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Chasing Se.ue.cing Pe.fe.tion:Marching Toward Highe. Accuracy and Lowe. Costs

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Ge.omics, Prote.mics & Bioinformatics 2024年第2期22卷 1-12页

作者： Hangxing Jia She.gjun Tan Yong e.Zhang CAS Ke. Laboratory of Zoological Syste.atics and e.olution&State.Ke. Laboratory of Inte.rate. Manage.e.t of Pe.t Inse.ts and Rode.ts Institute of ZoologyChinese Academy of SciencesBeijing 100101China Unive.sity of Chine.e.Acade.y of Scie.ce. Beijing 100049China CAS Ce.te. for e.ce.le.ce.in Animal e.olution and Ge.e.ics Chinese Academy of SciencesKunming 650223China

Ne.t-ge.e.ation se.ue.cing(NGS),re.re.e.te. by Illumina platforms,has be.n an e.se.tial corne.stone.of basic and applie. ***,the.se.ue.cing e.ror rate.of 1 pe. 1000 bp(10^(−3))re.re.e.ts a se.ious hurdle.for re.e.rch are.s focusing on rare.mutations,such as somatic mosaicism or microbe.*** e.amining the.high-fide.ity se.ue.cing me.hods de.e.ope. in the.past de.ade.we.summarize. thre. major factors unde.lying e.rors and the.corre.ponding 12 strate.ie. mitigating the.e.*** the. propose. a nove. frame.ork to classify 11 pre.xisting re.re.e.tative.me.hods according to the.corre.ponding combinatory strate.ie. and ide.tifie. thre. tre.ds that e.e.ge. during me.hodological *** furthe. e.te.de. this analysis to e.ght long-re.d se.ue.cing me.hods,e.phasizing e.ror re.uction ***,we.sugge.t two promising future.dire.tions that could achie.e.comparable.or e.e. highe. accuracy with lowe. costs in both NGS and long-re.d se.ue.cing.

关键词： Se.ue.cing e.ror High-fide.ity se.ue.cing Conse.sus se.ue.cing Single.mole.ule.se.ue.cing Rare.mutation

In vivo astrocyte.re.rogramming following spinal cord injury

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Ne.ral Re.e.e.ation Re.e.rch 2024年第3期19卷 487-488页

作者： Yannick N.Ge.be. Flore.ce.e.Pe.rin MMDN University of MontpellierEPHEINSERMMontpellierFrance Institut Unive.sitaire.de.France.IUF) ParisFrance

Harmful and he.pful role. of astrocyte. in spinal cord injury(SCI):SCI induce.gradable.se.sory,motor and autonomic impairme.ts that corre.ate.with the.le.ion se.e.ity and the.rostro-caudal location of the.injury *** abse.ce.of spontane.us axonal re.e.e.ation afte. injury re.ults from ne.ron-intrinsic and ne.ron-e.trinsic ***,not only adult ne.rons display limite. capability to re.row axons but also the.injury e.vironme.t contains inhibitors to axonal re.e.e.ation and a lack of growth-promoting *** othe. ce.l populations that re.pond to the.le.ion,re.ctive.astrocyte. we.e.first conside.e. as only de.rime.tal to spontane.us axonal ***,astrocyte..

关键词： injury impairme.t programming

Scanning transmission e.e.tron microscopy and atom probe.tomography analysis of non-stoichiome.ry long-pe.iod-stacking-orde.e. structure. in Mg-Ni-Y/Sm alloys

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Journal of Magne.ium and Alloys 2024年第3期12卷 954-965页

作者： Yime.g Che. Manue. Le.rée.Je.n-Louis Bobe. Ale.ande. Kvit CAMe.A Instrume.ts Inc MadisonWI 53711USA ICMCB Universitéde BordeauxPessacCEDEX 33608France NIAC&Mate.ials Scie.ce.De.artme.t University of WisconsinMadisonWI 53706USA

The.long-pe.iod-stacking-orde.e.(LPSO)structure.affe.ts the.me.hanical,corrosion and hydrolysis prope.tie. of Mg *** curre.t work e.ploys high angle.annular dark fie.d-scanning transmission e.e.tron microscopy(HAADF-STe.)and atom probe.tomography(APT)to inve.tigate.the.structural and local che.ical information of LPSO phase. forme. in Mg-Ni-Y/Sm te.nary alloys afte. e.te.de. isothe.mal *** on the.alloying e.e.e.ts and the.r conce.trations,Mg-Ni-Y/Sm de.e.ops a two-phase.LPSO+α-Mg structure.in which the.LPSO phase.contains de.e.ts,hybrid LPSO structure.and Mg ***-STe. and APT indicate.non-stoichiome.ric LPSO with incomple.e.Ni_(6)(Y/Sm)_(8) *** addition,the.APT quantitative.y de.e.mine. the.local composition of LPSO and confirms the.pre.e.ce.of Ni within the.Mg bonding *** re.ults provide.insight into a be.te. unde.standing of the.structure.and hydrolysis prope.tie. of LPSO-Mg alloys.

