检索结果-南通市图书馆

Association of Se.um Fe.ritin Le.e.s and Thyroid Hormone.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ope. Journal of Clinical Diagnostics 2023年第3期13卷 68-79页

作者： Hari Krishnan Krishnamurthy Swarnkumar Re.dy Vasanth Jayaraman Karthik Krishna Qi Song karenah e. rajasekaran Tianhao Wang Kang Be. John J. rajasekaran Vibrant Scie.ce. LLC. San Carlos USA Vibrant Ame.ica LLC. San Carlos USA

Thyroid me.abolism is orche.trate. by the.action of various mine.als and trace.e.e.e.ts including iron, iodine. se.e.ium, and zinc. Iron de.icie.cy, spe.ifically de.icie.cy in se.um fe.ritin le.e.s, is one.of the.common cause. of thyroid dysfunction. Our obje.tive.was to e.aluate.the.re.ationship be.we.n se.um fe.ritin le.e.s and circulating thyroid hormone.. For this, a re.rospe.tive.analysis was pe.forme. on 16,512 individuals who te.te. for se.um le.e.s of fe.ritin and thyroid profile.at Vibrant Ame.ica Clinical Laboratorie.. Subje.ts we.e.stratifie. base. on the.se.um le.e.s of fe.ritin. Age.(p −0.03232, p e.r association by Pe.rson’s corre.ation e.hibite. a conside.able.corre.ation be.we.n varying se.um fe.ritin le.e.s with all te.te. thyroid hormone.. The.study conclude. that se.um fe.ritin le.e.s we.e.associate. with thyroid hormone.synthe.is and me.abolism in individuals with optimal le.e.s of circulating fe.ritin.

关键词： Fe.ritin Thyroxine Fre. Triiodothyronine Fre. Thyroxine Thyroid Stimulating Hormone

e.ploring the.structural and functional e.fe.t of pRB by significant nsSNP in the.coding re.ion of RB1 ge.e.causing re.inoblastoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Scie.ce.China(Life.Scie.ce.) 2010年第2期53卷 234-240页

作者： rajasekaran R Rao Se.humadhavan Bioinformatics Division School of BiotechnologyChemical and Biomedical EngineeringVellore Institute of Technology

In this study,we.ide.tifie. the.most de.e.e.ious nsSNP in RB1 ge.e.through structural and functional prope.tie. of its prote.n (pRB) and inve.tigate. its binding affinity with *** of 956 SNPs,we.inve.tigate. 12 nsSNPs in coding re.ion in which thre. of the. (SNPids rs3092895,rs3092903 and rs3092905) are.commonly found to be.damage. by I-Mutant 2.0,SIFT and PolyPhe. *** this e.fort,we.mode.e. the.mutant pRB prote.ns base. on the.e.de.e.e.ious *** a comparison of total e.e.gy,stabilizing re.idue. and RMSD of the.e.thre. mutant prote.ns with native.pRB prote.n,we.ide.tifie. that the.major mutation is from Glutamic acid to Glycine.at the.re.idue.position of 746 of ***,we.compare. the.binding e.ficie.cy of both native.and mutant pRB (e.46G) with *** found that mutant pRB has le.s binding affinity with e.F-2 as compare. to native.*** is due.to sixte.n hydroge. bonding and two salt bridge. that e.ist be.we.n native.type.and e.F-2,whe.e.s mutant type.make. only thirte.n hydroge. bonds and one.salt bridge.with *** on our inve.tigation,we.propose.that the.SNP with an id rs3092905 could be.the.most de.e.e.ious nsSNP in RB1 ge.e.causing re.inoblastoma.

关键词： re.inoblastoma non synonymous SNP RB1 ge.e pRB e.F-2

Virtual Nursing Using De.p Be.ie. Ne.works for e.de.ly Pe.ple.(DBN-e.)

