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Use of Patient-Specific “4D” Tele-Education to Enhance Actual and Perceived Knowledge in Congenital Heart Disease (CHD) Patients

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Congenital Heart Disease 2024年第1期19卷 5-17页

作者： Molly Clarke karin Hamann Nancy Klein Laura Olivieri Yue-Hin Loke Department of Inpatient Cardiology Boston Children’s HospitalBoston02115USA Department of Cardiology Children’s National HospitalWashington20001USA Department of Cardiology Noninvasive Cardiac ImagingUniversity of Pittsburgh Medical Center Children’s Hospital of PittsburghPittsburgh15224USA

Background:Patients with congenital heart disease(CHD)will transition to lifelong adult congenital cardiac ***,their structural heart disease is challenging to convey via two-dimensional *** study utilized a tele-educational environment,with personalized three-dimensional(3D)modeling and health Details(3D+Details=“4D”),to improve actual and perceived knowledge,both important components of transition readiness in CHD ***:Participants aged≥13 years with a history of CHD and cardiac magnetic resonance imaging(MRI)studies were *** MRI datasets were then used to segment and create 3D heart models(using Mimics,Materialize Inc.).Participantsﬁrst completed the MyHeart Questionnaire,a validated survey of actual knowledge.A tele-educational session was then scheduled,during which participants were shown a 3D model of a normal heart,followed by their personal 3D heart model and speciﬁc health *** then repeated the actual knowledge survey,in addition to questionnaires assessing perceived knowledge pre-and post-session,as well as a satisfaction ***:Twenty-two patients were *** knowledge increased from 75%±15%to 89%±20%(p=0.00043)and perceived knowledge increased inﬁve of seven *** knowledge correlated with perceived knowledge(r=0.608,p<0.0001).Ninety-one percent of participants ranked the 3D model as“very satisfactory”and ninety-ﬁve percent ranked the educational session as“very help-ful”or“extremely helpful.”Conclusions:The use of“4D”tele-education increased both actual and perceived knowledge and may help improve transition readiness in CHD patients.

关键词： Congenital heart disease tele-education transition

A Setup for a Scenario-Driven Water Balance at Landscape Scale—Assessment with AKWA-M~-Embedded in a Model Framework for Land-Use Planning’s Decision Support in Mountainous Southwest China

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Journal of Earth Science 2010年第6期21卷 974-978页

作者： Andreas Wahren karin Berkhoff Albrecht Münch Sylvia Herrmann Karl-Heinz Feger Insitute of Soil Science and Site Ecology Technische Universitt Dresden Dr. Dittrich & Partner Hydro-Consult GmbH Institute of Environmental Planning Leibniz University Hannover

Land-cover changes cause a loss of natural vegetation in many parts of the world. In the Xishuangbanna （西双版纳） district （Yunnan （云南） Province）, rubber plantations replace tropical rainforests covering already an area of about 10% of the study area （2007）. There, land-use allocation is mostly driven by economic considerations. Thus, local planning authorities need decision support for land-use planning issues, which integrate socio-economic and ecological aspects. Within the NabanFrame, an agro-economic, ecological and social model was applied, which, altogether, interacted with a land allocation model via defined interfaces. Effects on the water cycle, ecological conditions as well as socio-economic should be considered by integrating the spatially distributed rainfali-runoff and water balance model AKWA-M in the model setup.

关键词： land-use water balance model rubber integrated land-use planning land-use prognosis.

Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve:galectin-3 participation

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Neural Regeneration Research 2020年第4期15卷 625-635页

作者： Henrique Rocha Mendonca Raul Carpi-Santos karin da Costa Calaza Ana Maria Blanco Martinez Laboratorio de Neurodegeneracao e Reparo Departamento de PatologiaPrograma de Pos-graduacao em Anatomia PatologicaFaculdade de MedicinaHospital Universitrio Clementino Fraga FilhoFederal University of Rio de JaneiroRio de JaneiroBrazil Polo Universitario Macae Unidade Integrada de Pesquisa em Produtos Bioativos e BiocienciasFederal University of Rio de JaneiroMacaeBrazil Laboratorio Integrado de Morfologia Instituto de Biodiversidade e SustentabilidadeNucleo de Pesquisas Ecologicas de MacaeFederal University of Rio de JaneiroMacaeBrazil Laboratorio de Neurobiologia Celular Instituto de Ciencias BiomedicasCentro de Ciencias da SaudeFederal University of Rio de JaneiroRio de JaneiroBrazil Laboratorio de Neurobiologia da Retina Departamento de NeurobiologiaPrograma de Pos-Graduacao em NeurocienciasFluminense Federal UniversityNiteroiBrazil

