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Universality of slip avalanches in a ductile Fe-based bulk metallic glass

作者： karin·Hall Barbara·Scheiner

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Journal of Iron and Steel Research International 2017年第4期24卷 366-371页

作者： Jiao-jiao Li Jun-wei Qiao karin A.Dahmen Wei-ming Yang Bao-long Shen Ming-wei Chen Laboratory of Applied Physics and Mechanics of Advanced Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024ShanxiChina Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024ShanxiChina Department of Physics University of Illinois at Urbana-ChampaignIllinois 61801USA State Key Laboratory for Geomechanics and Deep Underground Engineering School of Mechanics and Civil EngineeringChina University of Mining and TechnologyXuzhou 221116JiangsuChina School of Materials Science and Engineering Southeast UniversityNanjing 211189JiangsuChina Advanced Institute for Materials Research Tohoku UniversitySendal 980-8577Japan

Intermittent serrated flows of a novel ductile Fe60Ni20P13C7 bulk metallic glass（BMG）at variant strain rates were investigated by statistics *** and clutter distribution of slip-avalanche magnitudes are displayed during stable plastic flows at strain rates of 2×10-4 s-1 and 5×10-5 s-1,respectively,which means that serration behavior depends on the strain ***,the remarkable agreement between measured slip-avalanche magnitudes and the scaling behavior,i.e.a universal complementary cumulative distribution function（CCDF）predicted by mean-field theory（MFT）model,indicates that the plasticity of the present Fe-based BMGs can be tuned by imposed strain rates：Smax^6）ε-λ.This tuned plasticity is elucidated with expended free-volume ***,the scaling behavior of serrated flows for other strain rates can be predicted as well.

关键词： Bulk metallic glass Slip avalanche Plasticity Mean-field theory model Strain rate

Methodological choices of HR research conducted in Asia

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Frontiers of Business Research in China 2017年第2期11卷 167-185页

作者： karin Sanders Julie A. Cogin Cai-Hui Veronica Lin School of Management UNSW Business School University of New South Wales Room 528 Sydney Australia Australian Graduate School of Management (AGSM) UNSW Business School University of New South Wales Sydney Australia Queen's Management School Queen's University Belfast UK.

A twenty-year study of the Human Resource （HR） practices- outcome relationship has found that more rigorous methodologies have been adopted over time. However, several problematic features such as cross-sectionaL single-informant, and single-level designs continue to be adopted （Bainbridge et al., Human Resource Management, 2016）. Responding to calls for increased contextualization of research by investigating the relationship between the location of data collection and the methodological choices of researchers, this study answers the question ＂How unique are the methodological choices of HR research conducted in Asia？＂ Applying content analysis to 241 published articles, we compare internal, external, construct and statistical conclusion validity of studies collected in North America （n^66）, Europe （n=95） and Asia （n=80, including 57 studies from China）. Results show that despite similarities in cross-sectional, single-informant and single-level designs across regions, research conducted in Asia is mainly undertaken via field studies, using subjective outcome measures at the organizational level, following a post-predictive design. In addition, studies from Asia are more recent, and show a shorter time gap between data collection and publication. Theoretical and practical implications embedded in the dynamic context of Asia in general, and China more specifically are discussed.

关键词： Methodological choices Validity HRpractices China Contextualization

Comment on: Long-term hemodialysis improved and stabilized diabetic macular edema: two case reports

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1891-1892页

作者： Yusuke Kameda Yuta Suzuki Megumi Sugai karin Ishinabe Nichika Fukuoka Yotsuya-sanchome Ekimae Eye Clinic Tokyo 160-0004Japan

Dear Editor,With great excitement, we read the article titled “Longterm hemodialysis improved and stabilized diabetic macular edema: two case reports” by Fan and Yuan[1];a case series study which provided interestin... 详细信息

关键词： edema hemodialysis diabetic

Dual Targeting to Mitochondria and Chloroplasts： Characterization of Thr-tRNA Synthetase Targeting Peptide

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Molecular Plant 2009年第6期2卷 1298-1309页