关键词： Magne.ium alloys Long-range.orde.ing Atom probe.tomography(APT) STe. HAADF Hydrolysis prope.tie..

Alloge.ic Ste. Ce.l Transplantation and COVID-19 Antibodie.: Me.hanistic Insights and Re.ipie.t Conce.ns

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Ope. Journal of Immunology 2024年第2期14卷 16-32页

作者： Amna Ume. Asma Ume. Khayam Nasar Khan David Lawre.ce.Gre.ne.Umm e. Habiba Sabiha Shamim Pak-Ame.ican Hospital Pvt. Ltd. Islamabad Pakistan R3 Me.ical Re.e.rch LLC Scottsdale USA Be.lo Bio Labs and The.ape.tics (SMC) Pvt. Ltd. Islamabad Pakistan De.artme.t of Bioche.istry Rawalpindi Medical University Rawalpindi Pakistan Be.lo Bio LLC Scottsdale USA

Colle.ting umbilical cord ste. ce.ls is wide.y practice. due.to its nume.ous be.e.its. Ove. the.past de.ade. umbilical cord ste. ce.ls (UCSCs) have.shown e.fe.tive.e.s in tre.ting various conditions, such as bone.pathologie., ne.ropsychiatry disorde.s, he.e.itary dise.se., and me.abolic disorde.s. Howe.e., factors like.immunization affe.t the.quantity and quality of cord harve.ting. Studie. sugge.t that antibodie. from the.mothe. pass through the.umbilical cord to prote.t the.infant against infe.tions. Cle.ning the.umbilical cord be.ore.ste. ce.l e.traction is crucial to maintain ste.ility and ce.l inte.rity. Vaccinating a fe.ale.donor, including for COVID-19, typically doe. not dire.tly affe.t the.ste. ce.ls. Although vaccine. aim to trigge. an immunological re.ponse. the. ge.e.ally do not affe.t the.donor’s ste. ce.ls.

关键词： Vaccination Ste. Ce.l Alloge.e.c COVID Antibodie.

The.multi-impurity syste. in CdSe.nanoplate.e.s:e.e.tronic structure.and the.modynamic prope.tie.

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Communications in The.re.ical Physics 2024年第3期76卷 165-173页

作者： D A Baghdasaryan V A Harutynyan e.M Kazaryan H A Sarkisyan Russian-Arme.ian Unive.sity H Emin 1230051YerevanArmenia Institute.of Applie. Proble.s of Physics 25 Nersisyan St0014YerevanArmenia

This pape. the.re.ically studie. the.impurity state. and the.e.fe.ts of impurity conce.tration and configuration on the.optical,e.e.trical,and statistical prope.tie. of CdSe.nanoplate.e.s(NPLs).An image.charge.base. mode. of e.e.tron-impurity inte.action is *** charge.carrie. e.e.gy spe.tra and corre.ponding wave.functions de.e.ding on the.impurity numbe. and configuration are.*** e.e.tron binding e.e.gie. are.calculate. for diffe.e.t NPL *** is shown that the.image.charge.base. inte.action pote.tial that arise. due.to the.die.e.tric constants mismatch is much stronge. than the.inte.action pote.tial that doe. not take.such a mismatch into ***,it is de.onstrate. that the.binding e.e.gie. are.incre.sing with the.numbe. of *** calculate.the.canonical partition function using the.e.e.gy le.e.s of the.e.e.tron,which in turn is use. to obtain the.me.n e.e.gy,he.t capacity,and e.tropy of the.non-inte.acting e.e.tron *** the.modynamic prope.tie. of the.non-inte.acting e.e.tron gas that de.e.d on the.ge.me.ric parame.e.s of the.NPL,impurity numbe.,configuration,and te.pe.ature.are.studie..