Diabetes is a lifelong disease characterized by glucose metabolic imbalance,in which low insulin levels or impaired insulin signaling lead to hyperglycemic *** 20 years of diabetes progression,95%of patients will have diabetic retinopathy,the leading cause of visual defects in working-age people *** diabetes is considered a microvascular disease,recent studies have shown that neurodegeneration precedes vascular changes within the diabetic visual system,albeit its mechanisms are still under *** and oxidative stress are intrinsically related phenomena,since macrophage/microglia and astrocytes are the main sources of reactive oxygen species during central nervous system chronic degenerative diseases,and both pathological processes are increased in the visual system during *** present review will focus on recent findings of the contribution of oxidative stress derived from neuroinflammation in the early neurodegenerative aspects of the diabetic visual system and their relationship with galectin-3.

关键词： diabetes diabetic retinopathy galectin-3 neurodegeneration neuroinflammation optic nerve oxidative stress retina

Behavioral and neural auditory thresholds in a frog

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Current Zoology 2019年第3期65卷 333-341页

作者： Ryan C.TAYLOR karin AKRE Walter WILCZYNSKI Michael J.RYAN Department of Integrative Biology University of Texas at Austin Austin TX USA Department of Biological Sciences Salisbury University Salisbury MD USA Smithsonian Tropical Research Institute Balboa Republic of Panama Neuroscience Institute and Center for Behavioral Neuroscience Georgia State University Atlanta GA USA

Vocalizations play a critical role in mate recognition and mate choice in a number of taxa, especially, but not limited to, orthopterans, frogs, and birds. But receivers can only recognize and prefer sounds that they can hear. Thus a fundamental question linking neurobiology and sexual selection asks-what is the threshold for detecting acoustic sexual displays? In this study, we use 3 methods to assess such thresholds in tdngara frogs: behavioral responses, auditory brainstem responsesz and multi unit electrophysiological recordi ngs from the *** show that thresholds are lowest for multiunit recordings (ca. 45 dB SPL), and then for behavioral responses (ca. 61 dB SPL), with auditory brainstem responses exhibiting the highest thresholds (ca. 71 dB SPL). We discuss why these estimates differ and why, as with other studies, it is unlikely that they should be the same. Although all of these studies estimate thresholds they are not measuring the same thresholds;behavioral thresholds are based on signal salienee whereas the 2 neural assays estimate physiological thresholds. All 3 estimates, however, make it clear that to have an appreciation for detection and salienee of acoustic signals we must listen to those signals through the ears of the receivers.

关键词： anurans auditory brainstem responses auditory thresholds mate choice Physalaemus pustulosus signal recog nition thresholds sexual selection tungara frogs vocalizations

Sniffing Bacteria with a Carbon-Dot Artificial Nose

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Nano-Micro Letters 2021年第7期13卷 138-152页

作者： Nitzan Shauloff Ahiud Morag karin Yaniv Seema Singh Ravit Malishev Ofra Paz-Tal Lior Rokach Raz Jelinek Department of Chemistry Ben Gurion University of the Negev84105 Beer ShevaIsrael Department of Biotechnology Engineering Ben Gurion University of the Negev84105 Beer ShevaIsrael Chemistry Department Nuclear Research CenterNegevP.O.Box 900184190 Beer ShevaIsrael Department of Software and Information System Engineering Ben-Gurion University of the NegevBeer ShevaIsrael Ilse Katz Institute for Nanotechnology Ben Gurion University of the Negev84105 Beer ShevaIsrael