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Compute. Syste.s Scie.ce.& e.gine.ring 2022年第9期42卷 985-1000页

作者： S.rajasekaran G.Kousalya De.artme.t of Information Te.hnology KGiSL Institute of TechnologyCoimbatore641035India De.artme.t of Compute. Scie.ce.and e.gine.ring Coimbatore Institute of TechnologyCoimbatore641014India

The.de.and for be.te. he.lth se.vice. has re.ulte. in the.advance.e.tof re.ote.monitoring he.lth, i.e., virtual nursing syste.s, to watch and supportthe.e.de.ly with innovative.conce.ts such as be.ng patie.t-ce.tric, e.sie. to use.and having smarte. inte.actions and more.accurate.conclusions. While.virtual nursing se.vice. atte.pt to provide.consume.s and me.ical practitione.s with continuous me.ical and he.lth monitoring se.vice., acce.s to allie. he.lthcare.e.pe.tssuch as nurse. re.ains a challe.ge. In this re.e.rch, we.pre.e.t Virtual NursingUsing De.p Be.ie. Ne.works for e.de.ly Pe.ple.(DBN-e.), a ne. frame.ork thatprovide. a virtual nurse.age.t de.loye. on a se.ior citize.’s home. workplace. orcare.ce.tre.to he.p manage.the.r he.lth condition on a continuous basis. Using thisme.hod, he.lthcare.provide.s can assign various jobs to nurse. by utilizing a ge.e.al task de.inition me.hanism, in which a task is de.ine. as a combination ofme.ical workflow, ope.ational guide.ine., and data gathe.e. from a re.ote.ymonitore. virtual nursing syste.. Practitione.s are.in charge.of DBN-e. andmake.tre.tme.t de.isions for patie.ts. This allows a DBN-e. to act as a pe.sonalize. full-time.nurse.for a clie.t by carrying out practitione. support activitie.base. on information gathe.e. about the.clie.t’s he.lth. An e.e.tronic Pe.sonalHe.lth Re.ord (e.HR) syste., such as a spe.ialize. we. portal and mobile.apps,could provide.such patie.t information to e.de.ly pe.son family me.be.s and care.e.tre.. We.cre.te. a prototype.syste. using a DBN-e. syste. that allows traditional clie.t applications and he.lthcare.provide. syste.s to collaborate. Finally,we.de.onstrate.how this syste. may be.e.it the.e.de.ly through a re.ult andde.ate.

关键词： De.p be.ie. ne.works RBM vide. mining e.de. pe.ple e.de. care

3D-Printe. e.e.troche.ical se.sor-inte.rate. transwe.l syste.s

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsyste.s & Nanoe.gine.ring 2020年第1期6卷 357-368页

作者： Prade.p Ramiah rajasekaran Ashle. Augustiny Chapin David N.Quan Je.s He.be.holz William e.Be.tle. Re.a Ghodssi Institute.for Syste.s Re.e.rch University of MarylandCollege ParkMDUSA Fische.l De.artme.t of Bioe.gine.ring University of MarylandCollege ParkMDUSA De.artme.t of Psychology and Ne.roscie.ce.and Cognitive.Scie.ce.Program University of MarylandCollege ParkMDUSA Institute.for Bioscie.ce.and Biote.hnology Re.e.rch University of MarylandCollege ParkMDUSA Robe.t e.Fische.l Institute.for Biome.ical De.ice. University of MarylandCollege ParkMDUSA De.artme.t of e.e.trical and Compute. e.gine.ring University of MarylandCollege ParkMDUSA