作者： Anna-karin Berglund Erika Spanning Henrik Biverstahl Gianluca Maddalo Christian Tellgren-Roth Lena Maler Elzbieta Glaser Department of Biochemistry and Biophysics Arrhenius Laboratories for Natural Science Stockholm University SF-10691 Stockholm Sweden Department of Genetics and Pathology Rudbecklaboratoriet Uppsala University SE-751 85 Uppsala Sweden

There is a group of proteins that are encoded by a single gene, expressed as a single precursor protein and dually targeted to both mitochondria and chloroplasts using an ambiguous targeting peptide. Sequence analysis of 43 dual targeted proteins in comparison with 385 mitochondrial proteins and 567 chloroplast proteins ofArabidopsis thaliana revealed an overall significant increase in phenylalanines, leucines, and serines and a decrease in acidic amino acids and glycine in dual targeting peptides （dTPs）. The N-terminal portion of dTPs has significantly more serines than mTPs. The number of arginines is similar to those in mTPs, but almost twice as high as those in cTPs. We have investigated targeting determinants of the dual targeting peptide of Thr-tRNA synthetase （ThrRS-dTP） studying organellar import of N- and C-terminal deletion constructs of ThrRS-dTP coupled to GFR These results show that the 23 amino acid long N-terminal portion of ThrRS-dTP is crucial but not sufficient for the organellar import. The C-terminal deletions revealed that the shortest peptide that was capable of conferring dual targeting was 60 amino acids long. We have purified the ThrRS- dTP（2-60） to homogeneity after its expression as a fusion construct with GST followed by CNBr cleavage and ion exchange chromatography. The purified ThrRS-dTP（2-60） inhibited import of pF1β into mitochondria and of pSSU into chloroplasts at μM concentrations showing that dual and organelle-specific proteins use the same organellar import pathways. Furthermore, the CD spectra of ThrRS-dTP（2-60） indicated that the peptide has the propensity for forming α-helical structure in membrane mimetic environments; however, the membrane charge was not important for the amount of induced helical structure. This is the first study in which a dual targeting peptide has been purified and investigated by biochemical and biophysical means.

关键词： Dual targeting mitochondria chloroplast targeting peptide aminoacyl-tRNA synthetase

Wear Evaluation on Ni_3Al/MnS Composite Related to Metallurgical Processes

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Journal of Iron and Steel Research International 2012年第7期19卷 46-54页

作者： karin Gong LUO He-li ZHOU Zhi-feng TIAN Zhi-ling Lars Nyborg LI Chang-hai Department of Materials and Manufacturing Technology Chalmers University of Technology Gothenburg Se-412 96 Sweden China Iron and Steel Research Institute Group Beijing 100081 China Department of Manufacturing Engineering and Engineering Management City University of Hong Kong Hong Kong China

Iron alloyed Ni3Al with composition of Ni-18. 8Ab10. 7Fe-0. 5Mn-0. 5Ti-0. 2B in atom percent （NAC alloy） showed attractive tribological properties under unlubrication condition at room temperature. The alloy was prepared by hot isostatic pressing （HIP） process. The wear properties were associated with its intrinsic deformation mechanism. Unfortunately, the single phase NAC-alloy worked inadequately with its counterpart disk, and also showed a poor machinability. In the present work, NAC-alloy matrix composite with 6 % （volume percent） MnS particle addi- tion was studied to improve its wear behaviors and performance on machining. Two metallurgical processes of HIP and vacuum casting were applied to produce the testing materials. Pin-on-disk （POD） measurements were carried out at room temperature. A commercial vermicular graphite cast iron was selected as a reference material. The counter- part disk was made of a grey cast iron as liner material in ship engines. The contact pressures of 2.83 MPa and 5.66 MPa were normally applied in the tests. The investigation indicated that MnS particle addition in the NAC-alloy composites functions as an effective solid lubricant, and improved wear properties and machinability of the materials. Obvi- ously, as-cast NAC-alloy with in-situ formed MnS-phase was working more effectively with the counterpart, compa- ring to the HIPed NAC-alloy composite with MnS particles. At the high contact pressure of 5.66 MPa, the specific wear rate of the as-cast NAC-alloy composite was high. The phenomenon of the negative effect is mostly due to the brittle second NiAl phase as evidenced in the microstructure analysis.

