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Lower marine productivity increases agonistic interactions between sea lions and fur seals in Northern Pacific Patagonia

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Current Zoology 2022年第6期68卷 657-666页

作者： Felipe MONTALVA Hector PAVeS Diego PeReZ-VeNegAS karin g barrientos e Carola VALeNCIA Diego MIRANDA-URBINA Mauricio SegUeL Facultad de Ciencias Biologicas Pontificia Universidad Catolica de ChileSantiagoChile Departamento de Ciencias Basicas Facultad de CienciasUniversidad Santo TomasOsornoChile Centro de Investigacion y gestion de Recursos Naturales(CIgReN) Instituto de BiologıaFacultad de CienciasUniversidad de ValparaısoValparaısoChile Programa de Doctorado en Ciencias Agrarias Escuela de Graduados de laFacultad de Ciencias Agrarias y AlimentariasUniversidad Austral de ChileValdiviaChile Facultad de Medicina Veterinaria Sede PatagoniaUniversidad San SebastianPuerto MonttChile Instituto de Ciencias Biologicas Universidad de TalcaTalcaChile Department of Pathobiology Ontario Veterinary CollegeUniversity of GuelphGuelphCanada

Interspecific interactions are key drivers of individual and population-level fitness in a wide range of ***,in marine ecosystems,it is relatively unknown which biotic and abiotic factors impact behavioral interactions between competing *** assessed the impact of weather,marine productivity,and population structure on the behavioral agonistic interactions between South American fur seals(SAFSs),Arctocephalus australis,and South American sea lions(SASLs),Otaria byronia,in a breeding colony of *** hypothesized that agonistic interactions between SAFSs and SASLs respond to biotic and abiotic factors such as SAFS population structure,marine productivity,and *** found that SASL and SAFS interactions almost always resulted in negative impacts on the social structure or reproductive success of the SAFS *** adult males initiated stampedes of SAFS and/or abducted and predated SAFS *** SAFS males abundance and severe weather events were negatively correlated with agonistic interactions between ***,proxies for lower marine productivity such as higher sea surface temperature and lower catches of demerso-pelagic fish were the most important predictors of more frequent agonistic interactions between SAFS and *** the current scenario of decline in marine biomass due to global climate change and overfishing,agonistic interactions between competing marine predators could increase and exacerbate the negative impacts of environmental change in these species.

关键词： interspecific interactions climate change guafo Island sea surface temperature South American fur seal South American sea lion

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BaTiO3 solid solutions co-doped with gd3+ and eu3+:Synthesis,structural evolution and dielectric properties

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Journal of Rare earths 2024年第10期 1920-1926页

作者： R.Martínez-López M.Pérez-Labra J.A.Romero-Serrano F.R.barrientos-Hernández M.Reyes-Pérez M.I.Valenzuela-Carrillo g.Urbano-Reyes V.e.Reyes-Cruz g.I.Dávila-Pulido Academic Area of earth Sciences and Materials Autonomous University of Hidalgo State Metallurgy and Materials Department ESIQIE-IPNUPALM Autonomous University of Coahuila Boulevard Adolfo López Mateos S/n

In this paper,the synthesis,structural evolution,and dielectric properties of BaTiO3solid solutions codoped with rare earth elements(gd3+and eu3+) prepared using the solid-state reaction method are *** pure precursor powders of BaCl3,TiO2,gd2O3,and eu2O3were mixed in stoichiometric proportions,ground in an agate mortar before being uniaxially pressed at 250 MPa and sintered at 1300℃ in air atmosphere for 6 h to obtain Ba1-3xgd2xTi1-3xeu4xO3（x=0,0.0015,0.01 and0.1）.X-ray diffraction（XRD） and Rietveld's refinement results reveal the crystal phase ferroelectric tetragonal BaTiO3for the samples with x=0,0.0015 and 0.01, as well as a consistent increment in the lattice parameters caused by the *** solubility limit of gd3+and eu3+in the BaTiO3structure is reached for the sample with x>0.01,and the orthorhombic eu2TiO5and monoclinic BaTi2O5secondary phases were *** Raman results show the characteristic peaks of ferroelectric tetragonal BaTiO3around 716 cm-1（LO of A1 symmetry）,515 cm-1（TO of A1 symmetry）,and 305 cm-1（B1）.The maximum relative permittivity measured at 1 kHz was recorded to be 6151.8 for the sample with x=0.0015,and a decrease in the Curie temperature to 105℃ with respect to the undoped sample was *** punctual microanalysis for the samples with x=0.0015,0.01,and 0.1 reveals grains composed of Ba,Ti,O,gd,and eu homogeneously distributed in the *** Ba/Ti ratios for samples with x=0.0015,0.01 and 0.1 are 2.86,2.91,and 0.68,respectively,indicating substitution at the Ti site for samples with x=0.0015 and 0.01 and a substitution at the Ba site for the sample with x=0.1.

