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Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction

World Journal of Gastroenterology 2009年第35期15卷 4392-4401页

作者： Stephanie Schulz-Geske kati erdmann Ronald J Wong David K Stevenson Henning Schrder Nina Grosser Department of Pharmacology and Toxicology School of PharmacyMartin Luther University Halle-Wittenberg06099 HalleGermany Department of Pediatrics Stanford University School of MedicineStanfordCA 94305 United States Department of Pharmaceutics College of PharmacyUniversity of MinnesotaMinneapolisMN 55455 United States

AIM： To investigate the molecular mechanism and functional consequences of heme oxygenase-1 （HO-1） activation by lansoprazole in endothelial cells and macrophages. METHODS： Expression of HO-1 mRNA was analyzed by Northern blotting. Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-dependent reactive oxygen species （ROS） formation was measured with lucigenin-enhanced chemiluminescence. HO-1 promoter activity in mouse fibroblasts, stably transfected with a 15-kb HO-1 gene that drives expression of the reporter gene luciferase, was assessed usingin vivo bioluminescence imaging. RESULTS： Lansoprazole levels in endothelial cells increased HO-1 mRNA and HO-1 protein levels in macrophages. In addition, lansoprazole-induced ferritin protein levels in both cell systems. Moreover, induction of the antioxidant proteins HO-1 and ferritin by lansoprazole was followed by a decrease in NADPH- mediated ROS formation. The radical scavenging properties of lansoprazole were diminished in the presence of the HO inhibitor, chromium mesoporphyrin IX. Induction of HO-1 gene expression by lansoprazole was not related to oxidative stress or to the activation of the mitogen-activated protein kinase pathway. However, the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter ***： Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002.

关键词： Antioxidants Ferritin Heme oxygenase-1 Lansoprazole Reactive oxygen species

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The Role of TNF Related Apoptosis-Inducing Ligand in Neurodegenerative Diseases

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Cellular & Molecular Immunology 2005年第2期2卷 113-122页

作者： Y.Huang N.erdmann H.Peng Y.Zhao ThelaboratoryofNeurotoxicologyattheCenterforNeurovirology＆NeurodegenerativeDisorders ／／Dept.Pharmacology Dept.ofSurgery UniversityofNebraskaMedicalCenterOmahaNE68198-5880USA／／InstituteofAnimalResearchChineseAcademyofScienceChina

A hallmark of all forms of neurodegenerative diseases is impairment of neuronal functions,and in many cases neuronal cell *** the etiology of neurodegenerative diseases may be distinct,different diseases display a similar pathogenesis,for example abnormal immunity within the central nervous system(CNS),activation of macrophage/microglia and the involvement of proinflammatory *** studies show that neurons in a neurodegenerative state undergo a highly regulated programmed cell death,also called ***-related apoptosis-inducing ligand(TRAIL),a member of the TNF family,has been shown to be involved in apoptosis during many *** one member of a death ligand family,TRAIL was originally thought to target only tumor cells and was not present in ***,recent data showed that TRAIL was unregulated in HIV-1-infected and immune-activated macrophages,a major disease inducing cell during HIV-1-assoeiated dementia(HAD).TRAIL is also induced on neuron by β-amyloid protein,an important pathogen for Alzheimer's *** this review,we summarize the possible common aspects that TRAIL involved those neurodegenerative diseases,TRAIL induced apoptosis signaling in the CNS cells,and specific role of TRAIL in individual *** & Molecular Immunology.2005;2(2):113-122.

关键词： Alzheimer's disease HⅣ-1 associated dementia multiple sclerosis apoptosis TRAIL macrophage

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可去除染料--N-聚糖多方法深入分析中的缺失环节

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Engineering 2023年第7期26卷 132-150,I0006页

作者： Samanta Cajic RenéHennig Valerian Grote Udo Reichl erdmann Rapp Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg 39106Germany glyXera GmbH Magdeburg 39120Germany Otto-von-Guericke University Chair of Bioprocess EngineeringMagdeburg 39106Germany