关键词： HIP processing friction coefficient specific wear rate intermetallics sliding wear casting machinability

Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis

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Cellular & Molecular Immunology 2015年第4期12卷 493-503页

作者： Anna-karin E Palm Heike C Friedrich Anja Mezger Maya Salomonsson Linda K Myers Sandra Kleinau Department of Cell and Molecular Biology Uppsala University Uppsala Sweden Department of Pediatrics University of Tennessee Health ScienceCenter Memphis TN USA

Polyreactive innate-type B cells account for many B cells expressing self-reactivity in the periphery. Improper regulation of these B cells may be an important factor that underlies autoimmune disease. Here we have explored the influence of self-reactive innate B cells in the development of collagen-induced arthritis （CIA）, a mouse model of rheumatoid arthritis. We show that splenic marginal zone （MZ）, but not B- 1 B cells exhibit spontaneous IgM reactivity to autologous collagen II in na＇=＇ve mice. Upon immunization with heterologous collagen II in complete Freund＇s adjuvant the collagen-reactive MZ B cells expanded rapidly, while the B-1 B cells showed a modest anti-collagen response. The MZ B cells were easily activated by toll-like receptor （TLR） 4 and 9-1igands in vitro, inducing proliferation and cytokine secretion, implying that dual engagement of the B-cell receptor and TLRs may promote the immune response to self-antigen. Furthermore, collagen-primed MZ B cells showed significant antigen-presenting capacity as reflected by cognate T-cell proliferation in vitroand induction of IgG anti-collagen antibodies in vivo. MZ B cells that were deficient in complement receptors I and 2 demonstrated increased proliferation and cytokine production, while Fcy receptor lib deficiency of the cells lead to increased cytokine production and antigen presentation. In conclusion, our data highlight self-reactive MZ B cells as initiators of the autoimmune response in CIA, where complement and Fc receptors are relevant in controlling the self-reactivity in the cells.

关键词： arthritis complement receptors Fc receptors marginal zone B cells, mice

Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry

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World Journal of Gastroenterology 2021年第9期27卷 794-814页

作者： Sabrina L McIlwrath Marlene E Starr Abigail E High Hiroshi Saito karin N Westlund Research Service New Mexico Veterans Affairs Healthcare SystemAlbuquerqueNM 87108United States Department of Surgery University of KentuckyLexingtonKY 40536United States College of Liberal Arts University of TexasAustinTX 78712United States Department of Anesthesiology and Critical Care Medicine University of New Mexico Health Sciences CenterAlbuquerqueNM 87131United States

BACKGROUND Acute pancreatitis(AP)and recurring AP are serious health care problems causing excruciating pain and potentially lethal outcomes due to *** validated caerulein-(CAE)induced mouse model of acute/recurring AP produces secondary persistent hypersensitivity and anxiety-like behavioral changes for *** To determine efficacy of acetyl-L-carnitine(ALC)to reduce pain-related behaviors and brain microglial activation along the pain circuitry in *** Pancreatitis was induced with 6 hly intraperitoneal(i.p.)injections of CAE(50μg/kg),3 d a week for 6 wk in male C57BL/6J *** in week 4,mice received either vehicle or ALC until experiment’s *** hypersensitivity was assessed with von Frey *** hypersensitivity was determined with the hotplate ***-like behavior was tested in week 6 using elevated plus maze and open field *** activation in brain was quantified histologically by immunostaining for ionized calcium-binding adaptor molecule 1(Iba1).RESULTS Mice with CAE-induced pancreatitis had significantly reduced mechanical withdrawal thresholds and heat response latencies,indicating ongoing *** with ALC attenuated inflammation-induced hypersensitivity,but hypersensitivity due to abdominal wall injury caused by repeated intraperitoneal injections *** with pancreatitis displayed spontaneous anxiety-like behavior in the elevated plus maze compared to *** with ALC resulted in increased numbers of rearing activity events,but time spent in“safety”was not *** all the abdominal injections,pancreata were translucent if excised at experiment’s end and opaque if excised on the subsequent day,indicative of spontaneous *** mortem histopathological analysis performed on pancreas sections stained with Sirius Red and Fast Green identified wide-spread fibrosis and acinar cell atrophy in sections from mice with CAE-induced pancreatitis that was no

