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Compared efficacy of preservation solutions on the outcome of liver transplantation:meta-analysis

World Journal of Gastroenterology 2018年第16期24卷 1812-1824页

作者： Agnes Lilla Szilágyi Péter mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami margit Solymár Erika Pétervári márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann Institute of Surgical Research University of SzegedSzeged H-6720Hungary Institute of Bioanalysis University of PécsPécs H-7624Hungary Institute for Translational medicine and First Department of medicine University of PécsPécs H-7624Hungary mTA-SZTE Translational Gastroenterology Research Group Szeged H-6720Hungary János Szentágothai Research Center University of PécsPécs H-7624Hungary 1^st Department of Paediatrics University of SemmelweisBudapest H-1085Hungary Department of Cardiology 1^st Department of MedicineUniversity of PécsPécs H-7624Hungary

AIm To compare the effects of the four most commonly used preservation solutions on the outcome of liver *** A systematic literature search was performed using mEDLINE, Scopus, EmBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent *** Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted.

关键词： Liver transplantation Preservation solution Primary non-function One-year post-transplant graft survival Systematic review meta-analysis

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Alteration of Cylindrospermopsin Content of <i>Aphanizomenon ovalisporum</i>(Cyanobacteria, Nostocales) due to Step-Down from Combined Nitrogen to Dinitrogen

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Advances in microbiology 2013年第8期3卷 557-564页

作者： Gábor Vasas Gyula Surányi István Bácsi márta m-Hamvas Csaba máthé Sándor Gonda George Borbely Department of Botany Faculty of Science University of Debrecen Debrecen Hungary Department of Hidrobiology Faculty of Science University of Debrecen Debrecen Hungary

In this study we show that cylindrospermopsin (a cyanotoxin) content of filaments of Aphanizomenon ovalisporum ILC164 depended on growth on combined nitrogen or nitrogen fixation. Our results also demonstrated that the shift down of cyanobacterial filaments from combined nitrogen to dinitrogen fixing condition resulted in a significant decrease of cylindrospermopsin pool size which resumed a growth rate dependent manner as the heterocyst and nitrogenase formation appeared. The current study indicated that alteration of nitrogen metabolism of Aphanizomenon ovalisporum (Forti) induced changes in cyanotoxin (cylindrospermopsin) metabolism. In addition, this is the first report that isolated heterocysts, the differentiated anaerobic cells for nitrogen fixation of cyanobacteria, did not contain cylindrospermopsin.

关键词： Cylindrospermopsin Cyanobacteria Heterocyst Nitrogen Starvation Nitrogenase Cyanotoxin

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Plasma carnitine ester profile in adult celiac disease patients maintained on long-term gluten free diet

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World Journal of Gastroenterology 2005年第42期11卷 6671-6675页

作者： Judit Bene katalin Komlósi Beáta Gasztonyi márk Juhász Zsolt Tulassay Béla melegh Department of medical Genetics and Child Development School of medicine University of Pécs Hungary MTA PTE Clinical Genetics Research Group of Hungarian Academy of Sciences at the University of Pécs Hungary Department of medical Genetics and Child Development School of medicine University of Pécs Hungary 1st Department of medicine School of medicine University of Pécs Hungary 2nd Department of medicine Semmelweis University Budapest Hungary

