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西澳Connemarra和kathleen金矿床蚀变和未蚀变岩石的识别

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国外铀金地质 1991年第2期7卷 27-34页

作者： A. J. Eggo m. G. Doepel 李月湘石其光

本文阐述了识别西澳Youanmi地区Connemarra和kathleen金矿床蚀变和未蚀变岩石的地球化学研究结果。该区金矿化与碳酸盐、绢云母和浸染状黄铁矿伴生,蚀变晕远大于金矿脉本身,并可作为勘查的有利标志。从冲击钻孔采集岩粉样品的地球化学... 详细信息

本文阐述了识别西澳Youanmi地区Connemarra和kathleen金矿床蚀变和未蚀变岩石的地球化学研究结果。该区金矿化与碳酸盐、绢云母和浸染状黄铁矿伴生,蚀变晕远大于金矿脉本身,并可作为勘查的有利标志。从冲击钻孔采集岩粉样品的地球化学数据中,使用逐步判别分析寻找蚀变特征。对未知类似样品中Cu、Zn、Co、Sb、Ti、Zr(按重要性排列)的地化分析提供了伴随金矿化蚀变岩石的识别方法。

关键词：金矿矿床围岩蚀变

减少急性冠状动脉综合征和卒中患者求医的延误——美国心脏协会心血管护理委员会和卒中委员会的科学声明

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国际脑血管病杂志 2006年第10期14卷 721-733页

作者： Debra K. moser Laura P. Kimble mark J. Alberts Angelo Alonzo Janet B. Croft kathleen Dracup Kelly R. Evenson Alan S. Go mary m. Hand Rashmi U. Kothari George A. mensah Dexter L. morris Arthur m. Pancioli Barbara Riegel Julie Johnson Zerwic 李宏建曲东锋南京脑血管疾病分册杂志社 211135

在寻求急性冠状动脉综合征和卒中症状的治疗方面,患者延误是限制提供这些疾病的确定性治疗的主要因素。尽管数十年来的研究和公众教育活动一直旨在缩短患者延误时间,但大多数患者仍然不能及时求医。在本科学声明中,我们总结了以下证据：... 详细信息

在寻求急性冠状动脉综合征和卒中症状的治疗方面,患者延误是限制提供这些疾病的确定性治疗的主要因素。尽管数十年来的研究和公众教育活动一直旨在缩短患者延误时间,但大多数患者仍然不能及时求医。在本科学声明中,我们总结了以下证据：(1)证明早期治疗的益处；(2)描述患者延误问题的程度；(3)确定与患者延误及时求医有关的因素；(4)揭示当前减少患者延误措施的不足。最后,提出临床实践和今后研究的建议。

关键词：美国心脏协会科学声明急性冠状动脉综合征卒中卫生保健的提供

体素内无序运动mRI评价扩散与灌注鉴别诊断良性与恶性唾液腺肿瘤

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国际医学放射学杂志 2012年第4期 385-385页

作者： m. Sumi m.V. Cauteren T. Sumi m. Obara Y. Ichikawa T. Nakamura 唐光健 Radiology and Cancer Biology Nagasaki University School of Dentistry1-7-1 Sakamoto Nagasaki 852-8588 Japan

摘要目的前瞻性评价体素内无序运动(IVIm)参数(微血管内容量分数f;纯扩散系数D;与灌注相关无序微循环D*)对良性与恶性唾液腺肿瘤的鉴别。材料与方法此项前瞻性研究由学院审查委员会批准,向所有参与者提供书面知情同意通知。以IVIm理论... 详细信息

摘要目的前瞻性评价体素内无序运动(IVIm)参数(微血管内容量分数f;纯扩散系数D;与灌注相关无序微循环D*)对良性与恶性唾液腺肿瘤的鉴别。材料与方法此项前瞻性研究由学院审查委员会批准,向所有参与者提供书面知情同意通知。以IVIm理论为基础评价20例(65%)良性(12例多形性腺

关键词：唾液腺肿瘤体素无序运动 mRI

系统性硬皮病中自然杀伤细胞功能异常:细胞因子产物改变和杀伤活性缺陷

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世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 14-14页

作者： Horikawa m. Hasegawa m. Komura K. S. Sato 任建文 Department of Dermatology NagasakiUniversityGraduate School of Biomedical Sciences 1- 7- 1 Sakamoto Nagasaki 852- 8501 Japan Dr.

Natural killer (NK) cells are innate immune effectors that produce various immunoregulatory cytokines. Recent studies have shown that NK cells are involved in the initiation of autoimmunity. In this study, we determined abnormalities of NK cells in systemic sclerosis (SSc), an autoimmune connective tissue disease, by assessing the frequency and absolute number, activation marker expression, cytokine production, and killing activity. The frequency and absolute number of NK cells increased in diffuse cutaneous SSc (dcSSc), whereas they were normal in limited cutaneous SSc (IcSSc). NK cells from both dcSSc and IcSSc patients exhibited activated phenotypes characterized by up-regulated CD16 and CD69 expression and downregulated CD62L expression. Interferon (IFN)-γ production by non-stimulated NK cells from both dcSSc and IcSSc patientswas increased compared to the normal control, whereas on stimulation, a reduced amount of IFN-γ was produced. Interleukin (IL)- 5 and IL- 10 production by non- stimulated NK cells and IL- 6 production by stimulated NK cells were augmented in dcSSc patients, but not in IcSSc patients. Despite the augmented cytokine production by non-stimulated NK cells, natural cytotoxicity activity and granzyme B secretion was reduced in NK cells from dcSSc and IcSSc patients. These results suggested that altered NK cell function contributes to immunological abnormalities in SSc.

