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Leveraging quasi-periodic orbits for trajectory design in cislunar space

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Astrodynamics 2021年第2期5卷 139-165页

作者： Brian P.Mccarthy kathleen c.howell School of Aeronautics and Astronautics Neil Armstrong Hall of EngineeringWest LafayetteIN47907-2045USA

Incorporating quasi-periodic orbits into the preliminary design process offers a wide range of options to meet mission constraints and address the challenges in a complex trade *** this investigation,linear stability and quasi-periodic orbit family continuation schemes are examined to meet various types of *** in eclipse avoidance and transfer design are examined by leveraging quasi-periodic orbits and their associated hyperbolic manifolds in the lunar *** are transitioned to an ephemeris model to validate that geometries are maintained in higher-fidelity *** the natural dynamical structures associated with quasi-periodic orbits are leveraged,novel trajectory solutions can emerge.

关键词： multi-body dynamical systems quasi-periodic orbits trajectory analysis cislunar trajectory design near rectilinear halo orbit ephemeris dynamical model

Resilience, the 6th Vital Sign: conceptualizing, contextualizing, and Operationalizing All Six Vital Signs

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Health 2024年第7期16卷 657-673页

作者： Rose E. constantino Betty J. Braxter chi ching Vivian Hui Larissa c. Allen Lillian J. Wolfe Katherine H. Endres Jezyl cempron cutamora Laurence L. Garcia Daisy R. Palompon kathleen Thimsen Brayden N. Kameg Margarete L. Zalon Department of Health and community Systems School of Nursing University of Pittsburgh Pittsburgh PA USA Undergraduate Affairs School of Nursing University of Pittsburgh Pittsburgh PA USA The Hong Kong Polytechnic University Hong Kong China School of Nursing Adjunct Faculty at the University of Pittsburgh Pittsburgh PA USA School of Nursing University of Pittsburgh Pittsburgh PA USA Department of Health Promotion and Development School of Nursing University of Pittsburgh Pittsburgh PA USA college of Nursing Cebu Normal University Cebu City Philippines School of Nursing University of Nevada Las Vegas USA Department of Health and community Systems University of Pittsburgh PA USA Department of Nursing University of Scranton Scranton PA USA

There are five vital signs that healthcare providers assess: temperature, pulse, respiration, blood pressure, and pain. Normal levels for the five vital signs are published by the American Heart Association, and other specialty organizations, however, the sixth vital sign (resilience) which adopts the measure of immune resilience is suggested in this paper. Resilience is the ability of the immune system to respond to attacks and defend effectively against infections and inflammatory stressors, and psychological resilience is the capacity to resist, adapt, recover, thrive, and grow from a challenge or a stressor. Individuals with better optimal immune resilience had better health outcomes than those with minimal immune resilience. The purpose of this paper is to conceptualize, contextualize, and operationalize all six vital signs. We suggest measuring resilience subjectively and objectively. Subjectively, use a 5-item guided interview revised from the connor-Davidson Resilience Scale (cDRc), a scale of 10 items. The revised cDRc scale is a 5-item scale. The scale is rated on a 5-point Likert scale from 0 (not true) to 4 (true all the time). The total score ranges from 0 to 20, with higher total scores indicating greater resilience. The scale demonstrated good construct validity and internal consistency (α = 0.85) during the development of the scale. The cD-RISc had a good cronbach’s alpha level of 0.85. The Revised cD-RISc can be completed in 2 - 4 minutes. To measure resilience objectively, we suggest using Immune Resilience (IR) levels, the level of resilience to preserve and/or rapidly restore immune resilience functions that promote disease resistance and control inflammation and other inflammatory stress. IR levels are gauged with two peripheral blood metrics that quantify the balance between cD8 and cD4 T-cell levels and gene expression signatures tracking longevity-associated immunocompetence and mortality- or entropy-associated inflammation. IR deregulation i

关键词： conceptualization contextualization Operationalization Body Temperature Pulse Respiration Blood Pressure Pain Resilience

Attitude dynamics in the circular restricted three-body problem

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Astrodynamics 2018年第2期2卷 87-119页

作者： Davide Guzzetti kathleen connor howell School of Aerospace Engineering Tsinghua UniversityBeijing 100084China School of Aeronautics and Astronautics Purdue UniversityArmstrong Hall of Engineering701 W.Stadium Ave.West LafayetteIndiana 47907-2045USA

This document reflects the effort of constructing a basis for understanding attitude motion within a multi-body problem with application to spacecraft flight *** circular restricted three-body problem(cR3BP)is employed as a model for the orbital ***,attitude dynamics is discussed within the *** for bounded attitude librations and techniques for the identification of such behavior are presented:initially for a spacecraft fixed at an orbital equilibrium point,and later for a vehicle that moves on non-linear periodic *** previous works focus on specific challenges,this analysis serves to create a more general framework for attitude dynamics within the cR3BP.A larger framework enables additional *** example,a linkage is noted between regions of bounded motion that may appear on an attitude grid search map and families of periodic attitude ***,coupling effects between attitude and orbit dynamics within the cR3BP,ones that enable new options for trajectory design,are considered an important opportunity,and should be included in a general *** a proof of that concept,sailcraft trajectories are generated within a coupled orbit-attitude model only using a sequence of constant commands for the attitude actuators.

