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Breaking the spatial restriction of pluripotency acquisition by environmental stimuli

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Molecular Plant 2023年第2期16卷 301-302页

作者： Momoko ikeuchi Division of Biological Science Graduate School of Science and TechnologyNara Institute of Science and TechnologyIkomaJapan

Plant cells have remarkable developmental plasticity,and many of them have the intrinsic potential to acquire *** some stimuli such as auxin or wounding can trigger cellular pluripotency acquisition,various other envi... 详细信息

关键词： wound al. subsequent

Diverse Chromatic Acclimation Processes Regulating Phycoerythrocyanin and Rod-Shaped Phycobilisome in Cyanobacteria

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Molecular Plant 2019年第8期12卷 715-725页

作者： Yuu Hirose Song Ghihong Mai Watanabe Chinatsu Yonekawa Kazuyoshi Murata Masahiko ikeuchi Toshihiko Eki Department of Environmental and Life Sciences Toyohashi University of Technology1-1 HibarigaokaTempakuToyohashiAichi 441-8580Japan National Institute for Physiological Sciences(NIPS) 38 NishigonakaMyodaijiOkazakiAichi 444-8585Japan Department of Life Sciences(Biology) The University of Tokyo3-8-1 KomabaMeguroTokyo 153-8902Japan

Cyanobacteria have evolved various photoacclimation processes to perform oxygenic photosynthesis under different light *** acclimation(CA)is a widely recognized and ecologically important type of photoacclimation,whereby cyanobacteria alter the absorbing light colors of a supermolecular antenna complex called the *** date,several CA variants that regulate the green-absorbing phycoerythrin(PE)and/or the red-absorbing phycocyanin(PC)within the hemi-discoidal form of phycobilisome have been *** this study,we identified a unique CA regulatory gene cluster encoding yellow-green-absorbing phycoerythrocyanin(PEC)and a rod-membrane linker protein(CpcL)for the rod-shaped form of *** the cyanobacterium Leptolyngbya *** 6406,we revealed novel CA variants regulating PEC(CA7)and the rod-shaped phycobilisome(CAO),which maximize yellowgreen light-harvesting capacity and balance the excitation of photosystems,respective!*** of the distribution of CA gene clusters in 445 cyanobacteria genomes revealed eight CA variants responding to green and red light,which are classified based on the presence of PEC,PE,cpcL,and CA photosensor *** analysis further suggested that the emergence of CA7 was a single event and preceded that of heterocystous strains,whereas the acquisition of CAO occurred multiple *** together,these results offer novel insights into the diversity and evolution of the complex cyanobacterial photoacclimation mechanisms.

关键词： cyanobacteria chromatic acclimation cyanobacteriochrome phycobilisome phycoerythrocyanin

Three-dimensionally Perforated Calcium Phosphate Ceramics

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Journal of Wuhan University of Technology(Materials Science) 2005年第B12期20卷 223-225页

作者： Atsuo Ito T Sakurai Y Sogo M ikeuchi H Ohgushi T Mutsuzaki Institute for Human Science and Biomedical Engineering National Institute of Advanced Industrial Science and Technology Central 6 1-1-1 Higashi Tsukuba 305-8566 Japan Research Institute for Cell Engineering National Institute of Advanced Industrial Science and TechnologyAmagasaki Site 3-11-46 Nakouji Amagasaki Hyogo 661-0974 Japan Department of Orthopedic Surgery University of Tsukuba 1-1-1 Tennodai Tsukuba 305-8571 Japan

Porous calcium phosphate ceramics were produced by compression molding using a special mold followed by sintering. The porous calcium phosphate ceramics have three-dimensional and penetrated open pores 380-400μm in diacneter spaced at intervals of 200μm. The layers of the linear penetration pores alternately lay perpendicular to pore direction. The porosity was 59%-65% . The Ca/ P molar ratios of the porous calcium phos phate ceramics range from 1.5 to 1.85. A binder cantaining methyl cellulose was most effective for preparing the powder compact among vinyl acetate, polyvinyl alcohol, starch, stearic acid, methyl cellulose and their mixtures . Stainless steel, polystyrene, nylon and bamboo were used as the long columnar dies for the penetrated open pores. When polystyrene, nylon and bamboo were used as the long columnar male dies, the dies were burned oat during the sintering process. Using stainless steel as the male dies with the removal of the dies before heat treatment resulted in a higher level of densification of the calcium phosphate ceramic.

