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Changes in lipid metabolism in chronic hepatitis C

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World Journal of Gastroenterology 2005年第41期11卷 6422-6428页

作者： katalin Jármay Gizella Karácsony András Nagy Zsuzsa Schaff First Department of Internal Medicine Albert Szent-Gy(o|¨)rgyi Medical University SzegedHungary County Hospital Department of Cardiology KecskemétHungary 2nd Department of Pathology Semmelweis University BudapestHungary

AIM: To investigate the relationship between certain biochemical parameters of lipid metabolism in the serum and steatosis in the ***: The grade of steatosis (0-3) and histological activity index (HAI, 0-18) in liver biopsy specimens were correlated with serum alanine aminotransferase (ALT), total cholesterol and triglyceride levels in 142 patients with chronic hepatitis C (CH-C), and 28 patients with non-alcoholic fatty liver disease (NAFLD) without hepatitis C virus (HCV) infection. The serum parameters were further correlated with 1 797 age and sex matched control patients without any liver ***: Steatosis was detected in 90 out of 142 specimens (63%) with CH-C. The ALT levels correlated with the grade of steatosis, both in patients with CH-C and NAFLD (P＜0.01). Inserting the score values of steatosis as part of the HAI, correlation with the ALT level (P＜0.00001) was found. The triglyceride and cholesterol levels were significantly lower in patients with CH-C (with and without steatosis), compared to the NAFLD group and to the virus-free control ***: Our study confirms the importance of liver steatosis in CH-C which correlates with lower lipid levels in the sera. Inclusion of the score of steatosis into HAI, in case of CH-C might reflect the alterations in the liver tissue more precisely, while correlating with the ALT enzyme elevation.

关键词： Lipid metabolism, Chronic hepatitis C NAFLD

New serological markers in pediatric patients with inflammatory bowel disease

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World Journal of Gastroenterology 2014年第17期20卷 4873-4882页

作者： Márta Kovács katalin Eszter Müller Mária Papp Péter László Lakatos Mihály Cs?ndes Gábor Veres Department of Pediatrics Petz Aladár County and Teaching Hospital9023 Gy?rHungary 1~(st) Department of Pediatrics Semmelweis University1083 BudapestHungary 2~(nd) Department of Medicine University of Debrecen4032 DebrecenHungary 1~(st) Department of Medicine Semmelweis University1083 BudapestHungary Department of Gastroenterology Petz Aladár County and Teaching Hospital9023 Gy?rHungary

The spectrum of serological markers associated with inflammatory bowel disease (IBD) is rapidly growing. Due to frequently delayed or missed diagnoses, the application of non-invasive diagnostic tests for IBD, as well as differentiation between ulcerative colitis (UC) and Crohn’s disease (CD), would be useful in the pediatric population. In addition, the combination of pancreatic autoantibodies and antibodies against Saccharomyces cerevisiae antibodies/perinuclear cytoplasmic antibody (pANCA) improved the sensitivity of serological markers in pediatric patients with CD and UC. Some studies suggested that age-associated differences in the patterns of antibodies may be present, particularly in the youngest children. In CD, most patients develop stricturing or perforating complications, and a significant number of patients undergo surgery during the disease course. Based on recent knowledge, serum antibodies are qualitatively and quantitatively associated with complicated CD behavior and CD-related surgery. Pediatric UC is characterized by extensive colitis and a high rate of colectomy. In patients with UC, high levels of anti-CBir1 and pANCA are associated with the development of pouchitis after ileal pouch-anal anastomosis. Thus, serologic markers for IBD can be applied to stratify IBD patients into more homogeneous subgroups with respect to disease progression. In conclusion, identification of patients at an increased risk of rapid disease progression is of great interest, as the application of early and more aggressive pharmaceutical intervention could have the potential to alter the natural history of IBD, and reduce complications and hospitalizations.

