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mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity

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Bone Research 2020年第4期8卷 393-405页

作者： Xin Yi Laura E.Wright Gabriel m.Pagnotti Gunes Uzer katherine m.powell Joseph m.Wallace Uma Sankar Clinton T.Rubin Khalid mohammad Theresa A.Guise William R.Thompson Department of Physical Therapy School of Health and Rehabilitation SciencesIndiana UniversityIndianapolisIN 46202USA Department of medicine Division of EndocrinologySchool of MedicineIndiana UniversityIndianapolisIN 46202USA Department of mechanical and Biomedical Engineering Boise State UniversityBoiseID 83725USA Department of Biomedical Engineering Purdue School of Engineering and TechnologyPurdue UniversityIndianapolisIN 46202USA Department of Anatomy&Cell Biology Indiana UniversityIndianapolisIN 46202USA Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA

Exercise benefits the musculoskeletal system and reduces the effects of *** effects of exercise are multifactorial,where metabolic changes and tissue adaptation influence *** signals,a principal component of exercise,are anabolic to the musculoskeletal system and restrict cancer *** examined the mechanisms through which cancer cells sense and respond to low-magnitude mechanical signals introduced in the form of ***-magnitude,high-frequency vibration was applied to human breast cancer cells in the form of low-intensity vibration(LIV).LIV decreased matrix invasion and impaired secretion of osteolytic factors PTHLH,IL-11,and ***,paracrine signals from mechanically stimulated cancer cells,reduced osteoclast differentiation and resorptive *** the nucleus by knockdown of SUN1 and SUN2 impaired LIV-mediated suppression of invasion and osteolytic factor *** increased cell stiffness;an effect dependent on the LINC *** data show that mechanical vibration reduces the metastatic potential of human breast cancer cells,where the nucleus serves as a mechanosensory apparatus to alter cell structure and intercellular signaling.

关键词： invasion impaired skeletal

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Alcohol associated liver disease and bariatric surgery:Current perspectives and future directions

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 650-657页

作者： katherine m Cooper Alessandro Colletta Nicholas Hebda Deepika Devuni Department of medicine UMass Chan Medical SchoolWorcesterMA 01655United States Division of Gastroenterology UMass Chan Medical SchoolWorcesterMA 01655United States

Bariatric surgery is a routinely performed procedure and is associated with a reduction in all-cause mortality in patients with ***,bariatric sur-gery has also been linked to increased alcohol use with up to 30%of these patients developing alcohol use disorder(AUD).The mechanism of AUD after bariatric surgery is multifactorial and includes anatomic,metabolic,and neurohumoral changes associated with post-surgical *** patients are at increased risk of alcohol associated liver disease and,in some cases,require liver *** this article,we provide a scoping review of epidemiology,patho-physiology,and clinical outcomes of alcohol-related health conditions after bariatric surgery.

关键词： Obesity medicine Alcohol use disorder Roux-en-Y gastric bypass Vertical sleeve gastrectomy Liver transplant Simultaneous liver transplant and bariatric surgery

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Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder

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World Journal of Psychiatry 2024年第1期14卷 159-178页

作者： Renee J Dufault katherine m Adler David O Carpenter Steven G Gilbert Raquel A Crider College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States Department of Health Sciences University of New HavenWest HavenCT 06516United States Institute for Health and the Environment School of Public HealthState University of New YorkAlbanyNY 12222United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Department of Statistics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

BACKGROUND Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations,creating conditions for the neurodevelopmental disorders known as autism and attention deficit/hyperactivity disorder(ADHD).Children with these disorders have difficulty metabolizing and excreting heavy metals from their bloodstream,and the severity of their symptoms correlates with the heavy metal levels measured in their *** may play a key role in helping parents reduce their ultra-processed food and dietary heavy metal intake by providing access to effective nutritional epigenetics *** To test the efficacy of nutritional epigenetics instruction in reducing parental ultra-processed food *** The study utilized a semi-randomized test and control group pretest-posttest pilot study design with participants recruited from parents having a learning-disabled child with autism or ***-two parents who met the inclusion criteria were randomly selected to serve in the test(n=11)or control(n=11)*** test group participated in the six-week online nutritional epigenetics tutorial,while the control group did *** efficacy of the nutritional epigenetics instruction was determined by measuring changes in parent diet and attitude using data derived from an online diet survey administered to the participants during the pre and post intervention *** intake scores were derived for both ultra-processed and whole/organic *** sample t-tests were conducted to determine any differences in mean diet scores within each *** There was a significant difference in the diet scores of the test group between the pre-and post-intervention *** parents in the test group significantly reduced their intake of ultra-processed foods with a preintervention diet score of 70(mean=5.385,SD=2.534)and a post-intervention diet score of 113(mean=8.692,SD=1.750)and the

关键词： Epigenomics Parenteral nutrition Autism Attention deficit/hyperactivity disorder Ultra-processed foods Heavy metals