关键词： nanoplate.e.e. the.modynamic prope.tie. impurity state.

An Analysis of the.Accounting Costs Associate. with 20-Month DR TB Re.ime.s in Maputo City, Mozambique

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Journal of Tube.culosis Re.e.rch 2024年第2期12卷 73-90页

作者： Júlia Malache.António Isaías Be.zana Isabe.le.Munyangaju Be.e.ita José Dulce.osório e.y Nacarapa Claudia Mutaquiha Sime.o Nhabinde.Pe.e.ra Zindoga Unive.sidade.Catlica de.Moambique Beira Moambique Ce.tro de.e.tudos e.Apoio Psicolgico (Ce.P) Universidade Eduardo Mondlane Maputo Moambique ISGlobal Hospital Clnic Universitat de Barcelona Barcelona Spain Tinpswalo Association Vincentian Association to Fight AIDS and TB Chokwe Mozambique Programa Nacional de.Controlo da Tube.culose Ministrio da Sade de Moambique Maputo Mozambique Faculdade.de.e.onomia Universidade Eduardo Mondlane Maputo Moambique

Introduction: Socioe.onomic and de.ographic conditions in a country can influe.ce.tube.culosis incide.ce.and mortality, with ne.rly 95% of tube.culosis-re.ate. de.ths occurring in poore. countrie.. Mozambique.is among the.30 countrie. with the.highe.t TB burde.. Obje.tive. The.study aime. to e.timate.the.ave.age.dire.t me.ical cost of tre.ting drug-re.istant tube.culosis in 19 he.lth ce.te.s in Maputo City, Mozambique. Me.hods: A re.rospe.tive.analysis of dire.t me.ical costs was conducte. on patie.ts age. 18 and olde. who comple.e. 20-month drug-re.istant tube.culosis tre.tme.t re.ime.s in Maputo City in 2019. Re.ults: This analysis cove.e. 140 patie.ts who comple.e. a 20-month tre.tme.t re.ime., with 64.3% (78) be.ng male.and 35.7% (62) fe.ale. Approximate.y 50% of the.participants we.e.age. be.we.n 29 and 47. The.ave.age.dire.t me.ical cost of DRTB tre.tme.t was $4789.43, re.ching up to $6568.00, with a standard de.iation of $753.26, including clinical inte.ve.tions and tre.tme.t. Conclusion: The.dire.t me.ical costs for a basic tre.tme.t package.for a patie.t with drug-re.istant TB in Mozambique.e.ual 36 minimum wage.. De.e.oping alte.native.and innovative.funding me.hanisms and ide.tifying ways to mitigate.costs through the.use.of ge.e.ic me.icine. would be.be.e.icial.

关键词： Antitube.cular Age.ts Multidrug-Re.istant He.lthcare.Costs Tube.culosis Mozambique

A bacte.ial prote.n Rhp-PSP inhibits plant viral prolife.ation through e.doribonucle.se.activity

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Journal of Inte.rative.Agriculture 2024年第6期23卷 1967-1978页

作者： Lijie.Che. Qianze.Pe.g Xiaohua Du We.xing Zhang Ju’e.Che.g Shu’e.Sun De.ong Zhang Pin Su Yong Liu Longping Branch College of BiologyHunan UniversityChangsha 410082China State.Ke. Laboratory of Hybrid Rice.Institute.of Plant Prote.tion Hunan Academy of Agricultural SciencesChangsha 410125China

Plant virus cause. massive.crop losse. ***,the.e.is curre.tly no e.fe.tive.me.sure.to control plant viral ***,we.ide.tify an antiviral prote.n Rhp-PSP,produce. by the.bacte.ial Rhodopse.domonas palustris strain *** this study,we.discove. that the.antiviral activity of Rhp-PSP re.ie. on its e.doribonucle.se.*** the.arginine.R)re.idue.at position 129 onto alanine.A)abolishs its e.doribonucle.se.activity on coat prote.n(CP)RNA of tobacco mosaic virus(TMV),conse.ue.tially,compromise. the.antiviral activity of *** inve.tigation de.onstrate. that,the.mutant Rhp-PSP^(R129A)is unable.to form the.homotrime. as the.wild type.indicating the.importance.of quate.nary junction for the.e.doribonucle.se.*** of Rhp-PSP in Nicotiana be.thamiana significantly e.hance. the.re.istance.against TMV of se.dlings,while.e.pre.sion of Rhp-PSP^(R129A)did not,confirming that e.doribonucle.se.activity is re.ponsible.for the.antiviral activity of *** addition,foliar spray of Rhp-PSP solution on tomato and pe.pe. plants significantly re.uce. the.dise.se.inde. of viral dise.se.,indicating that Rhp-PSP shows pote.tial to de.e.op antiviral age.t in practice.

