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Immunobiodiversity:Conserved and specific immunity across land plants and beyond

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Molecular Plant 2024年第1期17卷 92-111页

作者： Baptiste Castel karima el Mahboubi Christophe Jacquet Pierre-Marc Delaux Laboratoire de Recherche en Sciences Végétales(LRSV) Universitéde ToulouseCNRSUPSToulouse INPCastanet-TolosanFrance

Angiosperms represent most plants that humans cultivate,grow,and ***,angiosperms are only one of five major land plant *** a whole lineage,plants also include algal *** these clades represent a tremendous genetic diversity that can be investigated to reveal the evolutionary history of any given *** this review,we describe the current model of the plant immune system,discuss its evolution based on the recent literature,and propose future directions for the *** angiosperms,plant–microbe interactions have been intensively studied,revealing essential cell surface and intracellular immune receptors,as well as metabolic and hormonal defense *** diversity at the genomic and functional levels demonstrates the conservation of these pathways across land plants,some of which are beyond *** basis of the conserved mechanisms,lineage-specific variations have occurred,leading to diversified reservoirs of immune *** rare cases,this diversity has been harnessed and successfully transferred to other species by integration of wild immune receptors or engineering of novel forms of receptors for improved resistance to *** propose that exploring further the diversity of immune mechanisms in the whole plant lineage will reveal completely novel sources of resistance to be deployed in crops.

关键词： evolution MPMI immunity plant evoMPMI symbiosis

Saffron(Crocus sativus L.) stigmas as a potential natural additive to improve oxidative stability attributes of sunflower(Helianthus annuus L.) oil stored under different conditions

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Grain & Oil Science and Technology 2024年第3期 133-149页

作者： Moussa Nid Ahmed karima Abourat Jamila Gagour el Hassan Sakar Khalid Majourhat Said Gharby Biotechnology Analytical Sciences and Quality Control Team Polydisciplinary Faculty of Taroudant University Ibnou Zohr Laboratory of Biology Ecology and Health FS Abdelmalek Essaadi University Geo-Bio-Environmental Engineering and Innovation Laboratory Polydisciplinary Faculty of Taroudant University Ibnou Zohr

The aim of our study was to explore the antioxidant potential of Moroccan saffron stigmas（SS） and examine their performance as a natural antioxidant in enhancing the stability and quality properties of edible sunflower oil（SO）, with a focus on understanding the critical importance of edible oil stability for predicting quality deterioration during storage. Bearing this in mind, our research was designed to compare the efficacy of three concentrations of dried SS（at 0.2%, 0.3%, and 0.6%） against tocobiol（a synthetic antioxidant） as a positive control（at 0.3% concentration）. This comparison was conducted under three distinct storage conditions namely accelerated ageing（60 ℃）, exposure to light at ambient temperature, and darkness, to evaluate their impact on preventing severe oxidation and extending oil shelf-life. Oxidation state evolution was evaluated through peroxide value（PV）, free fatty acid（FFA）, anisidine value（p-AV）, K270value（conjugated trienes）, total oxidation index（TOTOX）, iodine value（IV）, and fatty acid composition（FA）. Our results revealed notable differences in stability tracking parameters. Specifically, these parameters were higher in samples stored under accelerated conditions, followed by the samples stored in ambient light, while those stored in darkness showed the highest stability among the three storage conditions. Supplementation of sunflower oil with SS and tocobiol significantly enhanced its oxidation stability. Notably, SS exhibited exceptional effectiveness in stabilizing sunflower oil regardless of SS dose, with the highest efficacy observed at 0.6%. This was evidenced by the slower rate of oxidation parameters under various storage conditions, highlighting a superior antioxidant activity compared to both the non-enriched oil and tocobiol-enriched oil. Furthermore, saffron stigmas, used as a natural supplement,contributed to the preservation of polyunsaturated fatty acids, indicating its potential as a robust source of natural antioxidan

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Epidemiology of Pemphigus: A Single Center Experience in Morocco

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International Journal of Dermatology and Venereology 2022年第1期5卷 20-26页

作者： Farah el Hadadi Line Mezni karima Senouci Laila Benzekri Nadia Ismaili Mariame Meziane Department of Dermatology-Venereology Ibn Sina University HospitalMohammed V UniversityRabat 10100Morocco

Objective:Pemphigus is a life threatening autoimmune bullous disease which involves the skin and mucous membranes of the stratified squamous *** global distribution of Pemphigus varies according to genetic,ethnic,socioeconomic,and cultural *** purpose of our study is to evaluate the epidemiological features of pemphigus a single center in Morocco and compare our results with those reported ***:A retrospective analysis was conducted of 302 pemphigus patients seen between 1990 and 2020 in the Dermatology Department of Ibn Sina Hospital(Rabat,Morocco).We further collected all the Moroccan scientific researches published by now to ***:The average annual incidence was 0.32/100,000 *** incidence doubled to 0.72 in *** most common variant was pemphigus vulgaris(125 cases)followed by pemphigus erythematosus(99 cases),pemphigus foliaceous(40 cases),and vegetans(27 cases).The female to male ratio was 0.75,the average age at onset was 53 years old and the mean duration of the disease before diagnosis was ***:This study joins the main characteristics of pemphigus in the Maghreb and around the world(pemphigus vulgaris most frequent subtype).In 2020,an epidemiological peak occurred during the coronavirus disease 2019 pandemic;probably related to stress and delayed time consultation for fear of contracting the severe acute respiratory syndrome coronavirus 2.

