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Additive n.urorestorative effects of exercise an. docosahexaen.ic acid in.ake in.a mouse model of Parkin.on.s disease

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n.ural Regen.ration.Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Min.sa Mi-mba katherine Coulombe Cyn.ia Tremblay Vin.en.Émon. Martin. Sain.-Pierre Clémen.e Rouxel Lin. Berthiaume Pierre Julien.Fran.esca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe n.uroscien.e Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada In.titute of n.trition.an. Fun.tion.l Foods QuebecQCCanada Optin.tribrain.In.ern.tion.l Associated Laboratory(n.trin.uro FranceINAFCanada)QuebecQCCanada Axe En.ocrin.logie et n.phrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Départemen. de Médecin. Facultéde MédecineUniversitéLavalQuebecQCCanada Départemen. de Psychiatrie et n.uroscien.es Facultéde MédecineQuebecQCCanada

There is a n.ed to develop in.erven.ion. to slow or reverse the degen.ration.of dopamin. n.uron. in.Parkin.on.s disease after *** that preclin.cal an. clin.cal studies suggest ben.fits of dietary n.3 polyun.aturated fatty acids,such as docosahexaen.ic acid,an. exercise in.Parkin.on.s disease,we in.estigated whether both could syn.rgistically in.eract to in.uce recovery of the dopamin.rgic ***,mice received a un.lateral stereotactic in.ection.of 6-hydroxydopamin. in.o the striatum to establish an.an.mal model of n.grostriatal *** weeks after lesion.an.mals were fed a docosahexaen.ic acid-en.iched or a con.rol diet for the n.xt 8 *** this period,the an.mals had access to a run.in. wheel,which they could use or *** acid treatmen.,volun.ary exercise,or the combin.tion.of both had n. effect on.i)distan.e traveled in.the open.field test,(ii)the percen.age of con.raversive rotation. in.the apomorphin.-in.uction.test or(iii)the n.mber of tyrosin.-hydroxylase-positive cells in.the substan.ia n.gra pars ***,the docosahexaen.ic acid diet in.reased the n.mber of tyrosin.-hydroxylase-positive termin.ls an. in.uced a rise in.dopamin. con.en.ration. in.the lesion.d *** to docosahexaen.ic acid treatmen. or exercise alon.,the combin.tion.of docosahexaen.ic acid an. exercise(i)improved forelimb balan.e in.the steppin. test,(ii)decreased the striatal DOPAC/dopamin. ratio an.(iii)led to in.reased dopamin. tran.porter levels in.the lesion.d *** presen. results suggest that the combin.tion.of exercise an. docosahexaen.ic acid may act syn.rgistically in.the striatum of mice with a un.lateral lesion.of the dopamin.rgic system an. provide support for clin.cal trials combin.n. n.trition.an. physical exercise in.the treatmen. of Parkin.on.s disease.

关键词： 6-hydroxydopamin. dopamin. dopamin. tran.porter exercise n.urorestoration Parkin.on.s disease polyun.aturated fatty acids omega-3

Cuticular bacteria appear detrimen.al to social spiders in.mixed but n.t mon.culture exposure

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Curren. Zoology 2016年第4期62卷 377-384页

作者： Carl n. KEISER Taylor A. SHEARER lexan.er E. DEMARCO Hayley A. BRITTIn.HAM Karen.A. Kn.TSOn.Can.ice Kuo katherine ZHAO Jon.than.n. PRUITT Departmen. of Biological Scien.es University of Pittsburgh Pittsburgh PA 15260 USA

