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Clinical Efficacy and Tolerability of Cimicoxib in Dogs with Osteoarthritis: A Multicentre Prospective Study

Open Journal of Veterinary Medicine 2014年第5期4卷 78-90页

作者： Joanna Murrell Erik Grandemange Frederique Woehrle Julie Menard kate white School of Veterinary Medicine and Science University of Nottingham Nottingham UK School of Veterinary Sciences University of Bristol Bristol UK Vetoquinol S.A. Centre de Recherche Lure France Vétoquinol S.A. Centre de Recherche Lure France Vétoquinol S.A. Paris France

Background: Cimicoxib is a coxib recently licensed in Europe for pain and inflammation associated with osteoarthritis (OA), and the management of perioperative pain due to orthopaedic or soft tissue surgery. Purpose: This prospective study was to complete the product information for the end users by providing additional scientific data obtained after a thirty-day treatment course of cimicoxib in dogs with OA, and to collect owners’ feedback. Data were collected from nine European countries with 492 client owned dogs recruited to the trial. Dogs were treated once daily with 2 mg/kg cimicoxib orally. Immediately before, at Day (D) 15 and D30 after the start of treatment veterinarians and owners scored body condition, appetite, locomotion, lameness, pain on palpation and manipulation of the joint and joint effusion (veterinarians) and dog demeanor and well being (owners). In a subset of dogs, serum urea (n = 191), creatinine (n = 184), AST (n = 141) and ALT (n = 174) were measured at day (D) 0 and D30. Statistical tests were carried out to detect significant changes in the clinical parameters with time. Results and Discussion: Veterinary and owner assessments were analysed from 236 and 215 dogs respectively. Improvements in locomotion, mobility, pain scores and dog demeanor and body condition were identified;outcome measures assessed by veterinarians continued to improve after 15 days of treatment up to the 30-day time point. At D30 a significantly higher number of dogs had an urea concentration superior to the upper limit of the reference range. However, there was no significant difference for creatinine, ALT and AST. Conclusions: A 30-day treatment course with cimicoxib improved locomotion and decreased pain scores in dogs with OA, with minimal adverse effects. These data, support pre-clinical data in dogs receiving cimicoxib and are useful for veterinarians making decisions about which NSAID to administer to dogs that require pain management for OA.

关键词： Osteoarthritis Dogs NSAID Cimicoxib Pain Analgesia Owner Kidney Renal Mobility

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A prospective study of time to healing and hypertrophic scarring in paediatric burns:every day counts

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Burns & Trauma 2017年第1期5卷 44-49页

作者： Elizabeth Chipp Lisa Charles Clare Thomas kate Whiting Naiem Moiemen Yvonne Wilson Burns Centre Birmingham Children’s HospitalSteelhouse LaneBirminghamUK

Background: It is commonly accepted that burns taking longer than 3 weeks to heal have a much higher rate of hypertrophic scarring than those which heal more quickly. However, some of our patients develop hypertrophic scars despite healing within this 3-week period. Methods: We performed a prospective study of 383 paediatric burns treated non-operatively at a regional burns centre over a 2-year period from May 2011 to April 2013. Scar assessment was performed by a senior burns therapist using the Vancouver Scar Scale. Results: Overall rates of hypertrophic scarring were 17.2%. Time to healing was the strongest predictor of developing hypertrophic scarring, and the earliest hypertrophic scar developed in a patient who was healed after 8 days. The risk of hypertrophic scarring was multiplied by 1.138 for every additional day taken for the burn wound to heal. There was a trend towards higher rates of hypertrophic scarring in non-white skin types but this did not reach statistical significance. Conclusions: The risk of hypertrophic scarring increases with every day and, therefore, every effort should be made to get the wound healed as quickly as possible, even within the traditional 3-week period usually allowed for healing. We believe that the traditional dogma of aiming for healing within 3 weeks is overly simplistic and should be abandoned: in paediatric burns, every day counts.