关键词： pemphigus epidemiology Rabat Morocco autoimmune bullous disease desmoglein

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Assessment of ship manoeuvrability by using a coupling between a nonlinear transient manoeuvring model and mathematical programming techniques

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Journal of Hydrodynamics 2013年第5期25卷 788-804页

作者： TRAN KHANH Toan OUAHSINE Abdellatif NACEUR Hakim el WASSIFI karima Laboratoire Roberval Université de Technologie de Compiègne Laboratoire LAMIH Université de Valenciennes Université Cadi Ayyad Faculté des Sciences et Techniques

In this paper, a numerical method based on a coupling between a mathematical model of nonlinear transient ship manoeuvring motion in the horizontal plane and Mathematical Programming （MP） techniques is proposed. The aim of the proposed procedure is an efficient estimation of optimal ship hydrodynamic parameters in a dynamic model at the early design stage. The proposed procedure has been validated through turning circle and zigzag manoeuvres based on experimental data of sea trials of the 190 000- dwt oil tanker. Comparisons between experimental and computed data show a good agreement of overall tendency in manoeuvring traiectories.

关键词： ship manoeuvrability hydrodynamics coefficients nonlinear transient dynamics sensitivity analysis mathematical pro- gramming

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Spatial and statistical assessment of nitrate contamination in groundwater:Case of Sais Basin, Morocco

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Journal of Groundwater Science and Engineering 2020年第2期8卷 143-157页

作者： Abdelhakim LAHJOUJ Abdellah el HMAIDI karima BOUHAFA Laboratory of Geo-engineering and Environment Department of GeologyFaculty of SciencesMoulay Ismail UniversityP O Box 11202ZitouneMeknesMorocco Laboratory of Water Soiland PlantNational Institute of Agricultural Researchkm 10Road Haj KaddourP O Box 578 VNMeknesMorocco.

The objective of this study is to evaluate the nitrate contamination in the plioquaternary aquifer of Sais Basin based on a statistical approach. A total of 98 samples were collected in the cultivated area during the spring and autumn period of 2018. The results show that 55% and 57% of the samples in spring and autumn respectively exceed the threshold fixed by WHO(50 mg/L). However, nitrate concentrations do not show seasonal and spatial variation(p>0.05). The results of the correlation matrix, principal component analysis(PCA), and hierarchical cluster analysis(HCA) suggest that nitrate pollution is related to anthropogenic source. Moreover, multiple linear regression results show that NO3 is more positively explained in the spring period by Ca and SO4 and negatively explained by pH and HCO3. Regarding the autumn period, nitrate pollution is positively explained by Ca and negatively by pH. This study proposes a useful statistical platform for assessing nitrate pollution in groundwater.

关键词： Sais Basin Nitrate pollution Groundwater Multivariate statistics

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Comparison of Clinicopathological and Survival Features of Right and Left Colon Cancers: Experience of the Medical Oncology Department of Fez

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Journal of Cancer Therapy 2023年第6期14卷 291-298页

作者： Soukaina el Anssari Youssef elhaitmy Lamiae Amaadour karima Oualla Zineb Benbrahim Samia Arifi Nawfel Mellas Department of Medical Oncology University Hospital Center Hassan II City of Fez Morocco

Right-sided colon cancers (RCC) and left-sided colon cancers (LCC) have different epidemiological, physiological, pathological, genetic, and clinical characteristics, which result in differences in the course, prognosis, and outcome of disease. The objective of our study is to compare right-sided colon cancers and left-sided colon cancers regarding clinicopathological and survival characteristics. This is a retrospective study of 664 patients with colon cancer treated at the medical oncology department of Fez over a period from December 2009 to September 2020. Rectosigmoid, descending colon, and splenic flexure tumors were considered left-sided colon cancers, whereas ascending colon tumors were considered right-sided colon cancers. The Kaplan Meier method was used to estimate median survival. The study included 664 patients (female, 47%) having colon cancer with a median age of 60 years (23 - 83). Of the patients, 78.5% (n = 519) had LCC and 19.36 % (n = 128) had RCC. The rate of patients aged ≥ 65 years and the rate of patients with a family history of colon cancer was higher in the LCC patients. The proportion of poorly differentiated adenocarcinomas represented 3%, of which 63% had cancer of the right colon. There was a significantly higher proportion of higher T stage (T3-4: 62% vs 38%) in right sided tumors as compared to left sided tumors. The rate of metastatic patients was 64.1% in the RCC group and 43% in the LCC group. The median follow-up period was 14 months in the RCC group and 19 months in the LCC group with higher median overall survival in the LCC group (32 vs 21 months). We found histopathological differences between right and left sided colon cancer. Tumors on the right colon were found to be more aggressive, as expressed by poorer differentiation, higher T stage associated with a median overall survival better in left colon cancer.