关键词： calcium phosphate porous ceramic three-dimensionally perforated tissue engineering scaffold tricalcium phosphate

Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 311-322页

作者： Kei Kimura Naohito Beppu Hiroshi Doi Kozo Kataoka Tomoki Yamano Motoi Uchino Masataka Ikeda Hiroki ikeuchi Naohiro Tomita Division of Lower Gastrointestinal Surgery Department of SurgeryHyogo College of MedicineNishinomiyaHyogo 663-8501Japan Department of Radiology Hyogo College of MedicineNishinomiyaHyogo 663-8501Japan Department of Radiation Oncology Kindai University Faculty of MedicineSayamaOsaka 589-8511Japan Department of Inflammatory Bowel Disease Division of SurgeryHyogo College of MedicineNishinomiyaHyogo 663-8501Japan

BACKGROUND Preoperative chemoradiotherapy regimens using a second drug for locally advanced rectal cancer are still under clinical *** To investigate the clinical outcomes of patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy using tegafur/gimeracil/oteracil(S-1)plus irinotecan(CPT-11).METHODS This was a single-center retrospective study of 82 patients who underwent radical surgery for rectal cancer after chemoradiotherapy with S-1(80 mg/m2/d),CPT-11(60 mg/m2/d),and radiation(total 45 Gy)between 2009 and *** median follow-up was 51 mo(range:17–116 mo).RESULTS Twenty-nine patients(35.4%)had T3 or T4 rectal cancer with mesorectal fascia invasion,36(43.9%)had extramural vascular invasion,24(29.8%)had N2 rectal cancer and eight(9.8%)had lateral lymph node *** relative dose intensity was 90.1%for S-1 and 92.9%for ***-nine patients(96.3%)underwent R0 *** regard to pathological response,13 patients(15.9%)had a pathological complete response and 52(63.4%)a good response(tumor regression grade 2/3).The 5-year local recurrence-free survival,relapsefree survival and overall survival rates were 90.1%,72.5%and 91.3%,*** analyzed the risk factors for local recurrence-free survival by Cox regression analysis and none were *** described risk factors such as T4 stage,mesorectal fascia invasion or lateral lymph node swelling were not detected as negative factors for local recurrence-free *** We demonstrated good compliance and favorable tumor regression in patients with locally advanced rectal cancer treated with preoperative S-1 and CPT-11.

关键词： Preoperative chemoradiotherapy Rectal cancer Irinotecan Tegafur/gimeracil/oteracil Neoadjuvant chemoradiotherapy Radiation therapy

Helicobacter pylori infection and liver diseases: Epidemiology and insights into pathogenesis

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World Journal of Gastroenterology 2018年第32期24卷 3617-3625页

作者： Kazuya Okushin Takeya Tsutsumi Kazuhiko ikeuchi Akira Kado Kenichiro Enooku Hidetaka Fujinaga Kyoji Moriya Hiroshi Yotsuyanagi Kazuhiko Koike Department of Gastroenterology Graduate School of Medicine The University of Tokyo Department of Infection Control and Prevention Graduate School of Medicine The University of Tokyo Division of Infectious Diseases Advanced Clinical Research Center Institute of Medical Science The University of Tokyo Department of Infectious Diseases The University of Tokyo

Both Helicobacter pylori(H. pylori) infection and liver diseases, including nonalcoholic fatty liver disease(NAFLD), viral hepatitis, and hepatocellular carcinoma(HCC), have high prevalences worldwide, and the relationship between H. pylori infection and liver disease has been discussed for many years. Although positive correlations between H. pylori and NAFLD have been identified in some clinical and experimental studies, nega-tive correlations have also been obtained in high-quality clinical studies. Associations between H. pylori and the pathogenesis of chronic viral hepatitis, mainly disease progression with fibrosis, have also been suggested in some clinical studies. Concerning HCC, a possible role for H. pylori in hepatocarcinogenesis has been identified since H. pylori genes have frequently been detected in resected HCC specimens. However, no study hasrevealed the direct involvement of H. pylori in promoting the development of HCC. Although findings regarding the correlations between H. pylori and liver disease pathogenesis have been accumulating, the existing data do not completely lead to an unequivocal conclusion. Further high-quality clinical and experimental analyses are necessary to evaluate the efficacy of H. pylori eradication in ameliorating the histopathological changes observed in each liver disease.