关键词： Scar Hypertrophic Burn Time to healing Paediatric Skin type

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Cluster size distribution of cancer cells in blood using stopped-flow centrifugation along scale-matched gaps of a radially inclined rail

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Microsystems & Nanoengineering 2015年第1期1卷 97-105页

作者： Macdara Glynn Charles Nwankire kate Lemass David J.Kinahan Jens Ducrée Biomedical Diagnostics Institute National Centre for Sensor ResearchSchool of Physical SciencesDublin City UniversityIreland

There is increasing evidence that,in addition to their presence,the propensity of circulating tumour cells to form multi-cellular clusters bears significant information about both cellular resistance to chemotherapy and overall *** present a novel two-stage,stopped-flow,continuous centrifugal sedimentation strategy to measure the size distributions of events(defined here as cells or clusters thereof)in a blood *** off-chip removal of red blood cells,healthy white blood cells are sequestered by *** purified events are then resolved along a radially inclined rail featuring a series of gaps with increasing width,each connected to a designated outer collection *** isolation of candidate events independent of targetspecific epitopes is successfully demonstrated for HL60(EpCAM positive)and sk-mel28(EpCAM negative)cells using identical protocols and *** propensity to form clusters was quantified for a number of cell lines,showing a negligible,moderate or elevated tendency towards cluster *** show that the occupancy distribution of the collection bins closely correlates with the range of cluster sizes intrinsic to the specific cell line.

关键词： centrifugal microfluidics lab-on-a-disc cancer diagnostics cellular clustering

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Neonatal neuroimaging after repair of congenital diaphragmatic hernia and long-term neurodevelopmental outcome

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World Journal of Pediatric Surgery 2019年第3期2卷 2-8页

作者： Julia kate Gunn-Charlton Alice C Burnett Stephanie Malarbi Margaret M Moran Esther A Hutchinson Susan Greaves Rod W Hunt Newborn Intensive Care The Royal Children’s HospitalMelbourneVictoriaAustralia Neonatal Research Group Murdoch Children’s Research InstituteMelbourneVictoriaAustralia Department of Paediatrics The University of MelbourneMelbourneVictoriaAustralia Victorian Infant Brain Studies(VIBeS)Group Murdoch Children's Research InstituteMelbourneVictoriaAustralia Department of Occupational Therapy The Royal Children’s HospitalMelbourneVictoriaAustralia

Objective Previous outcome reports of congenital diaphragmatic hernia(CDH)have described neuroimaging anomalies and neurodevelopmental ***,the link between imaging and outcome has not been *** aimed to determine whether routine postoperative neonatal neuroimaging in infants with CDH detects later neurodevelopmental *** In a prospective cohort study within a clinical service in The Royal Children’s Hospital Newborn Intensive *** ultrasound was performed in 81 children and MRI in 57 children who subsequently underwent neurodevelopmental follow-up after surgery for *** scans were analyzed using a scoring system designed to identify injury,maturation and volume *** assessment occurred at 2 years(48)and neurocognitive assessment at 5 years(26)and/or 8 years(27).Brain imaging scores corrected for gestational age at scan time were correlated with outcome measures,adjusting for known clinical *** Clinically significant findings were identified on MRI of 16(28%)*** scores were in the normal range for all domains assessed at each *** impairment was seen in 23%at 2 years and verbal intellectual impairment in 25%at 8 *** cognitive scores were lower in 2-year-old children with white matter injury on MRI(p=0.03).Mean motor scores were lower in 2-year-old children with brain immaturity(p=0.01).Associations between MRI and 5-year and 8-year assessments were no longer significant when adjusting for known clinical *** Neuroimaging abnormalities were associated with worse neurodevelopment at 2 years,but not with later neurocognitive outcomes,after accounting for clinical risk factors.

关键词： hernia routine maturity

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A solution scan of societal options to reduce transmission and spread of respiratory viruses:SARS-CoV-2 as a case study

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Journal of Biosafety and Biosecurity 2021年第2期3卷 84-90页