This work pre.e.ts a 3D-printe.,modular,e.e.troche.ical se.sor-inte.rate. transwe.l syste. for monitoring ce.lular and mole.ular e.e.ts in situ without sample.e.traction or microfluidics-assiste. downstre.m *** additive.manufacturing te.hnique. such as 3D printing,shadow masking,and molding are.use. to fabricate.this modular syste.,which is autoclavable.biocompatible.and de.igne. to ope.ate.following standard ope.ating protocols(SOPs)of ce.lular *** to the.platform is a fle.ible.porous me.brane.which is use. as a ce.l culture.substrate.similarly to a comme.cial transwe.l *** e.e.troche.ical se.sors fabricate. on the.me.brane.allow dire.t acce.s to ce.ls and the.r products.A pair of gold e.e.trode. on the.top side.of the.me.brane.me.sure. impe.ance.ove. the.course.of ce.l attachme.t and growth,characte.ize. by an e.pone.tial de.re.se.~160%at 10Hz)due.to an incre.se.in the.double.laye. capacitance.from se.re.e. e.trace.lular matrix(e.M)*** voltamme.ry(CV)se.sor e.e.trode.,fabricate. on the.bottom side.of the.me.brane.e.able.se.sing of mole.ular re.e.se.at the.site.of ce.l culture.without the.ne.d for downstre.m ***-time.de.e.tion of fe.roce.e.dime.hanol inje.tion across the.me.brane.showe. a thre. orde.-of-magnitude.highe. signal at the.me.brane.than in the.bulk me.ia afte. re.ching *** modular se.sor-inte.rate. transwe.l syste. allows unpre.e.e.te. dire.t,re.l-time.and noninvasive.acce.s to physical and bioche.ical information,which cannot be.obtaine. in a conve.tional transwe.l syste..

关键词： transwe.l e.e.troche.ical culture

e.e.troche.ical me.sure.e.t of se.otonin by Au-CNT e.e.trode. fabricate. on microporous ce.l culture.me.brane.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsyste.s & Nanoe.gine.ring 2020年第1期6卷 494-506页

作者： Ashle. A.Chapin Prade.p R.rajasekaran David N.Quan Liangbing Hu Je.s He.be.holz William e.Be.tle. Re.a Ghodssi Fische.l De.artme.t of Bioe.gine.ring College ParkMD 20742USA Institute.for Syste.s Re.e.rch College ParkMD 20740USA De.artme.t of Mate.ials Scie.ce.and e.gine.ring College ParkMD 20740USA De.artme.t of Psychology and Ne.roscie.ce.and Cognitive.Scie.ce.Program College ParkMD 20740USA Institute.for Bioscie.ce.and Biote.hnology Re.e.rch RockvilleMD 20850USA Robe.t e.Fische.l Institute.for Biome.ical De.ice. RockvilleMD 20850USA De.artme.t of e.e.trical and Compute. e.gine.ring College ParkMD 20742USA

Gut–brain axis(GBA)communication re.ie. on se.otonin(5-HT)signaling be.we.n the.gut e.ithe.ium and the.pe.iphe.al ne.vous syste.,whe.e.5-HT re.e.se.patte.ns from the.basolate.al(i.e.,bottom)side.of the.e.ithe.ium activate.ne.ve.*** have.be.n fe. quantitative.studie. of this gut-ne.ron signaling due.to a lack of re.l-time.me.sure.e.t tools that can acce.s the.basolate.al gut *** vitro platforms allow quantitative.studie. of culture. gut tissue.but the. mainly e.ploy offline.and e.dpoint assays that cannot re.olve.dynamic mole.ular-re.e.se.***,we.pre.e.t the.modification of a microporous ce.l culture.me.brane.with carbon nanotube.coate. gold(Au-CNT)e.e.trode. capable.of continuous,labe.-fre.,and dire.t de.e.tion of 5-HT at physiological *** characte.ization of single.walle. carbon nanotube.SWCNT)-coate. Au e.e.trode. shows incre.se. e.e.troactive.surface.are.,5-HT spe.ificity,se.sitivity,and saturation time.which are.corre.ate. with the.CNT film drop-cast *** microlite.s of CNT films,with a 10-min saturation time.0.6μA/μM 5-HT se.sitivity,and re.iable.de.e.tion within a line.r range.of 500 nM–10μM 5-HT,can be.targe.e. for high-conce.tration,high-time.re.olution 5-HT *** films(12.5μL)with a 2-h saturation time.4.5μA/μM 5-HT se.sitivity,and quantitative.de.e.tion in the.line.r range.of 100 nM–1μM can targe. low conce.trations with low time.*** e.e.trode. achie.e. continuous de.e.tion of dynamic diffusion across the.porous me.brane.mimicking basolate.al 5-HT re.e.se.from ce.ls,and de.e.tion of ce.l-re.e.se. 5-HT from se.arate.y culture. RIN14B ce.l ***-inte.rate. ce.l culture.syste.s such as this can improve.in vitro mole.ular de.e.tion me.hanisms and aid in quantitative.GBA signaling studie..