As the roles of glycans in health and disease continue to be unraveled,it is becoming apparent that glycans’immense complexity cannot be *** fully delineate glycan structures,we developed an integrative approach combining a set of cost-effective,widespread,and easy-to-handle analytical *** key feature of our workflow is the exploitation of a removable fluorescent label—exemplified by 9-fluorenylmethyl chloroformate(Fmoc)—to bridge the gap between diverse glycoanalytical methods,especially multiplexed capillary gel electrophoresis with laser-induced fluorescence detection(xCGELIF)and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOFMS).Through the detailed structural analysis of selected,dauntingly complex N-glycans from chicken ovalbumin,horse serum,and bovine transferrin,we illustrate the capabilities of the presented ***,this approach“visualizes”N-glycans that have been difficult to identify thus far—such as the sulfated glycans on human immunoglobulin A—including minute changes in glycan structures,potentially providing useful new targets for biomarker discovery.

关键词： Glycoproteins N-glycans Reversible labeling Hydrophilic interaction liquid chromatography Capillary gel electrophoresis Mass spectrometry

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Preliminary age-based life history characteristics of the dogtooth tuna,Gymnosarda unicolor(Ruppell,1838),in the southwest Pacific Ocean

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Aquaculture and Fisheries 2023年第3期8卷 323-331页

作者： David J.Welch Adam K.Smith Kyne Krusic-Golub Sandra erdmann Stephen J.Newman C_(2)O Fisheries PO Box 3041CairnsQueensland4870Australia Centre for Sustainable Tropical Fisheries and Aquaculture College of Science and EngineeringJames Cook UniversityTownsville4811Australia Reef Ecologic TownsvilleQueensland4811Australia Fish Ageing Services Pty.Ltd. QueenscliffVictoria3225Australia Western Australian Fisheries and Marine Research Laboratories Department of Primary Industries and Regional DevelopmentGovernment of Western AustraliaNorth BeachWestern Australia6020Australia

Dogtooth tuna,Gymnosarda unicolor were sampled off the east coast of Australia(southwest Pacific Ocean)from 2007 to *** were determined by examining thin transverse sections of their sagittal otoliths and were based on counts of alternating opaque and translucent zones(annual growth increments).Growth was rapid during the first year of life,after which growth in length was much *** of the constrained von Bertalanffy growth function(fork length-at-age)were L∞=1164.77(mm,FL)and K=0.44 year^(-1).Preliminary estimates of longevity indicate a maximum observed age of at least 20 *** was a high degree of variation in the observed length and age of sexual maturity for *** this variation,the size at 50%maturity for female *** estimated in this study was 713 mm FL(<2 years of age).The diet of *** is very broad and covers a range of fish *** life history characteristics of *** overall,indicate that this species may be somewhat resilient to ***,reports of localised depletions,in association with heavy targeting by sports fishers,low effective population sizes and patchy recruitment indicate that this species is particularly vulnerable to overfishing.

关键词： Otoliths Age Life history Pacific ocean Diet Fisheries management

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Modified MMT Clay Using Species of Different Chemical Nature for Preparation HDPE Composites： Effect on Transport and Thermal Properties

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材料科学与工程（中英文A版） 2011年第6期1卷 778-789页

作者： erdmann Eleonora Monasterio Femanda Toro Maria Antonia Destefanis Hugo Instituto de Investigaciones para la Industria Quimica - INIQUI-CONICET lngenieria Universidad National de Salta C.P. 4400 Salta Argentina Instituto de Investigaciones para la lndustria Quimica - INIQULCONICET Consejo de lnvestigaciones- CIUNSa Facultad deCiencias Exactas Universidad Nacional de Salta C.P. 4400 Salta Argentina

Sodium montmorillonite (MMT) was modified with three cyclic species, and high density polyethylene (HDPE) was used as polymeric matrix. The cyclic species used for modifying the MMT were: ε-caprolactam (ε-CLa), ε-caprolactone (ε-CLo) and octamethylcyclotetrasiloxane (OMCTS). They were introduced into silicate interlamellar spaces using different ways. Clays were characterized by X-ray diffraction (XRD), infrared spectra (FTIR) and thermal gravimetric analysis (TG-DTG). Melt processing was used to prepare the HDPE/clay composites. The composites were studied by XRD and scanning electron microscopy (SEM), TG-DTG, differential scanning calorimetry (DSC) and pervaporation techniques. The results show the feasibility of obtaining MMT modified with different organic molecules, the addition of modified clays in the polymeric matrix affected the thermal and transport properties of the composites.