Continuous,real-time monitoring and identification of bacteria through detection of microbially emitted volatile molecules are highly sought albeit elusive *** introduce an artificial nose for sensing and distinguishing vapor molecules,based upon recording the capacitance of interdigitated electrodes(IDEs)coated with carbon dots(C-dots)exhibiting different *** of the C-dot-IDEs to volatile molecules induced rapid capacitance changes that were intimately dependent upon the polarities of both gas molecules and the electrode-deposited *** deciphered the mechanism of capacitance transformations,specifically substitution of electrode-adsorbed water by gas molecules,with concomitant changes in capacitance related to both the polarity and dielectric constants of the vapor molecules *** C-dot-IDE gas sensor exhibited excellent selectivity,aided by application of machine learning *** capacitive C-dot-IDE sensor was employed to continuously monitor microbial proliferation,discriminating among bacteria through detection of distinctive“volatile compound fingerprint”for each bacterial *** C-dot-IDE platform is robust,reusable,readily assembled from inexpensive building blocks and constitutes a versatile and powerful vehicle for gas sensing in general,bacterial monitoring in particular.

关键词： Carbon dots Bacterial detection Bacterially emitted volatile molecules Capacitive gas sensors Gas polarity

Bacterial communities associated with natural and commercially grown rooibos (Aspalathus linearis)

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Pedosphere 2020年第6期30卷 778-790页

作者： Casparus J.BRINK Anneke POSTMA Etienne SLABBERT Ferdinand POSTMA A.Muthama MUASYA karin JACOBS Department of Microbiology University of StellenboschPrivate Bag X1Stellenbosch 7600South Africa Central Analytical Facility University of StellenboschPrivate Bag X1Stellenbosch 7602South Africa Department of Biological Sciences University of Cape TownPrivate Bag X3Rondebosch 7701South Africa

Aspalathus linearis is a commercially important plant species endemic to the Cape Floristic Region of South Africa and is used to produce a herbal tea known as rooibos *** interactions between *** and soil bacteria play an important role in the survival of Aspalathus plants in the highly nutrient-poor,acidic fynbos *** aim of this study was to characterize and compare rhizosphere and bulk soil bacterial communities associated with natural and commercially grown ***,as well as the effect of seasonal changes on these *** communities were characterized using high throughput amplicon sequencing,and their correlations with soil chemical properties were *** N-fixing bacterial community was characterized using terminal restriction fragment length polymorphism and real time quantitative polymerase chain ***,Proteobacteria,and Acidobacteria were the most dominant bacterial phyla detected in this *** similar bacterial communities were associated with natural and commercially grown *** differences in the bacterial community were observed between rhizosphere and bulk soils collected in the dry season,while no significant differences were detected in the wet *** study provides insights into bacterial community structure and potential factors shaping bacterial community structure with commercially important ***.

关键词： bulk soil fynbos N-fixing bacterial community operational taxonomic unit rhizosphere soil 16S rRNA sequencing

A quantitative analytical method for valienone and its application in the evaluation of valienone production by a breakthrough microbial process

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Chinese Journal of Natural Medicines 2017年第10期15卷 794-800页

作者： CUI Li karin Yanagi SHI Ting LIU Zhang-Min BAI Lin-Quan FENG Yan State Key Laboratory of Microbial Metabolism School of Life Science & Biotechnology and Joint International Research Laboratory of Metabolic & Developmental Sciences Shanghai Jiao Tong University Shanghai 200240 China

Valienone is a significant natural carbasugar member of the C7-cyclitol family as a valuable precursor for glycosidase inhibitor *** is an intermediate of validamycin A biosynthesis pathway and exhibits minimal accumulation in the fermentation broth of the natural Streptomyces producer.A quantitative analytical method is crucial for the development of a breakthrough microbial process overcoming the consumption of the natural metabolic *** present study was designed to develop a pre-column derivatization high-performance liquid chromatography method for quantification of valienone and to help establish a straightforward fermentation process for valienone production by metabolically engineered Streptomyces hygroscopicus *** was derivatized by 2,4-dinitrophenylhydrazine(DNPH)in 10 mmol×L^(-1) H_3PO_4 at 37℃ for 45 min and the derivatives were separated on Eclipse XDB-C18(5 μm,4.6 mm×150 mm)column at 30 °C eluted with 50% acetonitrile for 18 *** derivatives were detected by diode array detector at 380 nm and the configurations of the derivatives were determined by computational *** method was shown to be effective,sensitive,and *** linearity was found in the range of 5–2 000 μg×mL^(-1).The intra-and inter-day precisions were 1.1%–2.7% and 1.7%–2.2%,*** absolute recovery of the spiked samples was 97.2%–102.6%.To date,this is the first reversed-phase high-performance liquid chromatography detection method for valienone in microbial culture *** method successfully helped evaluate the valienone production capability of the engineered Streptomyces hygroscopicus 5008 and could be promising for C7-cyclitol profiling of different engineered mutants combined with the metabonomics methods.

