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Clash of the Cytokine Titans： counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses

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Cellular & Molecular Immunology 2017年第1期14卷 22-35页

作者： katrin D Mayer-Barber Bo Yan Inflammation and Innate Immunity Unit Laboratory of Clinical Infectious Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health. Bethesda. MD 20892. USA

Over the past decades the notion of ＇inflammation＇ has been extended beyond the original hallmarks of rubor （redness）, calor （heat）, tumor （swelling） and dolor （pain） described by Celsus. We have gained a more detailed understanding of the cellular players and molecular mediators of inflammation which is now being applied and extended to areas of biomedical research such as cancer, obesity, heart disease, metabolism, auto-inflammatory disorders, autoimmunity and infectious diseases. Innate cytokines are often central components of inflammatory responses. Here, we discuss how the type I interferon and interleukin-1 cytokine pathways represent distinct and specialized categories of inflammatory responses and how these key mediators of inflammation counter-regulate each other.

关键词： cytokines infection inflammation interleukin-1 tuberculosis type-1 interferons

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肺泡复张策略复合高水平呼气末正压通气不影响血容量充足的病态肥胖患者的血流动力学

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麻醉与镇痛 2011年第3期7卷 66-69页

作者： Stephan H. Bohm, md Oliver C. Thamm, md Alexandra von Sandersleben, md katrin bang.rt, md Thomas E. Langwieler, md Gerardo Tusman, md Tim G. Strate, md, PhD Thomas G. Standl, md, PhD 邓希锦(译) Clinics of Anesthesiology Hospital Privado de Comunidad Mar del Plata Argentina General Visceral and Thoracic Surgery University Hospital Hamburg-Eppendorf Germany Hospital Privado de Comunidad Mar del Plata Argentina Department of Anesthesiology Hospital Privado de Comunidad Mar del Plata Argentina 不详

我们观察了20例血容量充足，准备行腹腔镜手术的病态肥胖（体重指数为50±9kg/m^2）患者，评估肺泡复张策略复合高水平呼气末正压通气（posidveend-expiratorypressure，PEEP）对其血流动力学的影响。肺泡复张策略是在有气腹和无气腹的... 详细信息

我们观察了20例血容量充足，准备行腹腔镜手术的病态肥胖（体重指数为50±9kg/m^2）患者，评估肺泡复张策略复合高水平呼气末正压通气（posidveend-expiratorypressure，PEEP）对其血流动力学的影响。肺泡复张策略是在有气腹和无气腹的情况下序贯进行，将PEEP水平逐渐升高，使平台压达到50—60cmH2O，呼吸10次／分，然后将PEEP水平逐渐降低。通过体循环和肺动脉导管的监测，没有发现肺泡复张及高水平PEEP对血流动力学产生显著的影响。经食管超声心动图显示左室舒张末期面积未发生变化，也无局部室壁运动异常的迹象。

关键词：呼气末正压通气血流动力学肥胖患者病态肥胖 P水平血容量肺泡复合

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A novel supplement with yeast b-glucan, prebiotic, minerals and Silybum marianum synergistically modulates metabolic and inflammatory pathways and improves steatosis in obese mice

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Journal of Integrative Medicine 2021年第5期19卷 439-450页

作者： Victor Abou Nehmi Gilson Masahiro Murata Ruan Carlos Macêdo de Moraes Gabriely Cristina AlvesLima Danielle Araujo De Miranda katrin Radloff Raquel Galvao Figuerêdo Costa Joyce de Cassia Rosade Jesus Jéssica Alves De Freitas Nayara Izabel Viana Ruan Pimenta Katia Ramos Moreira Leite JoséPinhata Otoch Ana Flávia Marcal Pessoa Laboratory of Medical Investigation(LIM-26) Department of SurgeryUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil Laboratory of Medical Investigation(LIM-29) Clinic Medical DepartmentUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil Department of Physiology Escola Paulista de Medicina/Universidade Federal de Sao PauloSP 04023062Brazil Max Rubner-Institut Federal Research Institute of Nutrition and FoodKarlsruheBW 76131Germany Cancer and Inflammation Program Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892United States Laboratory of Medical Investigation(LIM-55) Urology DepartmentUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil D'Or Institute for Research and Education RJ 22281-100Brazil Program in Anesthesiology Surgical Sciencesand Perioperative MedicineUniversity of Sao PauloSao PauloSP 01246903Brazil Brazilian Academic Consortium for Integrative Health(CABSIN) Natural Products CommitteeSao PauloSP 05449-070Brazil

Objective: To evaluate the synergic effects of a novel oral supplement formulation, containing prebiotics,yeast b-glucans, minerals and silymarin(Silybum marianum), on lipid and glycidic metabolism, inflammatory and mitochondrial proteins of the liver, in control and high-fat diet-induced obese ***: After an acclimation period, 32 male C57 BL/6 mice were divided into the following groups:nonfat diet(NFD) vehicle, NFD supplemented, high-fat diet(HFD) vehicle and HFD supplemented. The vehicle and experimental formulation were administered orally by gavage once a day during the last four weeks of the diet(28 consecutive days). We then evaluated energy homeostasis, inflammation, and mitochondrial protein expression in these groups of ***: After four weeks of supplementation, study groups experienced reduced glycemia, dyslipidemia,fat, and hepatic fibrosis levels. Additionally, proliferator-activated receptor-α, AMP-activated protein kinase-1α, peroxisome proliferator-activated receptor γ co-activator-1α, and mitochondrial transcription factor A expression levels were augmented;however, levels of inhibitor of nuclear factor-κB kinase subunit a and p65 nuclear factor-κB expression, and oxidative markers were reduced. Notably, the cortisol/C-reactive protein ratio, a well-characterized marker of the hypothalamic–pituitary–adrenal axis immune interface status, was found to be modulated by the ***: We discovered that the novel supplement was able to modify different antioxidant, metabolic and inflammatory pathways, improving the energy homeostasis and inflammatory status, and consequently alleviated hepatic steatosis.

关键词： Supplement Silymarin Prebiotic Obese Mice Steatosis Inflammation Mitochondrial biogenesis

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