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Electromagnetic Fields and Calcium Signaling by the Voltage Dependent Anion Channel

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Open Journal of Veterinary Medicine 2021年第1期11卷 57-86页

作者： Volker ullrich Hans-Jürgen Apell Department of Biology University of Konstanz Konstanz Germany

Electromagnetic fields (EMFs) can interact with biological tissues exerting positive as well as negative effects on cell viability, but the underlying sensing and signaling mechanisms are largely unknown. So far in excitable cells EMF exposure was postulated to cause Ca2+ influx through voltage-dependent Ca channels (VDCC) leading to cell activation and an antioxidant response. Upon further activation oxidative stress causing DNA damage or cell death may follow. Here we report collected evidence from literature that voltage dependent anion channels (VDAC) located not only in the outer microsomal membrane but also in the cytoplasmic membrane convert to Ca2+ conducting channels of varying capacities upon subtle changes of the applied EMF even in non-excitable cells like erythrocytes. Thus, VDAC can be targeted by external EMF in both types of membranes to release Ca2+ into the cytosol. The role of frequency, pulse modulation or polarization remains to be investigated in suitable cellular models. VDACs are associated with several other proteins, among which the 18 kDa translocator (TSPO) is of specific interest since it was characterized as the central benzodiazepine receptor in neurons. Exhibiting structural similarities with magnetoreceptors we propose that TSPO could sense the magnetic component of the EMF and thus together with VDAC could trigger physiological as well as pathological cellular responses. Pulsed EMFs in the frequency range of the brain-wave communication network may explain psychic disturbances of electromagnetic hypersensitive persons. An important support is

关键词： Ca Signaling VDAC Benzodiazepine Receptor Mechanistic Concept Pulsed EMFs Electromagnetic Hypersensitivity TSPO Erythrocytes NADH-Oxidase Apoptosis Magnetosensor Membrane Potential Oxidative Stress Brain Signaling Autism

Fast Trainable Capabilities in Software Engineering-Skill Development in Learning Factories

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计算机教育 2020年第12期 2-10页

作者： Andréullrich Malte Teichmann Norbert Gronau Department of Business Informatics University of PotsdamPotsdam 14482Germany

The increasing demand for software engineers cannot completely be fulfilled by university education and conventional training approaches due to limited ***,an alternative approach is necessary where potential software engineers are being educated in software engineering skills using new *** suggest micro tasks combined with theoretical lessons to overcome existing skill deficits and acquire fast trainable *** paper addresses the gap between demand and supply of software engineers by introducing an actionoriented and scenario-based didactical approach,which enables non-computer scientists to ***,the learning content is provided in small tasks and embedded in learning factory ***,different requirements for software engineers from the market side and from an academic viewpoint are analyzed and synthesized into an integrated,yet condensed skills *** enables the development of training and education units that focus on the most important skills demanded on the *** achieve this objective,individual learning scenarios are *** course,proper basic skills in coding cannot be learned over night but software programming is also no sorcery.

关键词： learning factory programming skills software engineering training

Unconventional bound states in the continuum from metamaterial-induced electron acoustic waves

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Advanced Photonics 2023年第5期5卷 77-85页

作者： Wenhui Wang Antonio Günzler Bodo D.Wilts ullrich Steiner Matthias Saba University of Fribourg Adolphe Merkle InstituteFribourgSwitzerland University of Salzburg Department of Chemistry and Physics of MaterialsSalzburgAustria