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effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry

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World Journal of gastroenterology 2021年第9期27卷 794-814页

作者： Sabrina L McIlwrath Marlene e Starr Abigail e High Hiroshi Saito karin N Westlund Research Service New Mexico Veterans Affairs Healthcare SystemAlbuquerqueNM 87108United States Department of Surgery University of KentuckyLexingtonKY 40536United States College of Liberal Arts University of TexasAustinTX 78712United States Department of Anesthesiology and Critical Care Medicine University of New Mexico Health Sciences CenterAlbuquerqueNM 87131United States

BACKgROUND Acute pancreatitis(AP)and recurring AP are serious health care problems causing excruciating pain and potentially lethal outcomes due to *** validated caerulein-(CAe)induced mouse model of acute/recurring AP produces secondary persistent hypersensitivity and anxiety-like behavioral changes for *** To determine efficacy of acetyl-L-carnitine(ALC)to reduce pain-related behaviors and brain microglial activation along the pain circuitry in *** Pancreatitis was induced with 6 hly intraperitoneal(i.p.)injections of CAe(50μg/kg),3 d a week for 6 wk in male C57BL/6J *** in week 4,mice received either vehicle or ALC until experiment’s *** hypersensitivity was assessed with von Frey *** hypersensitivity was determined with the hotplate ***-like behavior was tested in week 6 using elevated plus maze and open field *** activation in brain was quantified histologically by immunostaining for ionized calcium-binding adaptor molecule 1(Iba1).ReSULTS Mice with CAe-induced pancreatitis had significantly reduced mechanical withdrawal thresholds and heat response latencies,indicating ongoing *** with ALC attenuated inflammation-induced hypersensitivity,but hypersensitivity due to abdominal wall injury caused by repeated intraperitoneal injections *** with pancreatitis displayed spontaneous anxiety-like behavior in the elevated plus maze compared to *** with ALC resulted in increased numbers of rearing activity events,but time spent in“safety”was not *** all the abdominal injections,pancreata were translucent if excised at experiment’s end and opaque if excised on the subsequent day,indicative of spontaneous *** mortem histopathological analysis performed on pancreas sections stained with Sirius Red and Fast green identified wide-spread fibrosis and acinar cell atrophy in sections from mice with CAe-induced pancreatitis that was no

关键词： Acute recurrent pancreatitis Neuropathic pain Mechanical hypersensitivity Heat hypersensitivity Anxiety-like behavior Ionized calcium-binding adaptor molecule 1

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Improved outcome with standardized plan for clinical management of acute decompensated chronic heart failure

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Journal of geriatric Cardiology 2019年第1期16卷 12-18页

作者： Marie-Louise edvinsson Albin Stenberg karin Astrom-Olsson Department of emergency and Internal Medicine University'Hospital of LundSweden Institute of Clinical Sciences L und UniversityL undSweden Department of Cardiology University>Hospital of MalmoSweden

Background Our overall goal is to improve clinical care for inpatients with chronic heart failure(CHF).A retrospective assessment of CHF patients admitted to our hospital over the past decade(2005 vs.2014)indicated a need for better strategies to evaluate clinical treatment,implement best practices and achieve optimal patient *** that purpose,we developed a standardized plan to improve in-hospital treatment of acute decompensated CHF ***&Results Retrospective chart reviews were conducted to compare three cohorts of CHF patients admitted to the University Hospital of Lund at different time points over a 12-year period:2005(365 patients),2014(172 patients)and 2017-2018(57 patients).Little improvement was seen between 2005 and 2014 with respect to one-year mortality(35%vs.34%)and adequate treatment with recommended medications,e.g.,use of renin-angiotensin system blockers(45%vs.51%).A standardized treatment plan was devised to improve outcomes.A third cohort,treated under the plan(2017-2018),was compared with the 2014 ***-year mortality(18%vs.34%)and 30-day readmission(5%vs.30%)were dramatically decreased,and adherence to medication guidelines was *** elements of the plan included well-defined treatment procedures,enhanced communication and teamwork,education,adequate time for treatment(5 days)and post-discharge follow-up as *** peptide(NT-proBNP)levels were useful for assessing patient status,prognosis and response to *** Developmeof a standard plan for clinical management of acute decompensated CHF patients resulted in significant improvements in patient outcome,as reflected in decreased rates of 30-day readmission and one-year mortality.