关键词： Valienone Carbasugar Microbial process Derivatization HPLC

Phlegmonous appendicitis in children is characterized by eosinophilia in white blood cell counts

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World Journal of Pediatrics 2018年第5期14卷 504-509页

作者： Maximiliane I.Minderjahn Dag Schadlich Josephine Radtke karin Rothe Marc Reismann Department of Pediatric Surgery Charité–Universitatsmedizin BerlinAugustenburger Platz 113353 BerlinGermany

Background Phlegmonous and complicated appendicitis represent independent entities depending on hereditary immuno-logical mechanisms. However, clinically there are no means to distinguish uncomplicated phlegmonous from complicated appendicitis. The ability to distinguish these two forms of appendicitis is relevant as current attempts are to treat both forms of the disease differently. The aim of the present study was to investigate differences in white blood cell counts (WBCs) in these conditions to identify areas of interest for future molecular studies. Methods White blood cell counts of patients aged between 7 and 14 years who underwent appendectomy from January 2008 to June 2016 were investigated with special reference to particular cellular subpopulations. Results A total of 647 children were included in the study. Within distinct inflammatory patterns, significant eosinophilia and basophilia were found in phlegmonous inflammation compared with complicated inflammation (0.11±0.19×109/L vs. 0.046±0.104×109/L, P<0.0001, and 0.033±0.031×109/L vs. 0.028±0.024×109/L, P<0.001). Conclusions Compared with complicated disease, phlegmonous appendicitis seems to depend primarily on eosinophil inflam-mation. This observation is stable over time and indicates a direction for investigation of underlying genetic prerequisites.

关键词： Appendicitis Children Eosinophil granulocytes Immunology

Simulation-based design optimization of the holographic wavefront sensor in closed-loop adaptive optics

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Light(Advanced Manufacturing) 2022年第3期3卷 60-75页

作者： Andreas Zepp Szymon Gladysz karin Stein Wolfgang Osten Fraunhofer IOSB EttlingenFraunhofer Institute of OptronicsSystem Technologies and Image ExploitationGutleuthausstraБe 176275 EttlingenGermany University of Stuttgart Institute for Applied Optics ITOPfaffenwaldring 970569 StuttgartGermany

Adaptive optics systems are used to compensate for wavefront distortions introduced by atmospheric *** distortions are corrected by an adaptable device,normally a deformable *** control signal of the mirror is based on the measurement delivered by a wavefront *** characteristics of the wavefront sensor are the measurement accuracy,the achievable measurement speed and the robustness against *** modal holographic wavefront sensor can theoretically provide the highest bandwidth compared to other state of the art wavefront sensors and it is robust against scintillation ***,the measurement accuracy suffers from crosstalk effects between different aberration modes that are present in the *** this paper we evaluate whether the sensor can be used effectively in a closed-loop AO system under realistic turbulence *** simulate realistic optical turbulence represented by more than 2500 aberration modes and take different signal-to-noise ratios into *** determine the performance of a closed-loop AO system based on the holographic *** counter the crosstalk effects,careful choice of the key design parameters of the sensor is ***,we apply an optimization method to find the best sensor design for maximizing the measurement *** modifying this method to take the changing effective turbulence conditions during closed-loop operation into account,we can improve the performance of the system,especially for demanding signal-to-noise-ratios,even ***,we propose to implement multiple holographic wavefront sensors without the use of additional hardware,to perform multiple measurement at the same *** show that the measurement accuracy of the sensor and with this the wavefront flatness can be increased significantly without reducing the bandwidth of the adaptive optics system.

关键词： Adaptive optics Holography Holographic wavefront sensor Karhunen-Loève modes