关键词： Helicobacter pylori Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Hepatitis C virus Hepatitis B virus Viral hepatitis Hepatocellular carcinoma

Acute Exacerbation of Liver Disease Induced by Pegylated Interferon Alpha2a Treatment for Chronic Hepatitis C

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International Journal of Clinical Medicine 2010年第1期1卷 1-5页

作者： Hideaki Kato Hirokazu ikeuchi Makoto Nakamura 不详

A 66yearold female was referred to a local clinic for the treatment of chronic hepatitis C. Her family physician started the administration of PegIFN alpha2a in combination with ribavirin in September, 2008. Three months after the commencement of the therapy, alopecia was noted, and it gradually worsened. She also complained of general fatigue. Since her alopecia and general fatigue continued to worsen, her family physician decided to discontinue the PegIFN plus ribavirin therapy in February, 2009. On April 5, the patient complained of severe general fatigue as well as fever, and she was referred to the local clinic again. Blood chemistry tests demonstrated that her AST level increased from 200 IU on April 5 to 1000 IU on April 9 but her HCV RNA level stayed at 4.1 logIU/mL. Based on the findings of an elevated IgG level (2244 mg), AST/ALT > 1.5, and weak positivity for antismooth muscle antibody (1:40), an autoimmune mechanism was considered as the etiology of her liver damage. Despite treatment with 60 ml of glycyrrhizin, 1 g of gabexate mesylate, and 500 mg of methylprednisolone, she died on April 23. PegIFN induced acute liver failure is quite rare, but clinicians should aware of this lifethreatening side effect during and after interferon therapy.

关键词： Adverse Effect Autoimmune Hepatitis Chronic Hepatitis C Pegylated Interferon

Field-deployable rapid multiple biosensing system for detection of chemical and biological warfare agents

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Microsystems & Nanoengineering 2018年第1期4卷 498-508页

作者： Masato Saito Natsuko Uchida Shunsuke Furutani Mizuho Murahashi Wilfred Espulgar Naoki Nagatani Hidenori Nagai Yuki Inoue Tomohiko ikeuchi Satoshi Kondo Hirotaka Uzawa Yasuo Seto Eiichi Tamiya Department of Applied Physics Graduate School of EngineeringOsaka University2-1YamadaokaSuitaOsaka 565-0871Japan Advanced Photonics and Biosensing Open Innovation Laboratory(PhotoBIO-OIL) National Institute of Advanced Industrial Science and Technology(AIST)Photonics Center Osaka University P3 Bldg2-1 Yamada-OkaSuitaOsaka 565-0871Japan Nanomaterials Research Institute National Institute of Advanced Industrial Science and Technology(AIST)1-1-1 HigashiTsukuba 305-8565Japan Health Research Institute National Institute of Advanced Industrial Science and Technology(AIST)1-8-31 MidorigaokaIkedaOsaka 563-8577Japan Department of Applied Chemistry Graduate School of EngineeringOkayama University of Science1-1Ridai-choKita-kuOkayama-shi 700-0005Japan National Research Institute of Police Science 6-3-1 KashiwanohaKashiwaChiba 277-0882Japan

The threat of biological and chemical terror acts remains a growing worldwide *** is therefore a need to develop appropriate technology for the detection of chemical and biological warfare agents,with early identification intended for use by first ***,we disclose the developed autonomous air sampling and detection system for evaluation of the presence of chemical and biological warfare agents that can be harmful to the *** current device utilizes the designed mist generator-assisted air collection system(338 l min^(−1))and biosensing chip technologies,such as electrochemical measurement,Au nanoparticle-based localized surface plasmon resonance,and rapid microfluidic chip PCR for detection of minute concentrations lower than the mean lethal dose(LD_(50))of nerve gases(sarin and VX),toxic proteins(BTX/A/Hc and ricin),and pathogens(anthrax simulant).An operation time of only 5–15 min is needed for the collection and detection;sample preparation is already integrated into the system without the need for direct human *** addition to the system’s sensitivity and ease of use,its portability makes it highly beneficial for first responders,which could aid in immediate risk assessment and mitigation of on-site events.