关键词：聚乙烯复合材料高密度聚乙烯改性蒙脱土改性粘土化学性质热性能八甲基环四硅氧烷 TG-DTG

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复苏时需用钙剂吗?

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国外医学（麻醉学与复苏分册） 1992年第5期13卷 294-296页

作者： erdmann E Renschel-Janetschek E 胡兴国

心肌兴奋收缩偶联需有Ca^(++)参与,而Ca^(++)能增强心肌收缩力,心停搏时Ca^(++)能提高心室自律性,但心肺复苏时是否用钙争论较多。本文通过介绍钙对心肌的作用,心源性和败血症性休克时有关钙的研究以及心停搏时用钙的问题等方面对钙应... 详细信息

心肌兴奋收缩偶联需有Ca^(++)参与,而Ca^(++)能增强心肌收缩力,心停搏时Ca^(++)能提高心室自律性,但心肺复苏时是否用钙争论较多。本文通过介绍钙对心肌的作用,心源性和败血症性休克时有关钙的研究以及心停搏时用钙的问题等方面对钙应用的利弊进行了讨论。

关键词：复苏心肌钙拮抗剂

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Impact of solvents and surfactants on the self-assembly of nanostructured amine functionalized silica spheres for CO_(2) capture

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Journal of Energy Chemistry 2016年第2期25卷 325-333页

作者： Edith Berger Maximilian W.Hahn Thomas Przybilla Benjamin Winter erdmann Spiecker Andreas Jentys Johannes A.Lercher Department of Chemistry and Catalysis Research Center Technische Universitat Munchen Lichtenbergstraβe 485747 GarchingGermany Center for Nanoanalysis and Electron Microscopy(CENEM)&Institute of Micro-and Nanostructure Research Friedrich-Alexander-Universitat Erlangen-NurnbergCauerstraβe 691058 ErlangenGermany

Macroscopic SiO2 spheres with a homogeneous amine distribution were synthesized by a one-step emulsion based synthesis approach in a flow column reactor. The CO2 adsorption capacity of the nanostructured amine-functionalized silica spheres was studied in absence and presence of H2O. The structural properties were adjusted by varying solvents and surfactants during the synthesis and, at constant amine loadings, were found to be the main factor for influencing the CO2 sorption capacities. Under water-free conditions CO2 is bound to the amino groups via the formation of carbamates, which require two neighboring amino groups to adsorb one CO2 molecule. At constant amine concentrations sorbents with lower surface area allow to establish a higher amine density on the surface, which enhances the CO2 uptake capacities under dry conditions. In presence of H2O the CO2 adsorption changes to 1：1 stoichiometry due to stabilization of carbamates by protonation of H2O and formation of further species such as bicarbonates, which should in principle double the adsorption capacities. Low concentrations of physisorbed H2O（0.3 mmol/g） did not impair the adsorption capacity of the adsorbents for CO2, while at higher water uptakes（0.6 and 1.1 mmol/g） the CO2 uptake is reduced, which could be attributed to capillary condensation of H2O or formation of bulky reaction products blocking inner pores and access to active sites.

关键词： Carbon dioxide Amines Green solvent Surfactant Water(H2O) Carbamate Bicarbonate

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PROactive试验:吡格列酮对大血管事件影响的前瞻性临床研究———对有心肌梗死病史的2型糖尿病患者的亚组分析

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世界核心医学期刊文摘（心脏病学分册） 2006年第1期2卷 13-14页

作者： Erland erdmann

美国心脏协会(AHA)2005年科学会议上报告了吡格列酮对大血管事件影响的前瞻性临床试验(PROactive)的最新研究结果.其结果显示,口服降糖药吡格列酮使再发心肌梗死的风险降低了28%.最新的数据也显示,吡格列酮显著降低了大血管事件高危人... 详细信息

美国心脏协会(AHA)2005年科学会议上报告了吡格列酮对大血管事件影响的前瞻性临床试验(PROactive)的最新研究结果.其结果显示,口服降糖药吡格列酮使再发心肌梗死的风险降低了28%.最新的数据也显示,吡格列酮显著降低了大血管事件高危人群发生急性冠状动脉综合征的风险.与对照组相比,吡格列酮组严重心衰的报告数有所增加,但是这些患者中的绝对死亡数没有差异.PROactive研究人员得出结论,在1000例有心肌梗死病史的2型糖尿病患者的药物治疗中加入吡格列酮将在3年后预防22次再发心肌梗死和23次急性冠状动脉综合征事件.

