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Clinical significance of white gastric crypt openings observed via magnifying endoscopy

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World Journal of Gastroenterology 2013年第48期19卷 9392-9398页

作者： Masashi Kawamura Hitoshi Sekine Shu Abe Daisuke Shibuya katsuaki kato Takayuki Masuda Department of Gastroenterology Sendai City Hospital Miyagi 984-8501 Japan Department of Gastroenterology JR Sendai HospitalMiyagi 980-0022 Japan Cancer Detection Center Miyagi Cancer Society Miyagi 980-0011 Japan Division of Pathology Tohoku University School of Health Sciences Miyagi 980-8575 Japan

AIM:To evaluate the relationship between Helicobacter pylori(***)-induced gastritis and white gastric mucosal crypt openings(COs)in the gastric ***:A total of 175 consecutive patients(including 69 patients with gastric cancer)were enrolled in this *** used magnifying endoscopy(ME)to observe the mucosa microsurface of the lesser and greater curvature of the gastric corpus(350 areas in all).We focused on areas with a round pit microstructure(primarily observed in non-atrophied areas)and evaluated the white openings of these gastric *** classified the whiteness of the COs as the"white-edged dark spot"type(consisting of a dark spot bordered by white);the"white"type(pure white with no dark spot);and the"dense white pit(DWP)"type(dense white,resembling a snowball).Gastritis was also histologically evaluated according to the updated Sydney ***:We detected round COs using ME in 246 of the 350 areas *** histological examination showed significantly more mononuclear cells and neutrophil infiltration in the"white"and"DWP"types than the"white-edged dark spot"type(P<0.001).Furthermore,significantly high-grade inflammation and evidence of active ***-induced gastritis was observed in the"DWP"type(P<0.001).Significant differences were observed in the whiteness of COs between ***-positive(n=139)and negative(n=36)patients(P<0.001).The sensitivity and specificity of the"white"and"DWP"types for predicting *** infection were78.5%and 81.7%,*** the patients with gastric cancer,22.5%(18/80)had"white-edged dark spots",51.3%(41/80)had"white"COs,and 26.3%(21/80)had"DWP"-type COs."DWPs"were frequently observed among patients with undifferentiated gastric cancer[45.7%(16/35)].CONCLUSION:CO whiteness detected via ME was associated with histological evidence of gastritis and helps to predict the severity of inflammation and *** activity.

关键词： Magnifying endoscopy Helicobacter pylori Gastritis Gastric cancer Inflammation

Tongue-like Barrett's esophagus is associated with gastroesophageal reflux disease

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World Journal of Gastroenterology 2008年第26期14卷 4196-4203页

作者： Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Shigeyuki Kobayashi Ken Ariizumi Yasuhiko Abe Katsunori Iijima Akira Imatani Yoshifumi Inomata katsuaki kato Daisuke Shibuya Shigemitsu Aida Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of MedicineSendai 980-8574Japan Miyagi Cancer Society Sendai980-0011Japan Department of Gastroenterlogy Sendai City HospitalSendai 984-8501Japan

AIM:To test this hypothesis of barrett esophagus (BE) classified into two types and to further determine if there was any correlation between the shape of endoscopically suspected esophageal metaplasia (ESEM), prevalence of reflux esophagitis (RE) and heartburn. METHODS: A total of 6504 Japanese who underwent endoscopy for their annual stomach check-up were enrolled in this study. BE was detected without histological confirmation that is ESEM. We originally classified cases of ESEM into 3 types based on its shape: Tongue-like (T type), Dome-like (D type) and Wave-like (W type) ESEM. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a one-month period. RESULTS: ESEM was observed in 10.3% of 6504 subjects (ESEM < 1 cm, 9.4%; 1 cm ≤ ESEM < 3 cm, 1.7%; ESEM ≥ 3 cm, 0.5%). The frequency of ESEM was significantly higher in males compared with female subjects. Statistical analysis showed that the prevalence of heartburn and RE were significantly higher in the T type ESEM than in the W type ESEM (P < 0.05). CONCLUSION: The T type ESEM was strongly associated with reflux symptoms and RE whereas the W type ESEM was not associated with GERD.

