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Superior antibody and membrane protein‑specific T‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.cheng carolyn A.cohen Daniel leung Xiwei Wang Xiaofeng Mu Yuet chung Tsun Ming lau Manni Wang Wenyue Zhang Yanmei Zhang howard h.W.Wong leo c.h.Tsang Sara chaothai Tsz chun kwan John k.c.li karl c.k.chan.leo l.h.luk Jenson c.h.ho Wing Yan li Amos M.T.lee Jennifer h.Y.lam Sau Man chan Wilfred h.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public health The University of Hong KongHong KongChina hkU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(NcT04800133)investigated the superiority of antibody and T-cell responses of full-dose coronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-cc versus ID-cc)and post-dose 3(IMccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(Il-2)+cD4^(+),SNM-specific Il-2^(+)cD8^(+),S-specific Il-2^(+)cD8^(+),N-specific Il-2^(+)cD4^(+),N-specific Il-2^(+)cD8^(+)and M-specific Il-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to IM-cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific Il-2^(+)cD4^(+),interferon-γ+cD8^(+)and Il-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-cc,ID-cc,IM-ccc and ID-ccc,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine

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Single-atom catalysts for the electrochemical reduction of carbon dioxide into hydrocarbons and oxygenates

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carbon Energy 2024年第3期6卷 64-117页

作者： karl Adrian Gandionco Juwon kim lieven Bekaert Annick hubin Jongwoo lim Department of chemistry Seoul National UniversitySeoulRepublic of Korea Research Group Electrochemical and Surface Engineering(SURF) Department of Materials and ChemistryVrije Universiteit BrusselBrusselsBelgium

The electrochemical reduction of carbon dioxide offers a sound and economically viable technology for the electrification and decarbonization of the chemical and fuel *** this technology,an electrocatalytic material and renewable energy-generated electricity drive the conversion of carbon dioxide into high-value chemicals and carbon-neutral *** the past few years,single-atom catalysts have been intensively studied as they could provide near-unity atom utilization and unique catalytic ***-atom catalysts have become one of the state-of-the-art catalyst materials for the electrochemical reduction of carbon dioxide into carbon ***,it remains a challenge for single-atom catalysts to facilitate the efficient conversion of carbon dioxide into products beyond carbon *** this review,we summarize and present important findings and critical insights from studies on the electrochemical carbon dioxide reduction reaction into hydrocarbons and oxygenates using single-atom *** is hoped that this review gives a thorough recapitulation and analysis of the science behind the catalysis of carbon dioxide into more reduced products through singleatom catalysts so that it can be a guide for future research and development on catalysts with industry-ready performance for the electrochemical reduction of carbon dioxide into high-value chemicals and carbon-neutral fuels.

关键词： electrocatalysis electrochemical cO_(2)reduction hydrocarbons oxygenates single-atom catalysts

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Antibody and T cell responses against wild-type and Omicron SARS-coV-2 after third-dose BNT162b2 in adolescents

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Signal Transduction and Targeted Therapy 2023年第1期8卷 266-275页

作者： Xiaofeng Mu carolyn A.cohen Daniel leung Jaime S.Rosa Duque Samuel M.S.cheng Yuet chung howard h.W.Wong Amos M.T.lee Wing Yan li Issan Y.S.Tam Jennifer h.Y.lam Derek h.l.lee Sau Man chan leo c.h.Tsang karl c.k.chan John k.c.li leo l.h.luk Sara chaothai kelvin k.h.kwan Nym coco chu Masashi Mori Trushar Jeevan Ahmed kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina hkU-Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina School of Public health The University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Infectious Diseases St Jude Children’s Research HospitalMemphisTNUSA Department of Microbiology and Immunology Peter Doherty Institute for Infection and ImmunityUniversity of MelbourneMelbourneVICAustralia centre for Immunology&Infection c2i Hong KongChina

The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet *** this analysis,our study(NcT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-coV-2 before and after a third dose of BNT162b2 in healthy *** 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 *** antibody responses and S-specific IFN-γ^(+)and Il-2^(+)cD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of *** to adults,humoral responses for the third dose were non-inferior or superior in *** S-specific IFN-γ^(+)and Il-2^(+)cD4^(+)and cD8^(+)T cell responses in adolescents and adults were comparable or ***,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and *** from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise *** study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease.