关键词： Right-Sided Colon Cancers (RCC) Left-Sided Colon Cancers (LCC) Prognosis Survival

Cooperative system analysis of the Ebola virus epidemic model

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Infectious Disease Modelling 2018年第1期3卷 145-159页

作者： karima Kabli Soumia el Moujaddid Khadija Niri Abdessamad Tridane Department of Mathematics and Computing Ain Chock Science FacultyHassan II UniversityCasablancaMorocco Department of Mathematical Sciences United Arab Emirates UniversityP.O.Box 15551Al AinUnited Arab Emirates

This paper aims to study the global stability of an Ebola virus epidemic *** this epidemic ended in September 2015,it devastated several West African countries and mobilized the international *** the recent cases of Ebola in the Democratic Republic of the Congo(DRC),the threat of the reappearance of this fatal disease ***,we are obligated to be prepared for a possible re-emerging of the *** this work,we investigate the global stability analysis via the theory of cooperative systems,and we determine the conditions that lead to global stability diseases free and endemic equilibrium.

关键词： Ebola virus Basic reproduction number Cooperative systems Global stability Varying population size

Effect of epidermal growth factor on buffalo frozen spermatozoa biometry and metabolic activity

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Asian pacific Journal of Reproduction 2017年第1期6卷 46-51页

作者： Mohamed MM Kandiel Ahmed RM el-Khawagah karima Gh Mahmoud Department of Theriogenology Faculty of Veterinary MedicineBenha UniversityEgypt Department of Animal Reproduction and Artificial Insemination National Research CentreDokkiGizaEgypt

Objective:To assess the effects of epidermal growth factor (EGF) on the Egyptian buffalo bull frozen semen, EGF was incorporated at 0 (control), 50, 100, 200 and 400 ng/mL of extender (Bioxcell?).Methods:Semen features, spermatozoa biometry, total liberated amounts of enzymes (aspartate transaminase, alanine aminotransferase, lactate dehydrogenase, acid phosphatase and alkaline phosphatase) and lipid peroxidation markers (thiobarbituric acid reactive substances, malondialdehyde, glutathione peroxidase, nitric oxide, catalase (CAT) and superoxide dismutase (SOD)) were determined in the spermatozoa-free extracellular extender. Results:Spermatozoa membrane integrity significantly (Pell as acrosome and midpiece measures substantially differed with regard to EGF. Principle piece length and volume markedly decreased (at 100 and 200 ng/mL), while total tail/flagellum length increased (at 50 ng/mL) after EGF supplementation. EGF 50 ng/mL was associated with the decline of nitric oxide levels and catalase enzyme activity, but EGF 100 ng/mL significantly decreased the total liberated amounts of enzymes (aspartate transaminase, lactate dehydrogenase, acid phosphatase and alkaline phosphatase) as well as lipid peroxidation markers (thiobarbituric acid reactive substances and malondialdehyde).Conclusion:EGFin vitro supplementation would affect the semen characteristics of buffalo bull with 100 ng/mL counteracted the freezing mediated oxidative stress indicated with the lowest enzymes leakage and lipid peroxidation.

关键词： Buffalo Epidermal growth factor Lipid peroxidation Seminal enzymes Speriogram

Effect of melatonin and/or cysteamine on development and vitrification of buffalo embryos

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Asian pacific Journal of Reproduction 2017年第4期6卷 176-180页

作者： Mohamed MM el-Sokary Mohamed el-Raey karima GhM Mahmoud Mahmoud EA Abou el-Roos Gamal MS Sosa Department of Theriogenology Faculty of Veterinary MedicineBenha UniversityP.O:13736TokhKaliobiaEgypt Department of Anim.Reprod.&A.I. National Research CenterDokkiGizaEgypt

Objective:To assess the effects of melatonin and/or cysteamineonin vitro maturation, culturing and post-warming of buffalo ***: Buffalo oocytes were classified into control, cysteamine (50 μM), melatonin (10 ng/mL) and cysteamine (50 μM) + melatonin (10 ng/mL) treatment groups. In experiment 1, previous treatments were added duringin vitromaturation and culturing of buffalo ***:Cleavage and blastocyst rates were significantly (Pelatonin treated group (70.5±0.9 and 12.8±1.0, respectively). However this effect was potentiated when combined with cysteamine (74.0±1.7 and 14.8±1.7, respectively). In experiment 2, the treatements were added in maturtaion, culturing as well as post-warming culture media. Embryos at 7 d were *** assessement directly after warming showed significant increase (Pelatonin and their combination groups (76.8±2.8, 80.0±2.1 and 83.3±1.7, respectively) than control (65.8±2.4);but the viability after 24 h post-warming was the best in cysteamine + melatonin combination group (61.4±2.1).Conculsions: Enriching maturation, culturing and post-warming media of buffalo oocytes and embryos with melatonin and/or cysteamine have significantly beneficial effects on oocyte developmental competence as well as embryos vitrification procedure outcomes which in turn resulting in enhancement of commercial buffalo embryo production.

关键词： Melatonin Cysteamine Buffalo Oocyte Maturation Vitrification