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Science China(l.fe Sciences) 2011年第7期54卷 589-598页

作者： WANG DunCheng Dana l. KYl.IK kari l. murad Wendy M. TOYOFUKU Mark D. SCOTT Canadian Bl.od Services Vancouver V6T 1Z3 British Columbia Canada Centre for Bl.od Research and the Department of Pathol.gy and l.boratory Medicine University of British Col.mbia Vancouver V6T 1Z3 British Columbia Canada Department of Biol.gy College of St. Rose Albany 12208 New York USA

Devel.ping a practical.means of reducing al.oimmunization in chronical.y transfused patients woul. be of significant cl.nical.benefit. Immunocamoufl.ging red bl.od ceil. （RBCs） by membrane grafting of methoxypol.（ethyl.ne gl.col. （mPEG） may reduce the risk of al.o-immunization. The resul.s of this study showed that antibody recognition of non-ABO antigens was sig- nificantl. reduced in an mPEG-dose- and pol.mer size-dependent manner, with higher mol.cul.r weight mPEGs providing better immunoprotection. Furthermore, in vivo immunogenicity was significantl. reduced in mice serial.y transfused with mPEG-modified xenogeneic （sheep; sRBCs）, al.ogeneic （C57B1/6）, or syngeneic （Bal./c） RBCs. Fol.owing a primary transfu- sion of sRBCs, mice receiving mPEG-sRBCs showed a 〉90% reduction in anti-sRBC IgG antibody l.vel.. After two transfusions, mice receiving mPEG-sRBCs showed reductions of 〉80% in anti-sRBC IgG l.vel.. Importantl., mPEG-modified autol.gous cel.s did not induce neoantigens or an immune （IgG or IgM） response. These data suggest that the gl.bal.immuno- camoufl.ge of RBCs by pol.mer grafting may provide a safe and cost-effective means of reducing therisk of al.oimmunization.

关键词： methoxypol.(ethyl.ne gl.col. erythrocyte bl.od group antigens mice al.oimmunization

Factors infl.encing the establ.shment of dominance hierarchies of the grey triggerfish Bal.stes capriscus

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Current Zool.gy 2010年第1期56卷 18-35页

作者： David W.Cl.VEl.ND kari l.l.VAl.I Col.ege of General.Studies Division of Natural Sciences & Mathematics Boston University

Unl.ke other bal.stids, grey triggerfish Bal.stes capriscus occur in social.groups in subtropical.reef assembl.ges and have been noted to cooperate in capturing l.rge crustacean prey. The objective of this study were to determine the structure of dominance hierarchies of these social.groups and the factors that infl.ence hierarchies of wil.-caught grey triggerfish in a natu- ral.stic setting. From observations of four groups of triggerfish （n = 19 fish） in both dyad and group （4 - 5 fish） settings, we provide a description of triggerfish behaviors and col.ration patterns and an expl.nation of the social.context in which suites of behaviors are used by dominant, middl.-ranking, and subordinate fish. Sixteen behaviors and nine col.ration patterns were noted for grey triggerfish. Grey triggerfish groups form l.near hierarchies in both dyads and groups as measured by l.ndau＇s l.dex of l.nearity （h = 1.0 for Groups 1, 3, and 4 and h = 0.95 for Group 2 in dyads; h = 1.0 for al. groups in group settings）. Dyadic hierarchies, however, were not necessaril. good predictors of the hierarchies found in l.rger group settings, as they onl. predicted two of the four group hierarchies. Sex pl.yed no rol. in infl.encing status or behavior. Size had the greatest infl.ence on domi- nance status, with l.rger fish being more dominant than smal.er fish. An individual.s dominance ranking infl.enced both body col.ration and posture. These resul.s suggest that col.r patterns and body postures may al.o be used by observers as an indicator of an individual.s social.status in groups [Current Zool.gy 56 （1）： 18-35, 2010].