关键词： doses neutral protective

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Enemies atpeace:Recentprogressin Agrobacterium-mediated cereal transformation

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The crop Journal 2024年第2期12卷 321-329页

作者： Shaoshuai liu ke Wang Shuaifeng Geng Moammar hossain Xingguo Ye Aili li long Mao karl-heinz kogel State key laboratory of crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Institute of Phytopathology Centre for BioSystemsLand Use and NutritionJustus Liebig UniversityHeinrich Buff-Ring 26-32D-35392GiessenGermany

Agrobacterium tumefaciens mediated plant transformation is a versatile tool for plant genetic engineering following its discovery nearly half a century *** modifications were made in its application to increase efficiency,especially in the recalcitrant major cereals *** breakthroughs in transformation efficiency continue its role as a mainstream technique in cRISPR/cas-based genome editing and gene *** modifications led to higher transformation frequency and lower but more stable transgene copies with the capability to revolutionize modern *** this review,we provide a brief overview of the history of Agrobacterium-mediated plant transformation and focus on the most recent progress to improve the system in both the Agrobacterium and the host recipient.A promising future for transformation in biotechnology and agriculture is predicted.

关键词： Agrobacterium tumefaciens cereal species Genome editing Genetic engineering Plant breeding

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Dynamic convergent shock compression initiated by return current in high-intensity laser-solid interactions

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Matter and Radiation at Extremes 2024年第4期9卷 40-53页

作者： long Yang Martin Rehwald Thomas kluge Alejandro lasoGarcia Toma Toncian karl Zeil Ulrich Schramm Thomas E.cowan lingen huang helmholtz-Zentrum Dresden-Rossendorf 01328 DresdenGermany Technische Universitat Dresden 01062 DresdenGermany

We investigate the dynamics of convergent shock compression in solid cylindrical targets irradiated by an ultrafast relativistic laser *** particle-in-cell simulations and coupled hydrodynamic simulations reveal that the compression process is initiated by both magnetic pressure and surface ablation associated with a strong transient surface return current with density of the order of 10^(17) A/m^(2) and lifetime of 100 *** results show that the dominant compression mechanism is governed by the plasma β,i.e.,the ratio of thermal pressure to magnetic *** targets with small radius and low atomic number Z,the magnetic pressure is the dominant shock compression *** to a scaling law,as the target radius and Z increase,the surface ablation pressure becomes the main mechanism generating convergent ***,an indirect experimental indication of shocked hydrogen compression is provided by optical shadowgraphy measurements of the evolution of the plasma expansion *** results presented here provide a novel basis for the generation of extremely high pressures exceeding Gbar(100 TPa)to enable the investigation of high-pressure physics using femtosecond J-level laser pulses,offering an alternative to nanosecond kJ-laser pulse-driven and pulsed power Z-pinch compression methods.

关键词： shock convergent return

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Extracellular Vesicles from Mesenchymal Stromal cells (imEVs) Improve cold Preservation of Isolated Mitochondria

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Journal of Biosciences and Medicines 2024年第1期12卷 52-63页

作者： Xianpeng Jiang Sergey Rodin ken Braesch-Andersen catherine c. Baucom karl-henrik Grinnemo Brent Segal Elliott Mitochondrial center Sallie Astor Burdine Breast Foundation Baton Rouge Louisiana USA Mitosense Inc. Boston Massachusetts USA Department of Surgical Sciences Division of Cardiothoracic Surgery Cardio-Thoracic Translational Medicine (CTTM) Laboratory Uppsala University Uppsala University Hospital Uppsala Sweden

