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Elucidating regulatory processes of intense physical activity by multi-omics analysis

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Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko young-Mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie Munoz kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes kathleen A.Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

Influence of cardiorespiratory fitness and body composition on resting and post-exercise indices of vascular health in young adults

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Sports Medicine and Health Science 2024年第1期6卷 54-62页

作者： Rian Q.Landers-Ramos kathleen Dondero Ian Imery Nicholas Reveille Hannah A.Zabriskie Devon A.Dobrosielski Towson University Department of KinesiologyTowsonMDUSA University of Maryland School of Medicine Department of Physical Therapy and Rehabilitation SciencesBaltimoreMDUSA Johns Hopkins University Department of Cell BiologyBaltimoreMDUSA University of Florida Department of Applied Physiology and KinesiologyGainesvilleFLUSA

Poor cardiorespiratory fitness may mediate vascular impairments at rest and following an acute bout of exercise in young healthy *** study aimed to compare flow mediated dilation(FMD)and vascular augmentation index(AIx75)between young adults with low,moderate,and high levels of cardiorespiratory fitness before and after an acute bout of aerobic ***-three participants(22 men;21 women)between 18 and 29 years of age completed the *** were classified into low,moderate,and high health-related cardiorespiratory fitness groups according to age-and sex-based relative maximal oxygen consumption(V_O2 max)percentile *** was performed using Doppler ultrasound and AIx75 was performed using pulse wave analysis at baseline and 60-min after a 30-min bout of treadmill running at 70%V_O2 max.A significant interaction(p=0.047;ηp 2=0.142)was observed,with the moderate fitness group exhibiting a higher FMD post-exercise compared with baseline([6.7%3.1%]vs.[8.5%2.8%],p=0.028;d=0.598).We found a significant main effect of group for AIx75(p=0.023;ηp 2=0.168),with the high fitness group exhibiting lower AIx75 compared to low fitness group([10%10%]vs.[2%10%],respectively,p=0.019;g=1.07).This was eliminated after covarying for body fat percentage(p=0.489).Our findings suggest that resting FMD and AIx75 responses are not significantly influenced by cardiorespiratory fitness,but FMD recovery responses to exercise may be enhanced in individuals with moderate cardiorespiratory fitness levels.

关键词： Cardiorespiratory fitness Flow mediated dilation Augmentation index Vascular Acute exercise Body composition

Between Borders： Moroccan Migrations

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Journal of Literature and Art Studies 2012年第7期2卷 665-668页

作者： kathleen McNerney West Virginia University Morgantown USA

In the works of two young women from Morocco, themes of identity, belonging, class, race, gender, changing customs and language, and literary references abound. Since both writers are relative newcomers to their literary scenes, the only bibliography available consists of brief reviews. The author hopes to give their work a wider audience so that divulgation will lead to more criticism and the attention they deserve. The literary references in these two writers are very indicative of their adopted cultures： Najat El Hachmi＇s favorites are mostly Catalan writers, while Laila Lalami speaks of American authors who lived in Morocco, and both mention traditional Arabic literature. The work of both these writers is greatly enriched, if sometimes painfully, by their absorption into multiple cultures and identities.

关键词： Najat El Hachrni Laila Lalami Morroco/Spain immigration/emigration

Conditioned taste aversions

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2018年第1期4卷 92-100页

作者： kathleen C. Chambers University of Southern California Los AngelesCAUSA

When one becomes ill after consuming a meal, there is a propensity to target a particular taste as the cause of the illness. The qualities of the taste most likely targeted include more novel, less preferred, and higher protein content. This association between a particular taste and illness is a form of learning that is termed conditioned taste aversion (CTA). A consequence of the learned association is that the taste will become aversive. When experiencing the taste again, individuals will show aversive reactions such as expressions of loathing, will experience mimicked illness sensations such as nausea, and subsequently, will avoid further exposure to the taste. The ability to acquire CTA occurs across species and across ages within a species. In the rat animal model, however, age differences exist in the capability of acquiring CTAs when increasingly longer intervals are imposed between consumption of a novel sweet solution and onset of illness. Pups have a decreased ability compared to young adults while aged rats have an increased ability. Evidence suggests that the failure of pups to acquire CTA at longer intervals is due to an immature retrieval mechanism and the facili-tated ability of aged rats is due to a compromised clock mechanism that tracks the passage of time. Learned taste-illness association serves the critical function of informing individuals of the toxic nature of certain foods, thus preventing further illness and potentially death. Additionally, it contributes to the hypophagia observed during cancer chemotherapy and may contribute to the hypophagia found while suffering from bacterial infection, chronic med-ical conditions such as cancer, and restrictive food intake disorders such as anorexia nervosa.

关键词： Age differences Aversion reactions Avoidance Hypophagia Illness sensations

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血管性红斑急性扩大伴步态改变一例

英国医学杂志中文版 2019年第9期22卷 546-548页

作者： kathleen T Tedesco Jay Sarthy Navin Pinto Markus D Boos 赵雷(译) 扈玉华(校) Albany Medical College Albany NY USA Division of Hematology-Oncology Department of Pediatrics University of Washington School of Medicine and Seattle Children′s HospitalSeattle WA USA Division of Dermatology Department of Pediatrics University of Washington Schoolof Medicine and Seattle Children′s Hospital Seattle WA USA 河北医科大学第二医院东院神经外科河北医科大学第二医院神经外科

患儿女性,15个月,主因步态不稳1周,每天不明原因摔倒3~4次就诊于急诊科。患儿自12月龄起即可独立行走,不伴任何行走困难。患儿出生时,右臀内侧可见大片粉红色斑,临床检查诊断为先天性血管瘤。红斑伴随着患儿的生长而增长,至本次症状出... 详细信息

患儿女性,15个月,主因步态不稳1周,每天不明原因摔倒3~4次就诊于急诊科。患儿自12月龄起即可独立行走,不伴任何行走困难。患儿出生时,右臀内侧可见大片粉红色斑,临床检查诊断为先天性血管瘤。红斑伴随着患儿的生长而增长,至本次症状出现之时,红斑急速硬化,并在骶骨上方出现一个延续的红色肿块。

关键词：血管瘤红斑步态急性不明原因行走困难检查诊断患儿

儿童及青少年诊疗操作中的镇静：NICE指南概要

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英国医学杂志中文版 2011年第2期14卷 119-121页

作者： Mike Sury Ian Bullock Silvia Rabar kathleen DeMou 李晗歌(译) 黄宇光(校) Greal Ormond Street Hospital for Children NHS Trust London WC1N 3JH UK PORTEX Unit of Paediatric Anaesthesia Institute of Child Health University College London WCIN 1EH National Clinical Guideline Centre Royal College of Physicians London NW14LE 北京协和医院麻醉科

儿童的小操作常需要有效的镇静或麻醉。尽管镇静方式有很多种，但镇静并非总能奏效，因此可能会对患者造成痛楚和额外花费（与重复操作有关）；一些镇静方式有时还会导致患者发生意外的意识丧失，伴突发的、具有潜在危险的气道阻塞及呼... 详细信息

儿童的小操作常需要有效的镇静或麻醉。尽管镇静方式有很多种，但镇静并非总能奏效，因此可能会对患者造成痛楚和额外花费（与重复操作有关）；一些镇静方式有时还会导致患者发生意外的意识丧失，伴突发的、具有潜在危险的气道阻塞及呼吸抑制。

关键词：诊疗操作镇静 NICE 儿童青少年指南意识丧失呼吸抑制