Photonic bound states in the continuum(BICs)are spatially localized modes with infinitely long lifetimes,which exist within a radiation continuum at discrete energy *** states have been explored in various systems,including photonic and phononic crystal slabs,metasurfaces,waveguides,and integrated *** and availability of the BICs are important aspects for fully taming the BICs toward practical ***,we propose a generic mechanism to realize BICs that exist by first principles free of fine parameter tuning based on non-Maxwellian double-net metamaterials(DNMs).An ideal warm hydrodynamic double plasma(HDP)fluid model provides a homogenized description of DNMs and explains the robustness of the BICs found *** the HDP model,these are standing wave formations made of electron acoustic waves(EAWs),which are pure charge oscillations with vanishing electromagnetic *** BICs have various advantages,such as(i)frequency-comb-like collection of BICs free from normal resonances;(ii)robustness to symmetry-breaking perturbations and formation of quasi-BICs with an ultrahigh Q-factor even if subject to disorder;and(iii)giving rise to subwavelength microcavity resonators hosting quasi-BIC modes with an ultrahigh Q-factor.

关键词： bound states in the continuum double-net metamaterial metamaterial electron acoustic wave hydrodynamical plasma

Influence of temperature and strain rate on flow stress behavior of twin-roll cast, rolled and heat-treated AZ31 magnesium alloys

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Transactions of Nonferrous Metals Society of China 2015年第1期25卷 1-13页

作者： F.BERGE L.KRüGER H.OUAZIZ C.ullrich Faculty of Materials Science and Technology Institute of Materials EngineeringTechnical University Bergakademie Freiberg Faculty of Materials Science and Technology Institute of Materials ScienceTechnical University Bergakademie Freiberg

The effects of temperature and strain rate on the flow stress behavior of twin-roll cast, rolled and heat-treated AZ31 magnesium alloys were investigated under uniaxial tension. At high temperatures, dynamic recovery, continuous dynamic recrystallization, grain boundary sliding and the activation of additional slip systems lead to an improvement of the ductility of the alloys. The elongation to failure is nearly independent of the strain rate between 473 and 523 K at 10-2 s-1 and 10-1 s-1, which is related to the strain rate dependence of the critical resolved shear stress（CRSS） for nonbasal slip. Despite the high temperature, twins are even observed at 573 K and 10-3 s-1 because they have a low CRSS.

关键词： AZ31 magnesium alloy twin-roll casting strain rate temperature dynamic recrystallization flow stress

Mercury concentrations in a contaminated river system in Kazakhstan and biomonitoring of the local population

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Chinese Journal Of Geochemistry 2006年第B8期25卷 238-239页

作者： Susanne M. ullrich Huiwen HSIAO School of Civil Engineering & the Environment University of Southampton Highfield Southampton SO17 1BJ United Kingdom

Balance of Concerns: Satisfactory Pre-Anesthetic Patient Education and the Extent of Patient Worries

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Open Journal of Anesthesiology 2013年第9期3卷 402-407页

作者： Joerg Schnoor Ulrike Reuter Nils Engelmann ullrich Burkhardt Department of Anesthesiology and Intensive Care Medicine University Hospital Leipzig Leipzig Germany

Controversy exists whether or not patient’s concerns regarding anesthetics can be reduced by face-to-face pre-assessment with an anesthetist. Thus we were looking at concerns patients had before and after such a consultation. Patient satisfaction was rated by a validated questionnaire. A four-staged Likert-scale was used to quantify the extent of patients concerns. The totaling 461 patients were overall highly satisfied. 448 patients had “nil” to “minimal” concerns. After the assessment, 106 patients stated their concerns had been lessened (p 0.001). Having gone through the anesthetic pre-assessment center, 99.1% of all patients reported no considerable concerns regarding anesthetics whatsoever. A high level of patient satisfaction does not constitute a low level of concerns patients may hold over anesthetics, although a pre-operative consultation mitigated these concerns by 23%, whilst for 9% of all patients this pre-assessment led to a higher level of concerns.