关键词： three-body problem orbit-attitude dynamics bounded attitude librations turn and hold model

Adrenomedullin and endocrine control of immune cells during pregnancy

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cellular & Molecular Immunology 2014年第5期11卷 456-459页

作者： Brooke c Matson kathleen M caron Departments of cell Biology & Physiology University of North Carolina at Chapel Hill Chapel Hill NC USA Genetics University of North Carolina at Chapel Hill Chapel Hill NC USA

The immunology of pregnancy is complex and incompletely understood. Aberrant immune activity in the decidua and in the placenta is believed to play a role in diseases of pregnancy, such as infertility, miscarriage, fetal growth restriction and preeclampsia. Here, we briefly review the endocrine control of uterine natural killer cell populations and their functions by the peptide hormone adrenomedullin. Studies in genetic animal models have revealed the critical importance of adrenomedullin dosage at the maternal-fetal interface, with cells from both the maternal and fetal compartments contributing to essential aspects underlying appropriate uterine receptivity, implantation and vascular remodeling of spiral arteries. These basic insights into the crosstalk between the endocrine and immune systems within the maternal- fetal interface may ultimately translate to a better understanding of the functions and consequences of dysregulated adrenomedullin levels in clinically complicated pregnancies.

关键词： adrenomedullin preeclampsia pregnancy spiral artery remodeling uNK cells

conditioned taste aversions

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2018年第1期4卷 92-100页

作者： kathleen c. chambers University of Southern california Los AngelesCAUSA

When one becomes ill after consuming a meal, there is a propensity to target a particular taste as the cause of the illness. The qualities of the taste most likely targeted include more novel, less preferred, and higher protein content. This association between a particular taste and illness is a form of learning that is termed conditioned taste aversion (cTA). A consequence of the learned association is that the taste will become aversive. When experiencing the taste again, individuals will show aversive reactions such as expressions of loathing, will experience mimicked illness sensations such as nausea, and subsequently, will avoid further exposure to the taste. The ability to acquire cTA occurs across species and across ages within a species. In the rat animal model, however, age differences exist in the capability of acquiring cTAs when increasingly longer intervals are imposed between consumption of a novel sweet solution and onset of illness. Pups have a decreased ability compared to young adults while aged rats have an increased ability. Evidence suggests that the failure of pups to acquire cTA at longer intervals is due to an immature retrieval mechanism and the facili-tated ability of aged rats is due to a compromised clock mechanism that tracks the passage of time. Learned taste-illness association serves the critical function of informing individuals of the toxic nature of certain foods, thus preventing further illness and potentially death. Additionally, it contributes to the hypophagia observed during cancer chemotherapy and may contribute to the hypophagia found while suffering from bacterial infection, chronic med-ical conditions such as cancer, and restrictive food intake disorders such as anorexia nervosa.

关键词： Age differences Aversion reactions Avoidance Hypophagia Illness sensations

An aqueous 2.1 V pseudocapacitor with MXene and V-MnO_(2) electrodes

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Nano Research 2022年第1期15卷 535-541页

作者： Jiabin Wu Qun Li christopher E.Shuck kathleen Maleski Husam N.Alshareef Jun Zhou Yury Gogotsi Liang Huang Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Department of Materials Science and Engineering and A./.Drexel Nanomaterials Institute Drexel UniversityPhiladelphiaPennsylvania 19104USA Materials Science and Engineering Physical Science and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

MXenes have shown record-breaking redox capacitance in aqueous electrolytes,but in a limited voltage window due to oxidation under anodic potential and hydrogen evolution under high cathodic *** Ti3c2Tx Xene negative electrode with RuO_(2) or carbon-based positive electrodes expanded the voltage window in sulfuric acid electrolyte to about 1.5 ***,we present an asymmetric pseudocapacitor using abundant and eco-friendly vanadium doped MnO_(2) as the positive and Ti_(3)c_(2)Tx MXene as the negative electrode in a neutral 1M Li2SO4 *** all-pseudocapacitive asymmetric device not only uses a safer electrolyte and is a much less expensive counter-electrode than RuO_(2),but also can operate within a 2.1 V voltage window,leading to a maximum energy density of 46 Wh/*** study also demonstrates the possibility of using MXene electrodes to expand the working voltage window of traditional redox-capable materials.