关键词： Tongue-like endoscopically suspectedesophageal metaplasia Dome-like endoscopicallysuspected esophageal metaplasia Wave-likeendoscopically suspected esophageal metaplasia Gastroesophageal reflux disease

Prevalence of gastroesophageal reflux symptoms in a large unselected general population in Japan

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World Journal of Gastroenterology 2008年第9期14卷 1358-1364页

作者： Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Shigeyuki Kobayashi Ken Ariizumi Yasuhiko Abe Katsunori Iijima Akira Imatani Yoshifumi Inomata katsuaki kato Daisuke Shibuya Shigemitsu Aida Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of MedicineSendai CityJapan Miyagi Cancer Society Sendai CityJapan Department of Gastroenterology Sendai City Hospital Sendai cityJapan Division of Gastroenterology Tohoku University Graduate School of MedicineSendai CityJapan

AIM:To examine the prevalence of gastroesophageal reflux disease (GERD) symptoms in a large unselected general population in Japan. METHODS: In Japan, mature adults are offered regular check-ups for the prevention of gastric cancer. A notice was sent by mail to all inhabitants aged > 40 years. A total of 160 983 Japanese (60 774 male, 100 209 female; mean age 61.9 years) who underwent a stomach check up were enrolled in this study. In addition, from these 160 983 subjects, we randomly selected a total of 82 894 (34 275 male, 48 619 female; mean age 62.4 years) to evaluate the prevalence of abdominal pain. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a 1 mo period. RESULTS: The respective prevalences of the symptoms in males and females were: heartburn, 15.8% vs 20.7%; dysphagia, 5.4% vs 7.8%; and abdominal pain, 6.6% vs 9.6%. Among these symptoms, heartburn was significantly high compared with the other symptoms, and the prevalence of heartburn was significantly more frequent in females than in males in the 60-89-year agegroup. Dysphagia was also significantly more frequent in female patients. CONCLUSION: The prevalence of typical GERD symptoms (heartburn) was high, at about 20% of the Japan population, and the frequency was especially high in females in the 60-89 year age group.

关键词： Gastroesophageal reflux disease Heartburn Dysphagia Abdominal pain

In-Situ Observation of SiC Bulk Single Crystal Growth by XRD System

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Journal of Rare Earths 2006年第z1期24卷 49-53页

作者： Tomohisa kato Natl Inst Adv Ind Sci & Technol AIST Tsukuba Ibaraki 3058568 Japan

In-situ analysis for SiC bulk single crystal growth was reported using vertical X-ray diffractometer system. A furnace for SiC sublimation growth combined with the XRD system which possessed three kinds of functions including topography, rocking curve measurement and crystal growth rate monitoring was developed. These functions could contribute as a powerful tool finding the optimum growth condition by dynamic observation in the crucible. In this study, the in-situ X-ray topographs succeeded to capture dynamic elongation of defects and dislocation generated in the SiC growing crystals. The in-situ rocking curve measurement reviled appearance of mosaic structure in the SiC crystal grown with high growth rate. The in-situ growth rate monitoring also succeeded very precisely using the direct X-ray beam absorption. On the base of findings and facts obtained by the in-situ observations, the importance for the SiC growth was discussed.

关键词： defects X-ray diffraction X-ray topography growth from vapor single crystal growth semiconducting materials

Effects of hydraulic oil and lubricant additives on dynamic friction properties under various reciprocating sliding conditions

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Friction 2020年第2期8卷 471-480页

作者： Shinji kato Shinya SASAKI Engineering Headquarters Automotive ComponentsKYB Corporation2548DolaKani-shiGifu 509-0298Japan Department of Mechanical Engineering Faculty of Engineering Division ITokyo University of Science6-3-1NiijukuKatsushika-kuTokyo 125-8585Japan

The friction characteristics of a shock absorber are very complex because the reciprocating motion is not always *** this study,a device was developed and used to analyze the dynamic friction characteristics under various reciprocating sliding conditions to determine the sliding materials and hydraulic oils that improve the shock absorber *** study describes the influence of hydraulic oil additive on the fine reciprocating friction characteristics of steel and copper *** oils were prepared by blending a paraffinic mineral oil with zinc dithiophosphate(ZnDTP)and polyhydric alcohol ester as *** results show that the dynamic frictional characteristics vary mainly depending on the additive concentration.A specific additive formulation induces a unique amplitude-dependent friction *** addition,the influence of different additives on the lubrication mechanism is investigated based on the instrumental analysis of the friction surface.