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Sarcopenic obesity in patients awaiting liver transplant: Unique challenges for nutritional recommendations

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World Journal of Transplantation 2024年第2期14卷 40-47页

作者： Darya m Herscovici katherine m Cooper Alessandro Colletta michelle Rightmyer Alexandra Shingina Lauren D Feld Department of medicine UMass Chan Medical SchoolWorcesterMA 01655United States Division of Transplant Nutrition UMass Chan Medical SchoolWorcesterMA 01655United States Department of medicine Vanderbilt University Medical CenterNashvilleTN 37215United States Division of Gastroenterology UMass Chan Medical SchoolWorcesterMA 01655United States

Sarcopenic obesity increases the risk of mortality in patients with liver disease awaiting liver transplantation and in the post-transplant *** recommendations for individuals with sarcopenia differ from recommendations for patients with obesity or sarcopenic *** these nutrition guidelines have been established in non-cirrhotic patients,established guidelines for liver transplant candidates with sarcopenic obesity are *** this paper,we review existing literature on sarcopenic obesity in patients with chronic liver disease and address opportunities to improve nutritional counseling in patients awaiting liver transplantation.

关键词： Nutrition Sarcopenia Sarcopenic obesity Liver transplant Cirrhosis Chronic liver disease Body composition myostatin

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Association of initial assessment variables and mortality in severe pediatric traumatic brain injury

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World Journal of Pediatric Surgery 2024年第2期7卷 125-133页

作者： katherine C Bergus Kelli N Patterson Lindsey Asti Josh Bricker Tariku J Beyene Lauren N Schulz Dana m Schwartz Rajan K Thakkar Eric A Sribnick Pediatric Surgery Nationwide Children's HospitalColumbusOhioUSA CenterforSurgical Outcomes Research Nationwide Children's HospitalColumbusOhioUSA Neurologic Surgery The Ohio State UniversityColumbusOhioUSA Neurologic Surgery Nationwide Children's HospitalColumbusOhioUSA

Background Predictive scales have been used to prognosticate long-term outcomes of traumatic brain injury(TBI),but gaps remain in predicting mortality using initial trauma resuscitation *** sought to evaluate the association of clinical variables collected during the initial resuscitation of intubated pediatric severe patients with TBI with in-hospital *** Intubated pediatric trauma patientsma scale(GCS)score≤8)from January 2011 to December 2020 were *** between initial trauma resuscitation variables(temperature,pulse,mean arterial blood pressure,GCS score,hemoglobin,international normalized ratio(INR),platelet count,oxygen saturation,end tidal carbon dioxide,blood glucose and pupillary response)and mortality were evaluated with multivariable logistic *** Among 314 patients,median age was 5.5 years(interquartile range(IQR):2.2-12.8),GCS score was 3(IQR:3-6),Head Abbreviated Injury Score(hAIS)was 4(IQR:3-5),and most had a severe(25-49)Injury Severity Score(ISS)(48.7%,153/314).Overall mortality was 26.8%.GCS score,hAIS,ISS,INR,platelet count,and blood glucose were associated with in-hospital mortality(all pmortality *** 1-point increase in GCS score was associated with a 35%decrease in odds of *** hAIS,INR,and blood glucose increased,the odds of mortality *** each 1.0 unit increase in INR,the odds of mortality increased by 1427%.Conclusions Pediatric patients with severe TBI are at substantial risk for in-hospital *** are needed to examine whether earlier interventions targeting specific parameters of INR and blood glucose impact mortality.

关键词： mortality pediatric traumatic

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Dynamic energy system modeling using hybrid physics-based and machinelearning encoder–decoder models

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能源与人工智能(英文) 2022年第3期9卷 128-138页

作者： Derek machalek Jake Tuttle Klas Andersson Kody m.powell Department of Chemical Engineering University of UtahSalt Lake CityUTUnited States of America Taber International LLCUnited States of America Department of Space Earthand EnvironmentUniversity of ChalmersGothenburgSweden Department of mechanical Engineering University of UtahSalt Lake CityUTUnited States of America

Three model configurations are presented for multi-step time series predictions of the heat absorbed by thewater and steam in a thermal power plant. The models predict over horizons of 2, 4, and 6 steps into thefuture, where each step is a 5-minute increment. The evaluated models are a pure machine learning model, anovel hybrid machine learning and physics-based model, and the hybrid model with an incomplete dataset. Thehybrid model deconstructs the machine learning into individual boiler heat absorption units: economizer, waterwall, superheater, and reheater. Each configuration uses a gated recurrent unit (GRU) or a GRU-based encoder–decoder as the deep learning architecture. mean squared error is used to evaluate the models compared totarget values. The encoder–decoder architecture is over 11% more accurate than the GRU only models. Thehybrid model with the incomplete dataset highlights the importance of the manipulated variables to the *** hybrid model, compared to the pure machine learning model, is over 10% more accurate on averageover 20 iterations of each model. Automatic differentiation is applied to the hybrid model to perform a localsensitivity analysis to identify the most impactful of the 72 manipulated variables on the heat absorbed in theboiler. The models and sensitivity analyses are used in a discussion about optimizing the thermal power plant.

