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High Prevalent Hypovitaminosis D Is Associated with Dysregulation of Calcium-parathyroid Hormone-vitamin D Axis in Patients with Chronic Liver Diseases

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Journal of Clinical and Translational Hepatology 2019年第1期7卷 15-20页

作者： Krishnasamy Narayanasamy rajendran karthick A.Koodal Raj Department of Hepatology Madras Medical CollegeChennaiTamil NaduIndia Multidisciplinary Research Unit(MRU) Madras Medical CollegeChennaiTamil NaduIndia

Background and Aims:Although hypovitaminosis D is common among patients with chronic liver disease(CLD),the data are inconsistent on its prevalence and its relationship with *** study aimed to estimate the prevalence of hypovitaminosis D among patients with CLD and to determine the relationship between hypovitaminosis D and severity of liver dysfunction,and calcium(Ca),phosphate(PO4)and parathyroid hormone(PTH)levels in ***:The study included 236 CLD patients attending the Department of Hepatology,Rajiv Gandhi Government General Hospital(Chennai,India).Serum levels of 25-hydroxyvitamin D(25(OH)D),PTH,Ca,and PO4 were *** of liver dysfunction was graded using the Child-Turcotte-Pugh(CTP)***:The first report from our population showed that 162 of 236(68.6%)CLD patients had hypovitaminosis D(25(OH)D levels of<30 ng/mL),with higher frequency(124/162)76.5%among CTP B,C *** negative correlation(r=-0.288,p=0.0001)between 25(OH)D and CTP scores was noted in hypovitaminosis D *** of 25(OH)D was correlated negatively with PTH(r=-0.537,p=0.0001),positively with Ca(r=0.657,p=0.0001),and positively with PO4(r=0.477,p=0.0001)in sufficient vitamin D ***:Hypovitaminosis D is associated with higher CTP scores and is strongly associated with dysregulation of the Ca-PTH-vitamin D axis in *** measurement of vitamin D levels is essential,along with levels of PTH,Ca and PO4,to manage CLD patients.

关键词： Hypovitaminosis D Chronic liver disease Liver dysfunction Hypocalcemia Vitamin D

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Elevated Liver Enzymes along with Comorbidity Is a High Risk Factor for COVID-19 Mortality:A South Indian Study on 1,512 Patients

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 120-127页

作者： Narayanasamy Krishnasamy karthick rajendran Parimita Barua Arunkumar Ramachandran Priyadarshini Panneerselvam Muthukumaran Rajaram Institute of Hepatobiliary Sciences Madras Medical College and Rajiv Gandhi Government General HospitalChennaiTamil NaduIndia Multidisciplinary Research Unit(MRU) Madras Medical CollegeChennaiTamil NaduIndia

Background and Aims:Liver enzyme abnormalities in coronavirus 2019(COVID-19)are being addressed in the *** predictive risk of elevated liver enzymes has not been established for COVID-19 *** this study,we hypothesized that elevated liver enzymes at ad-mission can predict the outcome of COVID-19 disease with other known indicators,such as ***:This retrospective study included all the consecutive hos-pitalized patients with confirmed COVID-19 disease from March 4th to May 31st,*** study was conducted in Rajiv Gandhi Government General Hospital,Chennai,Ta-mil Nadu,*** assessed demography,clinical vari-ables,COVID-19 severity,laboratory parameters,and ***:We included 1,512 patients,and median age was 47 years(interquartile range:34-60)with 36.9%being *** enzyme level(aspartate aminotrans-ferase and/or alanine aminotransferase)was elevated in 450/1,512(29.76%)*** was present in 713/1,512(47.16%)*** with liver enzymes’elevation and presence of comorbidity were older,more frequently hospitalized in ICU and had more severe symp-toms of COVID-19 at the time of *** of liver enzymes’elevation with comorbidity was a high risk factor for death(OR:5.314,95%CI:2.278-12.393),as compared to patients with presence of comorbidity(OR:4.096,95%CI:1.833-9.157).Conclusions:Comorbid-ity combined with liver enzymes’elevation at presentation independently increased the risk of death in COVID-19 by at least 5-fold.

关键词： COVID-19 SARS-CoV-2 Liver enzyme Comorbidity Aspartate aminotransferase Alanine aminotransferase

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