Mitochondrial organelle transplantation (MOT) is an innovative strategy for the treatment of mitochondrial dysfunction such as cardiac ischemic reperfusion injuries, Parkinson’s diseases, brain and spinal cord injuries, and amyotrophic lateral sclerosis (AlS). however, one of the major challenges for widespread usage is a methodology for preservation of isolated mitochondria. Extracellular vesicles (EVs) are phospholipid bilayer-enclosed vesicles released from cells. EVs carry a cargo of proteins, nucleic acids, lipids, metabolites, and even organelles such as mitochondria. Purpose: To test if EVs enhance the stability of isolated mitochondria. Methods: We mixed isolated mitochondria of fibroblasts with EVs of mesenchymal stromal cells (imEVs) (9:1 in volume) and stored the mixture at 2°c - 6°c for different time periods. We measured morphology, mitochondrial membrane potential (MMP) and mitochondrial ATP content at 0, 2, 5 days. key findings: After 2 days of storage, the mito-chondria without imEVs lost approximate 70% MMP (RFU: 1822 ± 68), compared to the fresh mitochondria (RFU: 5458 ± 52) (p 0.05). In agreement with MMP, mitochondria without imEVs lost significant mitochondrial ATP content (p 0.05), after 2 days of cold storage, compared to fresh mitochondria. Microscopy showed that imEVs promoted aggregation of isolated mitochondria. Summary: The preliminary data showed that imEVs enhanced the stability of isolated mitochondria in cold storage.

关键词： Mitochondria Extracellular Vesicles Mitochondrial Preservation MOT imEVs

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Get it white: color-tunable Ac/Dc OlEDs

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light(Science & Applications) 2015年第1期4卷 492-497页

作者： Markus Frobel Tobias Schwab Mona kliem Simone hofmann karl leo Malte c Gather Institute for Applied Photophysics(IAPP) Dresden University of TechnologyD-01069 DresdenGermany School of Physics and Astronomy University of St AndrewsSt Andrews KY169SSUK

Organic light-emitting diodes(OlEDs)have gained considerable attention because of their use of inherently flexible materials and their compatibility with facile roll-to-roll and printing *** addition to high efficiency,flexibility and transparency,reliable color tunability of solid state light sources is a desirable feature in the lighting and display ***,we demonstrate a device concept for highly efficient organic light-emitting devices whose emission color can be easily adjusted from deep-blue through cold-white and warm-white to saturated *** approach exploits the different polarities of the positive and negative half-cycles of an alternating current(Ac)driving signal to independently address a fluorescent blue emission unit and a phosphorescent yellow emission unit which are vertically stacked on top of each *** electrode design is optimized for simple fabrication and driving and allows for two-terminal operation by a single *** presented concept for color-tunable OlEDs is compatible with application requirements and versatile in terms of emitter combinations.

关键词： alternating current color mixing color tuning vertical stacking white organic light-emitting devices

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long Term Administration of lannea acida Rich. (Anacardiaceae) Reverses the Imidacloprid-Induced Fertility Impairments in Adult Male Rat through Androgenic and Antioxidant Properties

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Journal of Biosciences and Medicines 2024年第3期12卷 62-76页

作者： Aimé césaire Momo Tetsatsi Gladis komguep Djuidje Prechmy carole Ngueyong Nsamou karl Gombeu Zeugang Yannick Tchatat Petnga Désiré Alumeti Munyali Esther Ngadjui Pepin Alango Nkeng-Effouet Pierre Watcho Faculty of health Sciences The University of Bamenda Bamenda Cameroon Animal Physiology and Phytopharmacology laboratory Faculty of Science University of Dschang Dschang Cameroon laboratory of Immunology and Molecular Biology The Evangelical University of Cameroon Bandjoun Cameroon School of Medicine and community health Evangelical University in Africa Bukavu DR Congo Alango Foundation Center for African Phytomedicine Dschang Cameroon