AIm： To determine the fasting plasma carnitine ester in patients with celiac disease. mETHODS： We determined the fasting plasma carnitine ester profile using ESI triple quadrupol mass spectrometry in 33 adult patients with biopsy-confirmed maturity onset celiac disease maintained on long term gluten free diet. RESULTS： The level of free camibine did not differ as the celiac disease patients were compared with the healthy controls, whereas the acetylcarnitine level was markedly reduced （4.703± 0.205 vs 10.227 ± 0.368 nmol/mL, P〈0.01）. The level of propionylcarnitine was 61.5%, butyrylcarnitine 56.9%, hexanoylcarnitine 75%, octanoylcarnitine 71.1%, octenoylcarnitine 52.1%, decanoylcarnitine 73.1%, cecenoylcarnitine 58.3%, lauroylcarnitine 61.5%, miristoylcarnitine 66.7%, miristoleylcarnitine 62.5% and oleylcarnitine 81.1% in the celiac disease patients compared to the control values, respectively （P〈0.01）. CONCLUSION： The marked decrease of circulating acetylcarnitine with 50-80 % decrease of 11 other carnitine esters shows that the carnitine ester metabolism can be influenced even in clinically asymptomatic and well being adult celiac disease patients, and gluten withdrawal alone does not necessarily normalize all elements of the disturbed carnitine homeostasis.

关键词： Plasma carnitine ester profile Celiac disease

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Clinical relevance of changes in bone metabolism in inflammatory bowel disease

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World Journal of Gastroenterology 2010年第44期16卷 5536-5542页

作者： Pal miheller katalin Lrinczy Peter Laszlo Lakatos 1st Department of medicine Semmelweis University

Low bone mineral density is an established, frequent, but often neglected complication in patients with inflammatory bowel disease (IBD). Data regarding the diagnosis, therapy and follow-up of low bone mass in IBD has been partially extrapolated from postmenopausal osteoporosis; however, the pathophysiology of bone loss is altered in young patients with IBD. Fracture, a disabling complication, is the most important clinical outcome of low bone mass. Estimation of fracture risk in IBD is difficult. Numerous risk factors have to be considered, and these factors should be weighed properly to help in the identification of the appropriate patients for screening. In this editorial, the authors aim to highlight the most important clinical aspects of the epidemiology, prevention, diagnosis and treatment of IBD-related bone loss.

关键词： Inflammatory bowel disease Crohn’s disease Osteoporosis Osteopenia Prevention

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基于短视频平台的企业广告内容特征对用户品牌认知的影响研究

基于短视频平台的企业广告内容特征对用户品牌认知的影响研究

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作者： katalin CHEN 上海交通大学

学位级别：硕士

随着移动互联网的迅速发展,用户的触媒习惯也在逐渐发生改变,集碎片化和内容化于一体的移动短视频成为用户接受各类信息的主要载体。用户对优质内容的巨大需求及其时间碎片化现象的日趋明显,使短视频与短视频平台在有效传递信息及提升... 详细信息

随着移动互联网的迅速发展,用户的触媒习惯也在逐渐发生改变,集碎片化和内容化于一体的移动短视频成为用户接受各类信息的主要载体。用户对优质内容的巨大需求及其时间碎片化现象的日趋明显,使短视频与短视频平台在有效传递信息及提升用户认知方面极具潜力;因此,本研究从企业广告内容的角度出发,旨在探讨企业广告内容特征对用户品牌认知的影响。本研究使用实证研究法,设计了两组组间实验,探讨了企业广告内容的关键特征(幽默和热情)与用户品牌认知之间的主效应关系;此外还将沉浸体验与卷入度纳入研究,探讨两者在主关系中是否具有中介作用与调节作用。通过对实验数据的分析,证实了企业广告内容关键特征对用户的品牌认知具有显著且直接的影响;实验1通过独立样本T检验证明了幽默特征与热情特征的广告内容分别对用户的品牌认知存在直接影响。此外通过实验2验证了沉浸体验在该关系中具有中介作用,即企业广告内容关键特征显著正向影响个体的沉浸体验,进而显著正向影响其品牌认知。但对调节作用的分析表明,卷入度在该关系中仅起到部分调节作用,即在热情特征对用户的品牌认知的影响中,卷入度具有显著的调节作用;但在幽默特征对用户品牌认知的影响中,卷入度不具有显著性,亦说明其不具有调节作用。

关键词：短视频广告内容特征沉浸体验卷入度品牌认知

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Graphene Oxide Application in Cement-Bound materials-State of the Art

