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商学院 2005年第1期 56-59页

作者： Karl E.Weick kathleen m.Sutcliffe

航空母舰的甲板被称为"世界上最危险的四又二分之一英亩"。你能想像有比航空母舰更好的参照系.以作为你自己致力于更谨慎、更警觉和更具回应力的楷模吗?

关键词：航空母舰甲板谨慎危险学管理想像楷模火线参照系回应

采用新的显色原位杂交法检测尿磷酸盐沉积性间叶瘤中的 FGF23 mRNA

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临床与实验病理学杂志 2015年第9期31卷 995-995页

作者： Carter J m caron B L Dogan A 康锶鹏余英豪不详解放军第180医院病理科泉州362000 南京军区福州总医院病理科福州350025

混合性结缔组织型尿磷酸盐沉积性间叶瘤（ PmT）是发生在骨与软组织的一种罕见肿瘤。大多数 PmT 患者因继发于成纤维细胞生长因子23（FGF23）激素产生,该激素能抑制肾近端小管对磷酸盐的重吸收导致患者发生持久性骨软化症。既往PmT患者 ... 详细信息

混合性结缔组织型尿磷酸盐沉积性间叶瘤（ PmT）是发生在骨与软组织的一种罕见肿瘤。大多数 PmT 患者因继发于成纤维细胞生长因子23（FGF23）激素产生,该激素能抑制肾近端小管对磷酸盐的重吸收导致患者发生持久性骨软化症。既往PmT患者 FGF23 mRNA检测多采用RT-PCR法,但其特异性低,且存在内在的非肿瘤组织污染风险限制了临床应用。该文作者介绍一种新的半定量原位FGF23 mRNA检测诊断PmT的方法,25例出现肿瘤性骨软化症（ TiO）的PmTs患者中位年龄52岁（范围5～73岁）,肿瘤位于不同骨骼及软组织,肿瘤直径平均3．9 cm（1．4～12 cm）。96%（22/23）的PmTs患者FGF23 mRNA表达：16例评为（-）；5例评为（-）；1例评为（＋）。这些病例中3例伴转移的恶性PmTs 亦检出FGF23 mRNA表达。对照组40例包括4例动脉瘤样骨囊肿、8例软骨黏液样纤维瘤、8例高级别骨肉瘤和瘤样钙质沉着症,以及其他各种软骨或骨形成肿瘤及软组织肿瘤 FGF23 mRNA 均阴性。

关键词： mRNA表达磷酸盐间叶瘤原位杂交法沉积测尿软骨黏液样纤维瘤成纤维细胞生长因子

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火线学应急

商学院 2005年第Z1期 58-59页

作者： Karl E.Weick kathleen m.Sutcliffe

关键词：航空母舰高可靠性组织飞行员飞行人员回应力弹射器指挥官

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演讲的基本

Dietary arachidonate in milk replacer triggers dual benefits of PGE2 signaling in LPS-challenged piglet alveolar macrophages

作者： (美)凯思琳·哲曼(kathleen m. German)[等]

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Journal of Animal Science and Biotechnology 2019年第2期10卷 435-448页

作者： kathleen R.Walter Xi Lin Sheila K.Jacobi Tobias Kaser Debora Esposito Jack Odle Department of Animal Science Plants for Human Health InstituteNorth Carolina State UniversityKannapolisNorth CarolinaUSA Department of Animal Science North Carolina State UniversityRaleighNorth CarolinaUSA Department of Animal Science Ohio State UniversityColumbusOhioUSA Department of Population Health and Pathobiology College of Veterinary MedicineNorth Carolina State UniversityRaleighNorth CarolinaUSA.