Much of an.an.mal＇s health status, life history, an. behavior are dictated by in.eraction. with its en.ogen.us an. exogen.us bacterial commun.ties. Un.ortun.tely, in.eraction. between.hosts an. members of their residen. bacterial commun.ty are often.ign.red in.an.mal behavior an. behavioral ecology. Here, we aim to iden.ify the n.ture of host-microbe in.eraction. in.a n.n.odel organ.sm, the African.social spider Stegodyphus dumicola. We collected an. iden.ified bacteria from the cuticles of spiders in.situ an. then.exposed spiders to bacterial mon.cultures cultures via topical application.or in.ection. We also topically in.culated spiders with a con.omitan. ＂cocktail＂ of bacteria an. measured the behavior of spiders daily for 24 days after in.culation. Lastly, we collected an. iden.ified bacteria from the cuticles of prey items in.the capture webs of spiders, an. then.fed spiders domestic crickets which had been.in.ected with these bacteria. We also in.ected 1 species of prey-born. bacteria in.o the hemolymph of spiders. On.y Bacillus thurin.ien.is caused in.reased mortality when.in.ected in.o the hemolymph of spiders, whereas n. bacterial mon.cultures caused in.reased mortality when.applied topically, relative to con.rol solution.. However, a bacterial cocktail of cuticular bacteria caused weight loss an. mortality when.applied topically, yet did n.t detectibly alter spider behavior. Con.umin. prey in.ected with prey-born. bacteria was associated with an.elon.ated lifespan.in.spiders. Thus, in.irect eviden.e from multiple experimen.s suggests that the effects of these bacteria on.spider survivorship appear con.in.en. on.their mode of colon.zation.an. whether they are applied in.mon.culture or within.a mixed cocktail. We urge that follow-up studies should test these host-microbe in.eraction. across differen. social con.exts to determin. the role that microbes play in.colon. performan.e.

关键词： cuticular bacteria sickn.ss behavior social spider Stegodyphus dumicola.

书写//后人类:作为认知集合的文学文本（英文）

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文艺理论研究 2018年第3期38卷 6-21页

作者： n.凯瑟琳·海耶斯杜克大学

后人类研究已经呈现出多种发展方向,借助其在计算机技术中的职能,或许可以绘制出其发展路径。本文认为,计算机媒体对后人类主义的传播及其概念化的过程影响深刻,并专门探讨数字技术对当下书写的重要作用。人类和计算机媒体通过认知集合... 详细信息

后人类研究已经呈现出多种发展方向,借助其在计算机技术中的职能,或许可以绘制出其发展路径。本文认为,计算机媒体对后人类主义的传播及其概念化的过程影响深刻,并专门探讨数字技术对当下书写的重要作用。人类和计算机媒体通过认知集合,可以参与各类互动,也可通过网络来流通信息、阐释和意义。本文选取的分析案例是两部电子文学文本:尼克·蒙特福特和史蒂芬妮·斯特里克兰德创作的《海与船柱之间》,以及约翰内斯·赫尔登和哈坎·琼森创作的《进化》。

关键词：后人类书写电子文学认知集合

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The role of emergen.y in.iden. type in.iden.ifyin. first respon.ers' health exposure risks

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Journ.l of Safety Scien.e an. Resilien.e 2023年第2期4卷 167-173页

作者： Emily J.Haas katherine n.Yoon.Alexa Furek Megan.Casey Susan.M.Moore n.tion.l Person.l Protective Techn.logy Laboratory(n.PTL) National Institute for Ocupational Safety and Health(NIOSH)PittsburghPA 15236United States n.tion.l Person.l Protective Techn.logy Laboratory(n.PTL) National Institute forOccupational Safety and Health(NIOSH)MorgantownWV2605United States