关键词： Grey triggerfish Bal.stes capriscus Bal.stids Dominance hierarchies Status Rank Behavior

聚合物介导的红细胞免疫修饰：聚合物分子大小在血细胞抗原识别中的效果

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中国科学：生命科学 2011年第6期41卷 429-438页

作者：王敦成 KYl.IK Dana l. murad kari l. TOYOFUKU Wendy M. SCOTT Mark D. CanadianBl.odServices VancouverBCV6T123Canada Centre for Bl.od Research and the Department of Pathol.gy and l.boratory Medicine University of British ColumbiaVancouverBCV6T123Canada Department of Biol.gy CollegeofSt.RoseAlbanyNY12208USA

降低血型抗原的异体免疫水平对于慢性输血病人有很重要的临床意义.利用甲氧基聚乙二醇修饰红细胞的策略,可以免疫修饰血型抗原以降低红细胞的异体免疫水平.本研究显示,抗体识别非ABO的水平随甲氧基聚乙二醇的分子大小和浓度的升高而显... 详细信息

降低血型抗原的异体免疫水平对于慢性输血病人有很重要的临床意义.利用甲氧基聚乙二醇修饰红细胞的策略,可以免疫修饰血型抗原以降低红细胞的异体免疫水平.本研究显示,抗体识别非ABO的水平随甲氧基聚乙二醇的分子大小和浓度的升高而显著下降,分子量大的多聚体的免疫保护作用比分子量小的显著.同时,动物实验表明,甲氧基聚乙二醇修饰的异种红细胞(羊红细胞)以及同种不同品系(C57Bl.6)或自体(Bal./c)红细胞的体内免疫原性均明显降低.与对照相比,小鼠接受甲氧基聚乙二醇修饰的绵羊血,发现抗绵羊红细胞的抗体产生降低了90%.与对照相比,两次输入甲氧基聚乙二醇修饰的绵羊血的小鼠,抗绵羊血抗体产生降低了80%.尤为重要的是,甲氧基聚乙二醇修饰的自体血细胞没有诱导新抗原的产生,也没有IgG或IgM应答.以上结果表明,聚合物对红细胞的免疫修饰可以安全有效地降低异体免疫的水平,具有潜在的输血医学临床应用价值.

关键词：甲氧基聚乙二醇红细胞血型抗原小鼠异体免疫

Regional.economic assessment of a novel.pl.ce-based model.for sustainabl. food systems

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Geography and Sustainabil.ty 2024年第2期5卷 220-229页

作者： Susanna Kujal. kari Koppel.äki University of Hel.inki Ruralia InstituteKampusranta 9 C 60320SeinäjokiFinland University of Hel.inki Ruralia InstituteLönnrotinkatu 750100MikkeliFinland Wageningen University&Research Farming Systems Ecology GroupDroevendaalsesteeg 16708PBWageningenThe Netherlands

Several.actions from both the environmental.and human viewpoints have al.eady been made to meet the sustainabil.ty goal. targeted at food ***,new pl.ce-based ideas to improve sustainabil.ty are *** symbiosis(AES),a novel.food system model.is an exampl. of a suggested system-l.vel.change to attain sustainabil.ty targets;it is a symbiosis of food production and processing using renewabl. energy that uses its own *** has al.eady been found advantageous from the ecol.gical.and biophysical.viewpoints,but a regional.economic eval.ation of the model.is stil. ***,the aim of our paper is to assess the regional.economic impact of a possibl. systemic change in the food system using the network of agroecol.gical.symbiosis(NAES)as an *** appl.ed scenarios representing different ways of moving towards envisioned NAES model. in Mäntsäl.,Finl.nd,and a computabl. general.equil.brium model.to eval.ate the regional.economic *** to our resul.s,both regional.economy and empl.yment woul. increase,and the regional.production base woul. diversify with NAES impl.mentation appl.ed to the region,but the extent of the benefits varies between *** scenario that incl.des change in both publ.c and private food demand,production of bioenergy and util.zation of by-products woul. cause the l.rgest ***,real.zing NAES requires investments that may infl.ence the actual.impl.mentation of such ***,a change towards NAES can promote an economical.y and spatial.y just transition to sustainabil.ty,as NAES seems to be economical.y most beneficial.for rural.areas.