关键词： biological and chemical agents biosensing electrochemical detection LSPR PCR rapid detection

Effects of High Pressure on the Textural and Sensory Properties of Minced Fish Meat Gels for the Dysphagia Diet

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Food and Nutrition Sciences 2016年第9期7卷 732-742页

作者： Keiko Yoshioka Ai Yamamoto Yasuyuki Matsushima Kenji Hachisuka Yoshihide ikeuchi Department of Nutritional Sciences Faculty of Nutritional Sciences Nakamura Gakuen University Fukuoka Japan Department of Rehabilitation Medicine University of Occupational and Environmental Health Kitakyushu Japan Graduate School of Agriculture Kyushu University Fukuoka Japan

A new product of minced fish meat with high pressurization was produced for individuals with difficulties in mastication and swallowing and for elderly people on a dysphagia diet. Minced fish meat was added to distilled water at ratios of 1:0.5, 1:1 and 1:1.5 by mixing with 1.5% NaCl. Half of the samples were modified by heating (H-gels) and half by high pressure at 400 MPa for 20 min (P-gels). The hardness of the H- and P-gels was 0.97 to 2.83 [×104 N/m2] and 2.25 to 10.03 [×104 N/m2], respectively. For SDS-PAGE analysis, low-molecular-weight proteins in the P-gel were released more easily than those in the H-gel by the difference in gel formation, which is related to the detection of α-actinin in the supernatant of pressurized actomyosin. The ultrastructural observations showed a regular filamentous network structure in the P-gel. For the sensory evaluation, the P-gels were determined to be more lustrous, juicier, more moderately elastic and smoother. These gels conformed to the criteria of Dietary Uses for Dyspahgic Patients and Japanese Dysphagia Diet 2013. High pressure treatment denatured the protein composition of the minced fish meat gel, which led to a clearer three-dimensional network structure. High pressure made it possible to form minced fish meat gels with a low salt concentration. Obtained minced fish meat gels were improved in textural properties by addition of water and under high pressure, which were different from the ones by traditional heating. Improvement in textural properties will raise the sensory evaluation for elderly and dysphagic people. It is expected that the pressurized gels will be practical for a dysphagia diet.

关键词： Minced Fish Meat Gel High Pressure Textural Properties Sensory Evaluation Dysphagia Diet

Plant regeneration in the new era:from molecular mechanisms to biotechnology applications

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Science China(Life Sciences) 2024年第7期67卷 1338-1367页

作者： Chunli Chen Yuxin Hu Momoko ikeuchi Yuling Jiao Kalika Prasad Ying Hua Su Jun Xiao Lin Xu Weibing Yang Zhong Zhao Wenkun Zhou Yun Zhou Jian Gao Jia-Wei Wang National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China College of Life Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of Sciences(CAS)China National Botanical GardenBeijing 100093China Division of Biological Sciences Graduate School of Science and TechnologyNara Institute of Science and TechnologyNara 630-0192Japan State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Center for Quantitative BiologyAcademy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Indian Institute of Science Education and Research Pune 411008IndiaThiruvananthapuram 695551India State Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai’an 271018China Sino-German Joint Research Center on Agricultural Biology Shandong Agricultural UniversityTai’an 271018China Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology(IGDB)CASBeijing 100101China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) IGDBCASBeijing 100101China National Key Laboratory of Plant Molecular Genetics CEMPSInstitute of Plant Physiology and Ecology(SIPPE)CASShanghai 200032China CEPAMS SIPPECASShanghai 200032China Hefei National Laboratory for Physical Sciences at the Microscale CEMPSSchool of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China Department of Botany and Plant Pathology and Center for Plant Biology Purdue UniversityWest Lafayette 47907USA School of Life Science and Technology Shang

Plants or tissues can be regenerated through various *** animal regeneration,cell totipotency and pluripotency are the molecular basis of plant *** systematic studies on Arabidopsis thaliana gradually unravel the fundamental mechanisms and principles underlying plant ***,plant hormones,cell division,epigenetic remodeling,and transcription factors play crucial roles in reprogramming somatic cells and reestablishing meristematic *** research on basal non-vascular plants and monocot crops has revealed that plant regeneration differs among species,with various plant species using distinct mechanisms and displaying significant differences in regenerative *** multi-omics studies at the single-cell level,tracking plant regeneration processes in real-time,and deciphering the natural variation in regenerative capacity will ultimately help understand the essence of plant regeneration,improve crop regeneration efficiency,and contribute to future crop design.

关键词： apical meristem model species regeneration phytohormone plant cell reprogramming somatic embryogenesis