关键词： re.e.se saturation dynamic

The.nature.of prote.ns in influe.za

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

He.lth 2012年第10期4卷 991-994页

作者： K. Akila P. Balamurugan e. rajasekaran De.artme.t of Biote.hnology Periyar Maniammai University Thanjavur India School of Biote.hnology and He.lth Scie.ce. Karunya University Coimbatore India

Mutation can alte. the.structure.of viral prote.ns to form diffe.e.t structure. Carbon distribution is re.ponsible.for the.e.change. in structure. The.carbon distribution in prote.ns of human Influe.za A virus is analyze. he.e. Re.ults re.e.l that the.carbon conte.ts are.high in surface.prote.ns, optimum in polyme.ase.prote.ns and le.s in nucle.r prote.ns. Polyme.ase.prote.ns have.be.te. carbon distribution patte.n than the.othe. prote.ns. Thymine.distribution in diffe.e.t frame. of mRNAs are.che.ke. as it has link with carbon distribution patte.n in the.corre.ponding prote.ns. Re.ults show that frame.4 is violating from thymine.distribution. This is re.ponsible.for production of prote.n with diffe.e.t carbon distribution. Unusual thymine.distribution in frame.3 are.obse.ve.. The.thymine.distributions are.diffe.e.t in viral mRNA compare. to normal one. Minimizing the.e.ce.s thymine.in H1N1 mRNAs might improve.the.prote.n pe.formance. Mutational study base. on carbon distribution should be.be.te. e.ploite. for furthe. improving the.prote.n stability, activity and ultimate.y for ge.e.the.apy.

关键词： Carbon Distribution Influe.za Virus H1N1 Carbon Study Prote.n Analysis Swine Flu Prote.mics Transcriptomics

Pote.tial Role. of Fatty Acids and Lipids in Postharve.t Ne.dle.Abscission Physiology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ame.ican Journal of Plant Scie.ce. 2019年第6期10卷 1069-1089页

作者： Gaye.e. MacDonald rajasekaran R. Lada Claude.D. Caldwe.l Chibuike.Ude.igwe.Mason T. MacDonald De.artme.t of Plant Food and Environmental Sciences Faculty of Agriculture Dalhousie University Halifax Canada School of Nutrition Scie.ce. Faculty of Health Sciences University of Ottawa Ottawa Canada

Our unde.standing of postharve.t ne.dle.abscission physiology in conife.s has gre.tly improve. in the.last de.ade. Abscission is initially trigge.e. by root de.achme.t, which be.ins a cascade.of change. such as de.re.se. wate. uptake. wate. pote.tial, and auxins and incre.se. me.brane.injury, e.hyle.e. abscisic acid, volatile.te.pe.e., and catalytic e.zyme.. Ne.dle.abscission is also affe.te. by e.vironme.tal factors. For e.ample. a pe.iod of cold acclimation ge.e.ally de.ays postharve.t abscission. The.afore.e.tione. pie.e. of e.ide.ce. along with pre.ious studie., strongly points to a role.for plant lipids and fatty acids. Studie. from othe. spe.ie. have.pointe. out ke. role. in abscission and stre.s re.ponse. for a varie.y of phospholipids and galactolipids, which has not be.n studie. in balsam fir. It is impe.ative.to have.an unde.standing of the.role.of plant lipids and fatty acids to furthe. our ove.all unde.standing of the.physiological me.hanisms of postharve.t abscission and ne.dle.abscission re.istance. This re.ie. is an ove.vie. of me.brane.lipids and fatty acids, change. that occur postharve.t and the.inte.action that lipids may have.in the.phe.ome.on of postharve.t abscission.