Fire-based emergen.y man.gemen. service(EMS)person.el are dispatched to various in.iden.s daily,man. of which have un.que occupation.l *** fully un.erstan. the variability of in.iden. types an. how to best pre-pare an. respon.,an.exploration.of the *** system of in.iden. types is *** study uses poten.ial exposure to SARS-CoV-2 as a case example to un.erstan. if an. how codin. categories for in.iden. call types may be updated to improve data stan.ardization.an. emergen.y respon.e decision.*** received emergen.y respon.e in.iden. data gen.rated by three fire departmen. computer-aided dispatch(CAD)systems between.March an. September *** in.iden. was labeled EMS,Fire,or *** the 162,766 in.iden.s,approximately 8.1%(n.13,144)n.ted poten.ial SARS-CoV-2 exposure within.their n.rrative description. of which 86.3%were coded as EMS,9.9%as Fire,an. 3.9%as *** assess codin. variability across in.iden. types,researchers used the origin.l 3-in.iden. type variable an. a n.w 5-in.iden. type variable reassign.d by researchers in.o EMS,Fire,Other,Hazmat,an. Motor *** regression. compared differen.es in.poten.ial exposure usin. the 3-an. 5-in.iden. type *** evaluatin. the 3-in.iden. type variable,those respon.-in. to a Fire versus an.EMS in.iden. were 84%less likely to be associated with poten.ial exposure to *** the 5-in.iden. type variable,those respon.in. to Fire in.iden.s were 77%less likely to be associated with a poten.ial exposure than.those respon.in. to EMS *** in.poten.ial exposure between.the 3-an. 5-in.iden. type models show the n.ed to un.erstan. how in.iden. types are *** demon.trates the n.ed for data stan.ardization.to accurately categorize in.iden. types to improve emergen.y preparedn.ss an. *** have implication. for in.iden. type codin. at fire departmen. mun.cipality an. n.tion.l levels.

关键词： Emergen.ymedical se Firefighter In.iden. type Surveillan.e Telecommun.cator

Thermodyn.mic an.lysis, syn.hesis, characterization. an. evaluation.of 1-ethyl-3-methylimidazolium chloride: Study of its effect on.pretreated rice husk

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Chin.se Journ.l of Chemical En.in.erin. 2023年第8期60卷 143-154页

作者： Eileen.katherine Coron.do-Aldan. Cin.y Lizeth Ferreira-Salazar n.bia Yin.th Piñeros-Castro Rubén.Vázquez-Medin. Felipe A.Perdomo Un.versidad de BogotáJorge Tadeo Lozan. Facultad de Ciencias Naturales e IngenieríaCra.422-61CundinamarcaBogotáColombia In.tituto Politecn.co n.cion.l CICATA QueretaroCerro Blanco 141Colinas del Cimatario76090 QueretaroMexico School of En.in.erin. University of EdinburghEdinburgh EH93FBUnited Kingdom

This work is focused on.the determin.tion.of the optimal reaction.con.ition. to syn.hesize the ion.c liquid 1-ethyl-3-methylimidazolium chloride([EMIM][Cl]) an. assess its suitability for the pretreatmen. of rice husk. The modified Un.FAC(Un.versal quasi-chemical Fun.tion.l-group Activity Coefficien.s)approach for ion.c liquids is used to develop a thermodyn.mic model that describes the reactive system methylimidazole(MIM), chloroethan.(C_(2)H_(5)Cl) an. [EMIM][Cl]. The model allows to study the phase equilibria coexisten.e(vapor–liquid equilibria an. solid–liquid equilibria) an. yields the theoretically optimal con.ition. to syn.hesize the ion.c liquid. The model prediction. are validated with the available experimen.al an. reported data. By implemen.in. the developed model, a simple way to syn.hesize ion.c liquid [EMIM][Cl] was foun. allowin. to study its in.luen.e on.the structure an. morphology of pretreated rice husk. The lign.cellulosic materials in.olved in.this study are characterized by their composition. en.ymatic digestibility, scan.in. electron.microscopy, an. crystallin.ty. Compared to un.reated material, [EMIM][Cl]-pretreated rice husk produces cellulose that can.be efficien.ly en.ymatic hydrolyzed with high sugar yields. This work offers a suitable methodology to in.lude the syn.hesis an. thermodyn.mics of the solven. media within.the design.of low-cost ion.c liquids for lign.cellulosic biomass pretreatmen..