关键词： 2型糖尿病患者再发心肌梗死吡格列酮前瞻性临床研究大血管急性冠状动脉综合征病史亚组分 e试验美国心脏协会

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Glutaminase mediated glutamate neurotoxicity by HIV-1 infected macrophage

Glutaminase mediated glutamate neurotoxicity by HIV-1 infect...

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第十五届国际药理学大会

作者： erdmann Nathan Herek Shelley Lopez Alicia Takashi Tsukamoto Ferraris Dana UNMC UNMC UNMC MGI Pharma. MGI Pharma.

＜正＞ Mononuclear phagocyte （MP, macrophages and microglia） dysfunction is thought to play a significant role in the pathogenesis of neurodegenerative disorders including HIV - 1 - associated dementia （HAD）. Glutamate is known to be elevated in HAD, and previous studies have reported HIV - 1 - infected human monocyte derived macrophage （MDM） increase the production of glutamate in a glutamine dependent manner. The enzyme glutaminase converts glutamine to glutamate in an energy free reaction. In this report, we demonstrate that HIV- 1 infected MDM condition media （MCM） induces neurotoxicity. Three glutaminase inhibitors and one control designed by MGI Pharma were blindly tested, with glutamate production measured by reverse - phase high performance liquid chromatography （RP-HPLC）.Two of the GPI inhibitors nearly abrogated the increased production of glutamate by HIV - infected MDM when delivered at micromolar concentrations （19560 and 14256）;the inhibitors did not directly affect cell viability or alter the progression of HIV infection. Glutaminase its and specific inhibitors may be important as a potential target for therapy in HIV - 1 mediated neuronal injury during HAD.

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Short-and long-term outcomes after hemihepatectomy for perihilar cholangiocarcinoma:does left or right side matter?

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 154-162,I0001,I0002页

作者： Lotte C.Franken Pim B.Olthof Joris I.erdmann Otto M.van Delden Joanne Verheij Marc G.Besselink Olivier R.Busch Thomas M.van Gulik Department of Surgery Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamThe Netherlands Department of Surgery Erasmus Medical CenterErasmus UniversityRotterdamThe Netherlands Department of Radiology and Nuclear Medicine Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands Department of Pathology Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands

Background:The only potentially curative option for patients with perihilar cholangiocarcinoma(PHC)is resection,typically an extrahepatic bile duct resection in combination with(extended)liver *** such as bile leakage and liver failure have been suggested to be more common after right-sided resections compared to left-sided resections,whilst superior oncological outcomes have been reported after right-sided ***,data on outcomes after right-sided or left-sided liver resections in PHC are ***,we aimed to investigate short-and long-term outcomes after left and right hemihepatectomy in patients with ***:In this retrospective study,patients undergoing major liver resection for suspected PHC in a tertiary center between 2000-2018 were *** who had undergone left-sided resections were compared to patients with right-sided resections in terms of complications(90-day mortality,overall and severe morbidity and specific complications).For long-term outcomes,only patients with pathologically proven PHC were included in the survival ***:A total of 178 patients undergoing hemihepatectomy for suspected PHC were analysed,including 76 left-sided and 102 right-sided *** 90-day mortality was 14%(24 out of 178),with no significant difference after left-sided resection(11%;8 out of 76)versus right-sided resection(16%;16 out of 102)(P=0.319).Severe morbidity(Clavein Dindo≥3)was also comparable in both groups:54%versus 61%(P=0.361).No differences in specific complications including bile leakage were observed,although liver failure appeared to occur more frequently after right hemihepatectomy(22%versus 11%,P=0.052).Five-year overall survival for pathologically proven PHC,excluding in-hospital mortality,did not differ;43.7%after left-sided resection *** 38.2%after right-sided resection(P=0.553).Conclusions:Both short-and long-term outcomes between patients undergoing left and right hemihepate

关键词： Perihilar cholangiocarcinoma(PHC) hepatectomy outcomes mortality survival

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