Background: Respiratory infections challenge the swine industry, despite common medicinal practices. The dual signaling nature of PGE2(supporting both inflammation and resolution) makes it a potent regulator of immune cell function. Therefore, the use of dietary long chain n-6 PUFA to enhance PGE2 effects merits ***: Day-old pigs(n = 60) were allotted to one of three dietary groups for 21 d(n = 20/diet), and received either a control diet(CON, arachidonate = 0.5% of total fatty acids), an arachidonate(ARA)-enriched diet(LC n-6,ARA = 2.2%), or an eicosapentaenoic(EPA)-enriched diet(LC n-3, EPA = 3.0%). Alveolar macrophages and lung parenchymal tissue were collected for fatty acid analysis. Isolated alveolar macrophages were stimulated with LPS in situ for 24 h, and m RNA was isolated to assess markers associated with inflammation and eicosanoid *** media were collected to assess PGE2 secretion. Oxidative burst in macrophages was measured by: 1)oxygen consumption and extracellular acidification(via Seahorse), 2) cytoplasmic oxidation and 3) nitric oxide production following 4, 18, and 24 h of LPS ***: Concentration of ARA(% of fatty acids, w/w) in macrophages from pigs fed LC n-6 was 86% higher than CON and 18% lower in pigs fed LC n-3(P mulation, abundance of COX-2 and TNF-α mRNA(P m vs. CON. However, ALOX5 abundance was1.6-fold lower than CON. macrophages from CON and LC n-6 groups were 4-fold higher in ALOX12/15 abundance(P mpared to LC n-3. Oxygen consumption and extracellular acidification rates increased over 4 h following LPS stimulation(P ment. Similarly, increases in cytoplasmic oxidation(P mulation but were unaffected by ***: We infer that enriching diets with arachidonic acid may be an ef

关键词： Arachidonic acid Cyclooxygenase Eicosanoid Eicosapentaenoic acid Inflammation Lipid mediator class switch LPS Lipoxin Porcine alveolar macrophage

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世界哲学简史

milk Replacer Acidification for Free-Access Feeding: Effects on the Performance and Health of Veal Calves

作者： (美)罗伯特·C. 所罗门(Robert C. Solomon) 凯瑟琳·m. 希金斯(kathleen m. Higgins)

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Open Journal of Animal Sciences 2016年第3期6卷 234-246页

作者： Cynthia G. Todd Ken E. Leslie Suzanne T. millman Jan m. Sargeant Heather migdal kathleen Shore Neil G. Anderson Trevor J. DeVries Department of Population medicine Ontario Veterinary College University of Guelph Guelph ON Canada Department of Veterinary Diagnostic & Production Animal medicine Iowa State University Ames IA USA Centre for Public Health and Zoonoses University of Guelph Guelph ON Canada Department of Animal Biosciences University of Guelph Guelph ON Canada Grober Nutrition Cambridge ON Canada Ontario ministry of Agriculture Food and Rural Affairs Veterinary Science and Policy Unit Elora ON Canada

Objectives of this study were to investigate the effects of milk replacer (mR) acidification for free- access feeding on pre- and post-weaning performance, morbidity and mortality of calves. Calves were randomly assigned to free-access feeding of acidified (ACID, n = 31) or non-acidified (NON, n = 31) mR, and weaned at 42 days. ACIDmR was prepared to pH 4.0 - 4.5 using formic acid. Intakes were measured daily and weights weekly. Samples of ACID and NON mR were analyzed for coliform and aerobic bacterial growth. After weaning, calves transitioned to a grain-fed veal diet, weighed every 2 weeks. At slaughter (approximately 6 months of age), lungs were evaluated for gross pathological changes and dressed carcass weights were obtained. Generalized linear mixed models were constructed to examine the effects of mR acidification. Differences by treatment group for pre- and post-weaning morbidity and mortality were tested using Pearson’s χ2 and Fisher’s exact tests. ACID calves consumed less mR than NON (10.6 vs. 11.7 L/d, P = 0.02). Acidification tended to promote earlier onset of starter ration consumption (32.0 vs. 39.5 d, hazard ratio = 1.5, P = 0.07), but did not affect average daily starter ration or water intakes across the pre-weaning period. ACID and NON calves did not differ for BW at weaning, pre- or post-weaning ADG or dressed carcass weight. ACID mR had less coliform (P mR, but odds of disease treatment and mortality did not differ. ACID calves tended to have lower odds of pulmonary lesions during post-mortem inspection than NON calves (OR = 0.3, P = 0.07). These results indicate that under free-access feeding conditions, acidification limited bacterial growth and mR intake, but there were no long-term impacts of acidification on calf performance or health. In conclusion, acidification to pH 4.0 - 4.5 will significantly reduce bacterial growth in milk fed to calves.