关键词： Ion.c liquids Fluid-phase equilibria Thermodyn.mics Waste treatmen. Un.FAC approach

Cryogel scaffolds: soft an. easy to use tools for n.ural tissue culture

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n.ural Regen.ration.Research 2022年第9期17卷 1981-1983页

作者： Ben.n.wlan. katherine R.Lon. School of Pharmacy an. Pharmaceutical Scien.es Cardiff UniversityCardiffUK Cen.re for Developmen.al n.urobiology Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonMRC Centre for Neurodevelopmental DisordersKing’s College LondonLondonUK

The mammalian.cen.ral n.rvous system(Cn.)is highly complex,with a vast array of processes an. in.eraction. occurrin. in.a dyn.mic an. often.tran.ien. *** these processes are combin.d to regulate our behavior remain. poorly *** has in.turn.led to a lack of un.erstan.in. of how these processes have gon. awry in.the man. disorders of the n.rvous *** order to address this,researchers n.ed a con.rolled way to man.pulate the n.rvous system in.in.vitro an. ex vivo cultures,in.both a specific area an. for a specific period of time to start to pick apart these *** date,this has been.techn.cally challen.in.,especially when.modelin. focal in.ury to the Cn. or when.workin. with human.brain.tissue.

关键词： culture n.ural tran.ien.

A chemical ecological in.estigation.of the allelopathic poten.ial of Lamium amplexicaulean. Lamium purpureum

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Open.Journ.l of Ecology 2012年第4期2卷 167-177页

作者： Chelsea D. Jon.s katherine E. Woods William n. Setzer Departmen. of Chemistry University of Alabama in Huntsville Huntsville USA

The overall goal of the project was to test the hypothesis that Lamium amplexicaule an. Lamium purpureum, weedy in.asive species to n.rth America, use phytotoxic allelochemicals in.in.erplan. competition. The chemical composition. of the essen.ial oils from the aerial parts of L. amplexicaule an. L. purpureum have been.obtain.d by hydrodistillation.an. an.lyzed by gas chromatography-mass spectrometry. The essen.ial oils an. several essen.ial oil compon.n.s have been.screen.d for phytotoxic activity on.lettuce (Lactuca sativa) an. peren.ial ryegrass (Lolium peren.e) as well as n.matocidal activity again.t Caen.rhabditis elegan., brin. shrimp (Artemia salin.) lethality, an. in.ecticidal activity again.t the red imported fire an. (Solen.psis in.icta × richteri). L. amplexicaule essen.ial oil was composed largely of α-pin.n., β- pin.n., 1-octen.3-ol, (E)-caryophyllen., an. germacren. D, while L. purpureum oil was domin.ted by α-pin.n., β-pin.n., 1-octen.3-ol, β-elemen., an. germacren. D. n.ither essen.ial oil exhibited n.table phytotoxicity or lethality again.t n.ma-todes, brin. shrimp, or fire an.s. It is un.ikely, therefore, that the allelopathy observed in.these Lamium species is due to volatile phytochemical con.tituen.s.

关键词： Allelopathy Essen.ial Oil Composition Lamium amplexicaule Lamium purpureum

Thermodyn.mics of the Secon. Dissociation.Con.tan.s (pK2) of Piperazin.-n.n.-bis-2-hydroxypropan.sulfon.c Acid (POPSO Sesquisodium Salt) an. Associated Thermodyn.mic Fun.tion. from (278.15 to 328.15) K

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Journ.l of Biophysical Chemistry 2014年第4期5卷 143-151页

作者： Rabin.ra n. Roy Lakshmi n. Roy katherine E. Hun.ley Taylor R. Wehmeyer Lucas S. Tebbe Hoffman.Departmen. of Chemistry Drury University Springfield MO USA

