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Journal of Coastal Life Medicine 2016年第12期4卷 961-964页

作者： Tasmia Rahman samira karim Zubair Khalid Labu Department of Pharmacy World University of Bangladesh151/8Green RoadDhakaBangladesh

Objective:To justify the folkloric use of Swietenia mahagoni(***)seeds,90%ethanolic extract and their aqueous and organic partitioning substances were evaluated for their possible antidiarrhoeal and antimicrobial potentials in ***:Crude ethanolic extract of *** seeds were subjected and partitioned into fractions using solvents at different *** and antidiarrheal activities were evaluated and subsequently outcomes were corresponded with the conventional standard ***:The antidiarrheal activity was assessed using mouse model,where unfractionated ethanolic extract significantly reduced,the number,onset,rate and weight of diarrheal *** fraction showed the limited number of defecation episodes of 27.0%and 40.9%at dose of 200 mg/kg and 400 mg/kg body weight respectively and reference drug,loperamide,showed 53%at a dose of 50 mg/*** extract fractions exhibited the significant potential to kill or subside the growth of known Gram-positive and Gram-negative ***:Ethanolic extract and their aqueous and organic fractious revealed the seeds of ***(Linn.)have the potential to be used as a remedy for diarrhea and known pathogenic microbes which ensured the folkloric use of the seeds of ***.

关键词： Swietenia mahagoni(Linn.) Folkloric use Antimicrobial Antidiarrheal activities

In vivo hypoglycemic, antinociceptive and in vitro antioxidant activities of methanolic bark extract of Crataeva nurvala

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Journal of Coastal Life Medicine 2017年第11期5卷 496-500页

作者： Uddin Jalal karim samira Gain Dwigbijoy Hassan Mahmudul Sultana Julie Azima Khalid Labu Zubair Phytochemical Research Laboratory Department of PharmacyWorld University of Bangladesh151/8 Green RoadDhaka-1205Bangladesh

Objective: To rationalize the folkloric use of hypoglycemic, antinociceptive and antioxidant potentials with phytochemical screening of methanolic bark extract of Crataeva nurvala (C. nurvala) in vivo and in vitro. Methods: The collected bark was dried and grinded. The coarse powder was soaked in 2000 mL of 90% methanol for several days then filtrated. At 40 °C the volume of crude methanolic extract (CME) was reduced by a vacuum rotary evaporator, then the aqueous methanol extract was separated into petroleum ether, carbon tetrachloride, and aqueous soluble fractions by Kupchan protocol. Then the extracts were subjected to evaluate in vivo analgesic, hypoglycemic activities in Swiss albino mice model and antioxidant in vitro. Results: In quantitative phytochemical analysis, total phenolic content was found maximum (235.94 mg of GAE/g) in aqueous soluble fraction;in case of antioxidant potentials, DPPH free radical scavenging assay showed IC50 value of 9.25 μg/mL exhibited by aqueous soluble fraction in comparison to ascorbic acid (8.27 μg/mL) as a reference standard. The CMEs potentially (P < 0.05) reduced the acetic acid-induced writhing and increased (P < 0.05;P< 0.01) latency period in the tail immersion method at a dose dependent manner. The CME significantly reduced blood sugar level of diabetic rat induced by alloxan monohydrate. Conclusions: This study was conducted to validate the extensive use of C. nurvala bark as folk medicine with antinociceptive, hypoglycemic and antioxidant effects. It can be concluded that the bark of C. nurvala possesses good antinociceptive, moderate hypoglycemic and antioxidant activities. However, further chemical and pharmacological revise are needed to elucidate the detail mode of action behind this and identify the responsible active principles.

关键词： Crataeva nurvala Antinociceptive Hypoglycemic Antioxidant

Biological investigations of medicinal plants of Heliotropium indicum indigenous to Bangladesh

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Journal of Coastal Life Medicine 2016年第11期4卷 874-878页

作者： karim samira Kawsar Md Farhina Rahman Laboni Azima Sultana Julie Uddin Jalal Zubair Khalid Labu Department of Pharmacy World University of Bangladesh(WUB)151/8 Green RoadDhakaBangladesh

Objective:To investigate the clot lysis,antimicrobic and membrane stabilizing potentials of ethanolic extractives of the leaves of Heliotropium indicum(***).Methods:Crude ethanolic extracts of *** leaves were partitioned successively using solvents of different polarity and subjected to determine qualitatively and quantitatively for the presence of different bioactive constitutes and fractions which were assessed for their possible clot lysis,antimicrobic,and membrane stabilizing activities as compared with the known ***:For the thrombolytic activity,the petroleum ether soluble fraction showed the highest percent of clot lysis(35.4%)among all fractions,while streptokinase and water resulted in 65.15%and 3.77%clot lysis,*** respect to the membrane stabilizing activity,carbon tetrachloride soluble fraction of *** profoundly interdicted the hemolysis of erythrocytes brought about by osmotic induction(39.24%)or by heat(40.20%).The other fractions exhibited less significant membrane stabilizing *** contrast,acetylsalicylic acid resulted in 72.25%±0.30%inhibition of osmotically induced hemolysis and showed a lower level of protection of heat induced hemolysis(42.56%).Crude ethanolic extracts were moderately sensitive against known pathogenic *** pharmacological activities of *** are due to the presence of bioactive compounds,we detected and quantified the presence of significant levels of flavonoid and tannin ***:The outcomes of this research show that the leaves of *** have the potential to be used as a remedy for thrombosis,inflammatory diseases and against few important bacterial pathogens.