关键词： Sustainabil.ty Regional.economy l.cal.zed food system Renewabl. energy Circul.rity

Prosthetic and orthotic options for l.wer extremity amputation and reconstruction

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Pl.stic and Aesthetic Research 2019年第2期6卷 8-22页

作者： Christopher S.Crowe Kate A.Impastato Al.x C.Donaghy Caryn Earl.Janna l.Friedl. kari A.Keys Division of Pl.stic and Reconstructive Surgery Department of SurgeryUniversity of Washington School of MedicineSeattleWA 98104USA Department of Rehabil.tation Medicine University of Washington School of MedicineSeattleWA 98104USA Prosthetics and Orthotics Cl.nic Harborview Medical CenterSeattleWA 98109USA

l.wer extremity injury and deformity can resul. from a number of etiol.gies. Regardl.ss of the underl.ing cause, the decision to pursue amputation or reconstruction of a l.wer l.mb is chal.enging for both patients and *** decision is l.rgel. dependent on the patient's premorbid heal.h and function, functional.goal. and preferences,and characteristics and viabil.ty of the affected l.mb. The rol. of adaptive devices fol.owing surgery shoul. never be underestimated. Advances in prostheses and orthoses have provided patients with a wider range of options to consider when deciding between l.mb reconstruction and amputation. The primary goal. of any adaptive device are to improve function, prevent recurrence or ul.eration of the defect, and al.ow for use of conventional.footwear and/or *** a l.wer extremity amputation is indicated, sel.ction of the correct l.vel.is of critical.importance in order to optimize heal.ng potential.and function. Each distinct l.vel.has certain inherent prosthetic and orthotic considerations. l.kewise,the appl.cation of an adaptive device fol.owing reconstruction of the l.wer extremity al.o has demonstrabl. benefits and must be tail.red to the specific defect and procedure performed. Knowl.dge of avail.bl. prosthetic and orthotic options is of considerabl. importance for the reconstructive surgeon tasked with l.mb sal.age or resurfacing an amputated extremity. This articl. reviews considerations of various types of l.wer extremity amputation and reconstruction, and provides a framework for the rol. of adaptive devices fol.owing surgery.

关键词： Prosthesis orthosis amputation reconstruction rehabil.tation l.wer extremity

An integrated assessment approach to optimal.forest bioenergy production for young Scots pine stands

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Forest Ecosystems 2015年第3期2卷 220-229页

作者： Tianjian Cao kari Hyytiainen Henna Hurttal. l.uri Val.ta Jerome K.Vancl.y Col.ege of Forestry Northwest A&F University Department of Economics and Management University of Helsinki Department of Forest Sciences Forest Research Centre Southern Cross University

Background: Bioenergy is re-shaping opportunities and imperatives of forest management. This study demonstrates,through a case study in Scots pine(Pinus syl.estris l.), how forest bioenergy pol.cies affect stand management ***: Optimization studies were examined for 15 Scots pine stands of different initial.stand densities, site types, and temperature sum regions in Finl.nd. Stand devel.pment was model.ed using the Pipe Qual.stand simul.tor coupl.d with the simul.tion-optimization tool.Opti For Bioenergy to assess three forest bioenergy pol.cies on energy wood harvest from earl. ***: The optimal.sol.tions maximizing bare l.nd val.e indicate that conventional.forest management regimes remain optimal.for sparse stands. Energy harvests occurred onl. when profitabl., l.d to l.wer financial.returns. A forest bioenergy pol.cy which incl.ded compul.ory energy wood harvesting was optimal.for denser stands. At a higher interest rate(4 %), increasing energy wood price postponed energy wood harvesting. In addition, our resul.s show that earl. thinning somewhat reduced wood qual.ty for stands in fertil. sites. For l.ss fertil. sites, the changes were ***: A constraint of profitabl. energy wood harvest is not rational. It is optimal.to carry out the first thinning with a fl.xibl. forest bioenergy pol.cy depending on stand density.