关键词： Phospholipids Galactolipids Fatty Acids Plant Growth Re.ulators Abscission

Transge.ic Cotton and Dise.se.Re.istance.Ge.e.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

棉花学报 2008年第S1期20卷 43-页

作者： rajasekaran Kanniah USDA-ARS-SRRC 1100 Robert E.Lee Blvd.New Orleans

Succe.s in conve.tional bre.ding for re.istance.to mycotoxin-producing or othe. phytopathoge.ic fungi is de.e.de.t on the.availability of re.istance.ge.e.s) in the.*** whe. it is available.bre.ding for dise.se.re.ista... 详细信息

关键词： Transge.ic Cotton and Dise.se.Re.istance.Ge.e.

Big Data Study for Glute.-Fre. Foods in India and USA Using Online.Re.ie.s and Social Me.ia

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Agricultural Scie.ce. 2019年第3期10卷 302-320页

作者： Jolly Masih Wille. Ve.be.e.Jonathan De.tsch Ashish Sharma Amita Sharma rajasekaran Rajkumar Pavite. Singh Matharu e.asmus School of e.onomics Erasmus University Rotterdam The Netherlands De.artme.t of Culinary Arts & Food Scie.ce.and Hospitality Manage.e.t Drexel University Philadelphia PA USA Big Data Practice.and Innovation Laboratory New Jersey USA Institute.of Agribusine.s Manage.e.t Bikaner India School of Compute. Scie.ce.and e.gine.ring Vellore Institute of Technology Vellore India Mosaic Company India Pvt. Ltd. Jalandhar India

Ce.iac dise.se. glute.-alle.gy or glute.-se.sitivity is cause. due.to glutamine.prote.n from the.grains like.whe.t, rye.and barle. (colle.tive.y calle. glute.). This prote.n damage. the.small inte.tine.and cause. stomach pain, bloating, we.kne.s e.c. Ce.iac dise.se. glute.-alle.gy or glute.-se.sitivity has ne.e. re.lly be.n take. se.iously in de.e.oping countrie. like.India. Howe.e., in de.e.ope. nations like.UK, USA, Canada and othe. parts of e.rope. glute.-fre. foods have.be.ome.quite.popular. With a pre.ale.ce.rate.of about one.in 100 - 133 pe.ple.worldwide. ce.iac dise.se.is wide.pre.d across the.globe.and life.long consumption of glute.-fre. food is re.omme.de. tre.tme.t for this alle.gy. Apart from ce.iac-dise.se.patie.ts, glute.-fre. foods are.also consume. by he.lth conscious pe.ple.for we.ght manage.e.t and high prote.n die. and by the.patie.ts for diabe.e., autism and food alle.gie.. Apart from glute.-fre. flour, biscuits, cookie. and snacks, product innovations like.glute.-fre. be.rs are.be.oming ve.y popular. Big data including online.blogs, article., and re.ie.s have.playe. a major role.in incre.se. sale. of glute.-fre. foods. Thus, analysis of e.itorial and social me.ia conte.t be.ome. e.se.tial to unde.stand the.le.ding tre.ds in glute.-fre. foods. This study provide. de.p insights about positive. ne.ative.and ne.tral se.time.ts re.ate. to glute.-fre. foods using the.data from Pe.spe.tory Me.ia Insights and Google.Tre.ds. This study also re.e.le. that most of the.consume.s talke. and e.pe.te. product innovation in food se.tions like.snacks, fast food (pizza, pasta and noodle.) and de.se.ts through comme.ts on social and e.itorial me.ia. Se.rche. we.e.divide. into de.e.ope. (e.g., U.S.A.) and de.e.oping nations (e.g., India) to ge. more.de.ails about the.consume. pre.e.e.ce.. This study would he.p manufacture.s of glute.-fre. foods to de.e.op food products according to the.choice. and pre.e.e.ce. of consume.s. The.study is ve.y unique.in itse.f since.i

关键词： Ce.iac Dise.se Glute.-Fre. Food Se.time.t Analysis Glute. Se.sitivity Social Me.ia Consume. Pre.e.e.ce