical Engineering Delhi Skill and Entrepreneurship UniversityDelhi 110089India Center for Energy Studies Department of Mechanical EngineeringJNTUH College of EngineeringKukatpallyHyderabad 500085Telangan1India

This paper investigates the effects of pH on stability and thermal properties of copper oxide(CuO),graphene oxide(GO),and their hybrid nanofluid(HNF)at different mixing ***,sol-gel and Hummer’s method was employed for the synthesis of CuO and GO nanoparticles(NPs),and they are characterized with various *** effects of two different surfactants were analyzed on nanofluid’s(NF’s)stability at different pH *** properties like thermal conductivity(TC)and viscosity(VST)of NFs were measured at different volume concentration(0.1 vol%to 1.0 vol%)and temperature range of 30-60℃,*** TC and VST of GO/CuO(50:50)HNF are higher than that of GO/CuO(20:80).The figure of merit(FOM)is determined for the studied *** correlations were presented to calculate the TC as well as VST of *** modern novel machine learning-based ensemble approaches were employed for predictive model development for TC and VST of considered *** comparison of prognostic models with Taylor’s diagram revealed that Bayesian optimized support vector machine(BoASVM)was superior to Bayesian optimized boosted regression trees(BoA-BRT)for both TC and VST models.

关键词： CuO Figure of merit Graphene oxide Machine learning pH Stability

Sustainable remediation of failed slope using helical soil nails

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Journal of Mountain Science 2023年第6期20卷 1742-1758页

作者： Saurabh RAWAT Ashok kumar GUPTA Pankaj sharma Department of Civil Engineering Jaypee University of Information Technology Department of Civil Engineering Chitkara University Institute of Engineering and TechnologyChitkara University

The performance of a helical soil nailed structure is dependent on the installation torque required and the consequent pullout resistance *** present research work aims at proposing theoretical models to estimate the required torque during installation of helical soil ***,theoretical models are also developed to predict the pullout capacity of single and group of the helical nail for uniform and staggered *** proposed model predicts the pure-elastic and elastic-plastic pullout behavior of different helical *** equation for estimating the capacity-totorque Ratio(Kt)has also been developed for different nail shaft *** results from the proposed models are validated with experimental results obtained from model testing of both single and group of helical *** predicted results are also compared for validation with the published *** results for installation torque and pullout load depict that the developed models predict values which are in accordance with the experimental results and are also found in good agreement with the published ***,the proposed models can effectively be used by the filed engineers for estimating the required installation torque and corresponding pullout capacities for single or double plate helical soil nails in cohesionless soil under surcharge pressure range of 0–50k Pa.

关键词： Theoretical torque Pullout force Pure elastic Elastic plastic Capacity to torque ratio

Pichia as yeast cell factory for production of industrially important bio-products:Current trends,challenges,and future prospects

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生物质资源与工程(英文) 2023年第2期8卷 108-124页

作者： Akansha Shrivastava Mamta Pal Rakesh kumar sharma Department of Biosciences Manipal University JaipurJaipur 303007India Sardar Swaran Singh National Institute of Bio-Energy Jalandhar 144601India

Yeast has been used as a cell factory for thousands of years to produce a wide variety of com-plex biofuels,bioproducts,biochemicals,food ingredients,and *** a variety of biotechnological production hosts,a few specific genera of yeast have proven *** developments in metabolic engineering and synthetic biology provide a workable long-term supply solution for these *** this review,we have covered recent advances in the design of yeast cell factories for the synthesis of terpenoids,alkaloids,phenylpropanoids,and other natural chemicals,primarily focusing on Pichia ***-edge solutions involving genetic and process engineering have also been ***,the review summarized recent advancements and challenges in synthetic and systems biology,as well as initiatives in metabolic engineering aimed at commercializing non-conventional yeasts like *** processes used in non-traditional yeasts to produce enzymes,therapeutic proteins,lipids,and metabolic products for industrial applications were thoroughly elaborated.