作者： William J.Sutherland Nigel G.Taylor David C.Aldridge Philip Martin Catherine Rhodes Gorm Shackelford Simon Beard Haydn Belfield Andrew J.Bladon Cameron Brick Alec P.Christie Andrew P.Dobson Harriet Downey Amelia S.C.Hood Fangyuan Hua Alice C.Hughes Rebecca M.Jarvis Douglas MacFarlane William H.Morgan Anne-ChristineMupepele Stefan J.Marciniak Cassidy Nelson SeánÓhÉigeartaigh Clarissa Rios Rojas Katherine A.Sainsbury Rebecca K.Smith Lalitha S.Sundaram Ann Thornton John Watkins Thomas B.white kate Willott Silviu O.Petrovan BioRISC(Biosecurity Research Initiative at St Catharine’s) St Catharine’s CollegeCambridge CB21RLUK Department of Zoology University of CambridgeThe David Attenborough BuildingPembroke StreetCambridge CB23QZUK Tour du Valat Research Institute for the Conservation of Mediterranean Wetlands13200 ArlesFrance Centre for the Study of Existential Risk University of CambridgeCB21SBUK Department of Social Psychology University of AmsterdamNieuwe Achtergracht 129 B1018 WT AmsterdamNetherlands Department of Ecology and Evolutionary Biology 117 Eno HallPrinceton UniversityNJ 08544USA Institute of Ecology College of Urban and Environmental SciencesPeking UniversityBeijing 100871PR China Centre for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesXishuangbannaYunnan 666303PR China Te Kura Putaiao-School of Science Auckland University of TechnologyAucklandNew Zealand School of Psychological Sciences University of Western AustraliaPerth35 Stirling HwyCrawley WA 6009Australia Nature Conservation and Landscape Ecology Biometry and Environmental System AnalysisUniversity of FreiburgGermany Cambridge Institute for Medical Research University of CambridgeCambridge Biomedical CampusThe Keith Peters BuildingHills RoadCambridge CB20XYUK Future of Humanity Institute University of OxfordOxford OX11PTUK Faculty of Kinesiology Sportand RecreationUniversity of Alberta2-130V Van Vliet 21 Complex(University Hall)EdmontonAlberta T6G 2H9Canada Division of Population Medicine School of MedicineCardiff UniversityCardiff CF144YSUK

Societal biosecurity–measures built into everyday society to minimize risks from pests and diseases–is an important aspect of managing epidemics and *** aimed to identify societal options for reducing the transmission and spread of respiratory *** used SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)as a case study to meet the immediate need to manage the COVID-19 pandemic and eventually transition to more normal societal conditions,and to catalog options for managing similar pandemics in the *** used a‘solution scanning’*** read the literature;consulted psychology,public health,medical,and solution scanning experts;crowd-sourced options using social media;and collated comments on a ***,we present a list of 519 possible measures to reduce SARS-CoV-2 transmission and *** provide a long list of options for policymakers and businesses to consider when designing biosecurity plans to combat SARS-CoV-2 and similar pathogens in the *** also developed an online application to help with this *** encourage testing of actions,documentation of outcomes,revisions to the current list,and the addition of further options.

关键词： Biosecurity Coronavirus COVID-19 Disease control New normal Public health

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内镜自体荧光成像技术将提高Barrett食管早期瘤检测率

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世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 30-31页

作者： Kara M.A. Peters F.P. Ten kate F.J.W. J.J.G.H.M. Bergman 赵天智 Dept. of Gastroenterol. and Hepatol. Academic Medical Center Meibergdreef 9 1105 AZ Amsterdam Netherlands Dr.

Background: The aim of this study was to investigate the feasibility of detecting high-grade dysplasia (HGD) and early cancer (EC) in Barrett’s esophagus (BE) with a prototype video autofluorescence endoscope. Methods: Sixty patients with BE were evaluated with a prototype, high-resolution video-endoscope that has separate charge-coupled devices for white light endoscopy (WLE) and autofluorescence imaging (AFI). Nondysplastic BE appears green on AFI, whereas potentially neoplastic areas appear blue/violet. The BE was first screened with WLE for visible abnormalities and then was examined by AFI to detect additional lesions. Lesions that raised a suspicion of neoplasia and control areas that were normal on AFI were sampled for histopathologic assessment. Finally, random 4-quadrant biopsy specimens were obtained at 2-cm intervals. Results: A diagnosis of HGD/EC was made in 22 patients; one patient had no visible abnormality, and 21 had endoscopically detectable areas with HGD/EC. In 6 of the latter 21 patients, the HGD/EC was detected with AFI alone; in another patient, HGD/EC was detected with AFI and random biopsies. In 14 patients, HGD/EC was detected with both WLE and AFI; in 3 of these 14 patients, additional lesions containing HGD/EC were detected by AFI alone. Conclusions: The results of this study suggest that video AFI may improve the detection of HGD/EC in patients with BE.

关键词： Barrett 自体荧光不典型增生瘤形成早期癌变组织病理学屏幕显示天智高分辨率四象限

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“超越团队界线”的影响力艺术

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职业 2008年第22期 21-21页

作者：云中飞 Erin white

今年早些时候,国际商业机器公司(International Business Machines Corp.)的一位经理凯特塔南特(kate Riley Tennant)希望重新分配部分工程师的工作。但是,这些员工并不归她领导。她必须说服几千英里之外的同事决定此事。

关键词：影响力培训课程界线客户化南特

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