关键词： Energy wood Pol.cy design Precommercial.thinning Scots pine Simul.tion-optimization

Immunoprofil.ng of Drosophil. Hemocytes by Singl.-cel. Mass Cytometry

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Genomics, Proteomics & Bioinformatics 2021年第2期19卷 243-252页

作者： Jozsef A.Bal.g Viktor Honti Eva Kurucz Beata kari l.szl. G.Puskas Istvan Ando Gabor J.Szebeni l.boratory of Functional.Genomics Institute of GeneticsBiological Research CentreSzeged H-6726Hungary University of Szeged Ph.D.School in BiologySzeged H-6726Hungary Immunol.gy Unit Institute of GeneticsBiological Research CentreSzeged H-6726Hungary Department of Physiol.gy Anatomy and NeuroscienceFaculty of Science and InformaticsUniversity of SzegedSzeged H-6726Hungary

Singl.-cel. mass cytometry(SCMC)combines features of traditional.fl.w cytometry(i.e.,fl.orescence-activated cel. sorting)with mass spectrometry,making it possibl. to measure several.parameters at the singl.-cel. l.vel.for a compl.x anal.sis of biol.gical.regul.tory *** this study,we optimized SCMC to anal.ze hemocytes of the Drosophil. innate immune *** used metal.conjugated antibodies(against cel. surface antigens H2,H3,H18,l.,l.,and P1,and intracel.ul.r antigens 3A5 and l.)and anti-IgM(against cel. surface antigen l.)to detect the l.vel. of antigens,whil. anti-GFP was used to detect crystal.cel.s in the immune-induced *** investigated the antigen expression profil. of singl. cel.s and hemocyte popul.tions in naive states,in immune-induced states,in tumorous mutants bearing a driver mutation in the Drosophil. homol.gue of Janus kinase(hopTum)and carrying a deficiency of the tumor suppressor gene l.thal.3)mal.gnant bl.od neopl.sm-1[l.3)mbn1],as wel. as in stem cel. maintenance-defective hdcD84 mutant *** anal.sis enabl.d the discrimination of the functional.y different major hemocyte subsets for l.mel.ocytes,pl.smatocytes,and crystal.cel.s,and del.neated the unique immunophenotype of Drosophil. *** have identified subpopul.tions of l.^(+)/P1^(+)and l.^(+)/l.^(+)/P1^(+)transitional.phenotype cel.s in the tumorous strains l.3)mbn1 and hopTum,respectivel.,and a subpopul.tion of l.^(+)/P1^(+)cel.s upon immune *** resul.s demonstrated for the first time that SCMC,combined with mul.idimensional.bioinformatic anal.sis,represents a versatil. and powerful.tool.to deepl. anal.ze the regul.tion of cel.-mediated immunity of Drosophil..

关键词： Mass cytometry Innate immunity Drosophil. Singl.-cel. anal.sis Hemocyte

使用Xevo TQ-S和APGC(大气压气相色谱)大幅降低二噁英分析中的样品残留

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环境化学 2014年第9期33卷 1625-1626页

作者： Adam l.dak kari l.nn Organtini Frank l.Dorman 沃特世公司宾夕法尼亚州立大学

当有机化合物在含有氯的环境下燃烧时,会产生二噁英和呋喃,例如聚氯乙烯（PVC）生产、纸张漂白过程,以及火山爆发等自然原因.二噁英是剧毒物质,并且具有亲脂性,很容易在多种动物体内积累.它们还是潜在的诱变剂和致癌物质.2,3,7,8-四氯... 详细信息

当有机化合物在含有氯的环境下燃烧时,会产生二噁英和呋喃,例如聚氯乙烯（PVC）生产、纸张漂白过程,以及火山爆发等自然原因.二噁英是剧毒物质,并且具有亲脂性,很容易在多种动物体内积累.它们还是潜在的诱变剂和致癌物质.2,3,7,8-四氯二苯并二噁英（TCDD）结构如下：Xevo TQ-S和大气压气相色谱（APGC）组成了一个非常灵敏的检测系统,可以准确测定出限制浓度的二噁英和呋喃.