关键词： Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Pediatric, Serologic markers, Antimicrobial antibodies, Anti-glycan antibodies, Pancreatic antibodies, Inflammatory bowel disease

Quality control,validation and user feedback of the European Flood Alert System(EFAS)

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International Journal of Digital Earth 2011年第S01期4卷 77-90页

作者： Ad De Roo Jutta Thielen Peter Salamon Konrad Bogner Sebastien Nobert Hannah Cloke David Demeritt Jalal Younis Milan Kalas katalin Bodis Davide Muraro Florian Pappenberger European Commission Joint Research Centre(JRC)IspraItaly European Centre for Medium Range Weather Forecast(ECMWF) ReadingUK Department of Geography King’s College LondonLondonUK Czech Hydrometeorological Institute PragueCzech Republic

The quality control,validation and verification of the European Flood Alert System(EFAS)are *** is designed as a flood early warning system at pan-European scale,to complement national systems and provide flood warnings more than 2 days before a *** average 2030 alerts per year are sent out to the EFAS partner network which consists of 24 National hydrological authorities responsible for transnational river *** control of the system includes the evaluation of the hits,misses and false alarms,showing that EFAS has more than 50%of the time ***,the skills of both the meteorological as well as the hydrological forecasts are evaluated,and are included here for a 10-year ***,end-user needs and feedback are systematically *** improvements,such as real-time river discharge updating,are currently implemented.

关键词： flood warning forecasting EFAS probabilistic skill

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激光弯曲机理的试验研究

北京航空航天大学学报 2002年第4期28卷 473-476页

作者：王秀凤 Janos takacs Gyorgy Krallics 北京航空航天大学机械工程及自动化学院 Budapest University of Technology and Economics

通过对试件在激光与材料非熔凝作用下动态变形过程的实时测量及光斑中心处横截面的金相分析 ,得知激光弯曲变形是热应变和相变共同作用的结果 .试验结果表明 :激光弯曲变形的大小和方向取决于材料吸收的能量、材料特性和材料的厚度 ,并... 详细信息

通过对试件在激光与材料非熔凝作用下动态变形过程的实时测量及光斑中心处横截面的金相分析 ,得知激光弯曲变形是热应变和相变共同作用的结果 .试验结果表明 :激光弯曲变形的大小和方向取决于材料吸收的能量、材料特性和材料的厚度 ,并给出了这些影响因素的变化规律 .研究结果进一步完善了激光弯曲的变形机理。

关键词：试验研究激光加工热应变相变激光弯曲机理柔性成形加工

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氟喹诺酮类抗菌药物的亲脂性

国外医药（抗生素分册） 1993年第3期14卷 209-212,217页

作者： takacs-Novák K 郭育红苗华

众所周知,像培氟沙星、诺氟沙星、环丙沙星、氧氟沙星、洛美沙星(结构见图1)等,都是近年开发的高效口服喹诺酮类抗菌药。

关键词：氟喹诺酮抗菌素亲脂性

Elevated miR-33a and miR-224 in steatotic chronic hepatitis Cliver biopsies

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World Journal of Gastroenterology 2014年第41期20卷 15343-15350页

作者： Gabor Lendvai katalin Jármay Gizella Karácsony Tünde Halász Ilona Kovalszky Kornélia Baghy Tibor Wittmann Zsuzsa Schaff András Kiss MTA-SE Tumor Progression Research Group Semmelweis University 1st Department of Medicine University of Szeged 2nd Department of Pathology Semmelweis University 1st Department of Pathology and Experimental Cancer Research Semmelweis University

AIM: To assess the expression of selected microRNAs (miRNA) in hepatitis C, steatotic hepatitis C, noninfected steatotic and normal liver tissues.