关键词： Acute recurrent pancreatitis Neuropathic pain Mechanical hypersensitivity Heat hypersensitivity Anxiety-like behavior Ionized calcium-binding adaptor molecule 1

Rare co-occurrence of osteogenesis imperfecta type Ⅰ and autosomal dominant polycystic kidney disease

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世界儿科杂志:英文版 2016年第4期12卷 501-503页

作者： Julia Hoefele karin Mayer Christoph Marschall Martin Alberer Hanns-Georg Klein Martin Kirschstein Center for Human Genetics and Laboratory Diagnostics Dr.Klein Dr.Rost and ColleaguesMartinsriedGermany Institute of Human Genetics Technische Universitat MünchenMunichGermany Department of Infectious Diseases and Tropical Medicine Ludwig-Maximilians UniversityMunichGermany Department of Pediatrics General HospitalCelleGermany

Background:There are several clinical reports about the co-occurrence of autosomal dominant polycystic kidney disease(ADPKD)and connective tissue disorders.A simultaneous occurrence of osteogenesis imperfecta(OI)type I and ADPKD has not been observed so ***:This report presents the first patient with OI type I and ***:Mutational analysis of PKD1 and COL1A1 in the index patient revealed a heterozygous mutation in each of the two *** analysis of the parents indicated the mother as a carrier of the PKD1 mutation and the father as a carrier of the COL1A1 *** simultaneous occurrence of both disorders has an estimated frequency of 3.5:***:In singular cases,ADPKD can occur in combination with other rare disorders,*** tissue disorders.

关键词： kidney disease osteogenesis imperfecta polycystic kidney

Participation of CD45,NKR-P1A and ANK61 antigen in rat hepatic NK cell(pit cell)-mediated target cell cytotoxicity

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World Journal of Gastroenterology 2000年第4期6卷 546-552页

作者： David Vermiilen Bülent Ahishali Vasilis Triantis karin Vanderkerken Peter J. K.Kuppen Eddie Wisse Laboratory for Cell Biology and Histology. Department of Hematology and immunology Free University of Brussels(VUB)Brussels-JetteBelgium K Vanderkerken is a postdoctoral researcher of the Fund for Scientific Research Flanders. Department of Surgery and Pathology Leiden University Medical CenterLeidenThe Netherlands

AIM Several triggering receptors have beendescribed to be involved in natural killer（NK）cell-mediated target *** these studies,NKcells derived from blood or spleen were *** are liver-specific NK cells that possess ahigher level of natural cytotoxicity and a differentmorphology when compared to blood NK *** aim of this study was to characterize the roleof the NK-triggering molecules NKR-P1A,ANK61antigen,and CD45 in pit cell-mediated killing oftarget *** 51Cr-release and DNA fragmentationwere used to quantify target cell lysis andapoptosis,*** Flow cytometric analysis showed thatpit cells expressed CD45,NKR-P1A,and *** of pit cells with monoclonalantibody（mAb）to CD45（ANK74）not onlyinhibited CC531s or YAC-1 target lysis but alsoapoptosis induced by pit *** mAbs to NKR-P1A（3.2.3）and ANK61 antigen（ANK61）had no effect on pit cell-mediated CC531s or YAC-1 targetcytolysis or apoptosis,while they did increase theFcγ receptor positive（FcγR+）P815 cytolysis *** enhanced cytotoxicity could beinhibited by 3,4-dichloroisocoumarin,an inhibitorof *** These results indicate that CD45participates in pit cell-mediated CC531s and YAC-1target cytolysis and ***-P1A andANK61 antigen on pit cells function as activationstructures against FcγR+ P815 cells,which wasmediated by the perforin/granzyme pathway.

关键词： hepatic NK cells pit cells cytolysis apoptosis perforin/granzyme pathway