The secon. acidic dissociation.con.tan.s of proton.ted piperazin.-n.n.-bis-2-hydroxypropan.-sulfon.c acid (POPSO sesquisodium salt) have been.determin.d at 12 differen. temperatures from (278.15 to 328.15) K in.ludin. 310.15 K. Electromotive-force measuremen. techn.que was used employin. hydrogen.silver chloride cells without liquid jun.tion. The results of pK2 are given.by the equation. pK2 = -1041.77/T + 51.0459 - 6.97646ln.. The un.ertain.y of the fit is ±0.0008. At 289.15 K, pK2 = 7.8029;whereas, at 310.15 K (body temperature), pK2 = 7.6862. Thus, the buffer solution. of POPSO an. its sodium salt are useful for pH con.rol in.the physiological pH region.of (7.0 to 8.5). The chan.es of Gibbs free en.rgy (G°), en.halpy (H°), en.ropy (S°) an. heat capacity Cp° were computed from the temperature derivative of the pK2 for the dissociation.of the zwitterion.c acid POPSO±-3 = POPSO-4 + H+ in.the stan.ard state. At 298.15 K, these results are compared with those of similar compon.n.s, which are the derivatives of the paren. compoun.s TAURIn., PIPERAZIn. an. MORPHOLIn..

关键词： pH Buffer Compoun. Liquid Jun.tion Thermodyn.mic Fun.tion. Activity Coefficien.s Electromotive-Force pK2

Fun.al in.ection.dyn.mics in.respon.e to temperature in.the lepidopteran.in.ect Galleria mellon.lla

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In.ect Scien.e 2018年第3期25卷 454-466页

作者： Vadim Y. Kryukov Olga n. Yaroslavtseva Miran.a M. A. Whitten.Maksim V. Tyurin.katherine J. Ficken.Carolyn.Greig n.dja R. Melo Viktor V. Glupov Ivan.M. Dubovskiy Tariq M. Butt In.titute of Systematics an. Ecology of An.mals Siberian Branch of Russian Academy of Science Novosibirsk Russia In.titute of Life Scien.e College of Medicine Swansea University Swansea Wales UK Departmen. of Bioscien.es College of Science Swansea University Swansea Wales UK

This study examin.s how the dyn.mics of fun.us-in.ect in.eraction. can.be modulated by temperature. The wax moth, Galleria mellon.lla, is a well-studied an. importan. model in.ect whose larvae in.the wild develop optimally at aroun. 34 ℃ in.beehives. However, surprisin.ly little research on.wax moths has been.con.ucted at relevan. temperatures. In.this study, the en.omopathogen.c fun.us Metarhizium robertsii in.licted rapid an. substan.ial mortality on.wax moth larvae main.ain.d at a con.tan. temperature of 24 ℃, but at 34 ℃ a 10 fold higher dose was required to achieve an.equivalen. mortality. The cooler temperature favored fun.al pathogen.city, with con.ial adhesion.to the cuticle, germin.tion.an. hemocoel in.asion.all sign.fican.ly en.an.ed at 24 ℃, compared with 34 ℃. The wax moth larvae immun. respon.es altered with the temperature, an. with the in.ective dose of the fun.us. En.yme-based immun. defen.es （lysozyme an. phen.loxidase） exhibited en.an.ed activity at the warmer temperature. A dramatic upregulation.in.the basal expression.of galiomicin.an. gallerimycin.was triggered by coolin., an. this was augmen.ed in.the presen.e of the fun.us. Profilin. of the predomin.n. in.ect epicuticular fatty acids revealed a 4-7 fold in.rease in.palmetic, oleic an. lin.leic acids in.larvae main.ain.d at 24 ℃ compared with those at 34 ℃, but these failed to exert fun.istatic effects on.topically applied fun.us. This study demon.trates the importan.e of choosin. en.iron.en.al con.ition. relevan. to the habitat of the in.ect host when.determin.n. the dyn.mics an. outcome of in.ect/fun.us in.eraction., an. has particular sign.fican.e for the application.of en.omopathogen. as biocon.rol agen.s.

关键词： biocon.rol en.omopathogen.c fun.us immun.ty Metarhizium temperature