关键词：系统性硬皮病自然杀伤细胞细胞因子产物细胞功能异常自身免疫性结缔组织病活性缺陷 NK细胞免疫效应细胞免疫调节因子 γ干扰素

不同海拔高度藏汉族老年人血压变化的特点及影响因素

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高原医学杂志 2011年第4期21卷 14-18页

作者：代青湘李占全王红心许慧宁高继东杨爱荣仝海英奥宫清人松林公藏坂本龙泰木村友美张永寿王建萍才仁松保尼玛乔海生青海大学附属医院 810001 日本综合环境地球研究所青海省海北州海晏县人民医院 812200 青海省玉树州玉树县人民医院 815000 青海省畜牧兽医科学院 810016

目的:通过对不同海拔地区藏汉族老年人进行健康调查,进一步了解高原地区老年人血压变化的特点及影响因素。方法:采用随机抽样的方法,对青海省玉树县(平均海拔3 700m)、海晏县(平均海拔3 000m以上)两地区506例60岁～87岁世居藏族及移居... 详细信息

目的:通过对不同海拔地区藏汉族老年人进行健康调查,进一步了解高原地区老年人血压变化的特点及影响因素。方法:采用随机抽样的方法,对青海省玉树县(平均海拔3 700m)、海晏县(平均海拔3 000m以上)两地区506例60岁～87岁世居藏族及移居汉族的血压进行健康调查。结果:①玉树县老年人高血压的患病率显著高于海晏县,收缩压(SBP)、舒张压(DBP)及体质指数(BmI)显著高于海晏县老年人,PmI均显著高于海晏县藏族,均PmI、脉率(HR)及血红蛋白(Hb)显著高于血压正常组,血氧饱和度(SpO2)低于血压正常组,P<0.05。结论:高原地区老年人高血压的患病率高于海拔较低的地区,汉族高血压的患病率高于藏族;高原低氧、低温环境是高原地区老年人血压增高的重要影响因素,移居汉族、超重及牧区镇城居民更易患高血压病。

关键词：高原老年人藏族血压低氧环境

HBV感染患者合并肝的黏膜相关淋巴组织淋巴瘤及肝细胞性肝癌

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世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 50-50页

作者： Takeshima F. Kunisaki m. Aritomi T. 王志宇 Second Dept. of Internal medicine Nagasaki Univ. School of Medicine 1-7-1 Sakamoto Nagasaki 852-8501 Japan Dr.

Primary hepatic mucosa associated lymphoid tissue (mALT) lymphoma is an extremely rare disease. A 65-year old female patient with chronic hepatitis B presented with multiple solid masses in segment (S) 4, S5, and S6 of the liver. The nodule in S5 was diagnosed preoperatively as hepatocellular carcinoma by computed tomography, magnetic resonance imaging, and angiography. The nodule in S4 was initially interpreted as lymphoid follicles by needle biopsy. Segmentectomy of S5 and partial resection of S6 were performed. microscopic examination of the S5 nodule revealed moderately differentiated hepatocellular carcinoma. The nodule from S6 showed nodular proliferation of atypical intermediate to medium sized lymphoid cells in the portal area and lymph epithelial lesions of bile ducts. The atypical lymphoid cells were positive for LCA, L-26 and bcl-2 and negative for UCHL-1. These features were consistent with the diagnosis of mALT lymphoma. This is the first case report of synchronous hepatic mALT lymphoma and hepatocellular carcinoma associated with chronic hepatitis B.

关键词：肝细胞性肝癌 HBV感染乙型肝炎淋巴瘤小淋巴细胞显微镜检淋巴滤泡切除术血管造影诊断穿刺活检

恶性黑色素瘤患者血清中可溶性细胞间黏附分子1及可溶性L选择素水平的临床意义

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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 40-40页

作者： Yamada m. Yanaba K. Takehara K. Sato S. 潘敏 De- partment of Dermatology Nagasaki University Graduate School of Biomedical Sciences 1- 7- 1 Sakamoto Nagasaki 852- 8501 Japan

Although several molecules have been evaluated as tumor markersof malignant melanoma (mm) progression, there are fewavailable markers sensitive enough to detect recurrence or metastasis. The objective of the present study was to determineclinical significance of serum soluble adhesion molecules in the monitoring of progression in patients with mm. Serum levels of soluble L- selectin (sL- selectin), sE- selectin, sP- selectin, and soluble intercellular adhesion molecule- 1 (sICAm- 1) were determined by ELISA in 57 mm patients. In a retrospective longitudinal study, nine serum samples from two mm patients were analyzed during a follow- up period of 4.0 and 4.3 years, respectively. Serum sICAm- 1 levels in mm patients were significantly higher than those in healthy controls and tended to be elevated as the disease stage progressed. In contrast, serum sL- selectin levels were significantly lower inmmpatients compared to healthy controls and tended to decrease as the disease stage progressed. There was no significant difference in serum sE- selectin and sP- selectin levels between mm patients and normal control. In a longitudinal study, increased sICAm- 1 and decreased sL- selectin levels were generally associated with the progression of mm. These results suggest that monitoring both sICAm- 1 and sL- selectin is available to evaluate the progression of mm.

关键词：恶性黑色素瘤选择素肿瘤标记物纵向调查黏附分子