关键词： Chronic heart failure Medication NT-proBNP Prognosis

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Nanoscale chemical imaging of individual chemotherapeutic cytarabineloaded liposomal nanocarriers

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Nano Research 2019年第1期12卷 197-203页

作者： karin Wieland georg Ramer Victor U. Weiss guenter Allmaier Bemhard Lendl Andrea Centrone Institute of Chemical Technologies and Analytics Research Division EnvironmentalProcess Analytics and SensorsTU WienVienna 1060Austria Center for Nanoscale Science and Technology National Institute of Standards and TechnologyGaithersburgMD 20899USA Institute for Research in electronics and Applied Physics University of MarylandCollege ParkMD 20742USA Institute of Chemical Technologies and Analytics Research Division Instrumental and Imaging Analytical ChemistryTU WienVienna 1060Austria

Dosage of chemotherapeutic drugs is a tradeoff between efficacy and *** are nanocarriers that increase therapy efficacy and minimize side-effects by delivering otherwise difficult to administer therapeutics with improved efficiency and ***,variabilities in liposome preparation require assessing drug encapsulation efficiency at the single liposome level,an information that,for non-fluorescent therapeutic cargos,is inaccessible due to the minute drug load per *** induced resonance (PTIR) provides nanoscale compositional specificity,up to now,by leveraging an atomic force microscope (AFM) tip contacting the sample to transduce the sample's photothermal ***,on soft samples (e.g.,liposomes) PTIR effectiveness is reduced due to the likelihood of tip-induced sample damage and inefficient AFM ***,individual liposomes loaded with the chemotherapeutic drug cytarabine are deposited intact from suspension via nano-electrospray gas-phase electrophoretic mobility molecular analysis (neS-geMMA) collection and characterized at the nanoscale with the chemically-sensitive PTIR method.A new tapping-mode PTIR imaging paradigm based on heterodyne detection is shown to be better adapted to measure soft samples,yielding cytarabine distribution in individual liposomes and enabling classification of empty and drug-loaded *** measurements highlight PTIR capability to detect ~ 103 cytarabine molecules (~ 1.7 zmol) label-free and non-destructively.

关键词： tapping photothermal induced resonance (PTIR) nanoscale chemical imaging liposomes cytarabine drug delivery nanocarriers

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energy harvesting textiles for a rainy day:woven piezoelectrics based on melt-spun PVDF microfibres with a conducting core

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npj Flexible electronics 2018年第1期2卷 67-75页

作者： Anja Lund karin Rundqvist erik Nilsson Liyang Yu Bengt Hagstrom Christian Muller Department of Chemistry and Chemical engineering Chalmers University of TechnologyGöteborg 41296Sweden The Swedish School of Textiles University of BorasBoras 50190Sweden Department of Materials Swerea IVFBox 104Mölndal 43122Sweden Department of Industrial and Materials Science Chalmers University of TechnologyGoteborg 41296Sweden

Recent advances in ubiquitous low-power electronics call for the development of light-weight and flexible energy *** textile format is highly attractive for unobtrusive harvesting of energy from e.g.,biomechanical ***,we report the manufacture and characterisation of fully textile piezoelectric generators that can operate under wet *** use a weaving loom to realise textile bands with yarns of melt-spun piezoelectric microfibres,that consist of a conducting core surrounded byβ-phase poly(vinylidene fluoride)(PVDF),in the warp *** core-sheath constitution of the piezoelectric microfibres results in a—for electronic textiles—unique *** inner electrode is fully shielded from the outer electrode(made up of conducting yarns that are integrated in the weft direction)which prevents shorting under wet *** a result,and in contrast to other energy harvesting textiles,we are able to demonstrate piezoelectric fabrics that do not only continue to function when in contact with water,but show enhanced *** piezoelectric bands generate an output of several volts at strains below one *** show that integration into the shoulder strap of a laptop case permits the continuous generation of four microwatts of power during a brisk *** promising performance,combined with the fact that our solution uses scalable materials and well-established industrial manufacturing methods,opens up the possibility to develop wearable electronics that are powered by piezoelectric textiles.

关键词： piezoelectric harvesting electrode

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Postmenopausal Osteoporosis and Osteopenia Management with a Combination of Once-Monthly Oral Ibandronate and Cholecalciferol—A Systematic Review

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International Journal of Clinical Medicine 2023年第1期14卷 34-57页

作者： Mauro geller Mendel Suchmacher Marcio Cohen Spyros g. e. Mezitis Flavia Wajnsztajn-Theil karin g. Cunha Rafael Nigri Teresópolis Medical Faculty Rio de Janeiro Federal University Rua Bruno Lobo Brazil Carlos Chagas Post-graduation Institute Rio de Janeiro Brazil Orthopedic Surgery and Trauma National Institute Rio de Janeiro Brazil Weill Medical College of Cornell University New York USA Lenox Hill Hospital Northwell Health New York USA Fluminense Federal University Antonio Pedro Hospital Rio de Janeiro Brazil New Jersey Medical School New York USA

Postmenopausal osteoporosis and osteopenia are chronic and uncurable conditions that invariably lead to an increased risk of vertebral, hip, and femoral neck fracture if left untreated. Clinical guidelines establish, in general, pharmacological combinations allied to lifestyle changes as the mainstay of their management, and also increasing bone marrow density, lowering fracture risk, and improving quality of life are their main therapeutic goals. The objective of this systematic review was to analyze the available data in the scientific medical literature regarding the role of the ibandronate and cholecalciferol combination in postmenopausal osteoporosis and osteopenia management. Based on our results, we concluded that the above combination is safe and feasible for the clinical control of both conditions.