关键词： Chronic hepatitis C Steatosis MicroRNA Expression miR-33a miR-224

Response of <i>Arabidopsis</i>Clones to Toxic Compounds Released by Various <i>Rhizoctonia</i>Species

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American Journal of Plant Sciences 2014年第3期5卷 364-371页

作者： Gyula Oros András Bittsánszky katalin Pilinszky Plant Protection Institute of the Centre for Agricultural Research of the Hungarian Academy of Sciences Budapest Hungary

Response of 3 Arabidopsis clones to 41 strains of eight Rhizoctonia species was studied in model experiments. The seed germination was decelerated in most of the cases, although the inhibitory effect varied within large limits. The pre-emergence damping off and root neck rot leading to damping off were the most frequent symptoms of disease syndrome caused by toxic metabolites. The clone transformed with cDNA clone overexpressing gstf4 gene exhibited significantly improved tolerance as compared to parental one, meanwhile the sensitivity of Dmannose pyrophosphorylase/mannose-1-pyrophosphatase deficient clone dramatically increased. Strains of R. solani of AG-2, AG-4 and AG-7 and Athelia rolfsii produced the most toxic metabolites, however, no strict relationships were revealed between taxonomic position of Rhizoctonia strains and toxicity of their metabolites.

关键词： Arabidopsis Rhizoctonia Toxin Athelia Ceratobasidium Ceratorhiza Thanatephorus Waitea

Diagnostic procedures for submucosal tumors in the gastrointestinal tract

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World Journal of Gastroenterology 2007年第24期13卷 3301-3310页

作者： Laura Graves Ponsaing katalin Kiss Annika Loft Lise Ingemann Jensen Mark Berner Hansen Department of Surgical Gastroenterology K Bispebjerg University Hospital of Copenhagen Denmark Department of Pathology Herlev University Hospital Gentofte Denmark Department of Nuclear Medicine CopenhagenUniversity Hospital Rigshospitalet Denmark Department of Radiology Bispebjerg University Hospital of Copenhagen Denmark

This review is part one of three, which will present an update on diagnostic procedures for gastrointestinal (GI) submucosal tumors (SMTs). Part two identifies the classification and part three the therapeutic methods regarding GI SMTs. Submucosal tumors are typically asymptomatic and therefore encountered incidentally. Advances in diagnostic tools for gastrointestinal submucosal tumors have emerged over the past decade. The aim of this paper is to provide the readers with guidelines for the use of diagnostic procedures, when a submucosal tumor is suspected. Literature searches were performed to find information on diagnostics for gastrointestinal submucosal tumors. Based on the searches, the optimal diagnostic procedures and specific features of the submucosal tumors could be outlined. Standard endoscppy, capsule endoscopy and push-and-pull enteroscopy (PPE) together with barium contrast X-ray do not alone provide sufficient information, when examining submucosal tumors. Endoscopic ultrasound (EUS), computed tomography (CT), magnetic resonance imaging (MRI) and fluorodeoxyglucose-labeled positron emission tomography (FDG-PET) are recommended as supplementary tools.

关键词： Submucosal tumor Diagnosis Endoscopy Endoscopic ultrasonography Computed tomography Magnetic resonance imaging Positron emission tomography Capsule endoscopy Push-and-pull enteroscopy Ponsaing LG, Kiss K, Loft A, Jensen LI, Hansen MB.

用塞曼双频激光器作光源的一种新颖长扫描表面的仪器设计(英文)

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光学学报 1991年第4期11卷 294-300页

作者：林跃 PETERZ.takacs 王润文陈祥祯 Instrumentation Division Brookhaven National LaboratoryUptonNY.11973U.S.A. 中国科学院上海光学精密机械研究所

本文报道一套光学结构用于同步辐射反射镜表面轮廓高精度大面积的测量。采用了光学外差测量与接收技术,以伺服聚焦双折射透镜组分离“o”光与“e”光的聚焦区域,并再共轴组合比较其相位差,从而获得表面起伏的误差值。线性运动的测量工... 详细信息

本文报道一套光学结构用于同步辐射反射镜表面轮廓高精度大面积的测量。采用了光学外差测量与接收技术,以伺服聚焦双折射透镜组分离“o”光与“e”光的聚焦区域,并再共轴组合比较其相位差,从而获得表面起伏的误差值。线性运动的测量工作台使镜面可测量范围从数微米到一米,而最小起伏量及曲率可达很高的测量精度。

关键词：轮廓仪激光器光外差反射镜