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Diagnostic procedures for submucosal tumors in the gastrointestinal tract

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World Journal of Gastroenterology 2007年第24期13卷 3301-3310页

作者： Laura Graves Ponsaing katalin kiss Annika Loft Lise Ingemann Jensen Mark Berner Hansen Department of Surgical Gastroenterology K Bispebjerg University Hospital of Copenhagen Denmark Department of Pathology Herlev University Hospital Gentofte Denmark Department of Nuclear Medicine CopenhagenUniversity Hospital Rigshospitalet Denmark Department of Radiology Bispebjerg University Hospital of Copenhagen Denmark

This review is part one of three, which will present an update on diagnostic procedures for gastrointestinal (GI) submucosal tumors (SMTs). Part two identifies the classification and part three the therapeutic methods regarding GI SMTs. Submucosal tumors are typically asymptomatic and therefore encountered incidentally. Advances in diagnostic tools for gastrointestinal submucosal tumors have emerged over the past decade. The aim of this paper is to provide the readers with guidelines for the use of diagnostic procedures, when a submucosal tumor is suspected. Literature searches were performed to find information on diagnostics for gastrointestinal submucosal tumors. Based on the searches, the optimal diagnostic procedures and specific features of the submucosal tumors could be outlined. Standard endoscppy, capsule endoscopy and push-and-pull enteroscopy (PPE) together with barium contrast X-ray do not alone provide sufficient information, when examining submucosal tumors. Endoscopic ultrasound (EUS), computed tomography (CT), magnetic resonance imaging (MRI) and fluorodeoxyglucose-labeled positron emission tomography (FDG-PET) are recommended as supplementary tools.

关键词： Submucosal tumor Diagnosis Endoscopy Endoscopic ultrasonography Computed tomography Magnetic resonance imaging Positron emission tomography Capsule endoscopy Push-and-pull enteroscopy Ponsaing LG, kiss K, Loft A, Jensen LI, Hansen MB.

Effect of ageing on colonic mucosal regeneration

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World Journal of Gastroenterology 2011年第25期17卷 2981-2986页

作者： Ferenc Sipos katalin Leiszter Zsolt Tulassay 2nd Department of Internal Medicine Semmelweis University Molecular Medicine Research Unit Hungarian Academy of Sciences

The physiologic and pathologic cellular and molecular changes occurring with age in the human colon affect both the inflammatory process leading to mucosal injury and the regenerative capacity of the *** the one hand,age-related telomere shortening and inflamm-ageing may lead to the development of colonic inflammation,which results in epithelial *** the other hand,the altered migration and function of regenerative stem cells,the age-related methylation of mucosal healing-associated genes,together with the alterations of growth factor signaling with age,may be involved in delayed mucosal *** connections of these alterations to the process of ageing are not fully *** understanding and customtailored modification of these mechanisms are of great clinical importance with regard to disease prevention and modern therapeutic ***,we aim to summarize the age-related microscopic and molecular changes of the human colon,as well as their role in altered mucosal healing.

关键词： Colon Mucosal repair Ageing Colorectalcancer Telomere shortening DNA methylation

Elevated miR-33a and miR-224 in steatotic chronic hepatitis Cliver biopsies

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World Journal of Gastroenterology 2014年第41期20卷 15343-15350页

作者： Gabor Lendvai katalin Jármay Gizella Karácsony Tünde Halász Ilona Kovalszky Kornélia Baghy Tibor Wittmann Zsuzsa Schaff András kiss MTA-SE Tumor Progression Research Group Semmelweis University 1st Department of Medicine University of Szeged 2nd Department of Pathology Semmelweis University 1st Department of Pathology and Experimental Cancer Research Semmelweis University

AIM: To assess the expression of selected microRNAs (miRNA) in hepatitis C, steatotic hepatitis C, noninfected steatotic and normal liver tissues.

关键词： Chronic hepatitis C Steatosis MicroRNA Expression miR-33a miR-224

Production of rhamnolipids-producing enzymes of Pseudomonas in E. coli and structural characterization

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Frontiers of Chemical Science and Engineering 2017年第1期11卷 133-138页

作者： Kata kiss Wei Ting Ng Qingxin Li Institute of Chemical & Engineering Sciences Agency for Science Technology and Research Jurong Island 627833 Singapore

Rhamnolipids are a class ofbiosurfactants that have a great potential to be used in industries. Five proteins/enzymes, namely RhlA, RhlB, RhlC, RhlG and RhlI, are critical for the production of rhamnolipids in Pseudomonas aeruginosa. Four of the 5 proteins except RhlC were successfully over-expressed in E. coli and three of them （RhlA, RhlB and RhlI） were purified and obtained in milligram quantities. The purified proteins were shown to be folded in solution. Homology models were built for RhlA, RhlB and RhlI. These results lay a basis for further structural and functional characterization of these proteins in vitro to favor the construction of super strains for rhamnolipids production.

关键词： rhamnolipids Pseudomonas RhlA RhlB,RhlI protein folding

Is the disease course predictable in inflammatory bowel diseases?

