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Performance Analysis of Magnetic Nanoparticles during Targeted Drug Delivery:Application of OHAM

Computer Modeling in Engineering & Sciences 2022年第2期130卷 723-749页

作者： Muhammad Zafar Muhammad Saif Ullah Tareq Manzoor Muddassir Ali kashif nazar Shaukat Iqbal HabibUllah Manzoor Rizwan Haider Woo Young Kim Institute of Energy and Environmental Engineering University of the PunjabQuaid-e-Azam CampusLahore54590Pakistan Energy Research Centre COMSATS University IslamabadLahore54000Pakistan Department of Energy Engineering Faculty of Mechanical and Aeronautical EngineeringUniversity of Engineering and TechnologyTaxila47080Pakistan Department of Mathematics COMSATS University IslamabadLahore54000Pakistan School of Systems and Technology University of Management Sciences and TechnologyLahore54770Pakistan Department of Electrical Electronics and TelecommunicationEngineeringUniversity of Engineering and TechnologyLahore(FSD Campus)Faisalabad38000Pakistan Department of Electronic Engineering Faculty of Applied Energy SystemJeju National UniversityJeju Special Self-Governing ProvinceJeju-si63243Korea

In recent years,the emergence of nanotechnology experienced incredible development in the field of medical *** the past decade,investigating the characteristics of nanoparticles during fluid flow has been one of the intriguing *** distribution and uniformity have emerged as substantial criteria in both medical and engineering *** effects of chemotherapy on healthy tissues are known to be a significant concern during cancer therapy.A novel treatment method of magnetic drug targeting(MDT)has emerged as a promising topical cancer treatment along with some attractive advantages of improving efficacy,fewer side effects,and reduce drug *** magnetic drug targeting,the appropriate movement of nanoparticles(magnetic)as carriers is essential for the therapeutic process in the blood clot removal,infection treatment,and tumor cell *** this study,we have numerically investigated the behavior of an unsteady blood flowinfused with magnetic nanoparticles during MDT under the influence of a uniform external magnetic field in a *** optimal homotopy asymptotic method(OHAM)is employed to compute the governing equation for unsteady electromagnetohydrodynamics *** influence of Hartmann number(Ha),particle mass parameter(G),particle concentration parameter(R),and electro-osmotic parameter(k)is investigated on the velocity of magnetic nanoparticles and blood *** obtained show that the electro-osmotic parameter,along with Hartmann’s number,dramatically affects the velocity of magnetic nanoparticles,blood flow velocity,and flow ***,results also reveal that at a higher Hartman number,homogeneity in nanoparticles distribution improved *** particle concentration andmass parameters effectively influence the capturing effect on nanoparticles in the blood flow using a micro-tube for magnetic drug ***,investigation also indicates that the OHAM analysis is efficient and quick to h

关键词： Hartmann number magnetic nanoparticles nonlinear analysis targeted drug delivery optimal homotopy asymptotic method(OHAM)

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