关键词： Ibandronate Cholecalciferol Postmenopausal Osteoporosis Postmenopausal Osteopenia Systematic Review

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Interactions Between TLR7 and TLR9 Agonists and Receptors Regulate Innate Immune Responses by Astrocytes and Microglia

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神经损伤与功能重建 2010年第2期5卷 122-134页

作者： NIRANJAN B. BUTCHI MIN DU karin e. PeTeRSON Laboratory of Persistent Viral Diseases Rocky Mountain LaboratoriesNational Institute of Allergy and Infectious Diseases

Toll样受体7(TLR7)和Toll样受体9(TLR9)是固有免疫反应中的重要介质。它们均定位于内涵体间隔,识别核酸和经过髓样分化因子88(MyD88)传导来的信号。本文分析TLR7和TLR9导致的在中枢神经系统固有免疫反应中起作用的星形胶质细胞和小胶质... 详细信息

Toll样受体7(TLR7)和Toll样受体9(TLR9)是固有免疫反应中的重要介质。它们均定位于内涵体间隔,识别核酸和经过髓样分化因子88(MyD88)传导来的信号。本文分析TLR7和TLR9导致的在中枢神经系统固有免疫反应中起作用的星形胶质细胞和小胶质细胞的活化。TLR7和TLR9激动剂引起星形胶质细胞和小胶质细胞相似的细胞因子反应,但二者仍有区别,小胶质细胞产生抗炎因子IL-10、抗凋亡因子g-CSF及IL-9,但星形胶质细胞不产生。对2种细胞的共刺激研究均显示,TLR7激动剂——咪喹莫特,能浓度依赖性地抑制TLR9激动剂引起的固有免疫反应。令人惊讶的是,这种抑制并非由TLR7介导,因为在TLR7的缺乏的情况下,TLR9激动剂导致的固有免疫反应仍然被抑制。固有免疫反应的抑制也并非由于抑制TLR9激动剂摄取所致。这提示咪喹莫特的抑制效应可能是直接作用,也许是通过阻滞Cpg-ODN结合和/或TLR9介导的信号转导所致,从而限制细胞活化。这种拮抗关系也存在于小胶质细胞中的这2类受体之间,TLR7的缺乏导致Cpg-ODN刺激的细胞因子反应增强。因此,在胶质细胞中,TLR7及其激动剂对TLR9介导的细胞因子反应有抑制作用。

关键词：大脑细胞因子共刺激咪喹莫特 Cpg-ODN

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Production and decay of polarized hyperon-antihyperon pairs

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Chinese Physics C 2023年第5期 35-54页

作者： karin Sch?nning Varvara Batozskaya Patrik Adlarson 周小蓉 Department of Physics and Astronomy Uppsala University Uppsala Institute of High energy Physics Chinese Academy of Sciences National Centre for Nuclear Research University of Science and Technology of China

Polarized hyperon-antihyperon pairs shed light on various unresolved puzzles in contemporary physics:How the strong interaction confines quarks into hadrons, how accurately the Standard Model describes microcosmos and even why our universe consists of so much more matter than antimatter. Thanks to their weak, parity violating decays, hyperons reveal their spin properties. This can be exploited e.g. the decomposition of the electromagnetic structure of hyperons, precision tests of flavour symmetry and searches for CP violation. At the BeSⅢ experiment at BePC-Ⅱ, Beijing, China, hyperon-antihyperon pairs can be produced in abundance. Recently collected large data samples have triggered the development of new methods that provide unprecedented precision and a plethora of new results have emerged. When applied at future high-intensity facilities like PANDA and STCF, precision physics will be taken to a new level which can contribute to the solution to the aforementioned puzzles.

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Production and decay of polarized hyperon-antihyperon pairs

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Chinese Physics C 2023年第5期47卷 29-48页

作者： karin Schonning Varvara Batozskaya Patrik Adlarson 周小蓉 Department of Physics and Astronomy Uppsala University Uppsala Sweden Institute of High energy Physics Chinese Academy of SciencesBeijing 100049China National Centre for Nuclear Research WarsawPoland University of Science and Technology of China Hefei 230026China

关键词： hyperon polarization CP violation form factors

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