检索结果-南通市图书馆

Suspected Resistance against Moxidectin in Sheep Strongylid Nematodes in Austria

Journal of Pharmacy and Pharmacology 2017年第3期5卷 109-117页

作者： Julia Schoiswohl Barbara Hinney Alexander Tichy karl bauer Anja Joachim Reinhild Krametter-Frotscher Department for Farm Animals and Veterinary Public Health University of Veterinary Medicine Vienna Vienna 1210 Austria Department of Pathobiology Institute of Parasitology University of Veterinary Medicine Vienna Vienna 1210 Austria Bioinformatics and Biostatistics Platform University of Veterinary Medicine Vienna Vienna 1210 Austria Animal Health Service Styria Graz 8010 Austria

Loss of efficacy due to resistance development against anthelmintics in livestock parasites is a growing concern worldwide. The aim of the present study was to determine the efficacy of moxidectin, a frequently-used macrocyclic lactone, against gastrointestinal nematodes of sheep in Austria. Individual faecal samples were collected from 243 adult sheep from 16 flocks in Styria and Salzburg before deworming and egg excretion （EPG （eggs per gram） of faeces） was determined using a modified McMaster technique. The animals were randomly assigned to a treatment group which received 0.2 mg/kg of body weight of moxidectin （Cydectin , Zoetis Schweiz GmbH, Zurich, Switzerland）, and an untreated control group. Fourteen days after deworming a FECRT （faecal egg count reduction test） for detection of anthelmintic resistance was performed. Before deworming, the infection rate for gastrointestinal strongylids was 94.7%, with EPG values of 0-5,800. The FECRT showed reduction rates between 93.08% and 99.78% and was sufficient in 15/16 flocks. The lower confidence interval was 70.0-100%. In 3/16 flocks this value was below the minimum for sufficient efficacy （70.0%, 79.0%, 85.0%）, and in two flocks the value （90,0%） was near the limit. These results indicated a （suspected） reduced efficacy of moxidectin in 5/16 examined flocks.

关键词： FECRT (faecal egg count reduction test) EPG (eggs per gram) faeces moxidectin anthelmintic resistance.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

长丝高速卷绕机

引用

国外纺织技术 1979年第3期 42-49页

作者： karl bauer 龚绍堂

纺织用长丝的低速纺丝,卷绕速度一般在800～1800米/分之间。近年来由于卷绕速度高达3000～4000米/分的纺丝机日益完美.使现代化的纺丝工厂能够生产性能更好的长

关键词：卷绕头槽辊筒管卷绕张力丝线导丝器卷绕速度高速纺丝长丝

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chirality enables thermal magnon transistors

引用

Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 161-166页

作者： Tao Yu Chengyuan Cai Gerrit E.W.bauer School of Physics Huazhong University of Science and TechnologyWuhan 430074China .WPI-AIMR and Institute for Materials Research and SCIS Tohoku UniversitySendai 980-8577Japan Kavli Institute for Theoretical Sciences University of Chinese Academy of SciencesBeijing 100190China

We report a theory of thermal spin pumping into proximity magnets under a transverse-bias-driven heat flow of magnons in magnetic films when the dipolar coupling to the magnetic gate is tuned to be “chiral”. While there is no rectification of the magnon current in the film, we predict that chirality diverts a large percentage(50% for perfect chirality) of it into the gate. This transverse thermal spin pumping effect can be controlled by rotating the film magnetization and may help manage the heat flow in future magnonic circuits.

关键词： magnon chirality quantum transport transistor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新生儿成熟度和产后日龄对血清钾水平的影响

引用

中国当代儿科杂志 2000年第1期2卷 4-7页

作者：肖昕 karl bauer Hans Versmold 暨南大学医学院附属第一医院儿科广州510632 Kinderklinik und Poliklinik Universitatsklinikum Benjamin Franklin Kinderklinik und Poliklinik Universitatsklinikum Benjamin Franklin

目的　探讨新生儿成熟度和产后日龄对血清钾浓度的影响。方法　回顾性分析了胎龄为 2 4～ 2 8周 (A组 ) ,2 9～ 3 2周 (B组 ) ,3 3～ 3 6周 (C组 )和 3 7～ 4 2周 (D组 )新生儿生后 1～ 72h内的血清钾水平及其变化。结果　①新生儿的胎... 详细信息