关键词： Patient Worries Patient Concerns Preoperative Patient Assessment Resilience Anxiolysis

No relationship between biopsy sites near the main testicular vessels or rete testis and successful sperm retrieval using conventional or microdissection biopsies in 220 non-obstructive azoospermic men

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Asian Journal of Andrology 2013年第6期15卷 795-798,I0009页

作者： J ullrich Schwarzer Heiko Steinfatt Heiko Steinfatt Manfred Schleyer Frank M Kōhn Klaus Fiedler2, Irene von Hertwig Gottfried Krüsmann Wolfgang Würfel Andrologie Centrum MOnchen MOnchen D-81241 Germany Kinderwunsch Centrum MOnchen MOnchen D-81241 Germany Andrologicum MOnchen MOnchen D-80331 Germany

In 220 consecutive patients with non-obstructive azoospermia, sperm retrieval was attempted by a combination of conventional and microdissection testicular sperm extraction （TESE）. For sperm retrieval, 2-3 conventional biopsies were performed followed by a microdissection TESE in cases of negative conventional biopsies. During the surgery, the vasculature of the testis was assessed using the operative microscope, and the location of positive biopsies was registered in relation to the blood supply. The overall sperm retrieval rate was 58.2%. From the initial conventional biopsies, sperm could be retrieved in 46.8% of the patients. With microdissection TESE, sperm could be retrieved from an additional 11.4% of the patients. The further use of microdissection TESE improved the sperm retrieval rate significantly （P=0.017）. No significant accumulation of positive biopsies was found towards the rete testis or the main testicular vessels.

关键词： intracytoplasmic sperm injection male infertility microdissection testicular sperm extraction non-obstructiveazoospermia sperm retrieval

低于再碰撞阈值下强激光场原子非序列双电离(英文)

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物理学进展 2010年第4期30卷 335-345页

作者：刘运全刘杰龚旗煌 Moshammer R ullrich J 物理学院和人工微结构和介观物理国家实验室北京大学北京100871 马克斯普朗克核物理所 D-69117海德堡德国应用物理与技术研究中心北京大学北京100084 北京应用物理与计算数学研究所北京100088

在最近的实验和理论研究中,我们探讨了氩原子和氖原子在红外强激光场中低于再碰撞阈值的非序列双电离问题。在研究中,我们发现在非序列双电离过程中,氖原子的电子关联表现为在激光偏振面内肩并肩出射,而对于氩原子的电子关联行为表现为... 详细信息

在最近的实验和理论研究中,我们探讨了氩原子和氖原子在红外强激光场中低于再碰撞阈值的非序列双电离问题。在研究中,我们发现在非序列双电离过程中,氖原子的电子关联表现为在激光偏振面内肩并肩出射,而对于氩原子的电子关联行为表现为在激光偏振面内的背对背出射,我们采用三维半经典模型(考虑电子隧道电离)很好地解释了实验结果。在阈值附近,我们发现电子在激光场中的多次散射以及电子再碰撞激发后电子隧道电离是氩原子反关联行为的主要原因,而电子在激光场作用下的单次碰撞是电子关联行为的主要原因。通过测量双电离过程中产生电子的横向电子动量分布,观察到了库伦聚焦效应,我们认为这是非经典的关联行为。最后,我们给出了氩原子和氖原子在激光场中阈值的解析模型,并给出了原子的关联和反关联激光强度区域。

关键词：强场非序列双电离再碰撞电离阈值

Comparison of Image Reconstruction Algorithms in EIT Imaging

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Journal of Biomedical Science and Engineering 2016年第10期9卷 137-142页

作者： Benjamin Schullcke Sabine Krueger Ziolek Bo Gong ullrich Mueller-Lisse Knut Moeller Institute of Technical Medicine Furtwangen University VS-Schwenningen Germany Department of Radiology University of Munich Munich Germany

Electrical Impedance Tomography (EIT) is a medical imaging technique which can be used to monitor the regional ventilation in patients utilizing voltage measurements made at the thorax. Several reconstruction algorithms have been developed during the last few years. In this manuscript we compare a well-established algorithm and a re-cently developed method for image reconstruction regarding EIT indices derived from the differently reconstructed images.

关键词： Electrical Impedance Tomography Ventilation Monitoring Image Reconstruction