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World Journal of Gastroenterology 2010年第21期16卷 2591-2599页

作者： Peter Laszlo Lakatos Lajos S kiss 1st Department of Medicine Semmelweis UniversityH-1083 BudapestKoranyi S 2AHungary

During the course of the disease,most patients with Crohn's disease(CD) may eventually develop a stricturing or a perforating complication,and a significant number of patients with both CD and ulcerative colitis will undergo *** recent years,research has focused on the determination of factors important in the prediction of disease course in inflammatory bowel diseases to improve stratification of patients,identify individual patient profiles,including clinical,laboratory and molecular markers,which hopefully will allow physicians to choose the most appropriate management in terms of therapy and intensity of *** review summarizes the available evidence on clinical,endoscopic variables and biomarkers in the prediction of short and long-term outcome in patients with inflammatory bowel diseases.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Disease course Predictive markers Clinical Serology Genetics

Current status of thiopurine analogues in the treatment in Crohn's disease

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World Journal of Gastroenterology 2011年第39期17卷 4372-4381页

作者： Peter Laszlo Lakatos Lajos S kiss 1st Department of Medicine Semmelweis University

In the last decades,with the development of biological therapy,the treatment paradigms in patients with Crohn＇s disease have continuously *** studies focusing on the optimal use of both traditional immunosuppressants and biological therapy have been published,investigating conventional,accelerated stepup and top-down *** addition,much emphasis has been placed in recent years on the de-termination of important predictive factors that could enable early patient stratification,which would lead to a tailored management *** this review,the authors try to highlight new evidence on the optimal timing,benefits,and risks of immunosupressants alone,or in combination,in patients with Crohn＇s disease.

关键词： Crohn's disease Immunosuppressives Azathioprine Thiopurine methyltrans ferase Biologicals

Who will carry out the tests that would be necessary for proper safety evaluation of food emulsifiers?

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Food Science and Human Wellness 2019年第2期8卷 126-135页

作者： katalin FCsáki∗ Éva Sebestyén National Food Chain Safety Office Directorate for Food Safety Risk AssessmentPO BOX 407H-1537 BudapestHungary

Surfactant food emulsifiers are among the most extensively used food *** all authorized food additives,emulsifiers have been evaluated by risk assessors,who consider them as ***,there are growing concerns among scientists about their possible harmful effects on intestinal barriers and *** is also suggested that emulsifier consumption might be one of the main causes of the rising incidence of a number of diseases,such as allergic diseases,celiac disease,type I diabetes and Crohn’s ***,it has recently been suggested that emulsifier consumption might contribute to the development of metabolic syndrome and can promote colitis-associated colorectal cancer *** paper provides an overview of the current scientific knowledge on possible effects of surfactant emulsifiers on intestinal barriers and also of regulatory risk assessment *** main objective is to reveal the reasons for the discrepancies between the opinions of risk assessors and the scientific *** would like to draw the attention of the academic world to the need of specific in vivo and/or clinical studies for each emulsifier in order to help risk assessors make adequate evaluations and rule out with certainty that authorized food emulsifiers pose a safety concern to consumers’health.

关键词： Food emulsifiers Surfactants Intestinal barriers Crohn’s diseases Microbiota Risk assessment EFSA

Recent advances on the synthesis and application of tetrahydro-y-carbolines

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Chinese Chemical Letters 2023年第12期34卷 93-110页

作者： Haibo Mei Klara Aradi Lorand kiss Jianlin Han jiangsu Co-lnnovation Center of Eficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China Institute of Organic Chemistry Research Centre for Natural SciencesStereochemistry Research GroupMagyar Tudsok krt.2117 BudapestHungary

Tetrahydro-y-carbolines(THyCs)constitute one of the most important subtypes of indole *** addition to being substructures of natural products,these structural motifs and moieties can often be found in pharmaceuticals due to their diverse bioactivities such as antiviral,antibacterial,antifungal,antiparasitic,antitumor,anti-inflammatory,and neuropharmacological *** the pharmacological and biological aspects of these scaffolds,they have considerable synthetic applications for the construction of further bioactive compounds,*** aim of this review is to summarize recent developments in the synthesis of this compound class.

关键词： Tetrahydro-y-carbolines Synthetic methods Bioactive molecuels Asymmetric synthesis Indole Polycyclic compounds

Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues

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Neural Regeneration Research 2015年第6期10卷 866-869页

作者： éva Korpos Ferenc Deák Ibolya kiss Institute of Physiological Chemistry and Pathobiochemistry University of Muenster Cells-in-Motion Cluster of Excellence University of Muenster Institute of Biochemistry Biological Research CentreHungarian Academy of Sciences Avidin Ltd.

The extracellular matrix （ECM） performs essential functions in the differentiation, maintenance and remodeling of tissues during development and regeneration, and it undergoes dynamic changes during remodeling concomitant to alterations in the cell-ECM interactions. Here we discuss recent data addressing the critical role of the widely expressed ECM protein, matrilin-2 （Matn2） in the timely onset of differentiation and regeneration processes in myogenic, neural and other tissues and in tumorigenesis. As a multiadhesion adaptor protein, it interacts with other ECM proteins and integrins. Matn2 promotes neurite outgrowth, Schwann cell migration, neuromuscular junction formation, skeletal muscle and liver regeneration and skin wound healing. Matn2 deposition by myoblasts is crucial for the timely induction of the global switch toward terminal myogenic differentiation during muscle regeneration by affecting transforming growth factor beta/bone morphogenetic protein 7/Smad and other signal transduction pathways. Depending on the type of tissue and the pathomechanism, Math2 can also promote or suppress tumor growth.

关键词： Schwann cells neurite outgrowth neuromuscular junction (NM]) multiple sclerosis TGF-β/BMP-7/Smad signaling myogenic differentiation Trf3 tumor suppression