Aim: The harmful effects of pesticides have been largely documented in recent times. But effective therapeutic solutions to pesticide related male infertility are yet to be established. This study investigated the curative effects of lannea acida on imidacloprid (IMI)-induced hypofertility in male Wistar rats. Methods: Rats of 150 – 200 g were administered IMI (22.5 mg/kg) for two weeks and partitioned into control (distilled water, vitamin E, clomiphene citrate) or test (aqueous (340 mg/kg), methanol (170 mg/kg) extract) groups for eight weeks treatment. Animals were sacrificed at the end of the treatment and samples were collected for sperm, antioxidant and hormonal analysis. Fertility tests were performed from treatment day 47 for fertility indices estimation. Results were expressed as mean ± SEM and one way ANOVA was applied using STATISTIcA Software. Results: Exposition to IMI resulted in a significant decrease in sperm count, motility, viability and normality, testosterone and lh, coupled to an increase in oxidative stress markers. Moreover, IMI impaired male fertility evidenced by a significant drop in fertility index and litter size. Similar to clomiphene citrate and vitamin E, plant extracts significantly improved the sperm parameters, sexual hormones and decreased the oxidative stress markers. More importantly, the fertility index and litter size were restored, especially with the aqueous extract. conclusion: Present results indicate that l. acida possesses curative potentials against IMI-induced hypofertility through its androgenic and antioxidant properties. however, the effects the extract on spermatozoa DNA structure and the fertility of offsprings from exposed parents are yet to be studied to conclude on total recovery from IMI toxicity.

关键词： Imidacloprid lannea acida hypofertility Male Rat

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Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds

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药物分析学报：英文版 2017年第5期7卷 338-342页

作者： laura J.Waters catherine V.Finch A.k.M.Mehedi h.Bhuiyan karl hemming John c.Mitchell Department of Pharmacy School of Applied Science University of Huddersfield Medway centre for Pharmaceutical Sciences University of Greenwich

This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine,with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability(k_p) values suggesting plasma-modified silicone membrane(PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.

关键词： Permeation PDMS Silicone Plasma Flux hydrophobicity

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Embryology of Iris sanguinea Donn ex horn. and its systematic relationship

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Journal of Forestry Research 2019年第6期30卷 2007-2020页

作者： lijuan Fan karl h.hasenstein ling Wang college of landscape Architecture Northeast Forestry UniversityHarbin 150040People’s Republic of China Department of Biology University of Louisiana at LafayetteLafayetteLA 70504USA

Iris sangumea Dorm ex horn. is a perennial cold-tolerant herbs of the Iris genus of Iridaceae, which has a well-formed, bright color and adaptability. Through understanding the fl ower bud differentiation, Sporogenesis, gametogenesis, fertilization and embryogenesis of I. sangumea, we developed fl owering regulation and control breeding. I. sangumea fl ower bud differentiation was observed in April for 21 days; in this stage, the early differentiation process was slow, temperature was more than 5 °c, if the temperature is shorter than this, most fl ower bud will have no differentiation, and turn to vegetative growth; later differentiation is faster and required temperature is from 5 to 8 °c and gradually rose to 10-12 °c. The temperature in April plays the defi nitely role in the number of bud differentiation. Three stamina contain tetrasporangiate anthers and a glandular tapetum. The anther wall is composed of four cell layers inclduding the epidermis, the endothecium, one middle layer and the secretory tapetum. The type of anther wall development the dicotyledonous type. After pollen maturation, the anther wall forms a double-layer containing only epidermis and endothecium. Simultaneous cytokinesis is of the continuous type during meiosis of microspore mother cell results in a zygomorphous or tetragonal tetrad. Mature pollen grains are two-celled. I. sangumea ’s stylar canal is hollow, open type style, and the gynoecium has three carpels. The ovaries have axial placentas. The ovule is anatropous, bitegmic and crassinucellate. The primary sporogenous cell differentiates directly as the megaspore. The megaspore tetrads are linear, T-shaped or juxtaposed. Generally, the fi rst of the tetrad megaspores at the chalaza becomes functional while the other three degenerate. A mature embryo sac with seven cells and eight nuclei embryo sac is of the polygonum type. For dichogamy, the male gametophyte matures about 2 days earlier than the female gametophyte. The pollen tube e

关键词： Iris sanguinea Donn ex horn Flower bud diff erentiation Embryology

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