关键词： Rhodopse.domonas palustris Rhp-PSP tobacco mosaic virus e.doribonucle.se antiviral activity

基于神经网络ODe.非线性MPC的De.建模与控制

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自动化学报 2024年

作者：黄鹏王亚午吴俊东苏春翌福岛e.文彦中国地质大学(武汉)自动化学院复杂系统先进控制与智能自动化湖北省重点实验室地球探测智能化技术教育部工程研究中心东京工科大学工学部康考迪亚大学Gina Cody工程与计算机科学学院

针对介电弹性体驱动器(Die.e.tric e.astome. actuator, De.)建模与控制的挑战性问题,提出基于神经网络常微分方程(Ordinary diffe.e.tial e.uation, ODe.和非线性模型预测控制(Mode. pre.ictive.control, MPC)的De.动力学建模与跟踪控制方法.首先,基于神经网络ODe.立De.的动力学模型以描述其复杂的动态行为.然后,基于所建立的De.动力学模型,设计非线性模型预测控制器实现其跟踪控制目标.最后,在所搭建的实验平台上进行一系列跟踪控制实验.在所有实验结果中, De.的运动均能很好地跟踪目标轨迹,且相对均方根误差均不超过3.30%,说明了所提动力学建模与跟踪控制方法的有效性.

关键词：介电弹性体驱动器神经网络常微分方程动力学建模非线性模型预测控制

e.aluation of a Wire.e.s Solar Powe.e. Pe.sonal We.the. Station

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Agricultural Scie.ce. 2024年第1期15卷 36-53页

作者： Robe.t J. Lascano Timothy S. Goe.e. De.nis C. Gitz III John e. Stout Cropping Syste.s Re.e.rch Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We.are.e.aluating dryland cotton production in Martin County, Te.as, me.suring cotton lint yie.d pe. unit of rainfall. Our goal is to colle.t rainfall data pe. 250 - 400 ha. Upon se.e.tion of a rainfall gauge. we.re.lize. that the.cost of using, for e.ample. a tipping bucke.-type.rain gauge.would be.too e.pe.sive.and thus se.rche. for an alte.native.me.hod. We.se.e.te. an all-in-one.comme.cially available.we.the. station;he.e.fte., re.e.re. to as a Pe.sonal We.the. Station (PWS) that is both wire.e.s and solar powe.e.. Our obje.tive.was to e.aluate.ave.age.me.sure.e.ts of rainfall obtaine. with the.PWS and to compare.the.e.to me.sure.e.ts obtaine. with an automatic we.the. station (AWS). For this purpose. we.installe. four PWS de.loye. within 20 m of the.Plant Stre.s and Wate. Conse.vation Me.e.rological Towe. that was use. as our AWS, locate. at USDA-ARS Cropping Syste.s Re.e.rch Laboratory, Lubbock, TX. In addition, we.me.sure. and compare. hourly ave.age.value. of short-wave.irradiance.(Rg), air te.pe.ature.(Tair) and re.ative.humidity (RH), and wind spe.d (WS), and calculate. value. of de.point te.pe.ature.(Tde.). This comparison was done.ove. a 242-day pe.iod (1 Octobe. 2022-31 May 2023) and re.ults indicate. that the.e.was no statistical diffe.e.ce.in me.sure.e.ts of rainfall be.we.n the.PWS and AWS. Hourly ave.age.value. of Rg me.sure. with the.PWS and AWS agre.d on cle.r days, but PWS me.sure.e.ts we.e.highe. on cloudy days. The.e.was no statistical diffe.e.ce.be.we.n PWS and AWS hourly ave.age.me.sure.e.ts of Tair, RH, and calculate. Tde.. Hourly ave.age.me.sure.e.ts of Rg and WS we.e.more.variable. We.conclude. that the.PWS we.se.e.te. will provide.ade.uate.value. of rainfall and othe. we.the. variable. to me.t our goal of e.aluating dryland cotton lint yie.d pe. unit rainfall.

关键词： Automation Se.sors Citize. We.the. Station Me.one. Rainfall We.the. Variable.