关键词： shock absorber dynamic friction reciprocating friction additive zinc dithiophosphate(ZnDTP)

GPS monitoring of temporal deformation of the Xianshuihe fault

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Science China Earth Sciences 2008年第9期51卷 1259-1266页

作者： TERUYUKI kato Earthquake Research Institute University of TokyoTokyo Japan

Highly precise (σ ~1 mm) temporal deformation measurements are taken across the Xianshuihe fault from two pairs of continuous GPS stations straddling the fault. Baseline vector changes of the two pairs of stations show clearly the difference in deformation behavior between the Qianning and Daofu segments of the fault: the former deforms steadily, and the latter deforms with a strong transient component. The transient deformation across the Daofu segment is possibly related to its irregular geometry, where the fault splits into two branches, that is, the east and west branches. An attempt is made to interpret the baseline vector changes using a kinematic fault model composed of a brittle layer in the upper crust, a ductile layer in the lower crust, and a transition zone in between. The slip in the transition zone of the south segment of the Xianshuihe fault is steady. The slips in the transition zones of the north and Daofu segments of the Xianshuihe fault, however, are not steady, and the average slip rates there are higher than that of the south segment. The difference in deformation behavior is probably associated with the rheological properties of the fault interface, suggesting that the overall fault strength of the south segment is greater than those of the north and Daofu segments, corresponding to longer earthquake recurrence time.

关键词： Xianshuihe fault GPS deformation field temporal change brittle-ductile transition zone

Diagnosis and therapies for gastric non-invasive neoplasia

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World Journal of Gastroenterology 2015年第44期21卷 12513-12518页

作者： Motohiko kato Department of Gastroenterology National Hospital Organization Tokyo Medical Center

There has been a great discrepancy of pathological diagnosis for gastric non-invasive neoplasia/dysplasia between Japanese and western pathologists. In Japan, lesions that most western pathologists diagnose as dysplasia are often considered adenocarcinoma based on nuclear and structural atypia regardless of the presence of invasion. In the Vienna classification, gastric non-invasive intraepithelial neoplasia(NIN) weredivided into low grade and high grade(including intramucosal cancer of Japanese criteria). The diagnosis by both endoscopy and pathology of biopsy specimen is difficult. Recent advances of diagnostic modality such as magnified endoscopy and imaged enhanced endoscopy is expected to improve the diagnostic yield for NIN. There are two treatment strategies for NIN, observation and diagnostic therapy by endoscopic resection(ER). ER is acceptable because of its less invasiveness and high local control rate, on the other hand, cancer-developing rate of low-grade NIN is reported to be low. Therefore there is controversy for the treatment of gastric NIN. Prospective study based on unified pathological definition is required in the future.

关键词： Gastric Non invasive intraepithelial neoplasia Ade

ON CORRELATION OF CAVITATION EROSION AND NOISE ON A FOIL SECTION

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Journal of Hydrodynamics 1990年第3期2卷 88-96页

作者： kato H Maeda M University of Tokyo 7-3-1HongoBunkyo-KuTokyo 113Japan

Tests with two different sized models were conducted in the Marine Propeller Cavitation Tunnel at the Univer- sity of *** two angles of attack the developed sheet-cloud and bubble cavitation *** pattern was recorded by pure indium specimens and noise was measured with a hydrophone mounted inside the *** broadband SPL was mainly used for correlation of noise with pit counting results from *** case of sheet- cloud cavitation power law relations between velocity and SPL have been found and there existed a linear relation- ship between SPL values and IgPR values(PR-pitting rate).However in case of bubble cavitation such power law relation does not exist between pitting rate and velocity,and neither between SPL and *** was noticed that the different trends of SPL for these two different types of cavitation could be qualitatively linked to their pitting rates by using some SPL values at high center frequencies.

关键词： ON CORRELATION OF CAVITATION EROSION AND NOISE ON A FOIL SECTION PP NACA

Functional imaging of astrocyte activity

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Neural Regeneration Research 2021年第6期16卷 1206-1207页

作者： Hiroki kato Tatsusada Okuno Department of Nuclear Medicine and Tracer Kinetics Osaka University Graduate School of Medicine2-2 Yamadaoka SuitaOsakaJapan Department of Neurology Osaka University Graduate School of Medicine2-2 Yamadaoka SuitaOsakaJapan

Astrocytes have become known to play a central role in various neuroinflammatory *** evaluation of astrocyte activity using functional imaging is becoming more *** metabolism or oxygen metabolism in the brain can be assessed using the established clinical imaging methods of F-18 fluorodeoxyglucose positron emission tomography(PET)and O-15 PET,***,until recently,the highly specific evaluation of metabolic activity in astrocytes has never been applied *** acetate is selectively taken up and metabolized by astrocytes,its usefulness as a tracer for measuring astrocyte activity has been proposed in basic research.

关键词： metabolism assessed clinical