关键词： Heliotropium indicum Thrombolytic Membrane stabilizing Antimicrobial activity

Wheat breeding for Hessian fly resistance at ICARDA

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The Crop Journal 2022年第6期10卷 1528-1535页

作者： Wuletaw Tadesse samira El-Hanafi karim El-Fakhouri Imane Imseg Fatima Ezzahra Rachdad Zakaria El-Gataa Mustapha El Bouhssini International Center for Agricultural Research in the Dry Areas(ICARDA) P.O.Box 6299RabatMorocco Biodiversity and Plant Sciences Program AbroBioSciencesMohammed VI Polytechnic UniversityLot 660-Hay Moulay Rachid43150 Ben GuerirMorocco

Hessian fly(HF),Mayetiola destructor(Say)is an important pest of wheat in North Africa,North America,Southern Europe,Northern Kazakhstan,Northwestern China,and New *** can cause up to 30%yield losses and sometimes can result in complete crop failure if infestation coincides with young stage of the wheat *** to-date have shown the availability of genetic diversity in the wheat genetic resources(landraces,wild relatives,cultivars,etc.)for resistance to Hessian *** 37 resistance genes have been reported from these wheat genetic resources for resistance to Hessian fly,of which,some have been deployed singly or in combination in the breeding programs to develop high yielding varieties with resistance to *** of resistant varieties in different agro-ecologies with other integrated management measures plays key role for the control of *** paper summarizes the importance,life cycle,mechanisms of resistance,gene mining,and wheat breeding efforts for HF resistance.

关键词： Breeding Gene introgression Hessian fly Resistance

Thyroid Disorders in Women with Polycystic Ovary Syndrome

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Journal of Biosciences and Medicines 2020年第4期8卷 128-141页

作者： Hasna Hena Pervin Rezaul karim Kazal A. K. M. Shahidur Rahman Tabassum Pervin Kaniz Fatema Saima Akhtar Chowdhury S. K. Mamun-Ar-Rashid samira Mahjabeen Department of Obstetrics and Gynaecology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Fetomaternal Medicine Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Officer on Special Duty (OSD) Director General of Health (DG Health) Dhaka Bangladesh Department of Medicine Khulna Medical College Hospital Khulna Bangladesh Department of Endocrinology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh

Background: Polycystic ovary syndrome (PCOS) is one of the common endocrinopathies of women in the reproductive age group. Thyroid hormones have various effects on the reproductive system of female. PCOS and thyroid dysfunction are linked to each other since several years. Objective: To evaluate and detect the thyroid dysfunction in patients with PCOS attending in a tertiary care hospital in Bangladesh. Methodology: This was a prospective cross sectional study conducted from November 2018 to October 2019 at Department of Obstetrics and Gynecology in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh on one hundred and fifty (150) PCOS women of reproductive age (15 - 45 years). All data of the study subjects regarding socio-demographic, anthropometric and clinical manifestations were recorded accordingly. Their thyroid function tests (serum level of FT3, FT4, TSH) were done at the hospital laboratory and results were recorded. Result: Mean (±SD) age of the study subjects was 24.57 ± 4.27 years. The maximum numbers [108 (72.0%)] of PCOS women were between 18 - 25 years age group. Among total (150) study population, 51 (34.0%) were overweight, 36 (24.0%) were obese and 63 (42.0%) were within normal weight level. Hirsutism was found in 87 (58%) study subjects while 24 (16%) subjects had acne in their face, 54 (36%) subjects had oligomenorrhea and 45 (30%) subjects had irregular periods. Among 150 PCOS women, 120 (80%) were married and 30 (20%) were single;of them primary infertility was detected in 58 (48.33%) women followed by the normal fertility status [51 (42.5%)] and 11 (9.17%) had secondary infertility. Among total (150) study subjects, 105 (70%) were in euthyroid state, hypothyroidism was found in 33 (22.0%) subjects and hyperthyroidism was detected in 12 (8%) subjects. Conclusions: Present study demonstrated that, thyroid disorders are prevalent in 30.0% of PCOS patients. Hypothyroidism is almost three-fold more prevalent than hyperthyroidism

关键词： Polycystic Ovary Syndrome (PCOS) Reproductive Age Thyroid Disorder

Characterization of Habitat of Rhamnus alaternus L. at the Jebel Tessala （North-Western Algeria）

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Journal of Chemistry and Chemical Engineering 2014年第11期8卷 1036-1048页

作者： Benchiha Walid Mahroug samira Bennaoum Zineb Bouterfas karim Department of Environment Faculty of Nature and Life Djillali Liabes University Sidi Bel A bbes 22000 Algeria