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材料科学与工程（中英文B版） 2021年第4期11卷 144-155页

作者： katalin Kopecskó Zaid Ali Abdulhussein Khaiqani Faculty of Civil Engineering Budapest University of Technology and EconomicsMűegyetem rakpart 3Budapest 1111Hungary

In recent years,the incorporation of nanoparticles in the cementitious matrix has been regarded as a prominent strategy in the research *** paper reviews the influences of the nanomaterial GO(graphene oxide)in cement bound materials,as GO has become one of the most well-known inclusion nanoparticles in the cementitious matrix in the last few *** study describes(i)the influences of the GO on enhancing hydration mechanism in the cementitious materials;and(ii)the improved performance of the cementitious materials,which are highly dependent on the functionalizing behavior of the *** this improves the properties of the *** paper reports the influences of GO on the workability of the mixtures and the durability enhancement of the cementitious ***,it demonstrates promising results of employing GO in the fabrication of novel building ***,tremendous progress in utilizing GO in scientific domains like materials technology has achieved a significant *** progress has been achieved by applying the GO in different fields such as solar cells and super ***,more intensive research is required to achieve comparable improvement in building materials which constitutes a significant future challenge.

关键词： materials. durability utilizing

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匈牙利土地管理制度及其对中国的借鉴

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东南学术 2009年第2期 72-82页

作者：林卿林翊王荧 Gombas katalin[匈] 福建师范大学经济学院教授、博士生导师福建师范大学经济学院博士研究生匈牙利西匈牙利大学地球信息学院

丰富的土地资源是匈牙利国家最为宝贵的财富,中匈有过相似的经济体制背景与土地管理制度改革历程,研究匈牙利土地管理制度具有重要的借鉴意义。文章分析了匈牙利土地管理制度演变过程,土地管理制度创新、效率、问题与发展趋势,土地市场... 详细信息

丰富的土地资源是匈牙利国家最为宝贵的财富,中匈有过相似的经济体制背景与土地管理制度改革历程,研究匈牙利土地管理制度具有重要的借鉴意义。文章分析了匈牙利土地管理制度演变过程,土地管理制度创新、效率、问题与发展趋势,土地市场发展,土地管理的主要法律,土地管理体系,以及可借鉴的经验。

关键词：句牙利土地管理制度

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Correlation between severity of endoscopic findings and apnea-hypopnea index in patients with gastroesophageal reflux disease and obstructive sleep apnea

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World Journal of Gastroenterology 2005年第6期11卷 839-841页

作者： Pál Demeter katalin Várdi Visy Pál magyar Department of Gastroenterology Department of Pulmonology

AIm: To assess the relationship between severity of gastroesophageal reflux disease and apnea-hypopnea index (AHI) as an indicator of the severity of obstructive sleep apnea. mETHODS: Data of 57 patients with proven obstructive sleep apnea and gastroesophageal reflux disease were analyzed. Patients were divided into two groups according to severity of the sleep apnea: 'mild-moderate' (A)-AHI 5≥5-30, n=27, 'severe' (B)-AHI >30, n=30. All patients underwent apnea monitoring during the night, upper panendoscopy and were asked about typical reflux symptoms. RESULTS: All examined patients in both groups showed a significant overweight and there was a positive correlation between body mass index and the degree of sleep apnea (P = 0.0002). The occurence of erosive reflux disease was significantly higher in 'severe' group (P = 0.0001). Using a logistic regression analysis a positive correlation was found between the endoscopic severity of reflux disease and the AHI (P = 0.016). Forty-nine point five percent of the patients experienced the typical symptoms of reflux disease at least three times a week and there was no significant difference between the two groups. CONCLUSION: A positive correlation can be found between the severity of gastroesophageal reflux disease and obstructive sleep apnea.

关键词： Obstructive sleep apnea Gastroesophageal reflux disease Severity Correlation

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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