关键词： MXene pseudocapacitors metal oxides supercapacitors manganese oxide

Perinatal transmission in infants of mothers with chronic hepatitis B in california

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World Journal of Gastroenterology 2017年第27期23卷 4942-4949页

作者： Jennifer c Burgis Darryl Kong catheryn Salibay Jennifer Zipprich kathleen Harriman Samuel So Department of Pediatrics Stanford University california Department of Public Health Immunization Branch Asian Liver center Stanford University

AIM To evaluate maternal hepatitis B virus(HBV) DNA as risk for perinatal HBV infection among infants of HBVinfected women in *** Retrospective analysis among infants born to hepatitis B surface antigen(HBs Ag)-positive mothers who received post vaccination serologic testing(PVST) between 2005 and 2011 in california. Demographic information was collected from the california Department of Public Health Perinatal Hepatitis B Program databaseand matched to birth certificate records. HBV DNA level and hepatitis B e antigen(HBe Ag) status were obtained from three large commercial laboratories in california and provider records if available and matched to mother infant pairs. Univariate analysis compared infected and uninfected infants. Multivariate analysis was restricted to infected infants and controls with complete maternal HBV DNA results using a predefined high HBV DNA level of > 2 × 107 IU/ml,a 5:1 ratio of cases to controls and a two-sided confidence level of 95%.RESULTS A total of 17687 infants were born to HBs Ag positive mothers in california between Jan 1 2005 and Dec 31,2011. Among 11473 infants with PVST,only 125(1.1%) were found to be HBV infected. Among these infected infants,lapses in Advisory committee on Immunization Practices recommended post exposure prophylaxis(PEP) occurred in only 9 infants. However,PEP errors were not significantly different between infected and uninfected infants. Among the 347 uninfected and infected infants who had maternal HBe Ag and HBV DNA level,case-control analysis found HBe Ag positivity(70.4% vs 28.9%,OR = 46.76,95%cI: 6.05-361.32,P cI: 12.22-247.55,P ciated with perinatal HBV infection. In multivariate logistic regression,maternal HBV DNA level ≥ 2 × 107 IU/ml was the only significant independent predictor of perinatal HBV infection. cONcLUSION In california,transmission is low and most infected infants rec

关键词： Perinatal 传播肝炎 B 病毒 DNA 怀孕肝炎 B 种痘测试的疫苗以后的血清学

Spontaneous pneumothorax in a single lung transplant recipient-a blessing in disguise: A case report

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World Journal of clinical cases 2020年第14期8卷 3031-3038页

作者： Himanshu Deshwal Subha Ghosh kathleen Hogan Olufemi Akindipe charles Randall Lane Atul c Mehta Division of Pulmonary Critical Care and Sleep MedicineNew York University Grossman School of MedicineNew YorkNY 10016United States Imaging Institute Section of Thoracic ImagingCleveland ClinicClevelandOH 44195United States Respiratory Institute Cleveland ClinicClevelandOH 44195United States

BAcKGROUND End-stage chronic obstructive pulmonary disease(cOPD)is one of the common lung diseases referred for lung *** to the international society of heart and lung transplantation,30%of all lung transplantations are carried out for cOPD *** compared to bilateral lung transplant,singlelung transplant(SLT)has similar short-term and medium-term results for *** patients with severe upper lobe predominant emphysema,lung volume reduction surgery is an excellent alternative which results in improvement in functional status and long-term *** 2018,endobronchial valves were approved by the Food and Drug Administration for severe upper lobe predominant emphysema as they demonstrated improvement in lung function,exercise capacity,and quality of ***,the role of endobronchial valves in native lung emphysema in SLT patients has not been *** SUMMARY We describe an unusual case of severe emphysema who underwent a successful SLT 15 years ago and had gradual worsening of lung function suggestive of chronic lung allograft ***,her lung function improved significantly after a spontaneous pneumothorax of the native lung resulting in auto-deflation of large *** This case highlights the clinical significance of native lung hyperinflation in single lung transplant recipient and how spontaneous decompression due to pneumothorax led to clinical improvement in our patient.

关键词： Native lung hyperinflation Single lung transplant Pneumothorax Bronchoscopic lung volume reduction Endobronchial valve case report

Increased locomotor activity in estrogen-treated ovariectomized rats is associated with nucleus accumbens dopamine and is not reduced by dietary sodium deprivation

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Integrative Zoology 2018年第6期13卷 783-794页

作者： Enith ESPINOSA kathleen S.cURTIS Oklahoma State University-center for Health Sciences TulsaOklahomaUSA

Estrogens are well known to increase locomotor activity in laboratory rodents;however,the underlying mechanism remains *** used voluntary wheel running by female rats as an index of locomotor behavior to investigate this *** first determined whether the estrogen-induced increase in locomotion was susceptible to inhibition by a physiological challenge,and next whether it was associated with dopaminergic activation in the central reward area,nucleus *** rats were given estradiol or the oil vehicle and housed in cages with or without running *** rats were given regular rodent chow for 1 week,a sodium-deficient diet for the next week,and then were returned to a regular diet for another *** the end of the last week,all rats were killed,brains were extracted and dopamine levels in the nucleus accumbens were *** expected,estradiol treatment increased distance ***,dietary sodium deprivation further increased running,but this appeared to be related to experience with wheel running,rather than to sodium deprivation,per *** was greater in the nucleus accumbens of estradiol-treated rats that ran compared to all other ***,the estrogen-induced increase in locomotion is a robust phenomenon that is not inhibited by a body sodium challenge and is associated with elevated levels of dopamine in reward *** findings raise the possibility that the estrogen-induced increase in locomotor activity,which occurs during a hormonal milieu conducive to reproduction,may reflect mate-seeking behavior and,thereby,maximize reproductive success.

关键词： locomotor activity reproductive hormones reward pathways