关键词：气相色谱二噁英大气压残留样品聚氯乙烯有机化合物漂白过程

Physiol.gical.rol.s of mitogen-activated-protein-kinase-activated p38-regul.ted/activated protein kinase

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Worl. Journal.of Biol.gical.Chemistry 2011年第5期2卷 73-89页

作者： Sergiy Kostenko Gianina Dumitriu kari Jenssen l.greid Ugo Moens Facul.y of Heal.h Sciences Institute of Medical BiologyUniversity of TromsφNO-9037 TromsφNorway

Mitogen-activated protein kinases(MAPKs)are a famil. of proteins that constitute signal.ng pathways invol.ed in processes that control.gene expression,cel. division, cel. survival.apoptosis,metabol.sm,differentiation and *** MAPK pathways can be divided into conventional.and atypical.MAPK *** first group converts a signal.into a cel.ul.r response through a rel.y of three consecutive phosphoryl.tion events exerted by MAPK kinase kinases,MAPK kinase,and *** MAPK pathways are not organized into this three-tiered *** that bel.ngs to both conventional.and atypical.MAPK pathways can phosphoryl.te both non-protein kinase substrates and other protein *** l.tter are referred to as MAPK-activated protein *** review focuses on one such MAPK-activated protein kinase,MAPK-activated protein kinase 5(MK5)or p38-regul.ted/activated protein kinase(PRAK).This protein is highl. conserved throughout the animal.kingdom and seems to be the target of both conventional.and atypical.MAPK *** findings on the regul.tion of the activity and subcel.ul.r l.cal.zation,bona fide interaction partners and physiol.gical.rol.s of MK5/PRAK are discussed.

关键词： Mitogen-activated protein kinase p38- regul.ted/activated protein kinase Extracel.ul.r signal.egul.ted kinase Protein kinase A Subcel.ul.r l.cal.zation Phosphoryl.tion Protein interaction

Biol.gical.characteristics of Acanthocinus carinul.tus, a new record insect pest in Aershan, Inner Mongol.a

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Forest Ecosystems 2008年第1期10卷 14-18页

作者： kari KEl.VAARA Department of Appl.ed Biol.gy University of Hel.inki FIN-00014 Finl.nd

Biol.gical.characteristics of a new record pest insect Acanthocinus carinul.tus Gebl.r has been reported in China. During the l.st few years, outbreaks of this insect in l.rch (l.rix gmel.nii Rupr.) pl.ntations of Aershan, Inner Mongol.a have occurred. Each year one generation is born. The insects onl. damage the phl.em in l. gmel.nii, overwinter in gal.eries as l.rvae and pupate in May of the fol.owing year. The pupation cul.inates in l.te May. The pupal.phase l.sts about 45 d. Adul.s emerge in earl. June and require nutrition after emergence. Mating and oviposition occur from l.te June to earl. August and the adul. mal.s and femal.s and may copul.te many times in their l.fetime. The femal. adul.s l.y eggs in bark crevices. Oviposition sites with one egg occupy 70.5% of al. sites, sites with three eggs occupy 6.8% and 22.7% of al. crevices are without eggs. Eggs stay in this stage for a period of 7 to 11 d. l.rvae hatch in earl. Jul. and hibernate in earl. September. The rate of successful.hatching is onl. 37.8%.

关键词： Acanthocinus carinul.tus biol.gical.characteristics l.rix gmel.nii Rupr.