关键词： Acidified milk Feeding Free-Access milk Feeding Health Growth Veal Calves

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管理团队如何化冲突为力量

中国新时代 2002年第14期 100-104页

作者： kathleen m.Eisenhardt ,JeanL.Kahwajy ,L.J.BourgeoisIll

人际冲突较少的团队,通常能将实质议题与人身攻击区隔开来,而在处理人际冲突上,有6项相同的技巧,包括:专注于事实、选择多元化、创造共同目标、运用幽默、平衡权力结构、以及寻求有条件的共识。

关键词：管理团队高阶议题人身攻击安卓经理人人际冲突人际关系冲突

Ecologic study of serum selenium and upper gastrointestinal cancers in Iran

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World Journal of Gastroenterology 2004年第17期10卷 2544-2546页

作者： mehdi Nouarie Akram Pourshams Farin Kamangar masood Sotoudeh mohammad Hossein Derakhshan mobammad Reza Akbari Hafez Fakheri mohammad Javad Zahedi kathleen Caldwell Christian *** Philip R.Taylor Reza malekzadeh Sanford m.Dawsey Digestive Disease Research Center Tehran University of Medical SciencesTehranIran National Cancer Institute NIHBethesdaMD20895-8314USA Centers for Disease Control AtlantaGeorgiaUSA

AIm: Both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient *** cancer registry data have shown very different rates of esophageal cancer (EC) and gastric cancer (GC) in four Provinces of Iran, namely Ardabil, mazandaran, Golestan,and Kerman. The aim of this study was to have a preliminary assessment of the hypothesis that high rates of EC in Golestan and high rates of GC in Ardabil may be partly attributable to selenium ***: We measured serum selenium in 300 healthy adults from ArdabU (n = 100), mazandaran (n = 50), Golestan (n = 100), and Kerman (n = 50), using inductively coupled plasma, with dynamic reaction cell, mass spectrometry (ICP-DRC-mS) at the US Centers for Disease Control (Atlanta,Georgia).RESULTS: The median serum selenium concentrations were very different in the four Provinces. The medians (IQR) for selenium in Ardabil, mazandarn, Golestan, and Kerman were 82 (75-94), 123 (111-132), 155 (141-173), and 119 (110-128) μg/L, respectively (Pm (r^2 = 0.76).The proportion of the populations with a serum selenium more than 90μg/L (the concentration at which serum selenoproteins are saturated) was 100% in Golestan,Kerman, and mazandaran but only 29% in ***: Our findings suggest nat selenium defidency is not a major contributor to the high incidence of EC seen in northeastern Iran, but it may play a role in the high incidence of GC in Ardabil Province.

关键词：生态研究免疫血清硒胃肠癌肿瘤伊朗消化系统

Targeting TGF-beta to suppress： metastasis

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中国药理通讯 2013年第2期30卷 43-44页

作者： Yu-an Yang Jia Weng michael Welsh Douglas Weinberg Dror Luger Nancy Guan Lucy Shan Josh Webster kathleen C. Flanders Xin Chen Joe Oppenheim Scott m. Lonning JohnmcPherson Latage m. Wakefield Lab of Cancer Biology and Genetics Center for Cancer ResearchNational Cancer Institute Bethesda MD Genzyme Corp. Framingham MA.

TGF-betas are pleiotropic growth factors with important roles in normal homeostasis and complex roles in tumorigenesis. In general TGF-betas function as tumor suppressors early in the tumorigenic process and as pro-metastatic factors later. metastasis-promoting activities include the enhancement of invasion and migration, the promotion of angiogenesis, and the suppression of immune surveillance. Overexpression of TGF-beta in many advanced human tumors correlates with metastasis and poor prognosis, and there is considerable interest in developing TGF-beta antagonists for cancer therapy. However, the complexity of TGF-beta action, involving the context-dependent interplay of many cellular targets, means that preclinical animal models are critical for evaluating such agents.

关键词： c-met抑制剂药效监控标志物肿瘤治疗