关键词： Hybrid model Encoder-decoder Time series Automatic differentiation Thermal power plant

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Primary and Secondary microplastic and Nanoplastic Regulations: Perspectives on Water Industry Impacts

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Journal of Environmental Protection 2024年第6期15卷 697-715页

作者： Shirin Estahbanati Giridhar Upadhyaya martha J. m. Wells katherine Y. Bell Brown and Caldwell New York NY USA Brown and Caldwell Irvine CA USA EnviroChem Services Cookeville TN USA Brown and Caldwell Nashville TN USA

Plastic pollution, both primary and secondary, is an environmental challenge, prompting regulatory actions at global and regional levels. With increasing research about the impacts of micro- and nanoplastics on ecosystems and human health, governments worldwide have undertaken efforts to address this issue. The global community has advanced regulatory efforts that have led to the implementation of national laws or regulations in numerous countries. These measures ban or restrict the use of primary and secondary microplastics and nanoplastics. An overview of global and European regulatory frameworks is presented to provide context for the United States (US). In the endeavor to document plastics regulation development in the US, a description of regulatory agencies and their roles in advancing policy and rules as well as future direction and areas for improvement in regulating plastics are introduced. A discussion of what emerging regulations mean to utilities and industries is also provided along with a comparison of regulatory frameworks.

关键词： microplastic Regulation Environmental Governance Plastic Pollution mitigation Regulatory Framework

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Arabidopsis ADC1 functions as an Nδ-acetylornithine decarboxylase

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Journal of Integrative Plant Biology 2020年第5期62卷 601-613页

作者： Yann-Ru Lou Sheaza Ahmed Jian Yan Adewale m.Adio Hannah m.powell Paul F.morris Georg Jander Boyce Thompson Institute for Plant Research IthacaNY 14853USA Department of Biological Sciences Bowling Green State UniversityBowling GreenOH 43403USA Key Laboratory of Agro-Environment in the Tropics Ministry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou 510642China Department of Biochemistry and molecular Biology Michigan State UniversityEast LansingMI 48824USA Bayer Crop Science 700 Chesterfield Parkway WestChesterfieldMO 63017USA

Polyamines are small aliphatic amines found in almost all organisms,ranging from bacteria to plants and *** most plants,putrescine,the metabolic precursor for longer polyamines,such as spermidine and spermine,is produced from arginine,with either agmatine or ornithine as *** we show that Arabidopsis thaliana(Arabidopsis)arginine de-carboxylase 1(ADC1),one of the two known arginine decarboxylases in Arabidopsis,not only synthesizes agmatine from arginine,but also converts *** to *** analyses indicate that duplication and neofunctionalization of ADC1 and NATA1,the enzymes that synthesize Nδ-acetylormithine in Arabidopsis,co-occur in a small number of related species in the *** ADC2,which is localized in the chloroplasts,ADC1 is in the endoplasmic reticulum together with NATA1,an indication that these two enzymes have access to the same substrate ***,these results are con-sistent with a model whereby NATA1 and ADC1 to-gether provide a pathway for the synthesis of N-acetylputrescine in Arabidopsis.

关键词： Arabidopsis Phylogenetic Together

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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Coordinated AR and microRNA regulation in prostate cancer

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Asian Journal of Urology 2020年第3期7卷 233-250页

作者： Ieva Eringyte Joanna N.Zamarbide Losada Sue m.powell Charlotte L.Bevan Claire E.Fletcher Imperial Centre for Translational and Experimental medicine Department of Surgery and CancerImperial College LondonHammersmith HospitalLondonUnited Kingdom

The androgen receptor(AR)remains a key driver of prostate cancer(PCa)progression,even in the advanced castrate-resistant stage,where testicular androgens are *** is therefore of critical importance to understand the molecular mechanisms governing its activity and regulation during prostate ***(miRs)are small w22 nt noncoding RNAs that regulate target gene,often through association with 30 untranslated regions(30UTRs)of *** display dysregulation during cancer progression,can function as oncogenes or tumour suppressors,and are increasingly recognised as targets or regulators of hormonal ***,understanding factors which modulate miRs synthesis is *** is increasing evidence for complex and dynamic bi-directional cross-talk between the multi-step miR biogenesis cascade and the AR signalling axis in *** review summarises the wealth of mechanisms by which miRs are regulated by AR,and conversely,how miRs impact AR’s transcriptional activity,including that of AR splice *** addition,we assess the implications of the convergence of these pathways on the clinical employment of miRs as PCa biomarkers and therapeutic targets.

关键词： microRNA Androgen receptor Androgen Prostate cancer Hormone Non-coding RNA

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