目的　探讨新生儿成熟度和产后日龄对血清钾浓度的影响。方法　回顾性分析了胎龄为 2 4～ 2 8周 (A组 ) ,2 9～ 3 2周 (B组 ) ,3 3～ 3 6周 (C组 )和 3 7～ 4 2周 (D组 )新生儿生后 1～ 72h内的血清钾水平及其变化。结果　①新生儿的胎龄、体重和尿量与血清钾水平存在着线性关系。②生后 1～ 2 4h ,A组新生儿的血清钾水平最高 ,B组次之 ,C和D组相当 ,为最低。生后 4 8h内 ,A和B组的血清钾水平开始下降 ,并于 72h内下降至C和D组新生儿水平。C和D组新生儿生后 72h内的血清钾水平无明显变化。③A ,B和C组早产儿生后 2 4h内高钾血症 (≥7.0mmol/L)发生率分别为 2 0 .0 % ,12 .5%和 4 .0 % ;2 4例高钾血症患儿经常规治疗后 ,14例 (58.3 % )于 72h内血钾降至 7.0mmol/L以下并存活 ;10例 (4 1.7% )高钾血症状态持续存在 ,其中 7例死亡。D组足月儿于生后 72h内未出现高钾血症。结论　新生儿的成熟度和产后胎龄影响血清钾水平 ;极不成熟新生儿 (2 4～ 3 2周 )在生后 2 4h内具有较高的血清钾水平 ,继之随生后日龄的增加而降低 ;早产儿可有致命性高钾血症存在 ,常规治疗仅部分有效。

关键词：新生儿高钾血症成熟度产后日龄

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reservoir quality evaluation of the Narimba Formation in Bass Basin,Australia:Implications from petrophysical analysis,sedimentological features,capillary pressure and wetting fluid saturation

引用

Energy Geoscience 2024年第1期5卷 37-53页

作者： Wafa Abdul Qader Al-Ojaili Mohamed Ragab Shalaby Wilfried bauer Department of Applied Geosciences German University of Technology in OmanOman Geology Department Faculty of ScienceUniversity of Brunei DarussalamBrunei Darussalam Geology Department Faculty of SciencesTanta UniversityTanta31527Egypt

The evaluation of reservoir quality was accomplished on the Late Paleocene to Early Eocene Narimba Formation in Bass Basin,*** study involved combination methods such as petrophysical analysis,petrography and sedimentological studies,reservoir quality and fluid flow units from derivative parameters,and capillary pressure and wetting fluid saturation *** and diagenetic features are affecting the reservoir ***,compaction,and presence of clay minerals such as kaolinite are found to reduce the quality while dissolution and secondary porosity are noticed to improve *** is believed that the Narimba Formation is a potential reservoir with a wide range of porosity and *** ranges from 3.1%to 25.4%with a mean of 15.84%,while permeability ranges between 0.01 mD and 510 mD,with a mean of 31.05 *** on the heterogenous lithology,the formation has been categorized into five groups based on permeability *** I showed an excellent to good quality reservoir with coarse *** impacts of both textural and diagenetic features improve the reservoir and producing higher reservoir quality index(RQI)and flow zone indicators(FZI)as well as mostly mega *** non-wetting fluid migration has the higher possibility to flow in the formation while displacement pressure recorded as *** II showed a fair quality reservoir with lower petrophysical properties in macro *** irreducible water saturation is increasing while the textural and digenetic properties are still enhancing the reservoir *** III reflects lower quality reservoir with mostly macro pores and higher displacement *** may indicate smaller grain size and increasing amount of cement and clay *** IV,and V are interpreted as a poor-quality reservoir that has lower RQI and *** textural and digenetic features are negatively affecting the reservoir and are leading to smaller pore size and pore throat radii(r35)

关键词： Narimba formation Petrophysics Reservoir quality Capillary pressure Wetting fluid saturation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Experienced Involvement (ExIn) in Social-Psychiatric Care of Germany-Challenges and Chances

引用

Sociology Study 2024年第3期14卷 129-142页

作者： Susanne Iris bauer Fulda University of Applied Sciences FuldaGermany

This study explores the integration of Experienced Involvement(ExIn)in social-psychiatric care in Germany,emphasizing both the challenges and opportunities it *** European Leonardo da Vinci Project(2005-2007)established a curriculum for ExIn,promoting participatory structures in psychiatric *** peer support is well-established in other European countries,Germany’s experience is still *** research uses a mixed methods design,combining quantitative surveys and qualitative interviews,to investigate the professional experiences of ExIn recovery companions and team colleagues in German clinics and support *** findings reveal numerous benefits:for social-psychiatric services,ExIn enhances service quality,inclusivity,and accessibility;for team colleagues,it fosters reflexivity,hope,and trust,and improves self-care;for service users,it provides empowerment,easy access to support,trust,and hope,and offers credible role *** these benefits,challenges such as stigmatization,lack of recognition,and financial constraints remain and require to be *** study highlights the need and provides implications for a dedicated and inclusive approach to effectively implementing ExIn,ultimately enriching psychiatric care through experiential knowledge and reducing prejudice within mental health services.