关键词： Natural product Pichia Non-conventional yeast Biosynthesis System biology Synthetic biology

Climate change detection and attribution in the Ganga-Brahmaputra-Meghna river basins

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Geoscience Frontiers 2021年第5期12卷 192-201页

作者： Chetan sharma Anoop kumar Shukla Yongqiang Zhang Civil Engineering Department JIETJodhpurRajasthanIndia Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Ganga-Brahmaputra-Meghna(GBM)river basin is the third-largest and one of the most populated river basins in the *** climate change is affecting most of the hydrometeorological variables across the globe,this study investigated the existence of climate change signal in all four climatological seasons in the GBM river basin and assessed the contribution of anthropogenic activities,i.e.,Greenhouse Gases(GHGs)emission in the *** decreasing trends in the monsoon and a small increase in pre-monsoon precipitation were *** change was detected in post-monsoon and winter season ***5 GCMs were used for climate change detection,change point estimation,and attribution *** Vector Machine(SVM)regression method was adopted to downscale GCM variables at the local ***-Carlo simulation approach was used to detect changes in different *** climate change‘signals’were detectable after the year 1980 using Signal to Noise ratio(SNR)method in the majority of central and north-western *** change point was detectable only in annual monsoon precipitation at the basin *** analysis indicated>50%contribution of anthropogenic activities(GHGs)to annual monsoon precipitation ***,there is high confidence that monsoon precipitation in GBM has significantly changed due to anthropogenic *** mitigation and adaption measures are also suggested,which may be adopted to manage the growing demand and water availability in the basin.

关键词： Ganga-Brahmaputra-Meghna(GBM) Climate change Support vector machine Signal to noise ratio Anthropogenic activities

Impact of frailty on endoscopic retrograde cholangiopancreatography outcomes in nonagenarians:A United States national experience

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 148-156页

作者： Sanket Dhirubhai Basida Dushyant Singh Dahiya Muhammad Nadeem Yousaf Brinda Basida Bhanu Siva Mohan Pinnam Manesh kumar Gangwani Hassam Ali Sahib Singh Yash R Shah Daksh Ahluwalia Mihir Prakash Shah Saurabh Chandan Neil R sharma Shyam Thakkar Department of Internal Medicine University of Missouri-ColumbiaColumbiaMO 65212United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Division of Gastroenterology and Hepatology University of MissouriColumbiaMO 65212United States Department of Rheumatology Medical College of GeorgiaAugusta UniversityNorth AugustaGA 30912United States Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Division of Interventional Oncology&Surgical Endoscopy GI Oncology Tumor Site TeamParkview Cancer InstituteParkview HealthFort WayneIN 46845United States Section of Gastroenterology&Hepatology West Virginia University School of MedicineMorgantownWV 26505United States

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an essential therapeutic tool for biliary and pancreatic *** and elderly patients,especially those aged≥90 years are generally considered a higher-risk population for ERCP-related *** To investigate outcomes of ERCP in the Non-agenarian population(≥90 years)concerning *** This is a cohort study using the 2018-2020 National Readmission *** aged≥90 were identified who underwent ERCP,using the international classification of diseases-10 code with clinical *** Hopkins’s adjusted clinical groups frailty indicator was used to classify patients as frail and *** primary outcome was mortality,and the secondary outcomes were morbidity and the 30 d readmission rate related to *** used univariate and multivariate regression models for *** A total of 9448 patients were admitted for any indications of *** and non-frail patients were 3445(36.46%)and 6003(63.53%)*** for ERCP were Choledocholithiasis(74.84%),Biliary pancreatitis(9.19%),Pancreatico-biliary cancer(7.6%),Biliary stricture(4.84%),and Cholangitis(1.51%).Mortality rates were higher in frail group[adjusted odds ratio(aOR)=1.68,P=0.02].The Intra-procedural complications were insigni-ficant between the two groups which included bleeding(aOR=0.72,P=0.67),accidental punctures/lacerations(aOR=0.77,P=0.5),and mechanical ventilation rates(aOR=1.19,P=0.6).Post-ERCP complication rate was similar for bleeding(aOR=0.72,P=0.41)and post-ERCP pancreatitis(aOR=1.4,P=0.44).Frail patients had a longer length of stay(6.7 d vs 5.5 d)and higher mean total charges of hospitalization($78807 vs$71392)compared to controls(P<0.001).The 30 d all-cause readmission rates between frail and non-frail patients were similar(P=0.96).CONCLUSION There was a significantly higher mortality risk and healthcare burden amongst nonagenarian frail patients undergoing ERCP compared

关键词： Endoscopic retrograde cholangiopancreatography Nonagenarians Frailty Mortality Healthcare burden