关键词： peer involvement professionalized peer support social psychiatry inclusion education of social works

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

引用

Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer Robert Ringseis Klaus Eder Karsten Krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

传统与现代的一场偶遇加拿大Muskoka别墅

引用

室内设计与装修 2024年第5期 136-141页

作者： Reigo & bauer Reigo&bauer 加拿大

Muskoka别墅坐落在安大略省风景秀丽的湖区,距离加拿大最大城市多伦多北部仅2小时车程,是一座拥有近200年历史的典型当地风格住宅。这座湖边别墅曾是一个庞大度假村的一部分,后来逐渐被拆除,如今被现任屋主作为夏季度假屋使用,并在过去... 详细信息

Muskoka别墅坐落在安大略省风景秀丽的湖区,距离加拿大最大城市多伦多北部仅2小时车程,是一座拥有近200年历史的典型当地风格住宅。这座湖边别墅曾是一个庞大度假村的一部分,后来逐渐被拆除,如今被现任屋主作为夏季度假屋使用,并在过去几十年里进行了不断的增建和更新。此次的设计工作,屋主邀请了Reigo&bauer设计工作室,这已经是他们第3次合作。屋主的诉求是尽可能保留和恢复别墅的原始魅力和历史底蕴,同时赋予空间当代的审美取向。

关键词：设计工作室安大略省历史底蕴别墅传统与现代加拿大度假村多伦多

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

引用

Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.J.Dijkstra C.Mota J.bauer H.Ferreira Rui L.Reis N.Neves S.Camarero-Espinosa M.B.Baker L.Moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density Click chemistry Human

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells

引用

The Innovation 2024年第3期5卷 138-145页

作者： Alfred Akinlalu Zachariah Flaten Komila Rasuleva Md Saimon Mia Aaron bauer Santhalingam Elamurugan Nega Ejjigu Sudipa Maity Amara Arshad Min Wu Wenjie Xia Jia Fan Ang Guo Sijo Mathew Dali Sun Department of Electrical and Computer Engineering University of Denver2155 E Wesley AvenueDenverCO 80210USA Biomedical Engineering Program North Dakota State University1401 Centennial BoulevardEngineering AdministrationRoom 203FargoND 58102USA Department of Pharmaceutical Sciences School of PharmacyNorth Dakota State University1001 S.1401 Albrecht Boulevard Sudro HallFargoND 58102USA Materials and Nanotechnology Program North Dakota State University1410 North 14th AvenueCIE 201FargoND 58102USA Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325000China Department of Aerospace Engineering Iowa State UniversityAmesIA 50011USA Center for Cellular and Molecular Diagnostics Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Department of Biochemistry and Molecular Biology Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Knoebel Institute for Healthy Aging University of Denver2155 E Wesley AvenueDenverCO 80210USA

Pancreatic adenocarcinoma(PDAC)is one of the most deadly cancers,characterized by extremely limited therapeutic options and a poor prognosis,as it is often diagnosed during late disease *** and selective treatments are urgently needed,since current therapies have limited efficacy and significant side *** proteomics analysis of extracellular vesicles,we discovered an imbalanced distribution of amino acids secreted by PDAC tumor *** findings revealed that PDAC cells preferentially excrete proteins with certain preferential amino acids,including isoleucine and histidine,via extracellular *** amino acids are associated with disease progression and can be targeted to elicit selective toxicity to PDAC tumor *** in vitro and in vivo experiments demonstrated that supplementation with these specific amino acids effectively eradicated PDAC ***,we also identified XRN1 as a potential target for these amino *** high selectivity of this treatment method allows for specific targeting of tumor metabolism with very low toxicity to normal ***,we found this treatment approach is easy-to-administer and with sustained tumor-killing ***,our findings reveal that exocytosed amino acids may serve as therapeutic targets for designing treatments of intractable PDAC and potentially offer alternative treatments for other types of cancers.

关键词： finding identif selectivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：